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Placebo: den mindst skadelige behandling ved artrose?

Bliddal H, Henriksen M, Christensen R.

Ugeskr Laeger. 2019 Jun 24;181(26). pii: V70556. Danish. No abstract available.


Muscle assessment using multi-frequency bioimpedance in a healthy Danish population aged 20-69 years: a powerful non-invasive tool in sports and in the clinic.

Bartels EM, Andersen EL, Olsen JK, Kristensen LE, Bliddal H, Danneskiold-Samsøe B, Harrison AP.

Physiol Rep. 2019 Jun;7(11):e14109. doi: 10.14814/phy2.14109.


Physical demand at work and sick leave due to low back pain: a cross-sectional study.

Petersen J, Kirkeskov L, Hansen BB, Begtrup LM, Flachs EM, Boesen M, Hansen P, Bliddal H, Kryger AI.

BMJ Open. 2019 May 22;9(5):e026917. doi: 10.1136/bmjopen-2018-026917.


Effect of liraglutide on body weight and pain in patients with overweight and knee osteoarthritis: protocol for a randomised, double-blind, placebo-controlled, parallel-group, single-centre trial.

Gudbergsen H, Henriksen M, Wæhrens EE, Overgaard A, Bliddal H, Christensen R, Boesen MP, Knop FKK, Astrup A, Rasmussen MU, Bartholdy C, Daugaard C, Bartels EM, Ellegaard K, Heitmann BL, Kristensen LE.

BMJ Open. 2019 May 5;9(5):e024065. doi: 10.1136/bmjopen-2018-024065.


Association between weight loss and spontaneous changes in physical inactivity in overweight/obese individuals with knee osteoarthritis: an 8-week prospective cohort study.

Bartholdy C, Christensen R, Kristensen LE, Gudbergsen H, Bliddal H, Overgaard A, Rasmussen MU, Henriksen M.

Arthritis Care Res (Hoboken). 2019 Mar 1. doi: 10.1002/acr.23868. [Epub ahead of print]


Effect of Magnetic Resonance Imaging vs Conventional Treat-to-Target Strategies on Disease Activity Remission and Radiographic Progression in Rheumatoid Arthritis: The IMAGINE-RA Randomized Clinical Trial.

Møller-Bisgaard S, Hørslev-Petersen K, Ejbjerg B, Hetland ML, Ørnbjerg LM, Glinatsi D, Møller J, Boesen M, Christensen R, Stengaard-Pedersen K, Madsen OR, Jensen B, Villadsen JA, Hauge EM, Bennett P, Hendricks O, Asmussen K, Kowalski M, Lindegaard H, Nielsen SM, Bliddal H, Krogh NS, Ellingsen T, Nielsen AH, Balding L, Jurik AG, Thomsen HS, Østergaard M.

JAMA. 2019 Feb 5;321(5):461-472. doi: 10.1001/jama.2018.21362.


A Phase II Trial of Lutikizumab, an Anti-Interleukin-1α/β Dual Variable Domain Immunoglobulin, in Knee Osteoarthritis Patients With Synovitis.

Fleischmann RM, Bliddal H, Blanco FJ, Schnitzer TJ, Peterfy C, Chen S, Wang L, Feng S, Conaghan PG, Berenbaum F, Pelletier JP, Martel-Pelletier J, Vaeterlein O, Kaeley GS, Liu W, Kosloski MP, Levy G, Zhang L, Medema JK, Levesque MC.

Arthritis Rheumatol. 2019 Jul;71(7):1056-1069. doi: 10.1002/art.40840. Epub 2019 Jun 7.


Opioid-Induced Reductions in Gait Variability in Healthy Volunteers and Individuals with Knee Osteoarthritis.

Henriksen M, Alkjær T, Raffalt PC, Jørgensen L, Bartholdy C, Hansen SH, Bliddal H.

Pain Med. 2019 Jan 12. doi: 10.1093/pm/pny286. [Epub ahead of print]


Ultrasound pathology of the entheses in an age and gender stratified sample of healthy adult subjects: a prospective cross-sectional frequency study.

Guldberg-Møller J, Terslev L, Nielsen SM, Kønig MJ, Torp-Pedersen ST, Torp-Pedersen A, Christensen R, Bliddal H, Ellegaard K.

Clin Exp Rheumatol. 2019 May-Jun;37(3):408-413. Epub 2018 Dec 19.


Added value of combining methotrexate with a biological agent compared to biological monotherapy in rheumatoid arthritis patients: A systematic review and meta-analysis of randomised trials.

