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Items: 1 to 50 of 251

1.

AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancer.

Muñoz-Lorente MA, Martínez P, Tejera Á, Whittemore K, Moisés-Silva AC, Bosch F, Blasco MA.

PLoS Genet. 2018 Aug 16;14(8):e1007562. doi: 10.1371/journal.pgen.1007562. eCollection 2018 Aug.

2.

TERRA recruitment of polycomb to telomeres is essential for histone trymethylation marks at telomeric heterochromatin.

Montero JJ, López-Silanes I, Megías D, F Fraga M, Castells-García Á, Blasco MA.

Nat Commun. 2018 Apr 18;9(1):1548. doi: 10.1038/s41467-018-03916-3.

3.

The red blood cell proportion of arachidonic acid relates to shorter leukocyte telomeres in Mediterranean elders: A secondary analysis of a randomized controlled trial.

Freitas-Simoes TM, Cofán M, Blasco MA, Soberón N, Foronda M, Corella D, Asensio EM, Serra-Mir M, Roth I, Calvo C, Valls-Pedret C, Casaroli-Marano RP, Doménech M, Rajaram S, Sabaté J, Ros E, Sala-Vila A.

Clin Nutr. 2018 Feb 17. pii: S0261-5614(18)30074-8. doi: 10.1016/j.clnu.2018.02.011. [Epub ahead of print]

PMID:
29478886
4.

Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres.

Povedano JM, Martinez P, Serrano R, Tejera Á, Gómez-López G, Bobadilla M, Flores JM, Bosch F, Blasco MA.

Elife. 2018 Jan 30;7. pii: e31299. doi: 10.7554/eLife.31299.

5.

Inhibition of TRF1 Telomere Protein Impairs Tumor Initiation and Progression in Glioblastoma Mouse Models and Patient-Derived Xenografts.

Bejarano L, Schuhmacher AJ, Méndez M, Megías D, Blanco-Aparicio C, Martínez S, Pastor J, Squatrito M, Blasco MA.

Cancer Cell. 2017 Nov 13;32(5):590-607.e4. doi: 10.1016/j.ccell.2017.10.006.

PMID:
29136505
6.

Modulation of telomere protection by the PI3K/AKT pathway.

Méndez-Pertuz M, Martínez P, Blanco-Aparicio C, Gómez-Casero E, Belen García A, Martínez-Torrecuadrada J, Palafox M, Cortés J, Serra V, Pastor J, Blasco MA.

Nat Commun. 2017 Nov 2;8(1):1278. doi: 10.1038/s41467-017-01329-2.

7.

Rattled: Analysis of Facial Trauma Among Toddlers.

Blasco MA, Kandinov A, Svider PF, Gonik NJ, Hanba C, Zuliani GF, Shkoukani MA, Carron MA.

Pediatr Emerg Care. 2017 Sep 25. doi: 10.1097/PEC.0000000000001284. [Epub ahead of print]

PMID:
28953099
8.

Gene therapy with the TRF1 telomere gene rescues decreased TRF1 levels with aging and prolongs mouse health span.

Derevyanko A, Whittemore K, Schneider RP, Jiménez V, Bosch F, Blasco MA.

Aging Cell. 2017 Dec;16(6):1353-1368. doi: 10.1111/acel.12677. Epub 2017 Sep 24.

9.

Systemic therapy for head and neck squamous cell carcinoma: Historical perspectives and recent breakthroughs.

Blasco MA, Svider PF, Raza SN, Jacobs JR, Folbe AJ, Saraf P, Eloy JA, Baredes S, Fribley AM.

Laryngoscope. 2017 Nov;127(11):2565-2569. doi: 10.1002/lary.26629. Epub 2017 Jun 5. Review.

PMID:
28581126
10.

Long Live Partial Reprogramming.

Marión RM, Blasco MA.

Circ Res. 2017 Apr 28;120(9):1381-1383. doi: 10.1161/CIRCRESAHA.117.310594. Review. No abstract available.

