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Items: 1 to 50 of 202

1.

Beyond the Warburg Effect: How Do Cancer Cells Regulate One-Carbon Metabolism?

Rosenzweig A, Blenis J, Gomes AP.

Front Cell Dev Biol. 2018 Aug 15;6:90. doi: 10.3389/fcell.2018.00090. eCollection 2018. Review.

2.

mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation.

He L, Gomes AP, Wang X, Yoon SO, Lee G, Nagiec MJ, Cho S, Chavez A, Islam T, Yu Y, Asara JM, Kim BY, Blenis J.

Mol Cell. 2018 Jun 7;70(5):949-960.e4. doi: 10.1016/j.molcel.2018.04.024. Epub 2018 May 31.

PMID:
29861159
3.

Female Sex and Gender in Lung/Sleep Health and Disease: Increased Understanding of Basic Biological, Pathophysiological and Behavioral Mechanisms Leading to Better Health for Female Patients with Lung Disease.

Han MK, Arteaga-Solis E, Blenis J, Bourjeily G, Clegg DJ, DeMeo D, Duffy J, Gaston B, Heller NM, Hemnes A, Henske EP, Jain R, Lahm T, Lancaster LH, Lee J, Legato MJ, McKee S, Mehra R, Morris A, Prakash YS, Stampfli MR, Gopal-Srivastava R, Laposky AD, Punturieri A, Reineck L, Tigno X, Clayton J.

Am J Respir Crit Care Med. 2018 May 10. doi: 10.1164/rccm.201801-0168WS. [Epub ahead of print]

PMID:
29746147
4.

The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer.

Maik-Rachline G, Zehorai E, Hanoch T, Blenis J, Seger R.

Sci Signal. 2018 Apr 10;11(525). pii: eaao3428. doi: 10.1126/scisignal.aao3428.

PMID:
29636389
5.

Unique Metabolic Adaptations Dictate Distal Organ-Specific Metastatic Colonization.

Schild T, Low V, Blenis J, Gomes AP.

Cancer Cell. 2018 Mar 12;33(3):347-354. doi: 10.1016/j.ccell.2018.02.001. Review.

6.

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation.

Zhang H, Freitas D, Kim HS, Fabijanic K, Li Z, Chen H, Mark MT, Molina H, Martin AB, Bojmar L, Fang J, Rampersaud S, Hoshino A, Matei I, Kenific CM, Nakajima M, Mutvei AP, Sansone P, Buehring W, Wang H, Jimenez JP, Cohen-Gould L, Paknejad N, Brendel M, Manova-Todorova K, Magalhães A, Ferreira JA, Osório H, Silva AM, Massey A, Cubillos-Ruiz JR, Galletti G, Giannakakou P, Cuervo AM, Blenis J, Schwartz R, Brady MS, Peinado H, Bromberg J, Matsui H, Reis CA, Lyden D.

Nat Cell Biol. 2018 Mar;20(3):332-343. doi: 10.1038/s41556-018-0040-4. Epub 2018 Feb 19.

7.

EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer.

Oldrini B, Hsieh WY, Erdjument-Bromage H, Codega P, Carro MS, Curiel-García A, Campos C, Pourmaleki M, Grommes C, Vivanco I, Rohle D, Bielski CM, Taylor BS, Hollmann TJ, Rosenblum M, Tempst P, Blenis J, Squatrito M, Mellinghoff IK.

Nat Commun. 2017 Dec 11;8(1):2035. doi: 10.1038/s41467-017-02185-w.

8.

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, Yu Y, Liu X, He L, Cavaliere PM, Chavez A, Zhang E, Isik M, Couvillon A, Dephoure NE, Blackwell TK, Yu JJ, Rabinowitz JD, Cantley LC, Blenis J.

Cell. 2017 Dec 14;171(7):1545-1558.e18. doi: 10.1016/j.cell.2017.10.037. Epub 2017 Nov 16.

PMID:
29153836
9.

TOR, the Gateway to Cellular Metabolism, Cell Growth, and Disease.

Blenis J.

Cell. 2017 Sep 21;171(1):10-13. doi: 10.1016/j.cell.2017.08.019. Epub 2017 Sep 6.

10.

Focal Adhesion- and IGF1R-Dependent Survival and Migratory Pathways Mediate Tumor Resistance to mTORC1/2 Inhibition.

Yoon SO, Shin S, Karreth FA, Buel GR, Jedrychowski MP, Plas DR, Dedhar S, Gygi SP, Roux PP, Dephoure N, Blenis J.

