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Items: 48


Autophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice.

Lachance V, Wang Q, Sweet E, Choi I, Cai CZ, Zhuang XX, Zhang Y, Jiang JL, Blitzer RD, Bozdagi-Gunal O, Zhang B, Lu JH, Yue Z.

Mol Neurodegener. 2019 Nov 27;14(1):43. doi: 10.1186/s13024-019-0342-4.


Wilm's tumor 1 promotes memory flexibility.

Mariottini C, Munari L, Gunzel E, Seco JM, Tzavaras N, Hansen J, Stern SA, Gao V, Aleyasin H, Sharma A, Azeloglu EU, Hodes GE, Russo SJ, Huff V, Birtwistle MR, Blitzer RD, Alberini CM, Iyengar R.

Nat Commun. 2019 Aug 21;10(1):3756. doi: 10.1038/s41467-019-11781-x.


Correction: Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden.

Haure-Mirande JV, Wang M, Audrain M, Fanutza T, Kim SH, Heja S, Readhead B, Dudley JT, Blitzer RD, Schadt EE, Zhang B, Gandy S, Ehrlich ME.

Mol Psychiatry. 2019 Mar;24(3):472. doi: 10.1038/s41380-018-0301-4.


Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden.

Haure-Mirande JV, Wang M, Audrain M, Fanutza T, Kim SH, Heja S, Readhead B, Dudley JT, Blitzer RD, Schadt EE, Zhang B, Gandy S, Ehrlich ME.

Mol Psychiatry. 2019 Mar;24(3):431-446. doi: 10.1038/s41380-018-0255-6. Epub 2018 Oct 3. Erratum in: Mol Psychiatry. 2018 Nov 21;:.


Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.

Audrain M, Haure-Mirande JV, Wang M, Kim SH, Fanutza T, Chakrabarty P, Fraser P, St George-Hyslop PH, Golde TE, Blitzer RD, Schadt EE, Zhang B, Ehrlich ME, Gandy S.

Mol Psychiatry. 2019 Sep;24(9):1383-1397. doi: 10.1038/s41380-018-0258-3. Epub 2018 Oct 3.


Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions.

Zakirova Z, Fanutza T, Bonet J, Readhead B, Zhang W, Yi Z, Beauvais G, Zwaka TP, Ozelius LJ, Blitzer RD, Gonzalez-Alegre P, Ehrlich ME.

PLoS Genet. 2018 Jan 24;14(1):e1007169. doi: 10.1371/journal.pgen.1007169. eCollection 2018 Jan.


Erratum: Infantile amnesia reflects a developmental critical period for hippocampal learning.

Travaglia A, Bisaz R, Sweet ES, Blitzer RD, Alberini CM.

Nat Neurosci. 2017 Jun 27;20(7):1033. doi: 10.1038/nn0717-1033a. No abstract available.


Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.

Haure-Mirande JV, Audrain M, Fanutza T, Kim SH, Klein WL, Glabe C, Readhead B, Dudley JT, Blitzer RD, Wang M, Zhang B, Schadt EE, Gandy S, Ehrlich ME.

Acta Neuropathol. 2017 Nov;134(5):769-788. doi: 10.1007/s00401-017-1737-3. Epub 2017 Jun 13.


Infantile amnesia reflects a developmental critical period for hippocampal learning.

Travaglia A, Bisaz R, Sweet ES, Blitzer RD, Alberini CM.

Nat Neurosci. 2016 Sep;19(9):1225-33. doi: 10.1038/nn.4348. Epub 2016 Jul 18. Erratum in: Nat Neurosci. 2017 Jun 27;20(7):1033.


The Parkinson's Disease-Associated Mutation LRRK2-G2019S Impairs Synaptic Plasticity in Mouse Hippocampus.

Sweet ES, Saunier-Rebori B, Yue Z, Blitzer RD.

J Neurosci. 2015 Aug 12;35(32):11190-5. doi: 10.1523/JNEUROSCI.0040-15.2015.


Critical Role of Histone Turnover in Neuronal Transcription and Plasticity.

Maze I, Wenderski W, Noh KM, Bagot RC, Tzavaras N, Purushothaman I, Elsässer SJ, Guo Y, Ionete C, Hurd YL, Tamminga CA, Halene T, Farrelly L, Soshnev AA, Wen D, Rafii S, Birtwistle MR, Akbarian S, Buchholz BA, Blitzer RD, Nestler EJ, Yuan ZF, Garcia BA, Shen L, Molina H, Allis CD.

Neuron. 2015 Jul 1;87(1):77-94. doi: 10.1016/j.neuron.2015.06.014.


Cocoa extracts reduce oligomerization of amyloid-β: implications for cognitive improvement in Alzheimer's disease.

Wang J, Varghese M, Ono K, Yamada M, Levine S, Tzavaras N, Gong B, Hurst WJ, Blitzer RD, Pasinetti GM.

