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Microfluidic platform for multimodal analysis of enzyme secretion in nanoliter droplet arrays.

Huemmer D, Bachler S, Köhler M, Blank LM, Zenobi R, Dittrich PS.

Anal Chem. 2018 Dec 20. doi: 10.1021/acs.analchem.8b04506. [Epub ahead of print]


From beech wood to itaconic acid: case study on biorefinery process integration.

Regestein L, Klement T, Grande P, Kreyenschulte D, Heyman B, Maßmann T, Eggert A, Sengpiel R, Wang Y, Wierckx N, Blank LM, Spiess A, Leitner W, Bolm C, Wessling M, Jupke A, Rosenbaum M, Büchs J.

Biotechnol Biofuels. 2018 Oct 11;11:279. doi: 10.1186/s13068-018-1273-y. eCollection 2018. Review.


Restoration of biofuel production levels and increased tolerance under ionic liquid stress is enabled by a mutation in the essential Escherichia coli gene cydC.

Eng T, Demling P, Herbert RA, Chen Y, Benites V, Martin J, Lipzen A, Baidoo EEK, Blank LM, Petzold CJ, Mukhopadhyay A.

Microb Cell Fact. 2018 Oct 8;17(1):159. doi: 10.1186/s12934-018-1006-8.


Analytical polyphosphate extraction from Saccharomyces cerevisiae.

Christ JJ, Blank LM.

Anal Biochem. 2018 Dec 15;563:71-78. doi: 10.1016/j.ab.2018.09.021. Epub 2018 Oct 1.


CO2 to succinic acid - Estimating the potential of biocatalytic routes.

Liebal UW, Blank LM, Ebert BE.

Metab Eng Commun. 2018 Jun 28;7:e00075. doi: 10.1016/j.mec.2018.e00075. eCollection 2018 Dec.


Using quantitative systems pharmacology to evaluate the drug efficacy of COX-2 and 5-LOX inhibitors in therapeutic situations.

Thiel C, Smit I, Baier V, Cordes H, Fabry B, Blank LM, Kuepfer L.

NPJ Syst Biol Appl. 2018 Aug 3;4:28. doi: 10.1038/s41540-018-0062-3. eCollection 2018.


Evolutionary freedom in the regulation of the conserved itaconate cluster by Ria1 in related Ustilaginaceae.

Geiser E, Hosseinpour Tehrani H, Meyer S, Blank LM, Wierckx N.

Fungal Biol Biotechnol. 2018 Jul 28;5:14. doi: 10.1186/s40694-018-0058-1. eCollection 2018.


Physiologic and metabolic characterization of Saccharomyces cerevisiae reveals limitations in the synthesis of the triterpene squalene.

Ebert BE, Czarnotta E, Blank LM.

FEMS Yeast Res. 2018 Dec 1;18(8). doi: 10.1093/femsyr/foy077.


Discovery and Evaluation of Biosynthetic Pathways for the Production of Five Methyl Ethyl Ketone Precursors.

Tokic M, Hadadi N, Ataman M, Neves D, Ebert BE, Blank LM, Miskovic L, Hatzimanikatis V.

ACS Synth Biol. 2018 Aug 17;7(8):1858-1873. doi: 10.1021/acssynbio.8b00049. Epub 2018 Aug 7.


Mass spectrometric characterization of siderophores produced by Pseudomonas taiwanensis VLB120 assisted by stable isotope labeling of nitrogen source.

Scholz K, Tiso T, Blank LM, Hayen H.

Biometals. 2018 Oct;31(5):785-795. doi: 10.1007/s10534-018-0122-6. Epub 2018 Jun 28.


Engineering Pseudomonas putida KT2440 for efficient ethylene glycol utilization.

Franden MA, Jayakody LN, Li WJ, Wagner NJ, Cleveland NS, Michener WE, Hauer B, Blank LM, Wierckx N, Klebensberger J, Beckham GT.

Metab Eng. 2018 Jul;48:197-207. doi: 10.1016/j.ymben.2018.06.003. Epub 2018 Jun 7.


Online in vivo monitoring of cytosolic NAD redox dynamics in Ustilago maydis.

Hartmann SK, Stockdreher Y, Wandrey G, Hosseinpour Tehrani H, Zambanini T, Meyer AJ, Büchs J, Blank LM, Schwarzländer M, Wierckx N.

