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The CINP guidelines on the definition and the evidence-based interventions for treatment-resistant Bipolar disorder.

Fountoulakis KN, Yatham L, Grunze H, Vieta E, Young A, Blier P, Tohen M, Kasper S, Moeller HJ.

Int J Neuropsychopharmacol. 2019 Dec 5. pii: pyz064. doi: 10.1093/ijnp/pyz064. [Epub ahead of print]


Linking paternally inherited mtDNA variants and sperm performance.

Bettinazzi S, Nadarajah S, Dalpé A, Milani L, Blier PU, Breton S.

Philos Trans R Soc Lond B Biol Sci. 2020 Jan 20;375(1790):20190177. doi: 10.1098/rstb.2019.0177. Epub 2019 Dec 2.


Cardiac mitochondrial plasticity and thermal sensitivity in a fish inhabiting an artificially heated ecosystem.

Pichaud N, Ekström A, Breton S, Sundström F, Rowinski P, Blier PU, Sandblom E.

Sci Rep. 2019 Nov 28;9(1):17832. doi: 10.1038/s41598-019-54165-3.


Single and repeated ketamine infusions for reduction of suicidal ideation in treatment-resistant depression.

Phillips JL, Norris S, Talbot J, Hatchard T, Ortiz A, Birmingham M, Owoeye O, Batten LA, Blier P.

Neuropsychopharmacology. 2019 Nov 23. doi: 10.1038/s41386-019-0570-x. [Epub ahead of print]


Atypical Temporal Dynamics of Resting State Shapes Stimulus-Evoked Activity in Depression-An EEG Study on Rest-Stimulus Interaction.

Wolff A, de la Salle S, Sorgini A, Lynn E, Blier P, Knott V, Northoff G.

Front Psychiatry. 2019 Oct 15;10:719. doi: 10.3389/fpsyt.2019.00719. eCollection 2019.


From Africa to Antarctica: Exploring the Metabolism of Fish Heart Mitochondria Across a Wide Thermal Range.

Hunter-Manseau F, Desrosiers V, Le François NR, Dufresne F, Detrich HW 3rd, Nozais C, Blier PU.

Front Physiol. 2019 Oct 4;10:1220. doi: 10.3389/fphys.2019.01220. eCollection 2019.


Integrated genome-wide methylation and expression analyses reveal functional predictors of response to antidepressants.

Ju C, Fiori LM, Belzeaux R, Theroux JF, Chen GG, Aouabed Z, Blier P, Farzan F, Frey BN, Giacobbe P, Lam RW, Leri F, MacQueen GM, Milev R, Müller DJ, Parikh SV, Rotzinger S, Soares CN, Uher R, Li Q, Foster JA, Kennedy SH, Turecki G.

Transl Psychiatry. 2019 Oct 8;9(1):254. doi: 10.1038/s41398-019-0589-0.


Ketamine for chronic depression: two cautionary tales

Talbot J, Phillips JL, Blier P.

J Psychiatry Neurosci. 2019 Nov 1;44(6):384-385. doi: 10.1503/jpn.190073.


Mitochondrial Traits Previously Associated With Species Maximum Lifespan Do Not Correlate With Longevity Across Populations of the Bivalve Arctica islandica.

Rodríguez E, Dégletagne C, Hagen TM, Abele D, Blier PU.

Front Physiol. 2019 Jul 26;10:946. doi: 10.3389/fphys.2019.00946. eCollection 2019.


Efficacy and Safety of Fixed-Dose Esketamine Nasal Spray Combined With a New Oral Antidepressant in Treatment-Resistant Depression: Results of a Randomized, Double-Blind, Active-Controlled Study (TRANSFORM-1).

Fedgchin M, Trivedi M, Daly EJ, Melkote R, Lane R, Lim P, Vitagliano D, Blier P, Fava M, Liebowitz M, Ravindran A, Gaillard R, Ameele HVD, Preskorn S, Manji H, Hough D, Drevets WC, Singh JB.

