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Items: 1 to 50 of 86

1.

Effects of Pharmacologically Targeting Neuroimmune Pathways on Alcohol Drinking in Mice Selectively Bred to Drink to Intoxication.

Ozburn AR, Metten P, Potretzke S, Townsley KG, Blednov YA, Crabbe JC.

Alcohol Clin Exp Res. 2019 Dec 18. doi: 10.1111/acer.14269. [Epub ahead of print]

PMID:
31853996
2.

Role of MyD88 in IL-1β and Ethanol Modulation of GABAergic Transmission in the Central Amygdala.

Bajo M, Patel RR, Hedges DM, Varodayan FP, Vlkolinsky R, Davis TD, Burkart MD, Blednov YA, Roberto M.

Brain Sci. 2019 Dec 7;9(12). pii: E361. doi: 10.3390/brainsci9120361.

3.

Glial gene networks associated with alcohol dependence.

Erickson EK, Blednov YA, Harris RA, Mayfield RD.

Sci Rep. 2019 Jul 29;9(1):10949. doi: 10.1038/s41598-019-47454-4.

4.

Scn4b regulates the hypnotic effects of ethanol and other sedative drugs.

Blednov YA, Bajo M, Roberts AJ, Da Costa AJ, Black M, Edmunds S, Mayfield J, Roberto M, Homanics GE, Lasek AW, Hitzemann RJ, Harris RA.

Genes Brain Behav. 2019 Jul;18(6):e12562. doi: 10.1111/gbb.12562. Epub 2019 May 2.

PMID:
30817077
5.

Toll-like receptor 3 activation increases voluntary alcohol intake in C57BL/6J male mice.

Warden AS, Azzam M, DaCosta A, Mason S, Blednov YA, Messing RO, Mayfield RD, Harris RA.

Brain Behav Immun. 2019 Mar;77:55-65. doi: 10.1016/j.bbi.2018.12.004. Epub 2018 Dec 11.

PMID:
30550931
6.

Toll-like receptor 3 dynamics in female C57BL/6J mice: Regulation of alcohol intake.

Warden AS, Azzam M, DaCosta A, Mason S, Blednov YA, Messing RO, Mayfield RD, Harris RA.

Brain Behav Immun. 2019 Mar;77:66-76. doi: 10.1016/j.bbi.2018.12.006. Epub 2018 Dec 11.

PMID:
30550930
7.

Silencing synaptic MicroRNA-411 reduces voluntary alcohol consumption in mice.

Most D, Salem NA, Tiwari GR, Blednov YA, Mayfield RD, Harris RA.

Addict Biol. 2019 Jul;24(4):604-616. doi: 10.1111/adb.12625. Epub 2018 Apr 17.

PMID:
29665166
8.

Apremilast Alters Behavioral Responses to Ethanol in Mice: I. Reduced Consumption and Preference.

Blednov YA, Da Costa AJ, Tarbox T, Ponomareva O, Messing RO, Harris RA.

Alcohol Clin Exp Res. 2018 May;42(5):926-938. doi: 10.1111/acer.13616. Epub 2018 Mar 24.

9.

Apremilast Alters Behavioral Responses to Ethanol in Mice: II. Increased Sedation, Intoxication, and Reduced Acute Functional Tolerance.

Blednov YA, Da Costa AJ, Harris RA, Messing RO.

Alcohol Clin Exp Res. 2018 May;42(5):939-951. doi: 10.1111/acer.13615. Epub 2018 Mar 24.

10.

Astrocyte-specific transcriptome responses to chronic ethanol consumption.

Erickson EK, Farris SP, Blednov YA, Mayfield RD, Harris RA.

Pharmacogenomics J. 2018 Jul;18(4):578-589. doi: 10.1038/s41397-017-0012-2. Epub 2018 Jan 5.

11.

Microglial-specific transcriptome changes following chronic alcohol consumption.

McCarthy GM, Farris SP, Blednov YA, Harris RA, Mayfield RD.

Neuropharmacology. 2018 Jan;128:416-424. doi: 10.1016/j.neuropharm.2017.10.035. Epub 2017 Oct 31.

12.

CNS cell-type localization and LPS response of TLR signaling pathways.

McCarthy GM, Bridges CR, Blednov YA, Harris RA.

F1000Res. 2017 Jul 19;6:1144. doi: 10.12688/f1000research.12036.1. eCollection 2017.

13.

Chronic ethanol consumption: role of TLR3/TRIF-dependent signaling.

McCarthy GM, Warden AS, Bridges CR, Blednov YA, Harris RA.

