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Items: 1 to 50 of 130

1.

Kinetic mechanism of Enterococcus faeciumd-aspartate ligase.

Škedelj V, Fonović UP, Molek P, Magnet S, Mainardi JL, Blanot D, Gobec S, Stojan J, Zega A.

Biochimie. 2019 Mar;158:217-223. doi: 10.1016/j.biochi.2019.01.012. Epub 2019 Jan 22.

PMID:
30682389
2.

Pectocin M1 (PcaM1) Inhibits Escherichia coli Cell Growth and Peptidoglycan Biosynthesis through Periplasmic Expression.

Chérier D, Giacomucci S, Patin D, Bouhss A, Touzé T, Blanot D, Mengin-Lecreulx D, Barreteau H.

Antibiotics (Basel). 2016 Oct 8;5(4). pii: E36.

3.

Catalytic mechanism of MraY and WecA, two paralogues of the polyprenyl-phosphate N-acetylhexosamine 1-phosphate transferase superfamily.

Al-Dabbagh B, Olatunji S, Crouvoisier M, El Ghachi M, Blanot D, Mengin-Lecreulx D, Bouhss A.

Biochimie. 2016 Aug;127:249-57. doi: 10.1016/j.biochi.2016.06.005. Epub 2016 Jun 14.

PMID:
27312048
4.

Identification and Partial Characterization of a Novel UDP-N-Acetylenolpyruvoylglucosamine Reductase/UDP-N-Acetylmuramate:l-Alanine Ligase Fusion Enzyme from Verrucomicrobium spinosum DSM 4136(T).

Naqvi KF, Patin D, Wheatley MS, Savka MA, Dobson RC, Gan HM, Barreteau H, Blanot D, Mengin-Lecreulx D, Hudson AO.

Front Microbiol. 2016 Mar 23;7:362. doi: 10.3389/fmicb.2016.00362. eCollection 2016.

5.

Crystallographic Study of Peptidoglycan Biosynthesis Enzyme MurD: Domain Movement Revisited.

Šink R, Kotnik M, Zega A, Barreteau H, Gobec S, Blanot D, Dessen A, Contreras-Martel C.

PLoS One. 2016 Mar 31;11(3):e0152075. doi: 10.1371/journal.pone.0152075. eCollection 2016.

6.

Unusual substrate specificity of the peptidoglycan MurE ligase from Erysipelothrix rhusiopathiae.

Patin D, Turk S, Barreteau H, Mainardi JL, Arthur M, Gobec S, Mengin-Lecreulx D, Blanot D.

Biochimie. 2016 Feb;121:209-18. doi: 10.1016/j.biochi.2015.12.006. Epub 2015 Dec 14.

PMID:
26700151
7.

In Vitro and In Vivo Analysis of the Gram-Negative Bacteria-Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells.

Soudais C, Samassa F, Sarkis M, Le Bourhis L, Bessoles S, Blanot D, Hervé M, Schmidt F, Mengin-Lecreulx D, Lantz O.

J Immunol. 2015 May 15;194(10):4641-9. doi: 10.4049/jimmunol.1403224. Epub 2015 Apr 13.

8.

Diaminopimelic Acid Amidation in Corynebacteriales: NEW INSIGHTS INTO THE ROLE OF LtsA IN PEPTIDOGLYCAN MODIFICATION.

Levefaudes M, Patin D, de Sousa-d'Auria C, Chami M, Blanot D, Hervé M, Arthur M, Houssin C, Mengin-Lecreulx D.

J Biol Chem. 2015 May 22;290(21):13079-94. doi: 10.1074/jbc.M115.642843. Epub 2015 Apr 6.

9.

MurD enzymes: some recent developments.

Šink R, Barreteau H, Patin D, Mengin-Lecreulx D, Gobec S, Blanot D.

Biomol Concepts. 2013 Dec;4(6):539-56. doi: 10.1515/bmc-2013-0024. Review.

PMID:
25436755
10.

Purification and biochemical characterisation of GlmU from Yersinia pestis.

Patin D, Bayliss M, Mengin-Lecreulx D, Oyston P, Blanot D.

Arch Microbiol. 2015 Apr;197(3):371-8. doi: 10.1007/s00203-014-1065-0. Epub 2014 Nov 23.

PMID:
25417006
11.

Enantioselective synthesis of α-benzylated lanthionines and related tripeptides for biological incorporation into E. coli peptidoglycan.