Int J Neuropsychopharmacol. 2019 Oct 1;22(10):616-630. doi: 10.1093/ijnp/pyz039.


Efficacy of Esketamine Nasal Spray Plus Oral Antidepressant Treatment for Relapse Prevention in Patients With Treatment-Resistant Depression: A Randomized Clinical Trial.

Daly EJ, Trivedi MH, Janik A, Li H, Zhang Y, Li X, Lane R, Lim P, Duca AR, Hough D, Thase ME, Zajecka J, Winokur A, Divacka I, Fagiolini A, Cubala WJ, Bitter I, Blier P, Shelton RC, Molero P, Manji H, Drevets WC, Singh JB.

JAMA Psychiatry. 2019 Jun 5. doi: 10.1001/jamapsychiatry.2019.1189. [Epub ahead of print]


Predicting Worsening Suicidal Ideation With Clinical Features and Peripheral Expression of Messenger RNA and MicroRNA During Antidepressant Treatment.

Belzeaux R, Fiori LM, Lopez JP, Boucekine M, Boyer L, Blier P, Farzan F, Frey BN, Giacobbe P, Lam RW, Leri F, MacQueen GM, Milev R, Müller DJ, Parikh SV, Rotzinger S, Soares CN, Uher R, Foster JA, Kennedy SH, Turecki G.

J Clin Psychiatry. 2019 May 7;80(3). pii: 18m12556. doi: 10.4088/JCP.18m12556.


Life-history trade-offs and limitations associated with phenotypic adaptation under future ocean warming and elevated salinity.

Jarrold MD, Chakravarti LJ, Gibbin EM, Christen F, Massamba-N'Siala G, Blier PU, Calosi P.

Philos Trans R Soc Lond B Biol Sci. 2019 Mar 18;374(1768):20180428. doi: 10.1098/rstb.2018.0428.


Metabolic remodelling associated with mtDNA: insights into the adaptive value of doubly uniparental inheritance of mitochondria.

Bettinazzi S, Rodríguez E, Milani L, Blier PU, Breton S.

Proc Biol Sci. 2019 Feb 13;286(1896):20182708. doi: 10.1098/rspb.2018.2708.


Single, Repeated, and Maintenance Ketamine Infusions for Treatment-Resistant Depression: A Randomized Controlled Trial.

Phillips JL, Norris S, Talbot J, Birmingham M, Hatchard T, Ortiz A, Owoeye O, Batten LA, Blier P.

Am J Psychiatry. 2019 May 1;176(5):401-409. doi: 10.1176/appi.ajp.2018.18070834. Epub 2019 Mar 29.


Age Dependent Dysfunction of Mitochondrial and ROS Metabolism Induced by Mitonuclear Mismatch.

Pichaud N, Bérubé R, Côté G, Belzile C, Dufresne F, Morrow G, Tanguay RM, Rand DM, Blier PU.

Front Genet. 2019 Feb 20;10:130. doi: 10.3389/fgene.2019.00130. eCollection 2019.


Symptomatic and Functional Outcomes and Early Prediction of Response to Escitalopram Monotherapy and Sequential Adjunctive Aripiprazole Therapy in Patients With Major Depressive Disorder: A CAN-BIND-1 Report.

Kennedy SH, Lam RW, Rotzinger S, Milev RV, Blier P, Downar J, Evans KR, Farzan F, Foster JA, Frey BN, Giacobbe P, Hall GB, Harkness KL, Hassel S, Ismail Z, Leri F, McInerney S, MacQueen GM, Minuzzi L, Müller DJ, Parikh SV, Placenza FM, Quilty LC, Ravindran AV, Sassi RB, Soares CN, Strother SC, Turecki G, Vaccarino AL, Vila-Rodriguez F, Yu J, Uher R; CAN-BIND Investigator Team.

J Clin Psychiatry. 2019 Feb 5;80(2). pii: 18m12202. doi: 10.4088/JCP.18m12202.


Switching medication products during the treatment of psychiatric illness.

Blier P, Margolese HC, Wilson EA, Boucher M.