Addict Biol. 2018 May;23(3):889-903. doi: 10.1111/adb.12539. Epub 2017 Aug 25.

14.

Glycine receptor α3 and α2 subunits mediate tonic and exogenous agonist-induced currents in forebrain.

McCracken LM, Lowes DC, Salling MC, Carreau-Vollmer C, Odean NN, Blednov YA, Betz H, Harris RA, Harrison NL.

Proc Natl Acad Sci U S A. 2017 Aug 22;114(34):E7179-E7186. doi: 10.1073/pnas.1703839114. Epub 2017 Aug 7.

15.

Mutation of the inhibitory ethanol site in GABAA ρ1 receptors promotes tolerance to ethanol-induced motor incoordination.

Blednov YA, Borghese CM, Ruiz CI, Cullins MA, Da Costa A, Osterndorff-Kahanek EA, Homanics GE, Harris RA.

Neuropharmacology. 2017 Sep 1;123:201-209. doi: 10.1016/j.neuropharm.2017.06.013. Epub 2017 Jun 13.

16.

Mechanistic insights into epigenetic modulation of ethanol consumption.

Ponomarev I, Stelly CE, Morikawa H, Blednov YA, Mayfield RD, Harris RA.

Alcohol. 2017 May;60:95-101. doi: 10.1016/j.alcohol.2017.01.016. Epub 2017 Mar 12.

17.

Sedative and Motor Incoordination Effects of Ethanol in Mice Lacking CD14, TLR2, TLR4, or MyD88.

Blednov YA, Black M, Benavidez JM, Da Costa A, Mayfield J, Harris RA.

Alcohol Clin Exp Res. 2017 Mar;41(3):531-540. doi: 10.1111/acer.13314. Epub 2017 Feb 3.

18.

Ethanol Consumption in Mice Lacking CD14, TLR2, TLR4, or MyD88.

Blednov YA, Black M, Chernis J, Da Costa A, Mayfield J, Harris RA.

Alcohol Clin Exp Res. 2017 Mar;41(3):516-530. doi: 10.1111/acer.13316. Epub 2017 Feb 1.

19.

Genetic and Pharmacologic Manipulation of TLR4 Has Minimal Impact on Ethanol Consumption in Rodents.

Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt JM, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, Hackam DJ, Mayfield RD, Koob GF, Roberto M, Homanics GE.

J Neurosci. 2017 Feb 1;37(5):1139-1155. doi: 10.1523/JNEUROSCI.2002-16.2016. Epub 2016 Dec 16.

20.

Inhibition of IKKβ Reduces Ethanol Consumption in C57BL/6J Mice.

Truitt JM, Blednov YA, Benavidez JM, Black M, Ponomareva O, Law J, Merriman M, Horani S, Jameson K, Lasek AW, Harris RA, Mayfield RD.

eNeuro. 2016 Oct 31;3(5). pii: ENEURO.0256-16.2016. eCollection 2016 Sep-Oct.

21.

Genes and Alcohol Consumption: Studies with Mutant Mice.

Mayfield J, Arends MA, Harris RA, Blednov YA.

Int Rev Neurobiol. 2016;126:293-355. doi: 10.1016/bs.irn.2016.02.014. Review.

22.

PPAR Agonists: I. Role of Receptor Subunits in Alcohol Consumption in Male and Female Mice.

Blednov YA, Black M, Benavidez JM, Stamatakis EE, Harris RA.

Alcohol Clin Exp Res. 2016 Mar;40(3):553-62. doi: 10.1111/acer.12976. Epub 2016 Feb 9.

23.

PPAR Agonists: II. Fenofibrate and Tesaglitazar Alter Behaviors Related to Voluntary Alcohol Consumption.

Blednov YA, Black M, Benavidez JM, Stamatakis EE, Harris RA.

Alcohol Clin Exp Res. 2016 Mar;40(3):563-71. doi: 10.1111/acer.12972. Epub 2016 Feb 9.

24.

Alcohol consumption induces global gene expression changes in VTA dopaminergic neurons.

Marballi K, Genabai NK, Blednov YA, Harris RA, Ponomarev I.

Genes Brain Behav. 2016 Mar;15(3):318-26. doi: 10.1111/gbb.12266. Epub 2015 Dec 28.

25.

Behavioral and Genetic Evidence for GIRK Channels in the CNS: Role in Physiology, Pathophysiology, and Drug Addiction.

Mayfield J, Blednov YA, Harris RA.

Int Rev Neurobiol. 2015;123:279-313. doi: 10.1016/bs.irn.2015.05.016. Epub 2015 Jun 22. Review.

26.

