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Cerebral metastases: do size, peritumoral edema, or multiplicity predict infiltration into brain parenchyma?

Fiss I, Hussein A, Barrantes-Freer A, Sperling S, Hernandez-Duran S, Wolfert C, Pukrop T, Ninkovic M, Bleckmann A, Rohde V, Mielke D, Schatlo B.

Acta Neurochir (Wien). 2019 Mar 15. doi: 10.1007/s00701-019-03842-3. [Epub ahead of print]


PI3K: A master regulator of brain metastasis-promoting macrophages/microglia.

Blazquez R, Wlochowitz D, Wolff A, Seitz S, Wachter A, Perera-Bel J, Bleckmann A, Beißbarth T, Salinas G, Riemenschneider MJ, Proescholdt M, Evert M, Utpatel K, Siam L, Schatlo B, Balkenhol M, Stadelmann C, Schildhaus HU, Korf U, Reinz E, Wiemann S, Vollmer E, Schulz M, Ritter U, Hanisch UK, Pukrop T.

Glia. 2018 Nov;66(11):2438-2455. doi: 10.1002/glia.23485. Epub 2018 Oct 25.


FGFR3 mRNA overexpression defines a subset of oligometastatic colorectal cancers with worse prognosis.

Fromme JE, Schmitz K, Wachter A, Grzelinski M, Zielinski D, Koppel C, Conradi LC, Homayounfar K, Hugo T, Hugo S, Lukat L, Rüschoff J, Ströbel P, Ghadimi M, Beißbarth T, Reuter-Jessen K, Bleckmann A, Schildhaus HU.

Oncotarget. 2018 Aug 14;9(63):32204-32218. doi: 10.18632/oncotarget.25941. eCollection 2018 Aug 14.


Using RNA-Seq Data for the Detection of a Panel of Clinically Relevant Mutations.

Wolff A, Perera-Bel J, Schildhaus HU, Homayounfar K, Schatlo B, Bleckmann A, Beißbarth T.

Stud Health Technol Inform. 2018;253:217-221.


Interhospital transport of ARDS patients on extracorporeal membrane oxygenation.

Heuer JF, Mirschel M, Bleckmann A, Quintel M, Moerer O.

J Artif Organs. 2019 Mar;22(1):53-60. doi: 10.1007/s10047-018-1065-y. Epub 2018 Aug 18.


High-frequency oscillatory ventilation guided by transpulmonary pressure in acute respiratory syndrome: an experimental study in pigs.

Klapsing P, Moerer O, Wende C, Herrmann P, Quintel M, Bleckmann A, Heuer JF.

Crit Care. 2018 May 9;22(1):121. doi: 10.1186/s13054-018-2028-7.


Acute and Long-Term Hemodynamic Effects of MitraClip Implantation on a Preexisting Secondary Right Heart Failure.

Hünlich M, Lubos E, Beuthner BE, Puls M, Bleckmann A, Beißbarth T, Tichelbäcker T, Rudolph V, Baldus S, Schäfer U, Treede H, Von Bardeleben RS, Blankenberg S, Schillinger W.

Biomed Res Int. 2018 Mar 14;2018:6817832. doi: 10.1155/2018/6817832. eCollection 2018.


Isolated metastasis of an EGFR-L858R-mutated NSCLC of the meninges: the potential impact of CXCL12/CXCR4 axis in EGFRmut NSCLC in diagnosis, follow-up and treatment.

Lüke F, Blazquez R, Yamaci RF, Lu X, Pregler B, Hannus S, Menhart K, Hellwig D, Wester HJ, Kropf S, Heudobler D, Grosse J, Moosbauer J, Hutterer M, Hau P, Riemenschneider MJ, Bayerlová M, Bleckmann A, Polzer B, Beißbarth T, Klein CA, Pukrop T.

Oncotarget. 2018 Apr 10;9(27):18844-18857. doi: 10.18632/oncotarget.24787. eCollection 2018 Apr 10.


