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Items: 1 to 50 of 101

1.

Mi3 syndrome. Myasthenia, migraine, myelopathy. New ultrarare disease.

Blasco F, Guillamó AE.

Med Clin (Barc). 2019 May 20. pii: S0025-7753(19)30245-3. doi: 10.1016/j.medcli.2019.03.016. [Epub ahead of print] English, Spanish. No abstract available.

PMID:
31122722
2.

Evaluating the long-term cost-effectiveness of fixed-ratio combination insulin degludec/liraglutide (IDegLira) for type 2 diabetes in Spain based on real-world clinical evidence.

Raya PM, Blasco FJA, Hunt B, Martin V, Thorsted BL, Basse A, Price H.

Diabetes Obes Metab. 2019 Jun;21(6):1349-1356. doi: 10.1111/dom.13660. Epub 2019 Mar 20.

3.

Effect of counting chamber depth on the accuracy of lensless microscopy for the assessment of boar sperm motility.

Soler C, Picazo-Bueno JÁ, Micó V, Valverde A, Bompart D, Blasco FJ, Álvarez JG, García-Molina A.

Reprod Fertil Dev. 2018 Jun;30(6):924-934. doi: 10.1071/RD17467.

PMID:
29724324
4.

Physiological determinants of individual variation in sensitivity to an organophosphate pesticide in Nile tilapia Oreochromis niloticus.

McKenzie DJ, Blasco FR, Belão TC, Killen SS, Martins ND, Taylor EW, Rantin FT.

Aquat Toxicol. 2017 Aug;189:108-114. doi: 10.1016/j.aquatox.2017.06.001. Epub 2017 Jun 9.

5.

A Cryptosporidium PI(4)K inhibitor is a drug candidate for cryptosporidiosis.

Manjunatha UH, Vinayak S, Zambriski JA, Chao AT, Sy T, Noble CG, Bonamy GMC, Kondreddi RR, Zou B, Gedeck P, Brooks CF, Herbert GT, Sateriale A, Tandel J, Noh S, Lakshminarayana SB, Lim SH, Goodman LB, Bodenreider C, Feng G, Zhang L, Blasco F, Wagner J, Leong FJ, Striepen B, Diagana TT.

Nature. 2017 Jun 15;546(7658):376-380. doi: 10.1038/nature22337. Epub 2017 May 31.

6.

The role of the autonomic nervous system in control of cardiac and air-breathing responses to sustained aerobic exercise in the African sharptooth catfish Clarias gariepinus.

Blasco FR, McKenzie DJ, Taylor EW, Rantin FT.

Comp Biochem Physiol A Mol Integr Physiol. 2017 Jan;203:273-280. doi: 10.1016/j.cbpa.2016.09.023. Epub 2016 Oct 5.

7.

Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors.

Fairhurst RA, Caravatti G, Guagnano V, Aichholz R, Blanz J, Blasco F, Wipfli P, Fritsch C, Maira SM, Schnell C, Seiler FH.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4729-4734. doi: 10.1016/j.bmcl.2016.08.041. Epub 2016 Aug 17.

PMID:
27575470
8.

Optimised method to estimate octanol water distribution coefficient (logD) in a high throughput format.

Low YW, Blasco F, Vachaspati P.

Eur J Pharm Sci. 2016 Sep 20;92:110-6. doi: 10.1016/j.ejps.2016.06.024. Epub 2016 Jun 29.

PMID:
27373604
9.

Artificial Neural Network Analysis of Pharmacokinetic and Toxicity Properties of Lead Molecules for Dengue Fever, Tuberculosis and Malaria.

Nilar SH, Lakshminarayana SB, Ma NL, Keller TH, Blasco F, Smith PW.

Curr Comput Aided Drug Des. 2016;12(1):52-61.

PMID:
26777113
10.

Identification and optimisation of 4,5-dihydrobenzo[1,2-d:3,4-d]bisthiazole and 4,5-dihydrothiazolo[4,5-h]quinazoline series of selective phosphatidylinositol-3 kinase alpha inhibitors.

Fairhurst RA, Gerspacher M, Imbach-Weese P, Mah R, Caravatti G, Furet P, Fritsch C, Schnell C, Blanz J, Blasco F, Desrayaud S, Guthy DA, Knapp M, Arz D, Wirth J, Roehn-Carnemolla E, Luu VH.