Biochim Biophys Acta Bioenerg. 2018 May 22. pii: S0005-2728(18)30128-2. doi: 10.1016/j.bbabio.2018.05.012. [Epub ahead of print]


Genetic Optimization Algorithm for Metabolic Engineering Revisited.

Alter TB, Blank LM, Ebert BE.

Metabolites. 2018 May 16;8(2). pii: E33. doi: 10.3390/metabo8020033.


Improved microscale cultivation of Pichia pastoris for clonal screening.

Eck A, Schmidt M, Hamer S, Ruff AJ, Förster J, Schwaneberg U, Blank LM, Wiechert W, Oldiges M.

Fungal Biol Biotechnol. 2018 May 3;5:8. doi: 10.1186/s40694-018-0053-6. eCollection 2018.


Metabolic engineering of Pseudomonas taiwanensis VLB120 with minimal genomic modifications for high-yield phenol production.

Wynands B, Lenzen C, Otto M, Koch F, Blank LM, Wierckx N.

Metab Eng. 2018 May;47:121-133. doi: 10.1016/j.ymben.2018.03.011. Epub 2018 Mar 14.


Integration of genome-scale metabolic networks into whole-body PBPK models shows phenotype-specific cases of drug-induced metabolic perturbation.

Cordes H, Thiel C, Baier V, Blank LM, Kuepfer L.

NPJ Syst Biol Appl. 2018 Feb 26;4:10. doi: 10.1038/s41540-018-0048-1. eCollection 2018.


Enzymatic quantification and length determination of polyphosphate down to a chain length of two.

Christ JJ, Blank LM.

Anal Biochem. 2018 May 1;548:82-90. doi: 10.1016/j.ab.2018.02.018. Epub 2018 Feb 24.


A breath of information: the volatilome.

Mansurova M, Ebert BE, Blank LM, Ibáñez AJ.

Curr Genet. 2018 Aug;64(4):959-964. doi: 10.1007/s00294-017-0800-x. Epub 2017 Dec 26.


Heterologous production of long-chain rhamnolipids from Burkholderia glumae in Pseudomonas putida-a step forward to tailor-made rhamnolipids.

Wittgens A, Santiago-Schuebel B, Henkel M, Tiso T, Blank LM, Hausmann R, Hofmann D, Wilhelm S, Jaeger KE, Rosenau F.

Appl Microbiol Biotechnol. 2018 Feb;102(3):1229-1239. doi: 10.1007/s00253-017-8702-x. Epub 2017 Dec 20.


Designer rhamnolipids by reduction of congener diversity: production and characterization.

Tiso T, Zauter R, Tulke H, Leuchtle B, Li WJ, Behrens B, Wittgens A, Rosenau F, Hayen H, Blank LM.

Microb Cell Fact. 2017 Dec 14;16(1):225. doi: 10.1186/s12934-017-0838-y.


Promoters from the itaconate cluster of Ustilago maydis are induced by nitrogen depletion.

Zambanini T, Hartmann SK, Schmitz LM, Büttner L, Hosseinpour Tehrani H, Geiser E, Beudels M, Venc D, Wandrey G, Büchs J, Schwarzländer M, Blank LM, Wierckx N.

Fungal Biol Biotechnol. 2017 Nov 28;4:11. doi: 10.1186/s40694-017-0040-3. eCollection 2017.


A comprehensive evaluation of constraining amino acid biosynthesis in compartmented models for metabolic flux analysis.

Lehnen M, Ebert BE, Blank LM.

Metab Eng Commun. 2017 Jul 11;5:34-44. doi: 10.1016/j.meteno.2017.07.001. eCollection 2017 Dec.


Multi-capillary Column Ion Mobility Spectrometry of Volatile Metabolites for Phenotyping of Microorganisms.

Halbfeld C, Baumbach JI, Blank LM, Ebert BE.

Methods Mol Biol. 2018;1671:229-258. doi: 10.1007/978-1-4939-7295-1_15.


Metabolic engineering of Ustilago trichophora TZ1 for improved malic acid production.

Zambanini T, Hosseinpour Tehrani H, Geiser E, Sonntag CK, Buescher JM, Meurer G, Wierckx N, Blank LM.

Metab Eng Commun. 2017 Jan 17;4:12-21. doi: 10.1016/j.meteno.2017.01.002. eCollection 2017 Jun.