From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards.

Perera-Bel J, Hutter B, Heining C, Bleckmann A, Fröhlich M, Fröhling S, Glimm H, Brors B, Beißbarth T.

Genome Med. 2018 Mar 15;10(1):18. doi: 10.1186/s13073-018-0529-2.


Refractory or relapsed aggressive B-cell lymphoma failing (R)-CHOP: an analysis of patients treated on the RICOVER-60 trial.

Glass B, Dohm AJ, Truemper LH, Pfreundschuh M, Bleckmann A, Wulf GG, Rosenwald A, Ziepert M, Schmitz N; German High-grade Lymphoma Study Group (DSHNHL).

Ann Oncol. 2017 Dec 1;28(12):3058-3064. doi: 10.1093/annonc/mdx556.


Whole Mount RNA-FISH on Ovules and Developing Seeds.

Bleckmann A, Dresselhaus T.

Methods Mol Biol. 2017;1669:159-171. doi: 10.1007/978-1-4939-7286-9_13.


Characterisation of tumour-derived microvesicles in cancer patients' blood and correlation with clinical outcome.

Menck K, Bleckmann A, Wachter A, Hennies B, Ries L, Schulz M, Balkenhol M, Pukrop T, Schatlo B, Rost U, Wenzel D, Klemm F, Binder C.

J Extracell Vesicles. 2017 Jul 16;6(1):1340745. doi: 10.1080/20013078.2017.1340745. eCollection 2017.


Ror2 Signaling and Its Relevance in Breast Cancer Progression.

Bayerlová M, Menck K, Klemm F, Wolff A, Pukrop T, Binder C, Beißbarth T, Bleckmann A.

Front Oncol. 2017 Jun 26;7:135. doi: 10.3389/fonc.2017.00135. eCollection 2017.


Sperm cells are passive cargo of the pollen tube in plant fertilization.

Zhang J, Huang Q, Zhong S, Bleckmann A, Huang J, Guo X, Lin Q, Gu H, Dong J, Dresselhaus T, Qu LJ.

Nat Plants. 2017 Jun 6;3:17079. doi: 10.1038/nplants.2017.79.


The adaptation of colorectal cancer cells when forming metastases in the liver: expression of associated genes and pathways in a mouse model.

Bocuk D, Wolff A, Krause P, Salinas G, Bleckmann A, Hackl C, Beissbarth T, Koenig S.

BMC Cancer. 2017 May 19;17(1):342. doi: 10.1186/s12885-017-3342-1.


Long-term outcomes after TAVI in patients with different types of aortic stenosis: the conundrum of low flow, low gradient and low ejection fraction.

Puls M, Korte KP, Bleckmann A, Huenlich M, Danner BC, Schoendube F, Hasenfuß G, Jacobshagen C, Schillinger W.

EuroIntervention. 2017 Jun 20;13(3):286-293. doi: 10.4244/EIJ-D-16-00801.


Diagnostic red flags: steroid-treated malignant CNS lymphoma mimicking autoimmune inflammatory demyelination.

Barrantes-Freer A, Engel AS, Rodríguez-Villagra OA, Winkler A, Bergmann M, Mawrin C, Kuempfel T, Pellkofer H, Metz I, Bleckmann A, Hernández-Durán S, Schippling S, Rushing EJ, Frank S, Glatzel M, Matschke J, Hartmann C, Reifenberger G, Müller W, Schildhaus HU, Brück W, Stadelmann C.

Brain Pathol. 2018 Mar;28(2):225-233. doi: 10.1111/bpa.12496. Epub 2017 Apr 6.


Isolation and Characterization of Microvesicles from Peripheral Blood.

Menck K, Bleckmann A, Schulz M, Ries L, Binder C.

J Vis Exp. 2017 Jan 6;(119). doi: 10.3791/55057.


Ror2 signaling is required for local upregulation of GDF6 and activation of BMP signaling at the neural plate border.

Schille C, Bayerlová M, Bleckmann A, Schambony A.