Tarp S, Jørgensen TS, Furst DE, Dossing A, Taylor PC, Choy EH, Suarez-Almazor ME, Lyddiatt A, Kristensen LE, Bliddal H, Christensen R.

Semin Arthritis Rheum. 2019 Jun;48(6):958-966. doi: 10.1016/j.semarthrit.2018.10.002. Epub 2018 Oct 9.


Quadriceps-strengthening exercise and quadriceps and knee biomechanics during walking in knee osteoarthritis: A two-centre randomized controlled trial.

DeVita P, Aaboe J, Bartholdy C, Leonardis JM, Bliddal H, Henriksen M.

Clin Biomech (Bristol, Avon). 2018 Nov;59:199-206. doi: 10.1016/j.clinbiomech.2018.09.016. Epub 2018 Sep 15.


Intra-articular 2.5% polyacrylamide hydrogel for the treatment of knee osteoarthritis: an observational proof-of-concept cohort study.

Henriksen M, Overgaard A, Hartkopp A, Bliddal H.

Clin Exp Rheumatol. 2018 Nov-Dec;36(6):1082-1085. Epub 2018 Jul 18.


Single- vs. double-dose gadolinium contrast in delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) in knee osteoarthritis: is dose reduction possible on 3-T MRI?

Hangaard S, Gade JS, Hansen P, Damm Nybing J, Gudbergsen H, Bliddal H, Boesen M.

Acta Radiol. 2019 Jun;60(6):749-754. doi: 10.1177/0284185118796694. Epub 2018 Aug 24.


Delayed gadolinium-enhanced MRI of menisci and cartilage (dGEMRIM/dGEMRIC) in obese patients with knee osteoarthritis: Cross-sectional study of 85 obese patients with intra-articular administered gadolinium contrast.

Hangaard S, Gudbergsen H, Daugaard CL, Bliddal H, Nybing JD, Nieminen MT, Casula V, Tiderius CJ, Boesen M.

J Magn Reson Imaging. 2018 Dec;48(6):1700-1706. doi: 10.1002/jmri.26190. Epub 2018 Aug 13.


The Development of Complex Digital Health Solutions: Formative Evaluation Combining Different Methodologies.

Lee A, Sandvei M, Asmussen HC, Skougaard M, Macdonald J, Zavada J, Bliddal H, Taylor PC, Gudbergsen H.

JMIR Res Protoc. 2018 Jul 16;7(7):e165. doi: 10.2196/resprot.9521.


Pain Mechanisms and Ultrasonic Inflammatory Activity as Prognostic Factors in Patients With Psoriatic Arthritis: A Prospective Cohort Study.

Højgaard P, Ellegaard K, Nielsen SM, Christensen R, Guldberg-Møller J, Ballegaard C, Dreyer L, Mease P, de Wit M, Skov L, Glintborg B, Bliddal H, Bartels EM, Amris K, Kristensen LE.

Arthritis Care Res (Hoboken). 2019 Jun;71(6):798-810. doi: 10.1002/acr.23693. Epub 2019 May 2.


The dynamics of the pain system is intact in patients with knee osteoarthritis: An exploratory experimental study.

Jørgensen TS, Henriksen M, Rosager S, Klokker L, Ellegaard K, Danneskiold-Samsøe B, Bliddal H, Graven-Nielsen T.

Scand J Pain. 2015 Jan 1;6(1):43-49. doi: 10.1016/j.sjpain.2014.11.002.


The course of pain hypersensitivity according to painDETECT in patients with rheumatoid arthritis initiating treatment: results from the prospective FRAME-cohort study.

Rifbjerg-Madsen S, Christensen AW, Boesen M, Christensen R, Danneskiold-Samsøe B, Bliddal H, Dreyer L, Locht H, Amris K.

Arthritis Res Ther. 2018 May 30;20(1):105. doi: 10.1186/s13075-018-1581-4.


Association between IL-6 production in synovial explants from rheumatoid arthritis patients and clinical and imaging response to biologic treatment: A pilot study.

Andersen M, Boesen M, Ellegaard K, Söderström K, Søe NH, Spee P, Mørch UGW, Torp-Pedersen S, Bartels EM, Danneskiold-Samsøe B, Karlsson L, Bliddal H.

PLoS One. 2018 May 22;13(5):e0197001. doi: 10.1371/journal.pone.0197001. eCollection 2018.


Reliability and Construct Validity of the SENS Motion® Activity Measurement System as a Tool to Detect Sedentary Behaviour in Patients with Knee Osteoarthritis.