Denoël T, Zervosen A, Lemaire C, Joris B, Hervé M, Blanot D, Zaragoza G, Luxen A.

Org Biomol Chem. 2014 Dec 28;12(48):9853-63. doi: 10.1039/c4ob01476f.

PMID:
25355616
12.

Stereoselective synthesis of lanthionine derivatives in aqueous solution and their incorporation into the peptidoglycan of Escherichia coli.

Denoël T, Zervosen A, Gerards T, Lemaire C, Joris B, Blanot D, Luxen A.

Bioorg Med Chem. 2014 Sep 1;22(17):4621-8. doi: 10.1016/j.bmc.2014.07.023. Epub 2014 Jul 23.

PMID:
25124861
13.

Design, synthesis and evaluation of second generation MurF inhibitors based on a cyanothiophene scaffold.

Hrast M, Anderluh M, Knez D, Randall CP, Barreteau H, O'Neill AJ, Blanot D, Gobec S.

Eur J Med Chem. 2014 Feb 12;73:83-96. doi: 10.1016/j.ejmech.2013.11.031. Epub 2013 Dec 12.

PMID:
24384549
14.

Specificity determinants for lysine incorporation in Staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex.

Ruane KM, Lloyd AJ, Fülöp V, Dowson CG, Barreteau H, Boniface A, Dementin S, Blanot D, Mengin-Lecreulx D, Gobec S, Dessen A, Roper DI.

J Biol Chem. 2013 Nov 15;288(46):33439-48. doi: 10.1074/jbc.M113.508135. Epub 2013 Sep 24.

15.

Biochemical characterization of MurF from Streptococcus pneumoniae and the identification of a new MurF inhibitor through ligand-based virtual screening.

Turk S, Hrast M, Sosic I, Barreteau H, Mengin-Lecreulx D, Blanot D, Gobec S.

Acta Chim Slov. 2013;60(2):294-9.

PMID:
23878932
16.

Discovery of the first inhibitors of bacterial enzyme D-aspartate ligase from Enterococcus faecium (Aslfm).

Škedelj V, Perdih A, Brvar M, Kroflič A, Dubbée V, Savage V, O'Neill AJ, Solmajer T, Bešter-Rogač M, Blanot D, Hugonnet JE, Magnet S, Arthur M, Mainardi JL, Stojan J, Zega A.

Eur J Med Chem. 2013 Sep;67:208-20. doi: 10.1016/j.ejmech.2013.06.017. Epub 2013 Jun 28.

PMID:
23867605
17.

Structure-activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF.

Hrast M, Turk S, Sosič I, Knez D, Randall CP, Barreteau H, Contreras-Martel C, Dessen A, O'Neill AJ, Mengin-Lecreulx D, Blanot D, Gobec S.

Eur J Med Chem. 2013 Aug;66:32-45. doi: 10.1016/j.ejmech.2013.05.013. Epub 2013 May 21.

PMID:
23786712
18.

Biochemical characterization of UDP-N-acetylmuramoyl-L-alanyl-D-glutamate: meso-2,6-diaminopimelate ligase (MurE) from Verrucomicrobium spinosum DSM 4136(T.).

McGroty SE, Pattaniyil DT, Patin D, Blanot D, Ravichandran AC, Suzuki H, Dobson RC, Savka MA, Hudson AO.

PLoS One. 2013 Jun 13;8(6):e66458. doi: 10.1371/journal.pone.0066458. Print 2013.

19.

The functional vanGCd cluster of Clostridium difficile does not confer vancomycin resistance.

Ammam F, Meziane-Cherif D, Mengin-Lecreulx D, Blanot D, Patin D, Boneca IG, Courvalin P, Lambert T, Candela T.

Mol Microbiol. 2013 Aug;89(4):612-25. doi: 10.1111/mmi.12299. Epub 2013 Jul 12.

20.

The structure of FemX(Wv) in complex with a peptidyl-RNA conjugate: mechanism of aminoacyl transfer from Ala-tRNA(Ala) to peptidoglycan precursors.

Fonvielle M, Li de La Sierra-Gallay I, El-Sagheer AH, Lecerf M, Patin D, Mellal D, Mayer C, Blanot D, Gale N, Brown T, van Tilbeurgh H, Ethève-Quelquejeu M, Arthur M.

Angew Chem Int Ed Engl. 2013 Jul 8;52(28):7278-81. doi: 10.1002/anie.201301411. Epub 2013 Jun 6. No abstract available.