Int J Psychiatry Clin Pract. 2019 Mar;23(1):2-13. doi: 10.1080/13651501.2018.1508724. Epub 2019 Feb 8. Review.


Leveraging Machine Learning Approaches for Predicting Antidepressant Treatment Response Using Electroencephalography (EEG) and Clinical Data.

Jaworska N, de la Salle S, Ibrahim MH, Blier P, Knott V.

Front Psychiatry. 2019 Jan 14;9:768. doi: 10.3389/fpsyt.2018.00768. eCollection 2018.


Optimized regimens of combined medications for the treatment of major depressive disorder: a double-blind, randomized-controlled trial.

Zuilhof Z, Norris S, Blondeau C, Tessier P, Blier P.

Neuropsychiatr Dis Treat. 2018 Nov 22;14:3209-3218. doi: 10.2147/NDT.S175203. eCollection 2018.


Energy metabolism and survival of the juvenile recruits of the American lobster (Homarus americanus) exposed to a gradient of elevated seawater pCO2.

Menu-Courey K, Noisette F, Piedalue S, Daoud D, Blair T, Blier PU, Azetsu-Scott K, Calosi P.

Mar Environ Res. 2019 Jan;143:111-123. doi: 10.1016/j.marenvres.2018.10.002. Epub 2018 Oct 9.


Synergistic effect of aripiprazole and escitalopram in increasing serotonin but not norepinephrine neurotransmission in the rat hippocampus.

Ebrahimzadeh M, El Mansari M, Blier P.

Neuropharmacology. 2019 Mar 1;146:12-18. doi: 10.1016/j.neuropharm.2018.11.006. Epub 2018 Nov 8.


Hybridization between char species (Salvelinus alpinus and Salvelinus fontinalis): a fast track for novel allometric trajectories.

Dupont Cyr BA, Dufresne F, Christen F, Desrosiers V, Proulx É, Le François NR, Vandenberg GW, Blier PU.

Biol Open. 2018 Oct 19;7(10). pii: bio033332. doi: 10.1242/bio.033332.


Involvement of 5-HT1A and 5-HT2A Receptors but Not α 2-Adrenoceptors in the Acute Electrophysiological Effects of Cariprazine in the Rat Brain In Vivo.

Herman A, El Mansari M, Adham N, Kiss B, Farkas B, Blier P.

Mol Pharmacol. 2018 Dec;94(6):1363-1370. doi: 10.1124/mol.118.113290. Epub 2018 Oct 15. Erratum in: Mol Pharmacol. 2019 Feb;95(2):235.


Large muscles are beneficial but not required for improving thermogenic capacity in small birds.

Milbergue MS, Blier PU, Vézina F.

Sci Rep. 2018 Sep 18;8(1):14009. doi: 10.1038/s41598-018-32041-w.


Effects of fasting and refeeding on protein and glucose metabolism in Arctic charr.

Cassidy AA, Blier PU, Le François NR, Dionne P, Morin PJ, Lamarre SG.

Comp Biochem Physiol A Mol Integr Physiol. 2018 Dec;226:66-74. doi: 10.1016/j.cbpa.2018.08.010. Epub 2018 Aug 23.


Mitochondrial phenotype during torpor: Modulation of mitochondrial electron transport system in the Chilean mouse-opossum Thylamys elegans.

Cortes PA, Bozinovic F, Blier PU.

Comp Biochem Physiol A Mol Integr Physiol. 2018 Jul;221:7-14. doi: 10.1016/j.cbpa.2017.12.014. Epub 2018 Mar 15.


Thermal tolerance and thermal sensitivity of heart mitochondria: Mitochondrial integrity and ROS production.

Christen F, Desrosiers V, Dupont-Cyr BA, Vandenberg GW, Le François NR, Tardif JC, Dufresne F, Lamarre SG, Blier PU.

Free Radic Biol Med. 2018 Feb 20;116:11-18. doi: 10.1016/j.freeradbiomed.2017.12.037. Epub 2017 Dec 30.