Bioorg Med Chem Lett. 2015 Sep 1;25(17):3575-81. doi: 10.1016/j.bmcl.2015.06.067. Epub 2015 Jun 26.

PMID:
26199119
11.

Discovery of Dengue Virus NS4B Inhibitors.

Wang QY, Dong H, Zou B, Karuna R, Wan KF, Zou J, Susila A, Yip A, Shan C, Yeo KL, Xu H, Ding M, Chan WL, Gu F, Seah PG, Liu W, Lakshminarayana SB, Kang C, Lescar J, Blasco F, Smith PW, Shi PY.

J Virol. 2015 Aug;89(16):8233-44.

12.

Lead optimization of spiropyrazolopyridones: a new and potent class of dengue virus inhibitors.

Zou B, Chan WL, Ding M, Leong SY, Nilar S, Seah PG, Liu W, Karuna R, Blasco F, Yip A, Chao A, Susila A, Dong H, Wang QY, Xu HY, Chan K, Wan KF, Gu F, Diagana TT, Wagner T, Dix I, Shi PY, Smith PW.

ACS Med Chem Lett. 2015 Feb 2;6(3):344-8. doi: 10.1021/ml500521r. eCollection 2015 Mar 12.

13.

Direct inhibitors of InhA are active against Mycobacterium tuberculosis.

Manjunatha UH, S Rao SP, Kondreddi RR, Noble CG, Camacho LR, Tan BH, Ng SH, Ng PS, Ma NL, Lakshminarayana SB, Herve M, Barnes SW, Yu W, Kuhen K, Blasco F, Beer D, Walker JR, Tonge PJ, Glynne R, Smith PW, Diagana TT.

Sci Transl Med. 2015 Jan 7;7(269):269ra3. doi: 10.1126/scitranslmed.3010597.

14.

Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model.

Lakshminarayana SB, Freymond C, Fischli C, Yu J, Weber S, Goh A, Yeung BK, Ho PC, Dartois V, Diagana TT, Rottmann M, Blasco F.

Antimicrob Agents Chemother. 2015 Feb;59(2):1200-10. doi: 10.1128/AAC.03274-14. Epub 2014 Dec 8.

15.

Severe hypoxia impairs lateralization in a marine teleost fish.

Lucon-Xiccato T, Nati JJ, Blasco FR, Johansen JL, Steffensen JF, Domenici P.

J Exp Biol. 2014 Dec 1;217(Pt 23):4115-8. doi: 10.1242/jeb.111229. Epub 2014 Oct 30.

16.

Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis.

Lakshminarayana SB, Boshoff HI, Cherian J, Ravindran S, Goh A, Jiricek J, Nanjundappa M, Nayyar A, Gurumurthy M, Singh R, Dick T, Blasco F, Barry CE 3rd, Ho PC, Manjunatha UH.

PLoS One. 2014 Aug 20;9(8):e105222. doi: 10.1371/journal.pone.0105222. eCollection 2014.

17.

Modulation of inflammation and pathology during dengue virus infection by p38 MAPK inhibitor SB203580.

Fu Y, Yip A, Seah PG, Blasco F, Shi PY, Hervé M.

Antiviral Res. 2014 Oct;110:151-7. doi: 10.1016/j.antiviral.2014.08.004. Epub 2014 Aug 14.

PMID:
25131378
18.

Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research.

Tuntland T, Ethell B, Kosaka T, Blasco F, Zang RX, Jain M, Gould T, Hoffmaster K.

Front Pharmacol. 2014 Jul 28;5:174. doi: 10.3389/fphar.2014.00174. eCollection 2014. Review.

19.

Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis.

Rao SP, Lakshminarayana SB, Kondreddi RR, Herve M, Camacho LR, Bifani P, Kalapala SK, Jiricek J, Ma NL, Tan BH, Ng SH, Nanjundappa M, Ravindran S, Seah PG, Thayalan P, Lim SH, Lee BH, Goh A, Barnes WS, Chen Z, Gagaring K, Chatterjee AK, Pethe K, Kuhen K, Walker J, Feng G, Babu S, Zhang L, Blasco F, Beer D, Weaver M, Dartois V, Glynne R, Dick T, Smith PW, Diagana TT, Manjunatha UH.