Bartholdy C, Gudbergsen H, Bliddal H, Kjærgaard M, Lykkegaard KL, Henriksen M.

Arthritis. 2018 Mar 1;2018:6596278. doi: 10.1155/2018/6596278. eCollection 2018.


The effect of intra-articular glucocorticosteroids and exercise on symptoms and bone marrow lesions in knee osteoarthritis: a secondary analysis of results from a randomized controlled trial.

Nielsen FK, Boesen M, Jurik AG, Bliddal H, Nybing JD, Ellegaard K, Bartholdy C, Bandak E, Henriksen M.

Osteoarthritis Cartilage. 2018 Jul;26(7):895-902. doi: 10.1016/j.joca.2018.02.900. Epub 2018 Mar 2.


Antibody-Mediated Neutralization of uPA Proteolytic Function Reduces Disease Progression in Mouse Arthritis Models.

Almholt K, Hebsgaard JB, Nansen A, Andersson C, Pass J, Rønø B, Thygesen P, Pelzer H, Loftager M, Lund IK, Høyer-Hansen G, Frisch T, Jensen CH, Otte KS, Søe NH, Bartels EM, Andersen M, Bliddal H, Usher PA.

J Immunol. 2018 Feb 1;200(3):957-965. doi: 10.4049/jimmunol.1701317. Epub 2017 Dec 27.


Some Cochrane risk-of-bias items are not important in osteoarthritis trials: a meta-epidemiological study based on Cochrane reviews.

Bolvig J, Juhl CB, Boutron I, Tugwell P, Ghogomu EAT, Pardo JP, Rader T, Wells GA, Mayhew A, Maxwell L, Lund H, Bliddal H, Christensen R; Editorial Board of the Cochrane Musculoskeletal Group.

J Clin Epidemiol. 2018 Mar;95:128-136. doi: 10.1016/j.jclinepi.2017.11.026. Epub 2017 Dec 6. Review.


C5a and C5aR are elevated in joints of rheumatoid and psoriatic arthritis patients, and C5aR blockade attenuates leukocyte migration to synovial fluid.

Hornum L, Hansen AJ, Tornehave D, Fjording MS, Colmenero P, Wätjen IF, Søe Nielsen NH, Bliddal H, Bartels EM.

PLoS One. 2017 Dec 8;12(12):e0189017. doi: 10.1371/journal.pone.0189017. eCollection 2017.


[Bursitis after vaccination in the shoulder region].

Bliddal H, Torp-Pedersen S, Falk-Riecke B, Bartels E.

Ugeskr Laeger. 2017 Oct 23;179(43). pii: V05170423. Danish.


No effects of functional exercise therapy on walking biomechanics in patients with knee osteoarthritis: exploratory outcome analyses from a randomised trial.

Henriksen M, Klokker L, Bartholdy C, Schjoedt-Jorgensen T, Bandak E, Bliddal H.

BMJ Open Sport Exerc Med. 2017 Mar 27;2(1):e000230. doi: 10.1136/bmjsem-2017-000230. eCollection 2016.


Weight loss for overweight and obese individuals with gout: a systematic review of longitudinal studies.

Nielsen SM, Bartels EM, Henriksen M, Wæhrens EE, Gudbergsen H, Bliddal H, Astrup A, Knop FK, Carmona L, Taylor WJ, Singh JA, Perez-Ruiz F, Kristensen LE, Christensen R.

Ann Rheum Dis. 2017 Nov;76(11):1870-1882. doi: 10.1136/annrheumdis-2017-211472. Epub 2017 Sep 2. Review.


Reliability of standing weight-bearing (0.25T) MR imaging findings and positional changes in the lumbar spine.

Hansen BB, Hansen P, Christensen AF, Trampedach C, Rasti Z, Bliddal H, Boesen M.

Skeletal Radiol. 2018 Jan;47(1):25-35. doi: 10.1007/s00256-017-2746-y. Epub 2017 Aug 15.


Osteoarthritis: Time to put steroid injections behind us?

Bliddal H, Henriksen M.

Nat Rev Rheumatol. 2017 Sep;13(9):519-520. doi: 10.1038/nrrheum.2017.118. Epub 2017 Jul 27. No abstract available.


Long-term weight-loss maintenance in obese patients with knee osteoarthritis: a randomized trial.

Christensen P, Henriksen M, Bartels EM, Leeds AR, Meinert Larsen T, Gudbergsen H, Riecke BF, Astrup A, Heitmann BL, Boesen M, Christensen R, Bliddal H.