Mol Cell. 2017 Aug 3;67(3):512-527.e4. doi: 10.1016/j.molcel.2017.06.033. Epub 2017 Jul 27.

11.

Adding Polyamine Metabolism to the mTORC1 Toolkit in Cell Growth and Cancer.

Gomes AP, Schild T, Blenis J.

Dev Cell. 2017 Jul 24;42(2):112-114. doi: 10.1016/j.devcel.2017.07.004.

12.

The tumor suppressor FLCN mediates an alternate mTOR pathway to regulate browning of adipose tissue.

Wada S, Neinast M, Jang C, Ibrahim YH, Lee G, Babu A, Li J, Hoshino A, Rowe GC, Rhee J, Martina JA, Puertollano R, Blenis J, Morley M, Baur JA, Seale P, Arany Z.

Genes Dev. 2016 Nov 15;30(22):2551-2564. Epub 2016 Dec 2.

13.

Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis.

Li C, Li N, Liu X, Zhang EY, Sun Y, Masuda K, Li J, Sun J, Morrison T, Li X, Chen Y, Wang J, Karim NA, Zhang Y, Blenis J, Reginato MJ, Henske EP, Yu JJ.

JCI Insight. 2016 Nov 17;1(19):e86629.

14.

mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress.

Li J, Shin S, Sun Y, Yoon SO, Li C, Zhang E, Yu J, Zhang J, Blenis J.

Cancer Res. 2016 Aug 15;76(16):4816-27. doi: 10.1158/0008-5472.CAN-15-2629. Epub 2016 May 17.

15.

Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.

Mullarky E, Lucki NC, Beheshti Zavareh R, Anglin JL, Gomes AP, Nicolay BN, Wong JC, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, Lyssiotis CA, Lairson LL, Cantley LC.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1778-83. doi: 10.1073/pnas.1521548113. Epub 2016 Feb 1. Erratum in: Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1585.

16.

CELL SIGNALING. Seeing mTORC1 specificity.

Buel GR, Blenis J.

Science. 2016 Jan 1;351(6268):25-6. doi: 10.1126/science.aad9696. No abstract available.

PMID:
26721988
17.

PtdIns(3,4,5)P3-Dependent Activation of the mTORC2 Kinase Complex.

Liu P, Gan W, Chin YR, Ogura K, Guo J, Zhang J, Wang B, Blenis J, Cantley LC, Toker A, Su B, Wei W.

Cancer Discov. 2015 Nov;5(11):1194-209. doi: 10.1158/2159-8290.CD-15-0460. Epub 2015 Aug 20.

18.

ERK2 Mediates Metabolic Stress Response to Regulate Cell Fate.

Shin S, Buel GR, Wolgamott L, Plas DR, Asara JM, Blenis J, Yoon SO.

Mol Cell. 2015 Aug 6;59(3):382-98. doi: 10.1016/j.molcel.2015.06.020. Epub 2015 Jul 16.

19.

ERK reinforces actin polymerization to power persistent edge protrusion during motility.

Mendoza MC, Vilela M, Juarez JE, Blenis J, Danuser G.

Sci Signal. 2015 May 19;8(377):ra47. doi: 10.1126/scisignal.aaa8859.

20.

A nexus for cellular homeostasis: the interplay between metabolic and signal transduction pathways.

Gomes AP, Blenis J.

Curr Opin Biotechnol. 2015 Aug;34:110-7. doi: 10.1016/j.copbio.2014.12.007. Epub 2015 Jan 3. Review.

21.

Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells.

Li J, Csibi A, Yang S, Hoffman GR, Li C, Zhang E, Yu JJ, Blenis J.

Proc Natl Acad Sci U S A. 2015 Jan 6;112(1):E21-9. doi: 10.1073/pnas.1417015112. Epub 2014 Dec 18.

22.

The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation.

Csibi A, Lee G, Yoon SO, Tong H, Ilter D, Elia I, Fendt SM, Roberts TM, Blenis J.

Curr Biol. 2014 Oct 6;24(19):2274-80. doi: 10.1016/j.cub.2014.08.007. Epub 2014 Sep 11.

23.

FLCN, a novel autophagy component, interacts with GABARAP and is regulated by ULK1 phosphorylation.

Dunlop EA, Seifan S, Claessens T, Behrends C, Kamps MA, Rozycka E, Kemp AJ, Nookala RK, Blenis J, Coull BJ, Murray JT, van Steensel MA, Wilkinson S, Tee AR.