Synaptic microRNAs Coordinately Regulate Synaptic mRNAs: Perturbation by Chronic Alcohol Consumption.

Most D, Leiter C, Blednov YA, Harris RA, Mayfield RD.

Neuropsychopharmacology. 2016 Jan;41(2):538-48. doi: 10.1038/npp.2015.179. Epub 2015 Jun 24.

27.

Role of interleukin-1 receptor signaling in the behavioral effects of ethanol and benzodiazepines.

Blednov YA, Benavidez JM, Black M, Mayfield J, Harris RA.

Neuropharmacology. 2015 Aug;95:309-20. doi: 10.1016/j.neuropharm.2015.03.015. Epub 2015 Apr 1.

28.

Glycine receptors containing α2 or α3 subunits regulate specific ethanol-mediated behaviors.

Blednov YA, Benavidez JM, Black M, Leiter CR, Osterndorff-Kahanek E, Harris RA.

J Pharmacol Exp Ther. 2015 Apr;353(1):181-91. doi: 10.1124/jpet.114.221895. Epub 2015 Feb 12.

29.

Peroxisome proliferator-activated receptors α and γ are linked with alcohol consumption in mice and withdrawal and dependence in humans.

Blednov YA, Benavidez JM, Black M, Ferguson LB, Schoenhard GL, Goate AM, Edenberg HJ, Wetherill L, Hesselbrock V, Foroud T, Harris RA.

Alcohol Clin Exp Res. 2015 Jan;39(1):136-45. doi: 10.1111/acer.12610. Epub 2014 Dec 16.

30.

Role of the IL-1 receptor antagonist in ethanol-induced regulation of GABAergic transmission in the central amygdala.

Bajo M, Herman MA, Varodayan FP, Oleata CS, Madamba SG, Harris RA, Blednov YA, Roberto M.

Brain Behav Immun. 2015 Mar;45:189-97. doi: 10.1016/j.bbi.2014.11.011. Epub 2014 Dec 3.

31.

Neuroimmune pathways in alcohol consumption: evidence from behavioral and genetic studies in rodents and humans.

Robinson G, Most D, Ferguson LB, Mayfield J, Harris RA, Blednov YA.

Int Rev Neurobiol. 2014;118:13-39. doi: 10.1016/B978-0-12-801284-0.00002-6.

32.

PPAR agonists regulate brain gene expression: relationship to their effects on ethanol consumption.

Ferguson LB, Most D, Blednov YA, Harris RA.

Neuropharmacology. 2014 Nov;86:397-407. doi: 10.1016/j.neuropharm.2014.06.024. Epub 2014 Jul 15.

33.

Inhibition of phosphodiesterase 4 reduces ethanol intake and preference in C57BL/6J mice.

Blednov YA, Benavidez JM, Black M, Harris RA.

Front Neurosci. 2014 May 27;8:129. doi: 10.3389/fnins.2014.00129. eCollection 2014.

34.

Innate immune factors modulate ethanol interaction with GABAergic transmission in mouse central amygdala.

Bajo M, Madamba SG, Roberto M, Blednov YA, Sagi VN, Roberts E, Rice KC, Harris RA, Siggins GR.

Brain Behav Immun. 2014 Aug;40:191-202. doi: 10.1016/j.bbi.2014.03.007. Epub 2014 Mar 24.

35.

GABAA receptors containing ρ1 subunits contribute to in vivo effects of ethanol in mice.

Blednov YA, Benavidez JM, Black M, Leiter CR, Osterndorff-Kahanek E, Johnson D, Borghese CM, Hanrahan JR, Johnston GA, Chebib M, Harris RA.

PLoS One. 2014 Jan 16;9(1):e85525. doi: 10.1371/journal.pone.0085525. eCollection 2014.

36.

Positively correlated miRNA-mRNA regulatory networks in mouse frontal cortex during early stages of alcohol dependence.

Nunez YO, Truitt JM, Gorini G, Ponomareva ON, Blednov YA, Harris RA, Mayfield RD.

BMC Genomics. 2013 Oct 22;14:725. doi: 10.1186/1471-2164-14-725.

37.

Bioinformatics analyses reveal age-specific neuroimmune modulation as a target for treatment of high ethanol drinking.

Agrawal RG, Owen JA, Levin PS, Hewetson A, Berman AE, Franklin SR, Hogue RJ, Chen Y, Walz C, Colvard BD, Nguyen J, Velasquez O, Al-Hasan Y, Blednov YA, Fowler AK, Syapin PJ, Bergeson SE.

Alcohol Clin Exp Res. 2014 Feb;38(2):428-37. doi: 10.1111/acer.12288. Epub 2013 Oct 11.