Sci Transl Med. 2013 Dec 4;5(214):214ra168. doi: 10.1126/scitranslmed.3007355.

20.

Activation of peripheral blood mononuclear cells by dengue virus infection depotentiates balapiravir.

Chen YL, Abdul Ghafar N, Karuna R, Fu Y, Lim SP, Schul W, Gu F, Herve M, Yokohama F, Wang G, Cerny D, Fink K, Blasco F, Shi PY.

J Virol. 2014 Feb;88(3):1740-7. doi: 10.1128/JVI.02841-13. Epub 2013 Nov 20.

21.

Development of a FACS-based assay for evaluating antiviral potency of compound in dengue infected peripheral blood mononuclear cells.

Fu Y, Chen YL, Herve M, Gu F, Shi PY, Blasco F.

J Virol Methods. 2014 Feb;196:18-24. doi: 10.1016/j.jviromet.2013.09.009. Epub 2013 Oct 18.

PMID:
24140514
22.

Therapeutic targeting of tumor growth and angiogenesis with a novel anti-S100A4 monoclonal antibody.

Hernández JL, Padilla L, Dakhel S, Coll T, Hervas R, Adan J, Masa M, Mitjans F, Martinez JM, Coma S, Rodríguez L, Noé V, Ciudad CJ, Blasco F, Messeguer R.

PLoS One. 2013 Sep 4;8(9):e72480. doi: 10.1371/journal.pone.0072480. eCollection 2013.

23.

Discovery of NVP-BYL719 a potent and selective phosphatidylinositol-3 kinase alpha inhibitor selected for clinical evaluation.

Furet P, Guagnano V, Fairhurst RA, Imbach-Weese P, Bruce I, Knapp M, Fritsch C, Blasco F, Blanz J, Aichholz R, Hamon J, Fabbro D, Caravatti G.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3741-8. doi: 10.1016/j.bmcl.2013.05.007. Epub 2013 May 14. Erratum in: Bioorg Med Chem Lett. 2013 Aug 15;23(16):4723.

PMID:
23726034
24.

The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588.

Manley PW, Blasco F, Mestan J, Aichholz R.

Bioorg Med Chem. 2013 Jun 1;21(11):3231-9. doi: 10.1016/j.bmc.2013.03.038. Epub 2013 Apr 1.

PMID:
23611771
25.

Pericoronal follicles of asymptomatic impacted teeth: a radiographic, histomorphologic, and immunohistochemical study.

Villalba L, Stolbizer F, Blasco F, Mauriño NR, Piloni MJ, Keszler A.

Int J Dent. 2012;2012:935310. doi: 10.1155/2012/935310. Epub 2012 Jan 23.

26.

Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805.

Baffert F, Régnier CH, De Pover A, Pissot-Soldermann C, Tavares GA, Blasco F, Brueggen J, Chène P, Drueckes P, Erdmann D, Furet P, Gerspacher M, Lang M, Ledieu D, Nolan L, Ruetz S, Trappe J, Vangrevelinghe E, Wartmann M, Wyder L, Hofmann F, Radimerski T.

Mol Cancer Ther. 2010 Jul;9(7):1945-55. doi: 10.1158/1535-7163.MCT-10-0053. Epub 2010 Jun 29.

27.

Immunosuppressive therapy and infection after kidney transplantation.

Fortun J, Martin-Davila P, Pascual J, Cervera C, Moreno A, Gavalda J, Aguado JM, Pereira P, Gurguí M, Carratala J, Fogueda M, Montejo M, Blasco F, Bou G, Torre-Cisneros J; RESITRA Transplant Network.

Transpl Infect Dis. 2010 Oct;12(5):397-405. doi: 10.1111/j.1399-3062.2010.00526.x.

PMID:
20553437
28.

Discovery and SAR of potent, orally available 2,8-diaryl-quinoxalines as a new class of JAK2 inhibitors.

Pissot-Soldermann C, Gerspacher M, Furet P, Gaul C, Holzer P, McCarthy C, Radimerski T, Regnier CH, Baffert F, Drueckes P, Tavares GA, Vangrevelinghe E, Blasco F, Ottaviani G, Ossola F, Scesa J, Reetz J.