Autophagy. 2014 Oct 1;10(10):1749-60. doi: 10.4161/auto.29640. Epub 2014 Jul 22.

24.

Phosphoproteomic analysis identifies the tumor suppressor PDCD4 as a RSK substrate negatively regulated by 14-3-3.

Galan JA, Geraghty KM, Lavoie G, Kanshin E, Tcherkezian J, Calabrese V, Jeschke GR, Turk BE, Ballif BA, Blenis J, Thibault P, Roux PP.

Proc Natl Acad Sci U S A. 2014 Jul 22;111(29):E2918-27. doi: 10.1073/pnas.1405601111. Epub 2014 Jul 7.

25.

Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells.

Sun Y, Gu X, Zhang E, Park MA, Pereira AM, Wang S, Morrison T, Li C, Blenis J, Gerbaudo VH, Henske EP, Yu JJ.

Cell Death Dis. 2014 May 15;5:e1231. doi: 10.1038/cddis.2014.204.

26.

Quantitative phosphoproteomic analysis reveals system-wide signaling pathways downstream of SDF-1/CXCR4 in breast cancer stem cells.

Yi T, Zhai B, Yu Y, Kiyotsugu Y, Raschle T, Etzkorn M, Seo HC, Nagiec M, Luna RE, Reinherz EL, Blenis J, Gygi SP, Wagner G.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):E2182-90. doi: 10.1073/pnas.1404943111. Epub 2014 Apr 29. Erratum in: Proc Natl Acad Sci U S A. 2014 Jul 29;111(30):11223.

27.

Grb10 promotes lipolysis and thermogenesis by phosphorylation-dependent feedback inhibition of mTORC1.

Liu M, Bai J, He S, Villarreal R, Hu D, Zhang C, Yang X, Liang H, Slaga TJ, Yu Y, Zhou Z, Blenis J, Scherer PE, Dong LQ, Liu F.

Cell Metab. 2014 Jun 3;19(6):967-80. doi: 10.1016/j.cmet.2014.03.018. Epub 2014 Apr 17.

28.

Akt-ivation of RNA splicing.

Lee G, Blenis J.

Mol Cell. 2014 Feb 20;53(4):519-20. doi: 10.1016/j.molcel.2014.02.010.

29.

Rapamycin: one drug, many effects.

Li J, Kim SG, Blenis J.

Cell Metab. 2014 Mar 4;19(3):373-9. doi: 10.1016/j.cmet.2014.01.001. Epub 2014 Feb 6. Review.

30.

Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells.

Li C, Lee PS, Sun Y, Gu X, Zhang E, Guo Y, Wu CL, Auricchio N, Priolo C, Li J, Csibi A, Parkhitko A, Morrison T, Planaguma A, Kazani S, Israel E, Xu KF, Henske EP, Blenis J, Levy BD, Kwiatkowski D, Yu JJ.

J Exp Med. 2014 Jan 13;211(1):15-28. doi: 10.1084/jem.20131080. Epub 2014 Jan 6.

31.

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis.

Liu P, Gan W, Inuzuka H, Lazorchak AS, Gao D, Arojo O, Liu D, Wan L, Zhai B, Yu Y, Yuan M, Kim BM, Shaik S, Menon S, Gygi SP, Lee TH, Asara JM, Manning BD, Blenis J, Su B, Wei W.

Nat Cell Biol. 2013 Nov;15(11):1340-50. doi: 10.1038/ncb2860. Epub 2013 Oct 27.

32.

Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis.

Gu X, Yu JJ, Ilter D, Blenis N, Henske EP, Blenis J.

Proc Natl Acad Sci U S A. 2013 Sep 10;110(37):14960-5. doi: 10.1073/pnas.1309110110. Epub 2013 Aug 27.

33.

AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve.

Er EE, Mendoza MC, Mackey AM, Rameh LE, Blenis J.

Sci Signal. 2013 Jun 11;6(279):ra45. doi: 10.1126/scisignal.2004015.

34.

Nutrient regulation of the mTOR complex 1 signaling pathway.

Kim SG, Buel GR, Blenis J.

Mol Cells. 2013 Jun;35(6):463-73. doi: 10.1007/s10059-013-0138-2. Epub 2013 May 20. Review.

35.

Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism.

Fendt SM, Bell EL, Keibler MA, Davidson SM, Wirth GJ, Fiske B, Mayers JR, Schwab M, Bellinger G, Csibi A, Patnaik A, Blouin MJ, Cantley LC, Guarente L, Blenis J, Pollak MN, Olumi AF, Vander Heiden MG, Stephanopoulos G.