PMID:
28450358
11.

Critically short telomeres and toxicity of chemotherapy in early breast cancer.

Quintela-Fandino M, Soberon N, Lluch A, Manso L, Calvo I, Cortes J, Moreno-Antón F, Gil-Gil M, Martinez-Jánez N, Gonzalez-Martin A, Adrover E, de Andres R, Viñas G, Llombart-Cussac A, Alba E, Mouron S, Guerra J, Bermejo B, Zamora E, García-Saenz JA, Simon SP, Carrasco E, Escudero MJ, Campo R, Colomer R, Blasco MA.

Oncotarget. 2017 Mar 28;8(13):21472-21482. doi: 10.18632/oncotarget.15592.

12.

Recent trends in oropharyngeal cancer funding and public interest.

Blasco MA, Svider PF, Tenbrunsel T, Vellaichamy G, Yoo GH, Fribley AM, Raza SN.

Laryngoscope. 2017 Jun;127(6):1345-1350. doi: 10.1002/lary.26471. Epub 2017 Apr 11.

PMID:
28397339
13.

Telomere-driven diseases and telomere-targeting therapies.

Martínez P, Blasco MA.

J Cell Biol. 2017 Apr 3;216(4):875-887. doi: 10.1083/jcb.201610111. Epub 2017 Mar 2. Review.

14.

p53 Modulates the Fate of Cardiac Progenitor Cells Ex Vivo and in the Diabetic Heart In Vivo.

Kannappan R, Matsuda A, Ferreira-Martins J, Zhang E, Palano G, Czarna A, Cabral-Da-Silva MC, Bastos-Carvalho A, Sanada F, Ide N, Rota M, Blasco MA, Serrano M, Anversa P, Leri A.

EBioMedicine. 2017 Feb;16:224-237. doi: 10.1016/j.ebiom.2017.01.028. Epub 2017 Jan 31.

15.

Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis.

Marión RM, López de Silanes I, Mosteiro L, Gamache B, Abad M, Guerra C, Megías D, Serrano M, Blasco MA.

Stem Cell Reports. 2017 Feb 14;8(2):460-475. doi: 10.1016/j.stemcr.2017.01.001. Epub 2017 Feb 2.

16.

Head and Neck Cancer.

Svider PF, Blasco MA, Raza SN, Shkoukani M, Sukari A, Yoo GH, Folbe AJ, Lin HS, Fribley AM.

Otolaryngol Head Neck Surg. 2017 Jan;156(1):10-13. doi: 10.1177/0194599816674672. Epub 2016 Nov 14.

PMID:
28045631
17.

Tissue damage and senescence provide critical signals for cellular reprogramming in vivo.

Mosteiro L, Pantoja C, Alcazar N, Marión RM, Chondronasiou D, Rovira M, Fernandez-Marcos PJ, Muñoz-Martin M, Blanco-Aparicio C, Pastor J, Gómez-López G, De Martino A, Blasco MA, Abad M, Serrano M.

Science. 2016 Nov 25;354(6315). pii: aaf4445.

PMID:
27884981
18.

Telomere Length Defines the Cardiomyocyte Differentiation Potency of Mouse Induced Pluripotent Stem Cells.

Aguado T, Gutiérrez FJ, Aix E, Schneider RP, Giovinazzo G, Blasco MA, Flores I.

Stem Cells. 2017 Feb;35(2):362-373. doi: 10.1002/stem.2497. Epub 2016 Sep 26.

19.

A genetic interaction between RAP1 and telomerase reveals an unanticipated role for RAP1 in telomere maintenance.

Martínez P, Gómez-López G, Pisano DG, Flores JM, Blasco MA.

Aging Cell. 2016 Sep 1. doi: 10.1111/acel.12517. [Epub ahead of print]

20.

Molecular Architecture of Full-length TRF1 Favors Its Interaction with DNA.

Boskovic J, Martinez-Gago J, Mendez-Pertuz M, Buscato A, Martinez-Torrecuadrada JL, Blasco MA.

