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Methods for Detection of Pyrin Inflammasome Assembly in Macrophages Infected with Yersinia spp.

Medici NP, Bliska JB.

Methods Mol Biol. 2019;2010:241-255. doi: 10.1007/978-1-4939-9541-7_17.


Characterization of Pyrin Dephosphorylation and Inflammasome Activation in Macrophages as Triggered by the Yersinia Effectors YopE and YopT.

Medici NP, Rashid M, Bliska JB.

Infect Immun. 2019 Feb 21;87(3). pii: e00822-18. doi: 10.1128/IAI.00822-18. Print 2019 Mar.


A Single Amino Acid Change in the Response Regulator PhoP, Acquired during Yersinia pestis Evolution, Affects PhoP Target Gene Transcription and Polymyxin B Susceptibility.

Fukuto HS, Vadyvaloo V, McPhee JB, Poinar HN, Holmes EC, Bliska JB.

J Bacteriol. 2018 Apr 9;200(9). pii: e00050-18. doi: 10.1128/JB.00050-18. Print 2018 May 1.


CCR2+ Inflammatory Monocytes Are Recruited to Yersinia pseudotuberculosis Pyogranulomas and Dictate Adaptive Responses at the Expense of Innate Immunity during Oral Infection.

Zhang Y, Khairallah C, Sheridan BS, van der Velden AWM, Bliska JB.

Infect Immun. 2018 Feb 20;86(3). pii: e00782-17. doi: 10.1128/IAI.00782-17. Print 2018 Mar.


White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection.

Han SJ, Glatman Zaretsky A, Andrade-Oliveira V, Collins N, Dzutsev A, Shaik J, Morais da Fonseca D, Harrison OJ, Tamoutounour S, Byrd AL, Smelkinson M, Bouladoux N, Bliska JB, Brenchley JM, Brodsky IE, Belkaid Y.

Immunity. 2017 Dec 19;47(6):1154-1168.e6. doi: 10.1016/j.immuni.2017.11.009. Epub 2017 Dec 5.


Effects of host cell sterol composition upon internalization of Yersinia pseudotuberculosis and clustered β1 integrin.

Kim J, Fukuto HS, Brown DA, Bliska JB, London E.

J Biol Chem. 2018 Jan 26;293(4):1466-1479. doi: 10.1074/jbc.M117.811224. Epub 2017 Dec 2.


Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components.

Zwack EE, Feeley EM, Burton AR, Hu B, Yamamoto M, Kanneganti TD, Bliska JB, Coers J, Brodsky IE.

Infect Immun. 2017 Sep 20;85(10). pii: e00778-16. doi: 10.1128/IAI.00778-16. Print 2017 Oct.


The Yersinia Virulence Factor YopM Hijacks Host Kinases to Inhibit Type III Effector-Triggered Activation of the Pyrin Inflammasome.

Chung LK, Park YH, Zheng Y, Brodsky IE, Hearing P, Kastner DL, Chae JJ, Bliska JB.

Cell Host Microbe. 2016 Sep 14;20(3):296-306. doi: 10.1016/j.chom.2016.07.018. Epub 2016 Aug 25.


Gut Check: IFNγ Delays Mucosal Recovery during Antibiotic Therapy.

Chung LK, Bliska JB.

Cell Host Microbe. 2016 Aug 10;20(2):128-9. doi: 10.1016/j.chom.2016.07.016.


The Importance of Role Models in Research.

Bliska JB.

PLoS Pathog. 2016 Jun 2;12(6):e1005426. doi: 10.1371/journal.ppat.1005426. eCollection 2016 Jun. No abstract available.


Uncovering an Important Role for YopJ in the Inhibition of Caspase-1 in Activated Macrophages and Promoting Yersinia pseudotuberculosis Virulence.

Schoberle TJ, Chung LK, McPhee JB, Bogin B, Bliska JB.

Infect Immun. 2016 Mar 24;84(4):1062-1072. doi: 10.1128/IAI.00843-15. Print 2016 Apr.


Yersinia versus host immunity: how a pathogen evades or triggers a protective response.

Chung LK, Bliska JB.

Curr Opin Microbiol. 2016 Feb;29:56-62. doi: 10.1016/j.mib.2015.11.001. Epub 2015 Nov 27. Review.