Cancer Res. 2013 Jul 15;73(14):4429-38. doi: 10.1158/0008-5472.CAN-13-0080. Epub 2013 May 17.

36.

The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4.

Csibi A, Fendt SM, Li C, Poulogiannis G, Choo AY, Chapski DJ, Jeong SM, Dempsey JM, Parkhitko A, Morrison T, Henske EP, Haigis MC, Cantley LC, Stephanopoulos G, Yu J, Blenis J.

Cell. 2013 May 9;153(4):840-54. doi: 10.1016/j.cell.2013.04.023.

37.

mTORC1 signaling aids in CADalyzing pyrimidine biosynthesis.

Buel GR, Kim SG, Blenis J.

Cell Metab. 2013 May 7;17(5):633-5. doi: 10.1016/j.cmet.2013.04.018.

38.

SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism.

Jeong SM, Xiao C, Finley LW, Lahusen T, Souza AL, Pierce K, Li YH, Wang X, Laurent G, German NJ, Xu X, Li C, Wang RH, Lee J, Csibi A, Cerione R, Blenis J, Clish CB, Kimmelman A, Deng CX, Haigis MC.

Cancer Cell. 2013 Apr 15;23(4):450-63. doi: 10.1016/j.ccr.2013.02.024. Epub 2013 Apr 4.

39.

Hippo-YAP and mTOR pathways collaborate to regulate organ size.

Csibi A, Blenis J.

Nat Cell Biol. 2012 Dec;14(12):1244-5. doi: 10.1038/ncb2634.

PMID:
23196842
40.

Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex.

Kim SG, Hoffman GR, Poulogiannis G, Buel GR, Jang YJ, Lee KW, Kim BY, Erikson RL, Cantley LC, Choo AY, Blenis J.

Mol Cell. 2013 Jan 10;49(1):172-85. doi: 10.1016/j.molcel.2012.10.003. Epub 2012 Nov 8.

41.

TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues.

Anjum R, Pae E, Blenis J, Ballif BA.

FEBS Lett. 2012 Sep 21;586(19):3471-6. doi: 10.1016/j.febslet.2012.07.075. Epub 2012 Aug 10.

42.

Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling.

Zhang W, Mendoza MC, Pei X, Ilter D, Mahoney SJ, Zhang Y, Ma D, Blenis J, Wang Y.

J Biol Chem. 2012 Apr 6;287(15):11850-8. doi: 10.1074/jbc.M111.258236. Epub 2012 Feb 15.

43.

Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation.

Shin S, Wolgamott L, Yu Y, Blenis J, Yoon SO.

Proc Natl Acad Sci U S A. 2011 Nov 22;108(47):E1204-13. doi: 10.1073/pnas.1110195108. Epub 2011 Nov 7.

44.

Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors.

Csibi A, Blenis J.

BMC Biol. 2011 Oct 21;9:69. doi: 10.1186/1741-7007-9-69. Review.

45.

Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling.

Yu Y, Yoon SO, Poulogiannis G, Yang Q, Ma XM, Villén J, Kubica N, Hoffman GR, Cantley LC, Gygi SP, Blenis J.

Science. 2011 Jun 10;332(6035):1322-6. doi: 10.1126/science.1199484.

46.

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation.

Mendoza MC, Er EE, Blenis J.

Trends Biochem Sci. 2011 Jun;36(6):320-8. doi: 10.1016/j.tibs.2011.03.006. Epub 2011 Apr 30. Review.

47.

ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex.

Mendoza MC, Er EE, Zhang W, Ballif BA, Elliott HL, Danuser G, Blenis J.

Mol Cell. 2011 Mar 18;41(6):661-71. doi: 10.1016/j.molcel.2011.02.031.

48.

ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation.

Kim SG, Choo AY, Blenis J.

Mol Cell. 2010 Nov 24;40(4):501-2. doi: 10.1016/j.molcel.2010.11.013.

49.

ERK-MAP Kinase signaling in the cytoplasm.

Mendoza MC, Er EE, Blenis J.

Methods Mol Biol. 2010;661:185-203. doi: 10.1007/978-1-60761-795-2_11.

PMID:
20811984
50.

A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions.

Lipinski MM, Hoffman G, Ng A, Zhou W, Py BF, Hsu E, Liu X, Eisenberg J, Liu J, Blenis J, Xavier RJ, Yuan J.

Dev Cell. 2010 Jun 15;18(6):1041-52. doi: 10.1016/j.devcel.2010.05.005.

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