J Alzheimers Dis. 2014;41(2):643-50. doi: 10.3233/JAD-132231.


Parental THC exposure leads to compulsive heroin-seeking and altered striatal synaptic plasticity in the subsequent generation.

Szutorisz H, DiNieri JA, Sweet E, Egervari G, Michaelides M, Carter JM, Ren Y, Miller ML, Blitzer RD, Hurd YL.

Neuropsychopharmacology. 2014 May;39(6):1315-23. doi: 10.1038/npp.2013.352. Epub 2014 Jan 2.


Targeted deletion of the gene encoding the La autoantigen (Sjögren's syndrome antigen B) in B cells or the frontal brain causes extensive tissue loss.

Gaidamakov S, Maximova OA, Chon H, Blewett NH, Wang H, Crawford AK, Day A, Tulchin N, Crouch RJ, Morse HC 3rd, Blitzer RD, Maraia RJ.

Mol Cell Biol. 2014 Jan;34(1):123-31. doi: 10.1128/MCB.01010-13. Epub 2013 Nov 4.


Receptor heteromerization expands the repertoire of cannabinoid signaling in rodent neurons.

Rozenfeld R, Bushlin I, Gomes I, Tzavaras N, Gupta A, Neves S, Battini L, Gusella GL, Lachmann A, Ma'ayan A, Blitzer RD, Devi LA.

PLoS One. 2012;7(1):e29239. doi: 10.1371/journal.pone.0029239. Epub 2012 Jan 3.


Synaptic stimulation of mTOR is mediated by Wnt signaling and regulation of glycogen synthetase kinase-3.

Ma T, Tzavaras N, Tsokas P, Landau EM, Blitzer RD.

J Neurosci. 2011 Nov 30;31(48):17537-46. doi: 10.1523/JNEUROSCI.4761-11.2011.


A critical role for IGF-II in memory consolidation and enhancement.

Chen DY, Stern SA, Garcia-Osta A, Saunier-Rebori B, Pollonini G, Bambah-Mukku D, Blitzer RD, Alberini CM.

Nature. 2011 Jan 27;469(7331):491-7. doi: 10.1038/nature09667.


Dysregulation of the mTOR pathway mediates impairment of synaptic plasticity in a mouse model of Alzheimer's disease.

Ma T, Hoeffer CA, Capetillo-Zarate E, Yu F, Wong H, Lin MT, Tampellini D, Klann E, Blitzer RD, Gouras GK.

PLoS One. 2010 Sep 20;5(9). pii: e12845. doi: 10.1371/journal.pone.0012845.


Testosterone-induced hypertrophy of L6 myoblasts is dependent upon Erk and mTOR.

Wu Y, Bauman WA, Blitzer RD, Cardozo C.

Biochem Biophys Res Commun. 2010 Oct 1;400(4):679-83. doi: 10.1016/j.bbrc.2010.08.127. Epub 2010 Sep 9.


REDD1 is a major target of testosterone action in preventing dexamethasone-induced muscle loss.

Wu Y, Zhao W, Zhao J, Zhang Y, Qin W, Pan J, Bauman WA, Blitzer RD, Cardozo C.

Endocrinology. 2010 Mar;151(3):1050-9. doi: 10.1210/en.2009-0530. Epub 2009 Dec 23.


Cell shape and negative links in regulatory motifs together control spatial information flow in signaling networks.

Neves SR, Tsokas P, Sarkar A, Grace EA, Rangamani P, Taubenfeld SM, Alberini CM, Schaff JC, Blitzer RD, Moraru II, Iyengar R.

Cell. 2008 May 16;133(4):666-80. doi: 10.1016/j.cell.2008.04.025.


Formation of regulatory patterns during signal propagation in a Mammalian cellular network.

Ma'ayan A, Jenkins SL, Neves S, Hasseldine A, Grace E, Dubin-Thaler B, Eungdamrong NJ, Weng G, Ram PT, Rice JJ, Kershenbaum A, Stolovitzky GA, Blitzer RD, Iyengar R.

Science. 2005 Aug 12;309(5737):1078-83.


Local protein synthesis mediates a rapid increase in dendritic elongation factor 1A after induction of late long-term potentiation.

Tsokas P, Grace EA, Chan P, Ma T, Sealfon SC, Iyengar R, Landau EM, Blitzer RD.

J Neurosci. 2005 Jun 15;25(24):5833-43.


Toward predictive models of mammalian cells.

Ma'ayan A, Blitzer RD, Iyengar R.

Annu Rev Biophys Biomol Struct. 2005;34:319-49. Review.


Teaching resources. Ligand-gated ion channels.

Blitzer RD.

Sci STKE. 2005 Apr 19;2005(280):tr12.