The comparative effectiveness of electroencephalographic indices in predicting response to escitalopram therapy in depression: A pilot study.

Baskaran A, Farzan F, Milev R, Brenner CA, Alturi S, Pat McAndrews M, Blier P, Evans K, Foster JA, Frey BN, Giacobbe P, Lam RW, Leri F, MacQueen GM, Müller DJ, Parikh SV, Rotzinger S, Soares CN, Strother SC, Turecki G, Kennedy SH; CAN-BIND Investigators Team.

J Affect Disord. 2018 Feb;227:542-549. doi: 10.1016/j.jad.2017.10.028. Epub 2017 Nov 3.


Pre-treatment EEG signal variability is associated with treatment success in depression.

Jaworska N, Wang H, Smith DM, Blier P, Knott V, Protzner AB.

Neuroimage Clin. 2017 Oct 31;17:368-377. doi: 10.1016/j.nicl.2017.10.035. eCollection 2018.


Partial inhibition of catecholamine activity and enhanced responsiveness to NMDA after sustained administration of vortioxetine.

Ebrahimzadeh M, El Mansari M, Blier P.

Neuropharmacology. 2018 Jan;128:425-432. doi: 10.1016/j.neuropharm.2017.10.036. Epub 2017 Nov 13.


Temperature-related differences in mitochondrial function among clones of the cladoceran Daphnia pulex.

Kake-Guena SA, Touisse K, Warren BE, Scott KY, Dufresne F, Blier PU, Lemieux H.

J Therm Biol. 2017 Oct;69:23-31. doi: 10.1016/j.jtherbio.2017.05.005. Epub 2017 May 22.


Functional Recovery in Major Depressive Disorder: Providing Early Optimal Treatment for the Individual Patient.

Oluboka OJ, Katzman MA, Habert J, McIntosh D, MacQueen GM, Milev RV, McIntyre RS, Blier P.

Int J Neuropsychopharmacol. 2018 Feb 1;21(2):128-144. doi: 10.1093/ijnp/pyx081. Review.


Potential Application of Eicosapentaenoic Acid Monoacylglyceride in the Management of Colorectal Cancer.

Morin C, Rodríguez E, Blier PU, Fortin S.

Mar Drugs. 2017 Sep 4;15(9). pii: E283. doi: 10.3390/md15090283.


What modulates animal longevity? Fast and slow aging in bivalves as a model for the study of lifespan.

Blier PU, Abele D, Munro D, Degletagne C, Rodriguez E, Hagen T.

Semin Cell Dev Biol. 2017 Oct;70:130-140. doi: 10.1016/j.semcdb.2017.07.046. Epub 2017 Aug 1. Review.


MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes.

Lopez JP, Fiori LM, Cruceanu C, Lin R, Labonte B, Cates HM, Heller EA, Vialou V, Ku SM, Gerald C, Han MH, Foster J, Frey BN, Soares CN, Müller DJ, Farzan F, Leri F, MacQueen GM, Feilotter H, Tyryshkin K, Evans KR, Giacobbe P, Blier P, Lam RW, Milev R, Parikh SV, Rotzinger S, Strother SC, Lewis CM, Aitchison KJ, Wittenberg GM, Mechawar N, Nestler EJ, Uher R, Kennedy SH, Turecki G.

Nat Commun. 2017 May 22;8:15497. doi: 10.1038/ncomms15497.


Eicosapentaenoic acid monoglyceride resolves inflammation in an ex vivo model of human peripheral blood mononuclear cell.

Morin C, Charbonneau L, Ouellet N, Ouellet H, Blier PU, Dufresne F, Fortin S.

Eur J Pharmacol. 2017 Jul 15;807:205-211. doi: 10.1016/j.ejphar.2017.05.018. Epub 2017 May 10.


Evolved genetic and phenotypic differences due to mitochondrial-nuclear interactions.

Baris TZ, Wagner DN, Dayan DI, Du X, Blier PU, Pichaud N, Oleksiak MF, Crawford DL.