PMID:
23744707
21.

Identification of a synthetic muramyl peptide derivative with enhanced Nod2 stimulatory capacity.

Rubino SJ, Magalhaes JG, Philpott D, Bahr GM, Blanot D, Girardin SE.

Innate Immun. 2013 Oct;19(5):493-503. doi: 10.1177/1753425912471691. Epub 2013 Jan 22.

PMID:
23339926
22.

The binding mode of second-generation sulfonamide inhibitors of MurD: clues for rational design of potent MurD inhibitors.

Simčič M, Sosič I, Hodošček M, Barreteau H, Blanot D, Gobec S, Grdadolnik SG.

PLoS One. 2012;7(12):e52817. doi: 10.1371/journal.pone.0052817. Epub 2012 Dec 20.

23.

Synthetic tripeptides as alternate substrates of murein peptide ligase (Mpl).

Hervé M, Kovač A, Cardoso C, Patin D, Brus B, Barreteau H, Mengin-Lecreulx D, Gobec S, Blanot D.

Biochimie. 2013 Jun;95(6):1120-6. doi: 10.1016/j.biochi.2012.12.011. Epub 2012 Dec 25.

PMID:
23270797
24.

Efficient access to peptidyl-RNA conjugates for picomolar inhibition of non-ribosomal FemX(Wv) aminoacyl transferase.

Fonvielle M, Mellal D, Patin D, Lecerf M, Blanot D, Bouhss A, Santarem M, Mengin-Lecreulx D, Sollogoub M, Arthur M, Ethève-Quelquejeu M.

Chemistry. 2013 Jan 21;19(4):1357-63. doi: 10.1002/chem.201201999. Epub 2012 Nov 29.

PMID:
23197408
25.

Colicin M, a peptidoglycan lipid-II-degrading enzyme: potential use for antibacterial means?

Touzé T, Barreteau H, El Ghachi M, Bouhss A, Barnéoud-Arnoulet A, Patin D, Sacco E, Blanot D, Arthur M, Duché D, Lloubès R, Mengin-Lecreulx D.

Biochem Soc Trans. 2012 Dec 1;40(6):1522-7. doi: 10.1042/BST20120189.

PMID:
23176510
26.

Functional and structural characterization of PaeM, a colicin M-like bacteriocin produced by Pseudomonas aeruginosa.

Barreteau H, Tiouajni M, Graille M, Josseaume N, Bouhss A, Patin D, Blanot D, Fourgeaud M, Mainardi JL, Arthur M, van Tilbeurgh H, Mengin-Lecreulx D, Touzé T.

J Biol Chem. 2012 Oct 26;287(44):37395-405. doi: 10.1074/jbc.M112.406439. Epub 2012 Sep 12.

27.

Dual Inhibitor of MurD and MurE Ligases from Escherichia coli and Staphylococcus aureus.

Tomašić T, Sink R, Zidar N, Fic A, Contreras-Martel C, Dessen A, Patin D, Blanot D, Müller-Premru M, Gobec S, Zega A, Kikelj D, Mašič LP.

ACS Med Chem Lett. 2012 Jun 27;3(8):626-30. doi: 10.1021/ml300047h. eCollection 2012 Aug 9.

28.

MurD enzymes from different bacteria: evaluation of inhibitors.

Barreteau H, Sosič I, Turk S, Humljan J, Tomašić T, Zidar N, Hervé M, Boniface A, Peterlin-Mašič L, Kikelj D, Mengin-Lecreulx D, Gobec S, Blanot D.

Biochem Pharmacol. 2012 Sep 1;84(5):625-32. doi: 10.1016/j.bcp.2012.06.006. Epub 2012 Jun 15.

PMID:
22705647
29.

Characterization of colicin M and its orthologs targeting bacterial cell wall peptidoglycan biosynthesis.

Barreteau H, El Ghachi M, Barnéoud-Arnoulet A, Sacco E, Touzé T, Duché D, Gérard F, Brooks M, Patin D, Bouhss A, Blanot D, van Tilbeurgh H, Arthur M, Lloubès R, Mengin-Lecreulx D.

Microb Drug Resist. 2012 Jun;18(3):222-9. doi: 10.1089/mdr.2011.0230. Epub 2012 Mar 20. Review.

PMID:
22432709
30.

Biochemical characterisation of the chlamydial MurF ligase, and possible sequence of the chlamydial peptidoglycan pentapeptide stem.