Am J Clin Nutr. 2017 Sep;106(3):755-763. doi: 10.3945/ajcn.117.158543. Epub 2017 Jul 26.


Point of no return for improvement of cartilage quality indicated by dGEMRIC before and after weight loss in patients with knee osteoarthritis: a cohort study.

Hangaard S, Gudbergsen H, Skougaard M, Bliddal H, Nybing JD, Tiderius CJ, Boesen M.

Acta Radiol. 2018 Mar;59(3):336-340. doi: 10.1177/0284185117720857. Epub 2017 Jul 11.


Relationship between weight loss in obese knee osteoarthritis patients and serum biomarkers of cartilage breakdown: secondary analyses of a randomised trial.

Bartels EM, Henrotin Y, Bliddal H, Centonze P, Henriksen M.

Osteoarthritis Cartilage. 2017 Oct;25(10):1641-1646. doi: 10.1016/j.joca.2017.06.009. Epub 2017 Jul 6.


Pain and pain mechanisms in patients with inflammatory arthritis: A Danish nationwide cross-sectional DANBIO registry survey.

Rifbjerg-Madsen S, Christensen AW, Christensen R, Hetland ML, Bliddal H, Kristensen LE, Danneskiold-Samsøe B, Amris K.

PLoS One. 2017 Jul 7;12(7):e0180014. doi: 10.1371/journal.pone.0180014. eCollection 2017.


The risk associated with spinal manipulation: an overview of reviews.

Nielsen SM, Tarp S, Christensen R, Bliddal H, Klokker L, Henriksen M.

Syst Rev. 2017 Mar 24;6(1):64. doi: 10.1186/s13643-017-0458-y. Review.


EQ-5D utility, response and drug survival in rheumatoid arthritis patients on biologic monotherapy: A prospective observational study of patients registered in the south Swedish SSATG registry.

Jørgensen TS, Turesson C, Kapetanovic M, Englund M, Turkiewicz A, Christensen R, Bliddal H, Geborek P, Kristensen LE.

PLoS One. 2017 Feb 2;12(2):e0169946. doi: 10.1371/journal.pone.0169946. eCollection 2017.


Marine Oil Supplements for Arthritis Pain: A Systematic Review and Meta-Analysis of Randomized Trials.

Senftleber NK, Nielsen SM, Andersen JR, Bliddal H, Tarp S, Lauritzen L, Furst DE, Suarez-Almazor ME, Lyddiatt A, Christensen R.

Nutrients. 2017 Jan 6;9(1). pii: E42. doi: 10.3390/nu9010042. Review.


Work disability in non-radiographic axial spondyloarthritis patients before and after start of anti-TNF therapy: a population-based regional cohort study from southern Sweden.

Wallman JK, Jöud A, Olofsson T, Jacobsson LTH, Bliddal H, Kristensen LE.

Rheumatology (Oxford). 2017 May 1;56(5):716-724. doi: 10.1093/rheumatology/kew473.


Risk of serious adverse effects of biological and targeted drugs in patients with rheumatoid arthritis: a systematic review meta-analysis.

Tarp S, Eric Furst D, Boers M, Luta G, Bliddal H, Tarp U, Heller Asmussen K, Brock B, Dossing A, Schjødt Jørgensen T, Thirstrup S, Christensen R.

Rheumatology (Oxford). 2017 Mar 1;56(3):417-425. doi: 10.1093/rheumatology/kew442. Review.


Hand-related physical function in rheumatic hand conditions: a protocol for developing a patient-reported outcome measurement instrument.

Klokker L, Terwee CB, Wæhrens EE, Henriksen M, Nolte S, Liegl G, Kloppenburg M, Westhoven R, Wittoek R, Kjeken I, Haugen IK, Schalet B, Gershon R, Bliddal H, Christensen R.

BMJ Open. 2016 Dec 14;6(12):e011174. doi: 10.1136/bmjopen-2016-011174.


Osteoarthritis year in review 2016: imaging.

Boesen M, Ellegaard K, Henriksen M, Gudbergsen H, Hansen P, Bliddal H, Bartels EM, Riis RG.

Osteoarthritis Cartilage. 2017 Feb;25(2):216-226. doi: 10.1016/j.joca.2016.12.009. Epub 2016 Dec 10. Review.


Hand bone loss in early rheumatoid arthritis during a methotrexate-based treat-to-target strategy with or without adalimumab-a substudy of the optimized treatment algorithm in early RA (OPERA) trial.