CCR2+ Inflammatory Dendritic Cells and Translocation of Antigen by Type III Secretion Are Required for the Exceptionally Large CD8+ T Cell Response to the Protective YopE69-77 Epitope during Yersinia Infection.

Zhang Y, Tam JW, Mena P, van der Velden AW, Bliska JB.

PLoS Pathog. 2015 Oct 15;11(10):e1005167. doi: 10.1371/journal.ppat.1005167. eCollection 2015 Oct.


Random mutagenesis identifies a C-terminal region of YopD important for Yersinia type III secretion function.

Solomon R, Zhang W, McCrann G, Bliska JB, Viboud GI.

PLoS One. 2015 Mar 25;10(3):e0120471. doi: 10.1371/journal.pone.0120471. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0130112.


Inflammasome activation in response to the Yersinia type III secretion system requires hyperinjection of translocon proteins YopB and YopD.

Zwack EE, Snyder AG, Wynosky-Dolfi MA, Ruthel G, Philip NH, Marketon MM, Francis MS, Bliska JB, Brodsky IE.

MBio. 2015 Feb 17;6(1):e02095-14. doi: 10.1128/mBio.02095-14.


The GAP activity of type III effector YopE triggers killing of Yersinia in macrophages.

Wang X, Parashar K, Sitaram A, Bliska JB.

PLoS Pathog. 2014 Aug 28;10(8):e1004346. doi: 10.1371/journal.ppat.1004346. eCollection 2014 Aug.


IQGAP1 is important for activation of caspase-1 in macrophages and is targeted by Yersinia pestis type III effector YopM.

Chung LK, Philip NH, Schmidt VA, Koller A, Strowig T, Flavell RA, Brodsky IE, Bliska JB.

MBio. 2014 Jul 1;5(4):e01402-14. doi: 10.1128/mBio.01402-14.


Epidemiology of pathogenic enterobacteria in humans, livestock, and peridomestic rodents in rural Madagascar.

Bublitz DC, Wright PC, Bodager JR, Rasambainarivo FT, Bliska JB, Gillespie TR.

PLoS One. 2014 Jul 1;9(7):e101456. doi: 10.1371/journal.pone.0101456. eCollection 2014.


TNFα and IFNγ but not perforin are critical for CD8 T cell-mediated protection against pulmonary Yersinia pestis infection.

Szaba FM, Kummer LW, Duso DK, Koroleva EP, Tumanov AV, Cooper AM, Bliska JB, Smiley ST, Lin JS.

PLoS Pathog. 2014 May 22;10(5):e1004142. doi: 10.1371/journal.ppat.1004142. eCollection 2014 May.


Effector CD8+ T cells are generated in response to an immunodominant epitope in type III effector YopE during primary Yersinia pseudotuberculosis infection.

Zhang Y, Mena P, Romanov G, Bliska JB.

Infect Immun. 2014 Jul;82(7):3033-44. doi: 10.1128/IAI.01687-14. Epub 2014 May 5.


CD11b+ Ly6Chi Ly6G- immature myeloid cells recruited in response to Salmonella enterica serovar Typhimurium infection exhibit protective and immunosuppressive properties.

Tam JW, Kullas AL, Mena P, Bliska JB, van der Velden AW.

Infect Immun. 2014 Jun;82(6):2606-14. doi: 10.1128/IAI.01590-13. Epub 2014 Apr 7.


Rabbit monoclonal antibodies directed at the T3SS effector protein YopM identify human pathogenic Yersinia isolates.

Rüter C, Silva MR, Grabowski B, Lubos ML, Scharnert J, Poceva M, von Tils D, Flieger A, Heesemann J, Bliska JB, Schmidt MA.

Int J Med Microbiol. 2014 May;304(3-4):444-51. doi: 10.1016/j.ijmm.2014.02.003. Epub 2014 Feb 18.


Direct neutralization of type III effector translocation by the variable region of a monoclonal antibody to Yersinia pestis LcrV.

Ivanov MI, Hill J, Bliska JB.

Clin Vaccine Immunol. 2014 May;21(5):667-73. doi: 10.1128/CVI.00013-14. Epub 2014 Mar 5.