J Biol Chem. 2016 Oct 7;291(41):21829-21835. Epub 2016 Aug 25.

21.

Telomeric RNAs are essential to maintain telomeres.

Montero JJ, López de Silanes I, Graña O, Blasco MA.

Nat Commun. 2016 Aug 17;7:12534. doi: 10.1038/ncomms12534.

22.

Generation of mice with longer and better preserved telomeres in the absence of genetic manipulations.

Varela E, Muñoz-Lorente MA, Tejera AM, Ortega S, Blasco MA.

Nat Commun. 2016 Jun 2;7:11739. doi: 10.1038/ncomms11739.

23.

Short Telomere Load, Telomere Length, and Subclinical Atherosclerosis: The PESA Study.

Fernández-Alvira JM, Fuster V, Dorado B, Soberón N, Flores I, Gallardo M, Pocock S, Blasco MA, Andrés V.

J Am Coll Cardiol. 2016 May 31;67(21):2467-76. doi: 10.1016/j.jacc.2016.03.530.

24.

ATRX driver mutation in a composite malignant pheochromocytoma.

Comino-Méndez I, Tejera ÁM, Currás-Freixes M, Remacha L, Gonzalvo P, Tonda R, Letón R, Blasco MA, Robledo M, Cascón A.

Cancer Genet. 2016 Jun;209(6):272-7. doi: 10.1016/j.cancergen.2016.04.058. Epub 2016 Apr 26.

PMID:
27209355
25.

Telomeres and telomerase as therapeutic targets to prevent and treat age-related diseases.

Bär C, Blasco MA.

F1000Res. 2016 Jan 20;5. pii: F1000 Faculty Rev-89. doi: 10.12688/f1000research.7020.1. eCollection 2016. Review.

26.

Molecular insights into the OGG1 gene, a cancer risk modifier in BRCA1 and BRCA2 mutations carriers.

Benitez-Buelga C, Vaclová T, Ferreira S, Urioste M, Inglada-Perez L, Soberón N, Blasco MA, Osorio A, Benitez J.

Oncotarget. 2016 May 3;7(18):25815-25. doi: 10.18632/oncotarget.8272.

27.

Telomerase gene therapy rescues telomere length, bone marrow aplasia, and survival in mice with aplastic anemia.

Bär C, Povedano JM, Serrano R, Benitez-Buelga C, Popkes M, Formentini I, Bobadilla M, Bosch F, Blasco MA.

Blood. 2016 Apr 7;127(14):1770-9. doi: 10.1182/blood-2015-08-667485. Epub 2016 Feb 22.

28.

Profiling of Sox4-dependent transcriptome in skin links tumour suppression and adult stem cell activation.

Foronda M, Morgado-Palacin L, Gómez-López G, Domínguez O, Pisano DG, Blasco MA.

Genom Data. 2015 Aug 3;6:21-4. doi: 10.1016/j.gdata.2015.07.030. eCollection 2015 Dec.

29.

Stem and progenitor cell division kinetics during postnatal mouse mammary gland development.

Giraddi RR, Shehata M, Gallardo M, Blasco MA, Simons BD, Stingl J.

Nat Commun. 2015 Oct 29;6:8487. doi: 10.1038/ncomms9487.

30.

Telomere shortening in enterocytes of patients with uncontrolled acute intestinal graft-versus-host disease.

Hummel S, Ventura Ferreira MS, Heudobler D, Huber E, Fahrenkamp D, Gremse F, Schmid K, Müller-Newen G, Ziegler P, Jost E, Blasco MA, Brümmendorf TH, Holler E, Beier F.

Blood. 2015 Nov 26;126(22):2518-21. doi: 10.1182/blood-2015-03-633289. Epub 2015 Oct 20.

31.

NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity.

Jacome A, Gutierrez-Martinez P, Schiavoni F, Tenaglia E, Martinez P, Rodríguez-Acebes S, Lecona E, Murga M, Méndez J, Blasco MA, Fernandez-Capetillo O.