Development. 2016 Sep 1;143(17):3182-94. doi: 10.1242/dev.135426.


A comparison between the GlideScope® classic and GlideScope® direct video laryngoscopes and direct laryngoscopy for nasotracheal intubation.

Heuer JF, Heitmann S, Crozier TA, Bleckmann A, Quintel M, Russo SG.

J Clin Anesth. 2016 Sep;33:330-6. doi: 10.1016/j.jclinane.2016.04.022. Epub 2016 May 19.


Use of the Impella Device for Acute Coronary Syndrome Complicated by Cardiogenic Shock - Experience From a Single Heart Center With Analysis of Long-term Mortality.

Schroeter MR, Köhler H, Wachter A, Bleckmann A, Hasenfuß G, Schillinger W.

J Invasive Cardiol. 2016 Dec;28(12):467-472. Epub 2016 Aug 15.


Maternal ENODLs Are Required for Pollen Tube Reception in Arabidopsis.

Hou Y, Guo X, Cyprys P, Zhang Y, Bleckmann A, Cai L, Huang Q, Luo Y, Gu H, Dresselhaus T, Dong J, Qu LJ.

Curr Biol. 2016 Sep 12;26(17):2343-50. doi: 10.1016/j.cub.2016.06.053. Epub 2016 Aug 11.


Sensitive whole mount in situ localization of small RNAs in plants.

Ghosh Dastidar M, Mosiolek M, Bleckmann A, Dresselhaus T, Nodine MD, Maizel A.

Plant J. 2016 Nov;88(4):694-702. doi: 10.1111/tpj.13270. Epub 2016 Sep 15.


Shared and distinct functions of the pseudokinase CORYNE (CRN) in shoot and root stem cell maintenance of Arabidopsis.

Somssich M, Bleckmann A, Simon R.

J Exp Bot. 2016 Aug;67(16):4901-15. doi: 10.1093/jxb/erw207. Epub 2016 May 26.


Computational Identification of Key Regulators in Two Different Colorectal Cancer Cell Lines.

Wlochowitz D, Haubrock M, Arackal J, Bleckmann A, Wolff A, Beißbarth T, Wingender E, Gültas M.

Front Genet. 2016 Apr 5;7:42. doi: 10.3389/fgene.2016.00042. eCollection 2016.


Osteolytic lesions occur rarely in patients with B-CLL and may respond well to ibrutinib.

Shumilov E, Wulf G, Ströbel P, Hasenkamp J, Hellige N, Bleckmann A, Haase D, Braulke F, Jung W, Schanz J, Binder M, Trümper L, Bacher U.

Leuk Lymphoma. 2016 Oct;57(10):2476-80. doi: 10.3109/10428194.2016.1151510. Epub 2016 Feb 25. No abstract available.


β-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases.

Bleckmann A, Conradi LC, Menck K, Schmick NA, Schubert A, Rietkötter E, Arackal J, Middel P, Schambony A, Liersch T, Homayounfar K, Beißbarth T, Klemm F, Binder C, Pukrop T.

Clin Exp Metastasis. 2016 Apr;33(4):309-23. doi: 10.1007/s10585-016-9780-3. Epub 2016 Feb 9.


Newly Constructed Network Models of Different WNT Signaling Cascades Applied to Breast Cancer Expression Data.

Bayerlová M, Klemm F, Kramer F, Pukrop T, Beißbarth T, Bleckmann A.

PLoS One. 2015 Dec 3;10(12):e0144014. doi: 10.1371/journal.pone.0144014. eCollection 2015.


Amino Acid Export in Developing Arabidopsis Seeds Depends on UmamiT Facilitators.

Müller B, Fastner A, Karmann J, Mansch V, Hoffmann T, Schwab W, Suter-Grotemeyer M, Rentsch D, Truernit E, Ladwig F, Bleckmann A, Dresselhaus T, Hammes UZ.

