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Items: 1 to 50 of 204

1.

LDH-A regulates the tumor microenvironment via HIF-signaling and modulates the immune response.

Serganova I, Cohen IJ, Vemuri K, Shindo M, Maeda M, Mane M, Moroz E, Khanin R, Satagopan J, Koutcher JA, Blasberg R.

PLoS One. 2018 Sep 24;13(9):e0203965. doi: 10.1371/journal.pone.0203965. eCollection 2018.

2.

Impact of the Tumor Microenvironment on Tumor-Infiltrating Lymphocytes: Focus on Breast Cancer.

Cohen IJ, Blasberg R.

Breast Cancer (Auckl). 2017 Sep 25;11:1178223417731565. doi: 10.1177/1178223417731565. eCollection 2017. Review.

3.

Biodistribution and Dosimetry of 18F-Meta-Fluorobenzylguanidine: A First-in-Human PET/CT Imaging Study of Patients with Neuroendocrine Malignancies.

Pandit-Taskar N, Zanzonico P, Staton KD, Carrasquillo JA, Reidy-Lagunes D, Lyashchenko S, Burnazi E, Zhang H, Lewis JS, Blasberg R, Larson SM, Weber WA, Modak S.

J Nucl Med. 2018 Jan;59(1):147-153. doi: 10.2967/jnumed.117.193169. Epub 2017 Jul 13.

4.

Enhancement of PSMA-Directed CAR Adoptive Immunotherapy by PD-1/PD-L1 Blockade.

Serganova I, Moroz E, Cohen I, Moroz M, Mane M, Zurita J, Shenker L, Ponomarev V, Blasberg R.

Mol Ther Oncolytics. 2016 Dec 14;4:41-54. doi: 10.1016/j.omto.2016.11.005. eCollection 2017 Mar 17.

5.

Inhibition of prostate cancer proliferation by Deferiprone.

Simões RV, Veeraperumal S, Serganova IS, Kruchevsky N, Varshavsky J, Blasberg RG, Ackerstaff E, Koutcher JA.

NMR Biomed. 2017 Jun;30(6). doi: 10.1002/nbm.3712. Epub 2017 Mar 8.

6.

Tumor stroma interaction is mediated by monocarboxylate metabolism.

Patel BB, Ackerstaff E, Serganova IS, Kerrigan JE, Blasberg RG, Koutcher JA, Banerjee D.

Exp Cell Res. 2017 Mar 1;352(1):20-33. doi: 10.1016/j.yexcr.2017.01.013. Epub 2017 Jan 26.

7.

Synthesis and evaluation of an (18)F-labeled pyrimidine-pyridine amine for targeting CXCR4 receptors in gliomas.

Demoin DW, Shindo M, Zhang H, Edwards KJ, Serganova I, Pillarsetty NV, Lewis JS, Blasberg RG.

Nucl Med Biol. 2016 Oct;43(10):606-11. doi: 10.1016/j.nucmedbio.2016.05.005. Epub 2016 May 14.

8.

Metabolic plasticity of metastatic breast cancer cells: adaptation to changes in the microenvironment.

Simões RV, Serganova IS, Kruchevsky N, Leftin A, Shestov AA, Thaler HT, Sukenick G, Locasale JW, Blasberg RG, Koutcher JA, Ackerstaff E.

Neoplasia. 2015 Aug;17(8):671-84. doi: 10.1016/j.neo.2015.08.005.

9.

Comparative Analysis of T Cell Imaging with Human Nuclear Reporter Genes.

Moroz MA, Zhang H, Lee J, Moroz E, Zurita J, Shenker L, Serganova I, Blasberg R, Ponomarev V.

J Nucl Med. 2015 Jul;56(7):1055-60. doi: 10.2967/jnumed.115.159855. Epub 2015 May 29.

10.

Surface-enhanced resonance Raman scattering nanostars for high-precision cancer imaging.

Harmsen S, Huang R, Wall MA, Karabeber H, Samii JM, Spaliviero M, White JR, Monette S, O'Connor R, Pitter KL, Sastra SA, Saborowski M, Holland EC, Singer S, Olive KP, Lowe SW, Blasberg RG, Kircher MF.