Bioorg Med Chem Lett. 2010 Apr 15;20(8):2609-13. doi: 10.1016/j.bmcl.2010.02.056. Epub 2010 Feb 19.

PMID:
20231096
29.

2-Amino-aryl-7-aryl-benzoxazoles as potent, selective and orally available JAK2 inhibitors.

Gerspacher M, Furet P, Pissot-Soldermann C, Gaul C, Holzer P, Vangrevelinghe E, Lang M, Erdmann D, Radimerski T, Regnier CH, Chene P, De Pover A, Hofmann F, Baffert F, Buhl T, Aichholz R, Blasco F, Endres R, Trappe J, Drueckes P.

Bioorg Med Chem Lett. 2010 Mar 1;20(5):1724-7. doi: 10.1016/j.bmcl.2010.01.069. Epub 2010 Jan 21.

PMID:
20138510
30.

Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series.

Achermann G, Ballard TM, Blasco F, Broutin PE, Büttelmann B, Fischer H, Graf M, Hernandez MC, Hilty P, Knoflach F, Koblet A, Knust H, Kurt A, Martin JR, Masciadri R, Porter RH, Stadler H, Thomas AW, Trube G, Wichmann J.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5746-52. doi: 10.1016/j.bmcl.2009.07.153. Epub 2009 Aug 4.

PMID:
19726184
31.

Design of novel aminopyrrolidine factor Xa inhibitors from a screening hit.

Zbinden KG, Anselm L, Banner DW, Benz J, Blasco F, Décoret G, Himber J, Kuhn B, Panday N, Ricklin F, Risch P, Schlatter D, Stahl M, Thomi S, Unger R, Haap W.

Eur J Med Chem. 2009 Jul;44(7):2787-95. doi: 10.1016/j.ejmech.2008.12.025. Epub 2009 Jan 3.

PMID:
19200624
32.

Observation of subpicosecond x-ray emission from laser-cluster interaction.

Dorchies F, Blasco F, Bonté C, Caillaud T, Fourment C, Peyrusse O.

Phys Rev Lett. 2008 May 23;100(20):205002. Epub 2008 May 21.

PMID:
18518543
33.

Pck1 gene silencing in the liver improves glycemia control, insulin sensitivity, and dyslipidemia in db/db mice.

Gómez-Valadés AG, Méndez-Lucas A, Vidal-Alabró A, Blasco FX, Chillon M, Bartrons R, Bermúdez J, Perales JC.

Diabetes. 2008 Aug;57(8):2199-210. doi: 10.2337/db07-1087. Epub 2008 Apr 28.

34.

Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration.

Peters JU, Lübbers T, Alanine A, Kolczewski S, Blasco F, Steward L.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):262-6. Epub 2007 Oct 30.

PMID:
18023344
35.

Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: structure-activity relationship elucidation.

Peters JU, Lübbers T, Alanine A, Kolczewski S, Blasco F, Steward L.

Bioorg Med Chem Lett. 2008 Jan 1;18(1):256-61. Epub 2007 Oct 30.

PMID:
17998160
36.

[Expert opinion on the basic surgical technique for laparoscopic ventral hernia repair].

Morales-Conde S, Abdel-Lah A, Angoso-Catalina F, Blasco F, Feliu-Pala X, Fernández-Lobato R, González de Francisco T, Guerrero Fernández-Marcote JA, Martín-Gómez M, Martínez-García F, Morales-Méndez S, Murillo J, Oliva H, Pina J, Planellas X, Robres J, Rodero D, Ruiz-Castillo J, Serrantes-Gómez A, Tovar-Martínez JL, Tuca F, Utrera A; GRRETHAL (Grupo Español para el Estudio del Tratamiento de las Hernias Abdominales por Laparoscopia).

Cir Esp. 2005 Oct;78(4):214-21. Review. Spanish.

37.

NarJ chaperone binds on two distinct sites of the aponitrate reductase of Escherichia coli to coordinate molybdenum cofactor insertion and assembly.

Vergnes A, Pommier J, Toci R, Blasco F, Giordano G, Magalon A.

J Biol Chem. 2006 Jan 27;281(4):2170-6. Epub 2005 Nov 14.

38.

Investigation of laser-irradiated Ar cluster dynamics from K-shell x-ray emission measurements.