Curr Biol. 2015 Dec 7;25(23):3126-31. doi: 10.1016/j.cub.2015.10.038. Epub 2015 Nov 25.


The 'Dispersal Rate' - a product dependent characteristic to predict the reliability of the calibrated in vitro SPF on WW5 plates.

Batzer J, Bleckmann A, Lerg H, Schwanke F, Schläger T.

Int J Cosmet Sci. 2016 Jun;38(3):294-304. doi: 10.1111/ics.12293. Epub 2016 Jan 25.


Fluorescent whole-mount RNA in situ hybridization (F-WISH) in plant germ cells and the fertilized ovule.

Bleckmann A, Dresselhaus T.

Methods. 2016 Apr 1;98:66-73. doi: 10.1016/j.ymeth.2015.10.019. Epub 2015 Oct 30.


Comparative study on gene set and pathway topology-based enrichment methods.

Bayerlová M, Jung K, Kramer F, Klemm F, Bleckmann A, Beißbarth T.

BMC Bioinformatics. 2015 Oct 22;16:334. doi: 10.1186/s12859-015-0751-5.


The metastatic infiltration at the metastasis/brain parenchyma-interface is very heterogeneous and has a significant impact on survival in a prospective study.

Siam L, Bleckmann A, Chaung HN, Mohr A, Klemm F, Barrantes-Freer A, Blazquez R, Wolff HA, Lüke F, Rohde V, Stadelmann C, Pukrop T.

Oncotarget. 2015 Oct 6;6(30):29254-67. doi: 10.18632/oncotarget.4201.


Real-time dynamics of peptide ligand-dependent receptor complex formation in planta.

Somssich M, Ma Q, Weidtkamp-Peters S, Stahl Y, Felekyan S, Bleckmann A, Seidel CA, Simon R.

Sci Signal. 2015 Aug 4;8(388):ra76. doi: 10.1126/scisignal.aab0598.


Anti-CSF-1 treatment is effective to prevent carcinoma invasion induced by monocyte-derived cells but scarcely by microglia.

Rietkötter E, Bleckmann A, Bayerlová M, Menck K, Chuang HN, Wenske B, Schwartz H, Erez N, Binder C, Hanisch UK, Pukrop T.

Oncotarget. 2015 Jun 20;6(17):15482-93.


A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity.

Kramer D, Schön M, Bayerlová M, Bleckmann A, Schön MP, Zörnig M, Dobbelstein M.

Cell Death Dis. 2015 Feb 12;6:e1634. doi: 10.1038/cddis.2015.17.


Calcium signaling during reproduction and biotrophic fungal interactions in plants.

Chen J, Gutjahr C, Bleckmann A, Dresselhaus T.

Mol Plant. 2015 Apr;8(4):595-611. doi: 10.1016/j.molp.2015.01.023. Epub 2015 Feb 7. Review.


Tumor-derived microvesicles mediate human breast cancer invasion through differentially glycosylated EMMPRIN.

Menck K, Scharf C, Bleckmann A, Dyck L, Rost U, Wenzel D, Dhople VM, Siam L, Pukrop T, Binder C, Klemm F.

J Mol Cell Biol. 2015 Apr;7(2):143-53. doi: 10.1093/jmcb/mju047. Epub 2014 Dec 11.


The beginning of a seed: regulatory mechanisms of double fertilization.

Bleckmann A, Alter S, Dresselhaus T.

Front Plant Sci. 2014 Sep 11;5:452. doi: 10.3389/fpls.2014.00452. eCollection 2014. Review.


Integrated miRNA and mRNA profiling of tumor-educated macrophages identifies prognostic subgroups in estrogen receptor-positive breast cancer.

Bleckmann A, Leha A, Artmann S, Menck K, Salinas-Riester G, Binder C, Pukrop T, Beissbarth T, Klemm F.

Mol Oncol. 2015 Jan;9(1):155-66. doi: 10.1016/j.molonc.2014.07.023. Epub 2014 Aug 16.


The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis.