Sci Transl Med. 2015 Jan 21;7(271):271ra7. doi: 10.1126/scitranslmed.3010633.

11.

Understanding the pharmacological properties of a metabolic PET tracer in prostate cancer.

Viola-Villegas NT, Carlin SD, Ackerstaff E, Sevak KK, Divilov V, Serganova I, Kruchevsky N, Anderson M, Blasberg RG, Andreev OA, Engelman DM, Koutcher JA, Reshetnyak YK, Lewis JS.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7254-9. doi: 10.1073/pnas.1405240111. Epub 2014 May 1.

12.

Imaging the norepinephrine transporter in neuroblastoma: a comparison of [18F]-MFBG and 123I-MIBG.

Zhang H, Huang R, Cheung NK, Guo H, Zanzonico PB, Thaler HT, Lewis JS, Blasberg RG.

Clin Cancer Res. 2014 Apr 15;20(8):2182-91. doi: 10.1158/1078-0432.CCR-13-1153. Epub 2014 Feb 26.

13.

Synthesis and evaluation of 18F-labeled benzylguanidine analogs for targeting the human norepinephrine transporter.

Zhang H, Huang R, Pillarsetty N, Thorek DL, Vaidyanathan G, Serganova I, Blasberg RG, Lewis JS.

Eur J Nucl Med Mol Imaging. 2014 Feb;41(2):322-32. doi: 10.1007/s00259-013-2558-9. Epub 2013 Oct 31.

14.

Targeting the Hsp90-associated viral oncoproteome in gammaherpesvirus-associated malignancies.

Nayar U, Lu P, Goldstein RL, Vider J, Ballon G, Rodina A, Taldone T, Erdjument-Bromage H, Chomet M, Blasberg R, Melnick A, Cerchietti L, Chiosis G, Wang YL, Cesarman E.

Blood. 2013 Oct 17;122(16):2837-47. doi: 10.1182/blood-2013-01-479972. Epub 2013 Aug 13.

15.

Relationships between LDH-A, lactate, and metastases in 4T1 breast tumors.

Rizwan A, Serganova I, Khanin R, Karabeber H, Ni X, Thakur S, Zakian KL, Blasberg R, Koutcher JA.

Clin Cancer Res. 2013 Sep 15;19(18):5158-69. doi: 10.1158/1078-0432.CCR-12-3300. Epub 2013 Jul 5.

16.

Molecular imaging of expression of vascular endothelial growth factor a (VEGF a) in femoral bone grafts transplanted into living mice.

Strachna O, Torrecilla D, Reumann MK, Serganova I, Kim J, Gieschler S, Boskey AL, Blasberg RG, Mayer-Kuckuk P.

Cell Transplant. 2014;23(7):901-12. doi: 10.3727/096368912X667015. Epub 2013 Apr 12.

17.

Noninvasive molecular imaging using reporter genes.

Brader P, Serganova I, Blasberg RG.

J Nucl Med. 2013 Feb;54(2):167-72. doi: 10.2967/jnumed.111.099788. Epub 2013 Jan 14. Review.

18.

Integrin αvβ3-targeted IRDye 800CW near-infrared imaging of glioblastoma.

Huang R, Vider J, Kovar JL, Olive DM, Mellinghoff IK, Mayer-Kuckuk P, Kircher MF, Blasberg RG.

Clin Cancer Res. 2012 Oct 15;18(20):5731-40. doi: 10.1158/1078-0432.CCR-12-0374. Epub 2012 Aug 22.

19.

Monitoring the induction of heat shock factor 1/heat shock protein 70 expression following 17-allylamino-demethoxygeldanamycin treatment by positron emission tomography and optical reporter gene imaging.

Doubrovin M, Che JT, Serganova I, Moroz E, Solit DB, Ageyeva L, Kochetkova T, Pillarsetti N, Finn R, Rosen N, Blasberg RG.