38.

Gene expression in brain and liver produced by three different regimens of alcohol consumption in mice: comparison with immune activation.

Osterndorff-Kahanek E, Ponomarev I, Blednov YA, Harris RA.

PLoS One. 2013;8(3):e59870. doi: 10.1371/journal.pone.0059870. Epub 2013 Mar 29.

39.

Chronic voluntary alcohol consumption results in tolerance to sedative/hypnotic and hypothermic effects of alcohol in hybrid mice.

Ozburn AR, Harris RA, Blednov YA.

Pharmacol Biochem Behav. 2013 Mar;104:33-9. doi: 10.1016/j.pbb.2012.12.025. Epub 2013 Jan 8.

40.

Mutation of a zinc-binding residue in the glycine receptor α1 subunit changes ethanol sensitivity in vitro and alcohol consumption in vivo.

McCracken LM, Blednov YA, Trudell JR, Benavidez JM, Betz H, Harris RA.

J Pharmacol Exp Ther. 2013 Feb;344(2):489-500. doi: 10.1124/jpet.112.197707. Epub 2012 Dec 10.

41.

Linking GABA(A) receptor subunits to alcohol-induced conditioned taste aversion and recovery from acute alcohol intoxication.

Blednov YA, Benavidez JM, Black M, Chandra D, Homanics GE, Rudolph U, Harris RA.

Neuropharmacology. 2013 Apr;67:46-56. doi: 10.1016/j.neuropharm.2012.10.016. Epub 2012 Nov 9.

42.

Chronic self-administration of alcohol results in elevated ΔFosB: comparison of hybrid mice with distinct drinking patterns.

Ozburn AR, Mayfield RD, Ponomarev I, Jones TA, Blednov YA, Harris RA.

BMC Neurosci. 2012 Oct 29;13:130. doi: 10.1186/1471-2202-13-130.

43.

Behavioral actions of alcohol: phenotypic relations from multivariate analysis of mutant mouse data.

Blednov YA, Mayfield RD, Belknap J, Harris RA.

Genes Brain Behav. 2012 Jun;11(4):424-35. doi: 10.1111/j.1601-183X.2012.00780.x. Epub 2012 Apr 6.

44.

Behavioral characterization of knockin mice with mutations M287L and Q266I in the glycine receptor α1 subunit.

Blednov YA, Benavidez JM, Homanics GE, Harris RA.

J Pharmacol Exp Ther. 2012 Feb;340(2):317-29. doi: 10.1124/jpet.111.185124. Epub 2011 Oct 28.

45.

Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.

Borghese CM, Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA.

J Pharmacol Exp Ther. 2012 Feb;340(2):304-16. doi: 10.1124/jpet.111.185116. Epub 2011 Oct 28.

46.

Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies.

Blednov YA, Ponomarev I, Geil C, Bergeson S, Koob GF, Harris RA.

Addict Biol. 2012 Jan;17(1):108-20. doi: 10.1111/j.1369-1600.2010.00284.x. Epub 2011 Feb 11.

47.

Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice.

Blednov YA, Benavidez JM, Geil C, Perra S, Morikawa H, Harris RA.

Brain Behav Immun. 2011 Jun;25 Suppl 1:S92-S105. doi: 10.1016/j.bbi.2011.01.008. Epub 2011 Jan 23.

48.

Testing the silence of mutations: Transcriptomic and behavioral studies of GABA(A) receptor α1 and α2 subunit knock-in mice.

Harris RA, Osterndorff-Kahanek E, Ponomarev I, Homanics GE, Blednov YA.

Neurosci Lett. 2011 Jan 13;488(1):31-5. doi: 10.1016/j.neulet.2010.10.075. Epub 2010 Nov 5.

49.

Loss of ethanol conditioned taste aversion and motor stimulation in knockin mice with ethanol-insensitive α2-containing GABA(A) receptors.

Blednov YA, Borghese CM, McCracken ML, Benavidez JM, Geil CR, Osterndorff-Kahanek E, Werner DF, Iyer S, Swihart A, Harrison NL, Homanics GE, Harris RA.

J Pharmacol Exp Ther. 2011 Jan;336(1):145-54. doi: 10.1124/jpet.110.171645. Epub 2010 Sep 27.

50.

Behavioral differences between C57BL/6J x FVB/NJ and C57BL/6J x NZB/B1NJ F1 hybrid mice: relation to control of ethanol intake.

Ozburn AR, Harris RA, Blednov YA.

Behav Genet. 2010 Jul;40(4):551-63. doi: 10.1007/s10519-010-9357-x. Epub 2010 Apr 4.

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