Patin D, Bostock J, Chopra I, Mengin-Lecreulx D, Blanot D.

Arch Microbiol. 2012 Jun;194(6):505-12. doi: 10.1007/s00203-011-0784-8. Epub 2012 Jan 10.

PMID:
22231476
31.

Colicin M hydrolyses branched lipids II from Gram-positive bacteria.

Patin D, Barreteau H, Auger G, Magnet S, Crouvoisier M, Bouhss A, Touzé T, Arthur M, Mengin-Lecreulx D, Blanot D.

Biochimie. 2012 Apr;94(4):985-90. doi: 10.1016/j.biochi.2011.12.019. Epub 2011 Dec 26.

PMID:
22210388
32.

Biochemical disclosure of the mycolate outer membrane of Corynebacterium glutamicum.

Marchand CH, Salmeron C, Bou Raad R, Méniche X, Chami M, Masi M, Blanot D, Daffé M, Tropis M, Huc E, Le Maréchal P, Decottignies P, Bayan N.

J Bacteriol. 2012 Feb;194(3):587-97. doi: 10.1128/JB.06138-11. Epub 2011 Nov 28.

33.

New 5-benzylidenethiazolidin-4-one inhibitors of bacterial MurD ligase: design, synthesis, crystal structures, and biological evaluation.

Zidar N, Tomašić T, Šink R, Kovač A, Patin D, Blanot D, Contreras-Martel C, Dessen A, Premru MM, Zega A, Gobec S, Mašič LP, Kikelj D.

Eur J Med Chem. 2011 Nov;46(11):5512-23. doi: 10.1016/j.ejmech.2011.09.017. Epub 2011 Sep 17.

PMID:
21963114
34.

Synthesis and biological evaluation of biotinyl hydrazone derivatives of muramyl peptides.

Blanot D, Lee J, Girardin SE.

Chem Biol Drug Des. 2012 Jan;79(1):2-8. doi: 10.1111/j.1747-0285.2011.01204.x. Epub 2011 Nov 4.

PMID:
21816004
35.

Novel 2-thioxothiazolidin-4-one inhibitors of bacterial MurD ligase targeting D-Glu- and diphosphate-binding sites.

Tomašić T, Kovač A, Simčič M, Blanot D, Grdadolnik SG, Gobec S, Kikelj D, Peterlin Mašič L.

Eur J Med Chem. 2011 Sep;46(9):3964-75. doi: 10.1016/j.ejmech.2011.05.070. Epub 2011 Jun 23.

PMID:
21703731
36.

Virtual screening for potential inhibitors of bacterial MurC and MurD ligases.

Tomašić T, Kovač A, Klebe G, Blanot D, Gobec S, Kikelj D, Mašič LP.

J Mol Model. 2012 Mar;18(3):1063-72. doi: 10.1007/s00894-011-1139-8. Epub 2011 Jun 12.

PMID:
21667288
37.

Design, Synthesis and in vitro Biochemical Activity of Novel Amino Acid Sulfonohydrazide Inhibitors of MurC.

Frlan R, Kovač A, Blanot D, Gobec S, Pečar S, Obreza A.

Acta Chim Slov. 2011 Jun;58(2):295-310.

PMID:
24062040
38.

Structure-based design of a new series of D-glutamic acid based inhibitors of bacterial UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase (MurD).

Tomasić T, Zidar N, Sink R, Kovac A, Blanot D, Contreras-Martel C, Dessen A, Müller-Premru M, Zega A, Gobec S, Kikelj D, Masic LP.

J Med Chem. 2011 Jul 14;54(13):4600-10. doi: 10.1021/jm2002525. Epub 2011 Jun 3.

PMID:
21591605
39.

Second-generation sulfonamide inhibitors of D-glutamic acid-adding enzyme: activity optimisation with conformationally rigid analogues of D-glutamic acid.

Sosič I, Barreteau H, Simčič M, Sink R, Cesar J, Zega A, Grdadolnik SG, Contreras-Martel C, Dessen A, Amoroso A, Joris B, Blanot D, Gobec S.

Eur J Med Chem. 2011 Jul;46(7):2880-94. doi: 10.1016/j.ejmech.2011.04.011. Epub 2011 Apr 9.

40.

Design and Synthesis of New Peptidomimetics as Potential Inhibitors of MurE.

Zivec M, Turk S, Blanot D, Gobec S.