Mol Imaging. 2012 Feb;11(1):67-76.

20.

Imaging: strategies, controversies, and opportunities.

Blasberg R, Piwnica-Worms D.

Clin Cancer Res. 2012 Feb 1;18(3):631-7. doi: 10.1158/1078-0432.CCR-11-2020.

21.

MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas.

Huang R, Cheung NK, Vider J, Cheung IY, Gerald WL, Tickoo SK, Holland EC, Blasberg RG.

FASEB J. 2011 Dec;25(12):4138-49. doi: 10.1096/fj.11-185033. Epub 2011 Aug 19.

22.

Metabolic imaging: a link between lactate dehydrogenase A, lactate, and tumor phenotype.

Serganova I, Rizwan A, Ni X, Thakur SB, Vider J, Russell J, Blasberg R, Koutcher JA.

Clin Cancer Res. 2011 Oct 1;17(19):6250-6261. doi: 10.1158/1078-0432.CCR-11-0397. Epub 2011 Aug 15.

23.

The synthesis and evaluation of N1-(4-(2-[18F]-fluoroethyl)phenyl)-N8-hydroxyoctanediamide ([18F]-FESAHA), a PET radiotracer designed for the delineation of histone deacetylase expression in cancer.

Zeglis BM, Pillarsetty N, Divilov V, Blasberg RA, Lewis JS.

Nucl Med Biol. 2011 Jul;38(5):683-96. doi: 10.1016/j.nucmedbio.2010.12.008. Epub 2011 Mar 3.

24.
25.

Comparison of corticotropin-releasing factor, dexamethasone, and temozolomide: treatment efficacy and toxicity in U87 and C6 intracranial gliomas.

Moroz MA, Huang R, Kochetkov T, Shi W, Thaler H, de Stanchina E, Gamez I, Ryan RP, Blasberg RG.

Clin Cancer Res. 2011 May 15;17(10):3282-92. doi: 10.1158/1078-0432.CCR-10-3203. Epub 2011 Mar 8.

26.

Imaging colon cancer response following treatment with AZD1152: a preclinical analysis of [18F]fluoro-2-deoxyglucose and 3'-deoxy-3'-[18F]fluorothymidine imaging.

Moroz MA, Kochetkov T, Cai S, Wu J, Shamis M, Nair J, de Stanchina E, Serganova I, Schwartz GK, Banerjee D, Bertino JR, Blasberg RG.

Clin Cancer Res. 2011 Mar 1;17(5):1099-110. doi: 10.1158/1078-0432.CCR-10-1430. Epub 2011 Jan 18.

27.

Imaging expression of the human somatostatin receptor subtype-2 reporter gene with 68Ga-DOTATOC.

Zhang H, Moroz MA, Serganova I, Ku T, Huang R, Vider J, Maecke HR, Larson SM, Blasberg R, Smith-Jones PM.

J Nucl Med. 2011 Jan;52(1):123-31. doi: 10.2967/jnumed.110.079004. Epub 2010 Dec 13.

28.

Selective killing of tumor neovasculature paradoxically improves chemotherapy delivery to tumors.

Escorcia FE, Henke E, McDevitt MR, Villa CH, Smith-Jones P, Blasberg RG, Benezra R, Scheinberg DA.

Cancer Res. 2010 Nov 15;70(22):9277-86. doi: 10.1158/0008-5472.CAN-10-2029. Epub 2010 Nov 2.

29.

Genetically engineered oncolytic Newcastle disease virus effectively induces sustained remission of malignant pleural mesothelioma.

Silberhumer GR, Brader P, Wong J, Serganova IS, Gönen M, Gonzalez SJ, Blasberg R, Zamarin D, Fong Y.

Mol Cancer Ther. 2010 Oct;9(10):2761-9. doi: 10.1158/1535-7163.MCT-10-0090. Epub 2010 Sep 21.

30.

Concurrent visualization of trafficking, expansion, and activation of T lymphocytes and T-cell precursors in vivo.

