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Items: 32


A post-translational modification of human Norovirus capsid protein attenuates glycan binding.

Mallagaray A, Creutznacher R, Dülfer J, Mayer PHO, Grimm LL, Orduña JM, Trabjerg E, Stehle T, Rand KD, Blaum BS, Uetrecht C, Peters T.

Nat Commun. 2019 Mar 21;10(1):1320. doi: 10.1038/s41467-019-09251-5.


Divalent Sialylated Precision Glycooligomers Binding to Polyomaviruses and the Effect of Different Linkers.

Baier M, Rustmeier NH, Harr J, Cyrus N, Reiss GJ, Grafmüller A, Blaum BS, Stehle T, Hartmann L.

Macromol Biosci. 2019 May;19(5):e1800426. doi: 10.1002/mabi.201800426. Epub 2019 Mar 18.


Sialic Acids in Nonenveloped Virus Infections.

Blaum BS, Stehle T.

Adv Carbohydr Chem Biochem. 2019;76:65-111. doi: 10.1016/bs.accb.2018.09.004. Epub 2018 Nov 7. Review.


Infectious Entry of Merkel Cell Polyomavirus.

Becker M, Dominguez M, Greune L, Soria-Martinez L, Pfleiderer MM, Schowalter R, Buck CB, Blaum BS, Schmidt MA, Schelhaas M.

J Virol. 2019 Mar 5;93(6). pii: e02004-18. doi: 10.1128/JVI.02004-18. Print 2019 Mar 15.


Synthesis of highly controlled carbohydrate-polymer based hybrid structures by combining heparin fragments and sialic acid derivatives, and solid phase polymer synthesis.

Baier M, Ruppertz JL, Pfleiderer MM, Blaum BS, Hartmann L.

Chem Commun (Camb). 2018 Sep 13;54(74):10487-10490. doi: 10.1039/c8cc04898c.


Structural Optimization of a Pyridinylimidazole Scaffold: Shifting the Selectivity from p38α Mitogen-Activated Protein Kinase to c-Jun N-Terminal Kinase 3.

Ansideri F, Macedo JT, Eitel M, El-Gokha A, Zinad DS, Scarpellini C, Kudolo M, Schollmeyer D, Boeckler FM, Blaum BS, Laufer SA, Koch P.

ACS Omega. 2018 Jul 31;3(7):7809-7831. doi: 10.1021/acsomega.8b00668. Epub 2018 Jul 12.


Spin ballet for sweet encounters: saturation-transfer difference NMR and X-ray crystallography complement each other in the elucidation of protein-glycan interactions.

Blaum BS, Neu U, Peters T, Stehle T.

Acta Crystallogr F Struct Biol Commun. 2018 Aug 1;74(Pt 8):451-462. doi: 10.1107/S2053230X18006581. Epub 2018 Jul 26. Review.


Biophysical analysis of sialic acid recognition by the complement regulator Factor H.

Schmidt CQ, Hipgrave Ederveen AL, Harder MJ, Wuhrer M, Stehle T, Blaum BS.

Glycobiology. 2018 Oct 1;28(10):765-773. doi: 10.1093/glycob/cwy061.


Polysialic acid is a cellular receptor for human adenovirus 52.

Lenman A, Liaci AM, Liu Y, Frängsmyr L, Frank M, Blaum BS, Chai W, Podgorski II, Harrach B, Benkő M, Feizi T, Stehle T, Arnberg N.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4264-E4273. doi: 10.1073/pnas.1716900115. Epub 2018 Apr 19.


The lectin self of complement factor H.

Blaum BS.

Curr Opin Struct Biol. 2017 Jun;44:111-118. doi: 10.1016/ Epub 2017 Feb 9. Review.


Complement Factor H and Simian Virus 40 bind the GM1 ganglioside in distinct conformations.

Blaum BS, Frank M, Walker RC, Neu U, Stehle T.