Postsynaptic signaling networks: cellular cogwheels underlying long-term plasticity.

Blitzer RD, Iyengar R, Landau EM.

Biol Psychiatry. 2005 Jan 15;57(2):113-9. Review.


Mitogen-activated protein kinase regulates early phosphorylation and delayed expression of Ca2+/calmodulin-dependent protein kinase II in long-term potentiation.

Giovannini MG, Blitzer RD, Wong T, Asoma K, Tsokas P, Morrison JH, Iyengar R, Landau EM.

J Neurosci. 2001 Sep 15;21(18):7053-62.


Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate.

Brown GP, Blitzer RD, Connor JH, Wong T, Shenolikar S, Iyengar R, Landau EM.

J Neurosci. 2000 Nov 1;20(21):7880-7.


Amyloid beta peptides activate the phosphoinositide signaling pathway in oocytes expressing rat brain RNA.

Blitzer RD, Wong T, Giovannini MG, Pangalos MN, Robakis NK, Landau EM.

Brain Res Mol Brain Res. 2000 Mar 10;76(1):115-20.


Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP.

Blitzer RD, Connor JH, Brown GP, Wong T, Shenolikar S, Iyengar R, Landau EM.

Science. 1998 Jun 19;280(5371):1940-2.


Metabotropic glutamate receptors limit adenylyl cyclase-mediated effects in rat hippocampus via protein kinase C.

Nouranifar R, Blitzer RD, Wong T, Landau E.

Neurosci Lett. 1998 Mar 13;244(2):101-5.


Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease.

Klein JT, Davis L, Olsen GE, Wong GS, Huger FP, Smith CP, Petko WW, Cornfeldt M, Wilker JC, Blitzer RD, Landau E, Haroutunian V, Martin LL, Effland RC.

J Med Chem. 1996 Jan 19;39(2):570-81.


Postsynaptic cAMP pathway gates early LTP in hippocampal CA1 region.

Blitzer RD, Wong T, Nouranifar R, Iyengar R, Landau EM.

Neuron. 1995 Dec;15(6):1403-14.


The cholinergic inhibition of afterhyperpolarization in rat hippocampus is independent of cAMP-dependent protein kinase.

Blitzer RD, Wong T, Nouranifar R, Landau EM.

Brain Res. 1994 May 23;646(2):312-4.


Whole-cell patch recording in brain slices.

Blitzer RD, Landau EM.

Methods Enzymol. 1994;238:375-84. No abstract available.


Chloride current assay for phospholipase C in Xenopus oocytes.

Landau EM, Blitzer RD.

Methods Enzymol. 1994;238:140-54. No abstract available.


Receptor-evoked Cl- current in Xenopus oocytes is mediated through a beta-type phospholipase C. Cloning of a new form of the enzyme.

Ma HW, Blitzer RD, Healy EC, Premont RT, Landau EM, Iyengar R.

J Biol Chem. 1993 Sep 25;268(27):19915-8.


Coupling of the expressed alpha 1B-adrenergic receptor to the phospholipase C pathway in Xenopus oocytes. The role of Go.

Blitzer RD, Omri G, De Vivo M, Carty DJ, Premont RT, Codina J, Birnbaumer L, Cotecchia S, Caron MG, Lefkowitz RJ, et al.

J Biol Chem. 1993 Apr 5;268(10):7532-7.


Nifedipine blocks calcium-dependent cholinergic depolarization in the guinea pig hippocampus.

Blitzer RD, Gil O, Omri G, Landau EM.

Brain Res. 1991 Mar 1;542(2):293-9.


Long-term potentiation in rat hippocampus is inhibited by low concentrations of ethanol.

Blitzer RD, Gil O, Landau EM.

Brain Res. 1990 Dec 24;537(1-2):203-8.


Cholinergic stimulation enhances long-term potentiation in the CA1 region of rat hippocampus.

Blitzer RD, Gil O, Landau EM.

Neurosci Lett. 1990 Nov 13;119(2):207-10.


Ethanol suppresses hippocampal cell firing through a calcium and cyclic AMP-sensitive mechanism.

Benson DM, Blitzer RD, Landau EM.

Eur J Pharmacol. 1989 May 30;164(3):591-4.


Functional muscarinic supersensitivity in denervated rat hippocampus.

Benson DM, Blitzer RD, Haroutunian V, Landau EM.

Brain Res. 1989 Jan 30;478(2):399-402.


Functional expression of brain cholecystokinin and bombesin receptors in Xenopus oocytes.

Moriarty TM, Gillo B, Sealfon S, Roberts JL, Blitzer RD, Landau EM.

Brain Res. 1988 Aug;464(1):75-9.


Characterization of the bupropion cue in the rat: lack of evidence for a dopaminergic mechanism.

Blitzer RD, Becker RE.

Psychopharmacology (Berl). 1985;85(2):173-7.


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