Na IK, Markley JC, Tsai JJ, Yim NL, Beattie BJ, Klose AD, Holland AM, Ghosh A, Rao UK, Stephan MT, Serganova I, Santos EB, Brentjens RJ, Blasberg RG, Sadelain M, van den Brink MR.

Blood. 2010 Sep 16;116(11):e18-25. doi: 10.1182/blood-2009-12-259432. Epub 2010 May 28.

31.

Plasma protein binding of luciferase substrates influences sensitivity and accuracy of bioluminescence imaging.

Keyaerts M, Heneweer C, Gainkam LO, Caveliers V, Beattie BJ, Martens GA, Vanhove C, Bossuyt A, Blasberg RG, Lahoutte T.

Mol Imaging Biol. 2011 Feb;13(1):59-66. doi: 10.1007/s11307-010-0325-x.

PMID:
20383591
32.

In vivo bioluminescence tomography with a blocking-off finite-difference SP3 method and MRI/CT coregistration.

Klose AD, Beattie BJ, Dehghani H, Vider L, Le C, Ponomarev V, Blasberg R.

Med Phys. 2010 Jan;37(1):329-38.

33.

Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts.

Quezada SA, Simpson TR, Peggs KS, Merghoub T, Vider J, Fan X, Blasberg R, Yagita H, Muranski P, Antony PA, Restifo NP, Allison JP.

J Exp Med. 2010 Mar 15;207(3):637-50. doi: 10.1084/jem.20091918. Epub 2010 Feb 15.

34.

Apparent diffusion coefficient of glial neoplasms: correlation with fluorodeoxyglucose-positron-emission tomography and gadolinium-enhanced MR imaging.

Holodny AI, Makeyev S, Beattie BJ, Riad S, Blasberg RG.

AJNR Am J Neuroradiol. 2010 Jun;31(6):1042-8. doi: 10.3174/ajnr.A1989. Epub 2010 Feb 11.

35.

Different strategies for reducing intestinal background radioactivity associated with imaging HSV1-tk expression using established radionucleoside probes.

Ruggiero A, Brader P, Serganova I, Zanzonico P, Cai S, Lipman NS, Hricak H, Blasberg RG.

Mol Imaging. 2010 Feb;9(1):47-58.

36.

Imaging a Genetically Engineered Oncolytic Vaccinia Virus (GLV-1h99) Using a Human Norepinephrine Transporter Reporter Gene.

Brader P, Kelly KJ, Chen N, Yu YA, Zhang Q, Zanzonico P, Burnazi EM, Ghani RE, Serganova I, Hricak H, Szalay AA, Fong Y, Blasberg RG.

Clin Cancer Res. 2009 Jun 1;15(11):3791-801. doi: 10.1158/1078-0432.CCR-08-3236. Epub 2009 May 26.

37.

Registration of planar bioluminescence to magnetic resonance and x-ray computed tomography images as a platform for the development of bioluminescence tomography reconstruction algorithms.

Beattie BJ, Klose AD, Le CH, Longo VA, Dobrenkov K, Vider J, Koutcher JA, Blasberg RG.

J Biomed Opt. 2009 Mar-Apr;14(2):024045. doi: 10.1117/1.3120495.

38.

Real-time imaging of HIF-1alpha stabilization and degradation.

Moroz E, Carlin S, Dyomina K, Burke S, Thaler HT, Blasberg R, Serganova I.

PLoS One. 2009;4(4):e5077. doi: 10.1371/journal.pone.0005077. Epub 2009 Apr 4.

39.

Multimodality imaging of TGFbeta signaling in breast cancer metastases.

Serganova I, Moroz E, Vider J, Gogiberidze G, Moroz M, Pillarsetty N, Doubrovin M, Minn A, Thaler HT, Massague J, Gelovani J, Blasberg R.

FASEB J. 2009 Aug;23(8):2662-72. doi: 10.1096/fj.08-126920. Epub 2009 Mar 26.

40.

A novel recombinant vaccinia virus expressing the human norepinephrine transporter retains oncolytic potential and facilitates deep-tissue imaging.