PLoS Genet. 2017 Mar 31;13(3):e1006517. doi: 10.1371/journal.pgen.1006517. eCollection 2017 Mar.


Progress on the Neuroscience-Based Nomenclature (NbN) for Psychotropic Medications.

Blier P, Oquendo MA, Kupfer DJ.

Neuropsychopharmacology. 2017 Sep;42(10):1927-1928. doi: 10.1038/npp.2017.33. Epub 2017 Feb 9. No abstract available.


Effects of levomilnacipran ER on noradrenergic symptoms, anxiety symptoms, and functional impairment in adults with major depressive disorder: Post hoc analysis of 5 clinical trials.

Blier P, Gommoll C, Chen C, Kramer K.

J Affect Disord. 2017 Mar 1;210:273-279. doi: 10.1016/j.jad.2016.11.011. Epub 2016 Nov 15.


Juvenile Fibromyalgia: A Primary Pain, or Pain Processing, Disorder.

Zemel L, Blier PR.

Semin Pediatr Neurol. 2016 Aug;23(3):231-241. doi: 10.1016/j.spen.2016.10.007. Epub 2016 Oct 14. Review.


Inverse agonists - What do they mean for psychiatry?

Nutt D, Stahl S, Blier P, Drago F, Zohar J, Wilson S.

Eur Neuropsychopharmacol. 2017 Jan;27(1):87-90. doi: 10.1016/j.euroneuro.2016.11.013. Epub 2016 Dec 7.


The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 3: The Clinical Guidelines.

Fountoulakis KN, Grunze H, Vieta E, Young A, Yatham L, Blier P, Kasper S, Moeller HJ.

Int J Neuropsychopharmacol. 2017 Feb 1;20(2):180-195. doi: 10.1093/ijnp/pyw109. Review.


Can multi-generational exposure to ocean warming and acidification lead to the adaptation of life history and physiology in a marine metazoan?

Gibbin EM, Chakravarti LJ, Jarrold MD, Christen F, Turpin V, Massamba N'Siala G, Blier PU, Calosi P.

J Exp Biol. 2017 Feb 15;220(Pt 4):551-563. doi: 10.1242/jeb.149989. Epub 2016 Nov 30.


Thermal sensitivity and phenotypic plasticity of cardiac mitochondrial metabolism in European perch, Perca fluviatilis.

Ekström A, Sandblom E, Blier PU, Dupont Cyr BA, Brijs J, Pichaud N.

J Exp Biol. 2017 Feb 1;220(Pt 3):386-396. doi: 10.1242/jeb.150698. Epub 2016 Nov 16.


The International College of Neuro-Psychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 2: Review, Grading of the Evidence, and a Precise Algorithm.

Fountoulakis KN, Yatham L, Grunze H, Vieta E, Young A, Blier P, Kasper S, Moeller HJ.

Int J Neuropsychopharmacol. 2017 Feb 1;20(2):121-179. doi: 10.1093/ijnp/pyw100. Review.


The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 1: Background and Methods of the Development of Guidelines.

Fountoulakis KN, Young A, Yatham L, Grunze H, Vieta E, Blier P, Moeller HJ, Kasper S.

Int J Neuropsychopharmacol. 2017 Feb 1;20(2):98-120. doi: 10.1093/ijnp/pyw091. Review.


Can trans-generational experiments be used to enhance species resilience to ocean warming and acidification?

Chakravarti LJ, Jarrold MD, Gibbin EM, Christen F, Massamba-N'Siala G, Blier PU, Calosi P.

Evol Appl. 2016 Jul 6;9(9):1133-1146. eCollection 2016 Oct.


The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 4: Unmet Needs in the Treatment of Bipolar Disorder and Recommendations for Future Research.

Fountoulakis KN, Vieta E, Young A, Yatham L, Grunze H, Blier P, Moeller HJ, Kasper S.

Int J Neuropsychopharmacol. 2017 Feb 1;20(2):196-205. doi: 10.1093/ijnp/pyw072. Review.

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