Ørnbjerg LM, Østergaard M, Jensen T, Hørslev-Petersen K, Stengaard-Pedersen K, Junker P, Ellingsen T, Ahlquist P, Lindegaard H, Linauskas A, Schlemmer A, Dam MY, Hansen I, Lottenburger T, Ammitzbøll CG, Jørgensen A, Krintel SB, Raun J, Hetland ML; OPERA Study Group, Slot O, Nielsen LK, Skjødt H, Majgaard O, Lorenzen T, Horn HC, Kowalski M, Johansen IL, Pedersen PM, Manilo N, Bliddal H.

Clin Rheumatol. 2017 Apr;36(4):781-789. doi: 10.1007/s10067-016-3489-1. Epub 2016 Dec 5.


A Standardized "Rescue" Exercise Program for Symptomatic Flare-up of Knee Osteoarthritis: Description and Safety Considerations.

Bartholdy C, Klokker L, Bandak E, Bliddal H, Henriksen M.

J Orthop Sports Phys Ther. 2016 Nov;46(11):942-946. Epub 2016 Sep 28.


Non-nociceptive pain in rheumatoid arthritis is frequent and affects disease activity estimation: cross-sectional data from the FRAME study.

Christensen AW, Rifbjerg-Madsen S, Christensen R, Dreyer L, Tillingsøe H, Seven S, Boesen M, Ellegaard K, Bliddal H, Danneskiold-Samsøe B, Amris K.

Scand J Rheumatol. 2016 Nov;45(6):461-469. Epub 2016 Mar 18.


The effects of intra-articular glucocorticoids and exercise on pain and synovitis assessed on static and dynamic magnetic resonance imaging in knee osteoarthritis: exploratory outcomes from a randomized controlled trial.

Riis RGC, Henriksen M, Klokker L, Bartholdy C, Ellegaard K, Bandak E, Hansen BB, Bliddal H, Boesen M.

Osteoarthritis Cartilage. 2017 Apr;25(4):481-491. doi: 10.1016/j.joca.2016.10.009. Epub 2016 Oct 13.


The association between histological, macroscopic and magnetic resonance imaging assessed synovitis in end-stage knee osteoarthritis: a cross-sectional study.

Riis RG, Gudbergsen H, Simonsen O, Henriksen M, Al-Mashkur N, Eld M, Petersen KK, Kubassova O, Bay Jensen AC, Damm J, Bliddal H, Arendt-Nielsen L, Boesen M.

Osteoarthritis Cartilage. 2017 Feb;25(2):272-280. doi: 10.1016/j.joca.2016.10.006. Epub 2016 Oct 11.


Defining the optimal biological monotherapy in rheumatoid arthritis: A systematic review and meta-analysis of randomised trials.

Tarp S, Furst DE, Dossing A, Østergaard M, Lorenzen T, Hansen MS, Singh JA, Choy EH, Boers M, Suarez-Almazor ME, Kristensen LE, Bliddal H, Christensen R.

Semin Arthritis Rheum. 2017 Jun;46(6):699-708. doi: 10.1016/j.semarthrit.2016.09.003. Epub 2016 Sep 14. Review.


Anti-Drug Antibodies, Drug Levels, Interleukin-6 and Soluble TNF Receptors in Rheumatoid Arthritis Patients during the First 6 Months of Treatment with Adalimumab or Infliximab: A Descriptive Cohort Study.

Eng GP, Bouchelouche P, Bartels EM, Bliddal H, Bendtzen K, Stoltenberg M.

PLoS One. 2016 Sep 8;11(9):e0162316. doi: 10.1371/journal.pone.0162316. eCollection 2016.


Conventional Supine MRI With a Lumbar Pillow-An Alternative to Weight-bearing MRI for Diagnosing Spinal Stenosis?: A Cross-sectional Study.

Hansen BB, Hansen P, Grindsted J, Rasti Z, Bliddal H, Riis RGC, Boesen M.

Spine (Phila Pa 1976). 2017 May 1;42(9):662-669. doi: 10.1097/BRS.0000000000001889.


How widespread should pain be to be defined as widespread?

Amris K, Wæhrens EE, Bliddal H, Danneskiold-Samsøe B.

Pain. 2016 Aug;157(8):1831-2. doi: 10.1097/j.pain.0000000000000585. No abstract available.


Comparable effects of exercise and analgesics for pain secondary to knee osteoarthritis: a meta-analysis of trials included in Cochrane systematic reviews.

Henriksen M, Hansen JB, Klokker L, Bliddal H, Christensen R.

J Comp Eff Res. 2016 Jul;5(4):417-31. doi: 10.2217/cer-2016-0007. Epub 2016 Jun 27.


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