Chen N, Zhang Q, Yu YA, Stritzker J, Brader P, Schirbel A, Samnick S, Serganova I, Blasberg R, Fong Y, Szalay AA.

Mol Med. 2009 May-Jun;15(5-6):144-51. doi: 10.2119/molmed.2009.00014. Epub 2009 Feb 25.

41.

Imaging of lymph node micrometastases using an oncolytic herpes virus and [F]FEAU PET.

Brader P, Kelly K, Gang S, Shah JP, Wong RJ, Hricak H, Blasberg RG, Fong Y, Gil Z.

PLoS One. 2009;4(3):e4789. doi: 10.1371/journal.pone.0004789. Epub 2009 Mar 10.

42.

Molecular imaging: reporter gene imaging.

Serganova I, Mayer-Kukuck P, Huang R, Blasberg R.

Handb Exp Pharmacol. 2008;(185 Pt 2):167-223. doi: 10.1007/978-3-540-77496-9_8. Review.

PMID:
18626603
43.

Imaging transgene activity in vivo.

Gade TP, Koutcher JA, Spees WM, Beattie BJ, Ponomarev V, Doubrovin M, Buchanan IM, Beresten T, Zakian KL, Le HC, Tong WP, Mayer-Kuckuk P, Blasberg RG, Gelovani JG.

Cancer Res. 2008 Apr 15;68(8):2878-84. doi: 10.1158/0008-5472.CAN-07-6028.

44.

Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas.

Becher OJ, Hambardzumyan D, Fomchenko EI, Momota H, Mainwaring L, Bleau AM, Katz AM, Edgar M, Kenney AM, Cordon-Cardo C, Blasberg RG, Holland EC.

Cancer Res. 2008 Apr 1;68(7):2241-9. doi: 10.1158/0008-5472.CAN-07-6350.

45.

Escherichia coli Nissle 1917 facilitates tumor detection by positron emission tomography and optical imaging.

Brader P, Stritzker J, Riedl CC, Zanzonico P, Cai S, Burnazi EM, Ghani ER, Hricak H, Szalay AA, Fong Y, Blasberg R.

Clin Cancer Res. 2008 Apr 15;14(8):2295-302. doi: 10.1158/1078-0432.CCR-07-4254. Epub 2008 Mar 27.

46.

Imaging of HSV-tk Reporter gene expression: comparison between [18F]FEAU, [18F]FFEAU, and other imaging probes.

Miyagawa T, Gogiberidze G, Serganova I, Cai S, Balatoni JA, Thaler HT, Ageyeva L, Pillarsetty N, Finn RD, Blasberg RG.

J Nucl Med. 2008 Apr;49(4):637-48. doi: 10.2967/jnumed.107.046227. Epub 2008 Mar 14.

47.

3'-deoxy-3'-[18F]fluorothymidine positron emission tomography is a sensitive method for imaging the response of BRAF-dependent tumors to MEK inhibition.

Solit DB, Santos E, Pratilas CA, Lobo J, Moroz M, Cai S, Blasberg R, Sebolt-Leopold J, Larson S, Rosen N.

Cancer Res. 2007 Dec 1;67(23):11463-9.

48.

HSP70-inducible hNIS-IRES-eGFP reporter imaging: response to heat shock.

Che J, Doubrovin M, Serganova I, Ageyeva L, Beresten T, Finn R, Blasberg R.

Mol Imaging. 2007 Nov-Dec;6(6):404-16.

PMID:
18053411
49.

Imaging of hypoxia-driven gene expression in an orthotopic liver tumor model.

Brader P, Riedl CC, Woo Y, Ponomarev V, Zanzonico P, Wen B, Cai S, Hricak H, Fong Y, Blasberg R, Serganova I.

Mol Cancer Ther. 2007 Nov;6(11):2900-8. Epub 2007 Nov 7.

50.

Human reporter genes: potential use in clinical studies.

Serganova I, Ponomarev V, Blasberg R.

Nucl Med Biol. 2007 Oct;34(7):791-807. Epub 2007 Aug 9. Review.

PMID:
17921031

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