Editorial: Yersinia pestis survives in neutrophils and sends a PS to macrophages: bon appetit!

Fukuto HS, Bliska JB.

J Leukoc Biol. 2014 Mar;95(3):383-5. doi: 10.1189/jlb.1013556. No abstract available.


Yersinia pestis and the plague of Justinian 541-543 AD: a genomic analysis.

Wagner DM, Klunk J, Harbeck M, Devault A, Waglechner N, Sahl JW, Enk J, Birdsell DN, Kuch M, Lumibao C, Poinar D, Pearson T, Fourment M, Golding B, Riehm JM, Earn DJ, Dewitte S, Rouillard JM, Grupe G, Wiechmann I, Bliska JB, Keim PS, Scholz HC, Holmes EC, Poinar H.

Lancet Infect Dis. 2014 Apr;14(4):319-26. doi: 10.1016/S1473-3099(13)70323-2. Epub 2014 Jan 28.


Modulation of innate immune responses by Yersinia type III secretion system translocators and effectors.

Bliska JB, Wang X, Viboud GI, Brodsky IE.

Cell Microbiol. 2013 Oct;15(10):1622-31. doi: 10.1111/cmi.12164. Epub 2013 Jul 29. Review.


Salmonella "sops" up a preferred electron receptor in the inflamed intestine.

Bliska JB, van der Velden AW.

MBio. 2012 Aug 14;3(4):e00226-12. doi: 10.1128/mBio.00226-12. Print 2012.


Roles of chaperone/usher pathways of Yersinia pestis in a murine model of plague and adhesion to host cells.

Hatkoff M, Runco LM, Pujol C, Jayatilaka I, Furie MB, Bliska JB, Thanassi DG.

Infect Immun. 2012 Oct;80(10):3490-500. doi: 10.1128/IAI.00434-12. Epub 2012 Jul 30.


YopJ-induced caspase-1 activation in Yersinia-infected macrophages: independent of apoptosis, linked to necrosis, dispensable for innate host defense.

Zheng Y, Lilo S, Mena P, Bliska JB.

PLoS One. 2012;7(4):e36019. doi: 10.1371/journal.pone.0036019. Epub 2012 Apr 26.


Interleukin-10 induction is an important virulence function of the Yersinia pseudotuberculosis type III effector YopM.

McPhee JB, Mena P, Zhang Y, Bliska JB.

Infect Immun. 2012 Jul;80(7):2519-27. doi: 10.1128/IAI.06364-11. Epub 2012 Apr 30.


Surface organelles assembled by secretion systems of Gram-negative bacteria: diversity in structure and function.

Thanassi DG, Bliska JB, Christie PJ.

FEMS Microbiol Rev. 2012 Nov;36(6):1046-82. doi: 10.1111/j.1574-6976.2012.00342.x. Epub 2012 May 24. Review.


Synthesis, chemical reactivity as Michael acceptors, and biological potency of monocyclic cyanoenones, novel and highly potent anti-inflammatory and cytoprotective agents.

Zheng S, Santosh Laxmi YR, David E, Dinkova-Kostova AT, Shiavoni KH, Ren Y, Zheng Y, Trevino I, Bumeister R, Ojima I, Wigley WC, Bliska JB, Mierke DF, Honda T.

J Med Chem. 2012 May 24;55(10):4837-46. doi: 10.1021/jm3003922. Epub 2012 May 7.


Structural insights into RipC, a putative citrate lyase β subunit from a Yersinia pestis virulence operon.

Torres R, Chim N, Sankaran B, Pujol C, Bliska JB, Goulding CW.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jan 1;68(Pt 1):2-7. doi: 10.1107/S1744309111048056. Epub 2011 Dec 24.


Letter to the Editor and response.

McPhee JB, Bliska JB.

Innate Immun. 2011 Dec;17(6):558-9. doi: 10.1177/1753425911426251. No abstract available.


A transposon site hybridization screen identifies galU and wecBC as important for survival of Yersinia pestis in murine macrophages.

Klein KA, Fukuto HS, Pelletier M, Romanov G, Grabenstein JP, Palmer LE, Ernst R, Bliska JB.

J Bacteriol. 2012 Feb;194(3):653-62. doi: 10.1128/JB.06237-11. Epub 2011 Dec 2.