Acta Chim Slov. 2011 Mar;58(1):95-109.

PMID:
24061949
41.

X-ray structure and site-directed mutagenesis analysis of the Escherichia coli colicin M immunity protein.

Gérard F, Brooks MA, Barreteau H, Touzé T, Graille M, Bouhss A, Blanot D, van Tilbeurgh H, Mengin-Lecreulx D.

J Bacteriol. 2011 Jan;193(1):205-14. doi: 10.1128/JB.01119-10. Epub 2010 Oct 29.

42.

Discovery of novel 5-benzylidenerhodanine and 5-benzylidenethiazolidine-2,4-dione inhibitors of MurD ligase.

Zidar N, Tomasić T, Sink R, Rupnik V, Kovac A, Turk S, Patin D, Blanot D, Contreras Martel C, Dessen A, Müller Premru M, Zega A, Gobec S, Peterlin Masic L, Kikelj D.

J Med Chem. 2010 Sep 23;53(18):6584-94. doi: 10.1021/jm100285g.

PMID:
20804196
43.

Purification and biochemical characterization of Mur ligases from Staphylococcus aureus.

Patin D, Boniface A, Kovač A, Hervé M, Dementin S, Barreteau H, Mengin-Lecreulx D, Blanot D.

Biochimie. 2010 Dec;92(12):1793-800. doi: 10.1016/j.biochi.2010.07.009. Epub 2010 Jul 24.

PMID:
20659527
44.

Deciphering the catalytic domain of colicin M, a peptidoglycan lipid II-degrading enzyme.

Barreteau H, Bouhss A, Gérard F, Duché D, Boussaid B, Blanot D, Lloubès R, Mengin-Lecreulx D, Touzé T.

J Biol Chem. 2010 Apr 16;285(16):12378-89. doi: 10.1074/jbc.M109.093583. Epub 2010 Feb 16.

45.

Activation of the L,D-transpeptidation peptidoglycan cross-linking pathway by a metallo-D,D-carboxypeptidase in Enterococcus faecium.

Sacco E, Hugonnet JE, Josseaume N, Cremniter J, Dubost L, Marie A, Patin D, Blanot D, Rice LB, Mainardi JL, Arthur M.

Mol Microbiol. 2010 Feb;75(4):874-85. doi: 10.1111/j.1365-2958.2009.07014.x. Epub 2009 Dec 16.

46.

5-Benzylidenethiazolidin-4-ones as multitarget inhibitors of bacterial Mur ligases.

Tomasić T, Zidar N, Kovac A, Turk S, Simcic M, Blanot D, Müller-Premru M, Filipic M, Grdadolnik SG, Zega A, Anderluh M, Gobec S, Kikelj D, Peterlin Masic L.

ChemMedChem. 2010 Feb 1;5(2):286-95. doi: 10.1002/cmdc.200900449.

PMID:
20024979
47.

Functional and biochemical analysis of the Chlamydia trachomatis ligase MurE.

Patin D, Bostock J, Blanot D, Mengin-Lecreulx D, Chopra I.

J Bacteriol. 2009 Dec;191(24):7430-5. doi: 10.1128/JB.01029-09. Epub 2009 Oct 9.

48.

Phosphorylated hydroxyethylamines as novel inhibitors of the bacterial cell wall biosynthesis enzymes MurC to MurF.

Sova M, Kovac A, Turk S, Hrast M, Blanot D, Gobec S.

Bioorg Chem. 2009 Dec;37(6):217-22. doi: 10.1016/j.bioorg.2009.09.001. Epub 2009 Sep 10.

PMID:
19804894
49.

The elucidation of the structure of Thermotoga maritima peptidoglycan reveals two novel types of cross-link.

Boniface A, Parquet C, Arthur M, Mengin-Lecreulx D, Blanot D.

J Biol Chem. 2009 Aug 14;284(33):21856-62. doi: 10.1074/jbc.M109.034363. Epub 2009 Jun 19.

50.

Preparative enzymatic synthesis of polyprenyl-pyrophosphoryl-N-acetylglucosamine, an essential lipid intermediate for the biosynthesis of various bacterial cell envelope polymers.

Al-Dabbagh B, Blanot D, Mengin-Lecreulx D, Bouhss A.

Anal Biochem. 2009 Aug 15;391(2):163-5. doi: 10.1016/j.ab.2009.05.011. Epub 2009 May 12.

PMID:
19442646

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