Glycobiology. 2016 May;26(5):532-9. doi: 10.1093/glycob/cwv170. Epub 2015 Dec 28.


Trichodysplasia spinulosa-Associated Polyomavirus Uses a Displaced Binding Site on VP1 to Engage Sialylated Glycolipids.

Ströh LJ, Gee GV, Blaum BS, Dugan AS, Feltkamp MC, Atwood WJ, Stehle T.

PLoS Pathog. 2015 Aug 24;11(8):e1005112. doi: 10.1371/journal.ppat.1005112. eCollection 2015 Aug.


The Greater Affinity of JC Polyomavirus Capsid for α2,6-Linked Lactoseries Tetrasaccharide c than for Other Sialylated Glycans Is a Major Determinant of Infectivity.

Ströh LJ, Maginnis MS, Blaum BS, Nelson CD, Neu U, Gee GV, O'Hara BA, Motamedi N, DiMaio D, Atwood WJ, Stehle T.

J Virol. 2015 Jun;89(12):6364-75. doi: 10.1128/JVI.00489-15. Epub 2015 Apr 8.


Glycan engagement dictates hydrocephalus induction by serotype 1 reovirus.

Stencel-Baerenwald J, Reiss K, Blaum BS, Colvin D, Li XN, Abel T, Boyd K, Stehle T, Dermody TS.

mBio. 2015 Mar 3;6(2):e02356. doi: 10.1128/mBio.02356-14.


Structural basis for sialic acid-mediated self-recognition by complement factor H.

Blaum BS, Hannan JP, Herbert AP, Kavanagh D, Uhrín D, Stehle T.

Nat Chem Biol. 2015 Jan;11(1):77-82. doi: 10.1038/nchembio.1696. Epub 2014 Nov 24.


Structure analysis of the major capsid proteins of human polyomaviruses 6 and 7 reveals an obstructed sialic acid binding site.

Ströh LJ, Neu U, Blaum BS, Buch MH, Garcea RL, Stehle T.

J Virol. 2014 Sep;88(18):10831-9. doi: 10.1128/JVI.01084-14. Epub 2014 Jul 9.


BIR2 affects complex formation of BAK1 with ligand binding receptors in plant defense.

Halter T, Imkampe J, Blaum BS, Stehle T, Kemmerling B.

Plant Signal Behav. 2014 Apr 29;9. pii: e28944. [Epub ahead of print]


Structure of the pseudokinase domain of BIR2, a regulator of BAK1-mediated immune signaling in Arabidopsis.

Blaum BS, Mazzotta S, Nöldeke ER, Halter T, Madlung J, Kemmerling B, Stehle T.

J Struct Biol. 2014 Apr;186(1):112-21. doi: 10.1016/j.jsb.2014.02.005. Epub 2014 Feb 17.


A structure-guided mutation in the major capsid protein retargets BK polyomavirus.

Neu U, Allen SA, Blaum BS, Liu Y, Frank M, Palma AS, Ströh LJ, Feizi T, Peters T, Atwood WJ, Stehle T.

PLoS Pathog. 2013;9(10):e1003688. doi: 10.1371/journal.ppat.1003688. Epub 2013 Oct 10.


The GM2 glycan serves as a functional coreceptor for serotype 1 reovirus.

Reiss K, Stencel JE, Liu Y, Blaum BS, Reiter DM, Feizi T, Dermody TS, Stehle T.

PLoS Pathog. 2012;8(12):e1003078. doi: 10.1371/journal.ppat.1003078. Epub 2012 Dec 6.


Structures of Merkel cell polyomavirus VP1 complexes define a sialic acid binding site required for infection.

Neu U, Hengel H, Blaum BS, Schowalter RM, Macejak D, Gilbert M, Wakarchuk WW, Imamura A, Ando H, Kiso M, Arnberg N, Garcea RL, Peters T, Buck CB, Stehle T.