A protective epitope in type III effector YopE is a major CD8 T cell antigen during primary infection with Yersinia pseudotuberculosis.

Zhang Y, Mena P, Romanov G, Lin JS, Smiley ST, Bliska JB.

Infect Immun. 2012 Jan;80(1):206-14. doi: 10.1128/IAI.05971-11. Epub 2011 Nov 7.


Biochemical, structural and molecular dynamics analyses of the potential virulence factor RipA from Yersinia pestis.

Torres R, Swift RV, Chim N, Wheatley N, Lan B, Atwood BR, Pujol C, Sankaran B, Bliska JB, Amaro RE, Goulding CW.

PLoS One. 2011;6(9):e25084. doi: 10.1371/journal.pone.0025084. Epub 2011 Sep 26.


Type III secretion system-dependent translocation of ectopically expressed Yop effectors into macrophages by intracellular Yersinia pseudotuberculosis.

Zhang Y, Romanov G, Bliska JB.

Infect Immun. 2011 Nov;79(11):4322-31. doi: 10.1128/IAI.05396-11. Epub 2011 Aug 15.


A Yersinia effector with enhanced inhibitory activity on the NF-κB pathway activates the NLRP3/ASC/caspase-1 inflammasome in macrophages.

Zheng Y, Lilo S, Brodsky IE, Zhang Y, Medzhitov R, Marcu KB, Bliska JB.

PLoS Pathog. 2011 Apr;7(4):e1002026. doi: 10.1371/journal.ppat.1002026. Epub 2011 Apr 21.


Mathematical relationship between cytokine concentrations and pathogen levels during infection.

Zhang Y, Bliska JB.

Cytokine. 2011 Feb;53(2):158-62. doi: 10.1016/j.cyto.2010.09.008. Epub 2010 Nov 18.


TNFα and IFNγ contribute to F1/LcrV-targeted immune defense in mouse models of fully virulent pneumonic plague.

Lin JS, Park S, Adamovicz JJ, Hill J, Bliska JB, Cote CK, Perlin DS, Amemiya K, Smiley ST.

Vaccine. 2010 Dec 16;29(2):357-62. doi: 10.1016/j.vaccine.2010.08.099. Epub 2010 Sep 15.


A Yersinia effector protein promotes virulence by preventing inflammasome recognition of the type III secretion system.

Brodsky IE, Palm NW, Sadanand S, Ryndak MB, Sutterwala FS, Flavell RA, Bliska JB, Medzhitov R.

Cell Host Microbe. 2010 May 20;7(5):376-87. doi: 10.1016/j.chom.2010.04.009.


The smpB-ssrA mutant of Yersinia pestis functions as a live attenuated vaccine to protect mice against pulmonary plague infection.

Okan NA, Mena P, Benach JL, Bliska JB, Karzai AW.

Infect Immun. 2010 Mar;78(3):1284-93. doi: 10.1128/IAI.00976-09. Epub 2010 Jan 11.


Yersinia pestis can bypass protective antibodies to LcrV and activation with gamma interferon to survive and induce apoptosis in murine macrophages.

Noel BL, Lilo S, Capurso D, Hill J, Bliska JB.

Clin Vaccine Immunol. 2009 Oct;16(10):1457-66. doi: 10.1128/CVI.00172-09. Epub 2009 Aug 26.


How Yersinia pestis becomes a foreign obstruction in the digestive system of the macrophage.

Klein KA, Bliska JB.

Autophagy. 2009 Aug;5(6):882-3. Epub 2009 Aug 22. No abstract available.


Yersinia pestis can reside in autophagosomes and avoid xenophagy in murine macrophages by preventing vacuole acidification.

Pujol C, Klein KA, Romanov GA, Palmer LE, Cirota C, Zhao Z, Bliska JB.

Infect Immun. 2009 Jun;77(6):2251-61. doi: 10.1128/IAI.00068-09. Epub 2009 Mar 16.


Intracellular pathogenic bacteria and fungi--a case of convergent evolution?

Bliska JB, Casadevall A.

Nat Rev Microbiol. 2009 Feb;7(2):165-71. doi: 10.1038/nrmicro2049. Epub 2008 Dec 22. Review.


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