EMBO J. 2015 Nov 3;34(21):2604-19. doi: 10.15252/embj.201591829. Epub 2015 Oct 6.

32.

Telomere dynamics in patients with del (5q) MDS before and under treatment with lenalidomide.

Beier F, Masouleh BK, Buesche G, Ventura Ferreira MS, Schneider RK, Ziegler P, Wilop S, Vankann L, Gattermann N, Platzbecker U, Giagounidis A, Götze KS, Nolte F, Hofmann WK, Haase D, Kreipe H, Panse J, Blasco MA, Germing U, Brümmendorf TH.

Leuk Res. 2015 Sep 21. pii: S0145-2126(15)30380-5. doi: 10.1016/j.leukres.2015.09.003. [Epub ahead of print]

PMID:
26427727
33.

A mutation in the POT1 gene is responsible for cardiac angiosarcoma in TP53-negative Li-Fraumeni-like families.

Calvete O, Martinez P, Garcia-Pavia P, Benitez-Buelga C, Paumard-Hernández B, Fernandez V, Dominguez F, Salas C, Romero-Laorden N, Garcia-Donas J, Carrillo J, Perona R, Triviño JC, Andrés R, Cano JM, Rivera B, Alonso-Pulpon L, Setien F, Esteller M, Rodriguez-Perales S, Bougeard G, Frebourg T, Urioste M, Blasco MA, Benítez J.

Nat Commun. 2015 Sep 25;6:8383. doi: 10.1038/ncomms9383.

34.

Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells.

Ruiz S, Lopez-Contreras AJ, Gabut M, Marion RM, Gutierrez-Martinez P, Bua S, Ramirez O, Olalde I, Rodrigo-Perez S, Li H, Marques-Bonet T, Serrano M, Blasco MA, Batada NN, Fernandez-Capetillo O.

Nat Commun. 2015 Aug 21;6:8036. doi: 10.1038/ncomms9036.

35.

Therapeutic effect of androgen therapy in a mouse model of aplastic anemia produced by short telomeres.

Bär C, Huber N, Beier F, Blasco MA.

Haematologica. 2015 Oct;100(10):1267-74. doi: 10.3324/haematol.2015.129239. Epub 2015 Jul 23.

36.

Replicating through telomeres: a means to an end.

Martínez P, Blasco MA.

Trends Biochem Sci. 2015 Sep;40(9):504-15. doi: 10.1016/j.tibs.2015.06.003. Epub 2015 Jul 15. Review.

PMID:
26188776
37.

Epigenetic silencing of Oct4 by a complex containing SUV39H1 and Oct4 pseudogene lncRNA.

Scarola M, Comisso E, Pascolo R, Chiaradia R, Marion RM, Schneider C, Blasco MA, Schoeftner S, Benetti R.

Nat Commun. 2015 Jul 9;6:7631. doi: 10.1038/ncomms8631.

38.

Mice with Pulmonary Fibrosis Driven by Telomere Dysfunction.

Povedano JM, Martinez P, Flores JM, Mulero F, Blasco MA.

Cell Rep. 2015 Jul 14;12(2):286-99. doi: 10.1016/j.celrep.2015.06.028. Epub 2015 Jul 2.

39.

Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence.

Sedic M, Skibinski A, Brown N, Gallardo M, Mulligan P, Martinez P, Keller PJ, Glover E, Richardson AL, Cowan J, Toland AE, Ravichandran K, Riethman H, Naber SP, Näär AM, Blasco MA, Hinds PW, Kuperwasser C.

Nat Commun. 2015 Jun 24;6:7505. doi: 10.1038/ncomms8505.

40.

Therapeutic inhibition of TRF1 impairs the growth of p53-deficient K-RasG12V-induced lung cancer by induction of telomeric DNA damage.

García-Beccaria M, Martínez P, Méndez-Pertuz M, Martínez S, Blanco-Aparicio C, Cañamero M, Mulero F, Ambrogio C, Flores JM, Megias D, Barbacid M, Pastor J, Blasco MA.