Dorchies F, Caillaud T, Blasco F, Bonté C, Jouin H, Micheau S, Pons B, Stevefelt J.

Phys Rev E Stat Nonlin Soft Matter Phys. 2005 Jun;71(6 Pt 2):066410. Epub 2005 Jun 27.

PMID:
16089883
39.

Membrane-associated maturation of the heterotetrameric nitrate reductase of Thermus thermophilus.

Zafra O, Cava F, Blasco F, Magalon A, Berenguer J.

J Bacteriol. 2005 Jun;187(12):3990-6.

40.

[Fever without an infectious focus and liver transplantation: Infection due to human herpes virus type 6 in transplanted patients].

Blasco F, Moreno JM, García-Navarro MJ, Cuervas-Mons V.

Enferm Infecc Microbiol Clin. 2005 May;23(5):327-8. Spanish. No abstract available.

PMID:
15899185
41.

Evidence for an EPR-detectable semiquinone intermediate stabilized in the membrane-bound subunit NarI of nitrate reductase A (NarGHI) from Escherichia coli.

Grimaldi S, Lanciano P, Bertrand P, Blasco F, Guigliarelli B.

Biochemistry. 2005 Feb 1;44(4):1300-8.

PMID:
15667223
42.

[Prolonged treatment with linezolid with good hematologic tolerability].

Ramos A, García MJ, Blasco F, Valverde ML.

Rev Esp Quimioter. 2004 Sep;17(3):266-7. Spanish. No abstract available.

43.

Structural and biochemical characterization of a quinol binding site of Escherichia coli nitrate reductase A.

Bertero MG, Rothery RA, Boroumand N, Palak M, Blasco F, Ginet N, Weiner JH, Strynadka NC.

J Biol Chem. 2005 Apr 15;280(15):14836-43. Epub 2004 Dec 22.

44.

Expression profiles of a human pancreatic cancer cell line upon induction of apoptosis search for modulators in cancer therapy.

Blasco F, Peñuelas S, Cascalló M, Hernández JL, Alemany C, Masa M, Calbó J, Soler M, Nicolás M, Pérez-Torras S, Gómez A, Tarrasón G, Noé V, Mazo A, Ciudad CJ, Piulats J.

Oncology. 2004;67(3-4):277-90.

PMID:
15557790
45.

A new type of NADH dehydrogenase specific for nitrate respiration in the extreme thermophile Thermus thermophilus.

Cava F, Zafra O, Magalon A, Blasco F, Berenguer J.

J Biol Chem. 2004 Oct 29;279(44):45369-78. Epub 2004 Jul 28.

46.

Involvement of the molybdenum cofactor biosynthetic machinery in the maturation of the Escherichia coli nitrate reductase A.

Vergnes A, Gouffi-Belhabich K, Blasco F, Giordano G, Magalon A.

J Biol Chem. 2004 Oct 1;279(40):41398-403. Epub 2004 Jul 9.

47.

The catalytic subunit of Escherichia coli nitrate reductase A contains a novel [4Fe-4S] cluster with a high-spin ground state.

Rothery RA, Bertero MG, Cammack R, Palak M, Blasco F, Strynadka NC, Weiner JH.

Biochemistry. 2004 May 11;43(18):5324-33.

PMID:
15122898
48.

CYP175A1 from Thermus thermophilus HB27, the first beta-carotene hydroxylase of the P450 superfamily.

Blasco F, Kauffmann I, Schmid RD.

Appl Microbiol Biotechnol. 2004 Jun;64(5):671-4. Epub 2004 Jan 16.

PMID:
14727092
49.

Insights into the respiratory electron transfer pathway from the structure of nitrate reductase A.

Bertero MG, Rothery RA, Palak M, Hou C, Lim D, Blasco F, Weiner JH, Strynadka NC.

Nat Struct Biol. 2003 Sep;10(9):681-7. Epub 2003 Aug 10.

PMID:
12910261
50.

Photon acceleration of ultrashort laser pulses by relativistic ionization fronts.

Dias JM, Lopes NC, Silva LO, Figueira G, Mendonça JT, Stenz C, Blasco F, Dos Santos A, Mysyrowicz A.

Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Nov;66(5 Pt 2):056406. Epub 2002 Nov 15.

PMID:
12513606

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