Zatula N, Wiese M, Bunzendahl J, Birchmeier W, Perske C, Bleckmann A, Brembeck FH.

Oncotarget. 2014 Aug 30;5(16):6770-87.


Male-female communication triggers calcium signatures during fertilization in Arabidopsis.

Denninger P, Bleckmann A, Lausser A, Vogler F, Ott T, Ehrhardt DW, Frommer WB, Sprunck S, Dresselhaus T, Grossmann G.

Nat Commun. 2014 Aug 22;5:4645. doi: 10.1038/ncomms5645.


Impact of frailty on short- and long-term morbidity and mortality after transcatheter aortic valve implantation: risk assessment by Katz Index of activities of daily living.

Puls M, Sobisiak B, Bleckmann A, Jacobshagen C, Danner BC, Hünlich M, Beißbarth T, Schöndube F, Hasenfuß G, Seipelt R, Schillinger W.

EuroIntervention. 2014 Sep;10(5):609-19. doi: 10.4244/EIJY14M08_03.


Failure of acute procedural success predicts adverse outcome after percutaneous edge-to-edge mitral valve repair with MitraClip.

Puls M, Tichelbäcker T, Bleckmann A, Hünlich M, von der Ehe K, Beuthner BE, Rüter K, Beißbarth T, Seipelt R, Schöndube F, Hasenfuß G, Schillinger W.

EuroIntervention. 2014;9(12):1407-17. doi: 10.4244/EIJV9I12A238.


[71-year-old patient with loss of appetite, urge to defecate, and diarrhea].

Hasenkamp J, Bleckmann A, Mekolli A.

Dtsch Med Wochenschr. 2014 May;139(18):941-2. doi: 10.1055/s-0034-1369933. Epub 2014 Apr 23. German. No abstract available.


Discrepancies between medical oncologists and surgeons in assessment of resectability and indication for chemotherapy in patients with colorectal liver metastases.

Homayounfar K, Bleckmann A, Helms HJ, Lordick F, Rüschoff J, Conradi LC, Sprenger T, Ghadimi M, Liersch T.

Br J Surg. 2014 Apr;101(5):550-7. doi: 10.1002/bjs.9436. Epub 2014 Feb 20.


[Diabetes increases short- and long-term mortality after transcatheter aortic valve implantation (TAVI)].

Puls M, Bleckmann A, Jacobshagen C, Danner BC, Hasenfuß G, Seipelt R, Schillinger W.

Dtsch Med Wochenschr. 2014 Apr;139(16):822-8. doi: 10.1055/s-0034-1369863. Epub 2014 Apr 10. German.


Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction.

Unsöld B, Kaul A, Sbroggiò M, Schubert C, Regitz-Zagrosek V, Brancaccio M, Damilano F, Hirsch E, Van Bilsen M, Munts C, Sipido K, Bito V, Detre E, Wagner NM, Schäfer K, Seidler T, Vogt J, Neef S, Bleckmann A, Maier LS, Balligand JL, Bouzin C, Ventura-Clapier R, Garnier A, Eschenhagen T, El-Armouche A, Knöll R, Tarone G, Hasenfuß G.

Cardiovasc Res. 2014 Jan 1;101(1):97-107. doi: 10.1093/cvr/cvt235. Epub 2013 Oct 15.


Zoledronic acid inhibits macrophage/microglia-assisted breast cancer cell invasion.

Rietkötter E, Menck K, Bleckmann A, Farhat K, Schaffrinski M, Schulz M, Hanisch UK, Binder C, Pukrop T.

Oncotarget. 2013 Sep;4(9):1449-60.


Relaxins enhance growth of spontaneous murine breast cancers as well as metastatic colonization of the brain.

Binder C, Chuang E, Habla C, Bleckmann A, Schulz M, Bathgate R, Einspanier A.

Clin Exp Metastasis. 2014 Jan;31(1):57-65. doi: 10.1007/s10585-013-9609-2. Epub 2013 Aug 21.

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