EMBO Mol Med. 2015 Jul;7(7):930-49. doi: 10.15252/emmm.201404497.

41.

Single-cell telomere-length quantification couples telomere length to meristem activity and stem cell development in Arabidopsis.

González-García MP, Pavelescu I, Canela A, Sevillano X, Leehy KA, Nelson ADL, Ibañes M, Shippen DE, Blasco MA, Caño-Delgado AI.

Cell Rep. 2015 May 12;11(6):977-989. doi: 10.1016/j.celrep.2015.04.013. Epub 2015 Apr 30.

42.

Chronic replicative stress induced by CCl4 in TRF1 knockout mice recapitulates the origin of large liver cell changes.

Beier F, Martinez P, Blasco MA.

J Hepatol. 2015 Aug;63(2):446-55. doi: 10.1016/j.jhep.2015.03.022. Epub 2015 Mar 27.

PMID:
25819337
43.

Altered telomere homeostasis and resistance to skin carcinogenesis in Suv39h1 transgenic mice.

Petti E, Jordi F, Buemi V, Dinami R, Benetti R, Blasco MA, Schoeftner S.

Cell Cycle. 2015;14(9):1438-46. doi: 10.1080/15384101.2015.1021517.

44.

Role for telomerase in pulmonary hypertension.

Mouraret N, Houssaïni A, Abid S, Quarck R, Marcos E, Parpaleix A, Gary-Bobo G, Dubois-Randé JL, Derumeaux G, Boczkowski J, Delcroix M, Blasco MA, Lipskaia L, Amsellem V, Adnot S.

Circulation. 2015 Feb 24;131(8):742-755. doi: 10.1161/CIRCULATIONAHA.114.013258. Epub 2014 Dec 30.

45.

Impact of chemotherapy on telomere length in sporadic and familial breast cancer patients.

Benitez-Buelga C, Sanchez-Barroso L, Gallardo M, Apellániz-Ruiz M, Inglada-Pérez L, Yanowski K, Carrillo J, Garcia-Estevez L, Calvo I, Perona R, Urioste M, Osorio A, Blasco MA, Rodriguez-Antona C, Benitez J.

Breast Cancer Res Treat. 2015 Jan;149(2):385-94. doi: 10.1007/s10549-014-3246-6. Epub 2014 Dec 21.

46.

Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction.

Bär C, Bernardes de Jesus B, Serrano R, Tejera A, Ayuso E, Jimenez V, Formentini I, Bobadilla M, Mizrahi J, de Martino A, Gomez G, Pisano D, Mulero F, Wollert KC, Bosch F, Blasco MA.

Nat Commun. 2014 Dec 18;5:5863. doi: 10.1038/ncomms6863.

47.

Genome-wide analysis of in vivo TRF1 binding to chromatin restricts its location exclusively to telomeric repeats.

Garrobo I, Marión RM, Domínguez O, Pisano DG, Blasco MA.

Cell Cycle. 2014;13(23):3742-9. doi: 10.4161/15384101.2014.965044.

48.

Identification of TERRA locus unveils a telomere protection role through association to nearly all chromosomes.

López de Silanes I, Graña O, De Bonis ML, Dominguez O, Pisano DG, Blasco MA.

Nat Commun. 2014 Sep 3;5:4723. doi: 10.1038/ncomms5723.

49.

Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation.

Foronda M, Martínez P, Schoeftner S, Gómez-López G, Schneider R, Flores JM, Pisano DG, Blasco MA.

Cell Rep. 2014 Jul 24;8(2):487-500. doi: 10.1016/j.celrep.2014.06.031. Epub 2014 Jul 17.

50.

SIRT1 is necessary for proficient telomere elongation and genomic stability of induced pluripotent stem cells.

De Bonis ML, Ortega S, Blasco MA.

Stem Cell Reports. 2014 Apr 17;2(5):690-706. doi: 10.1016/j.stemcr.2014.03.002. eCollection 2014 May 6.

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