PLoS Pathog. 2012;8(7):e1002738. doi: 10.1371/journal.ppat.1002738. Epub 2012 Jul 26.


Structural and functional characterization of the product of disease-related factor H gene conversion.

Herbert AP, Kavanagh D, Johansson C, Morgan HP, Blaum BS, Hannan JP, Barlow PN, Uhrín D.

Biochemistry. 2012 Mar 6;51(9):1874-84. doi: 10.1021/bi201689j. Epub 2012 Feb 22.


Functional binding of hexanucleotides to 3C protease of hepatitis A virus.

Blaum BS, Wünsche W, Benie AJ, Kusov Y, Peters H, Gauss-Müller V, Peters T, Sczakiel G.

Nucleic Acids Res. 2012 Apr;40(7):3042-55. doi: 10.1093/nar/gkr1152. Epub 2011 Dec 10.


Preparation of heparin/heparan sulfate oligosaccharides with internal N-unsubstituted glucosamine residues for functional studies.

Wei Z, Deakin JA, Blaum BS, Uhrín D, Gallagher JT, Lyon M.

Glycoconj J. 2011 Dec;28(8-9):525-35. doi: 10.1007/s10719-011-9352-3. Epub 2011 Sep 21.


Structural basis for engagement by complement factor H of C3b on a self surface.

Morgan HP, Schmidt CQ, Guariento M, Blaum BS, Gillespie D, Herbert AP, Kavanagh D, Mertens HD, Svergun DI, Johansson CM, Uhrín D, Barlow PN, Hannan JP.

Nat Struct Mol Biol. 2011 Apr;18(4):463-70. doi: 10.1038/nsmb.2018. Epub 2011 Feb 13.


Interaction of human β-defensin 2 (HBD2) with glycosaminoglycans.

Seo ES, Blaum BS, Vargues T, De Cecco M, Deakin JA, Lyon M, Barran PE, Campopiano DJ, Uhrín D.

Biochemistry. 2010 Dec 14;49(49):10486-95. doi: 10.1021/bi1011749. Epub 2010 Nov 17.


Lysine and arginine side chains in glycosaminoglycan-protein complexes investigated by NMR, cross-linking, and mass spectrometry: a case study of the factor H-heparin interaction.

Blaum BS, Deakin JA, Johansson CM, Herbert AP, Barlow PN, Lyon M, Uhrín D.

J Am Chem Soc. 2010 May 12;132(18):6374-81. doi: 10.1021/ja1000517.


The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome.

Ferreira VP, Herbert AP, Cortés C, McKee KA, Blaum BS, Esswein ST, Uhrín D, Barlow PN, Pangburn MK, Kavanagh D.

J Immunol. 2009 Jun 1;182(11):7009-18. doi: 10.4049/jimmunol.0804031.


A new map of glycosaminoglycan and C3b binding sites on factor H.

Schmidt CQ, Herbert AP, Kavanagh D, Gandy C, Fenton CJ, Blaum BS, Lyon M, Uhrín D, Barlow PN.

J Immunol. 2008 Aug 15;181(4):2610-9.


Structural basis for complement factor H linked age-related macular degeneration.

Prosser BE, Johnson S, Roversi P, Herbert AP, Blaum BS, Tyrrell J, Jowitt TA, Clark SJ, Tarelli E, Uhrín D, Barlow PN, Sim RB, Day AJ, Lea SM.

J Exp Med. 2007 Oct 1;204(10):2277-83. Epub 2007 Sep 24.


Structure shows that a glycosaminoglycan and protein recognition site in factor H is perturbed by age-related macular degeneration-linked single nucleotide polymorphism.

Herbert AP, Deakin JA, Schmidt CQ, Blaum BS, Egan C, Ferreira VP, Pangburn MK, Lyon M, Uhrín D, Barlow PN.

J Biol Chem. 2007 Jun 29;282(26):18960-8. Epub 2007 Mar 13.

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