Comprehensive Real-Time Analysis of the Yeast Volatilome.

Tejero Rioseras A, Garcia Gomez D, Ebert BE, Blank LM, Ibáñez AJ, Sinues PM.

Sci Rep. 2017 Oct 27;7(1):14236. doi: 10.1038/s41598-017-14554-y.


A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity.

Kuepfer L, Clayton O, Thiel C, Cordes H, Nudischer R, Blank LM, Baier V, Heymans S, Caiment F, Roth A, Fluri DA, Kelm JM, Castell J, Selevsek N, Schlapbach R, Keun H, Hynes J, Sarkans U, Gmuender H, Herwig R, Niederer S, Schuchhardt J, Segall M, Kleinjans J.

Arch Toxicol. 2018 Jan;92(1):553-555. doi: 10.1007/s00204-017-2041-7. Epub 2017 Aug 29. No abstract available.


Fermentation and purification strategies for the production of betulinic acid and its lupane-type precursors in Saccharomyces cerevisiae.

Czarnotta E, Dianat M, Korf M, Granica F, Merz J, Maury J, Baallal Jacobsen SA, Förster J, Ebert BE, Blank LM.

Biotechnol Bioeng. 2017 Nov;114(11):2528-2538. doi: 10.1002/bit.26377. Epub 2017 Aug 17.


Anionic Extraction for Efficient Recovery of Biobased 2,3-Butanediol-A Platform for Bulk and Fine Chemicals.

Drabo P, Tiso T, Heyman B, Sarikaya E, Gaspar P, Förster J, Büchs J, Blank LM, Delidovich I.

ChemSusChem. 2017 Aug 24;10(16):3252-3259. doi: 10.1002/cssc.201700899. Epub 2017 Aug 2.


Efficient itaconic acid production from glycerol with Ustilago vetiveriae TZ1.

Zambanini T, Hosseinpour Tehrani H, Geiser E, Merker D, Schleese S, Krabbe J, Buescher JM, Meurer G, Wierckx N, Blank LM.

Biotechnol Biofuels. 2017 May 19;10:131. doi: 10.1186/s13068-017-0809-x. eCollection 2017.


Regulation of solvent tolerance in Pseudomonas putida S12 mediated by mobile elements.

Hosseini R, Kuepper J, Koebbing S, Blank LM, Wierckx N, de Winde JH.

Microb Biotechnol. 2017 Nov;10(6):1558-1568. doi: 10.1111/1751-7915.12495. Epub 2017 Apr 11.


A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations.

Thiel C, Cordes H, Fabbri L, Aschmann HE, Baier V, Smit I, Atkinson F, Blank LM, Kuepfer L.

PLoS Comput Biol. 2017 Feb 2;13(2):e1005280. doi: 10.1371/journal.pcbi.1005280. eCollection 2017 Feb.


Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans.

Thiel C, Cordes H, Baier V, Blank LM, Kuepfer L.

CPT Pharmacometrics Syst Pharmacol. 2017 Feb;6(2):136-146. doi: 10.1002/psp4.12153. Epub 2017 Jan 28.


Novel insights into biosynthesis and uptake of rhamnolipids and their precursors.

Wittgens A, Kovacic F, Müller MM, Gerlitzki M, Santiago-Schübel B, Hofmann D, Tiso T, Blank LM, Henkel M, Hausmann R, Syldatk C, Wilhelm S, Rosenau F.

Appl Microbiol Biotechnol. 2017 Apr;101(7):2865-2878. doi: 10.1007/s00253-016-8041-3. Epub 2016 Dec 17.


Draft Genome Sequences of Itaconate-Producing Ustilaginaceae.

Geiser E, Ludwig F, Zambanini T, Wierckx N, Blank LM.

Genome Announc. 2016 Dec 15;4(6). pii: e01291-16. doi: 10.1128/genomeA.01291-16.


Let's talk about flux or the importance of (intracellular) reaction rates.

Blank LM.

Microb Biotechnol. 2017 Jan;10(1):28-30. doi: 10.1111/1751-7915.12455. Epub 2016 Nov 11. No abstract available. Erratum in: Microb Biotechnol. 2017 Jul;10 (4):978.


Genetic and biochemical insights into the itaconate pathway of Ustilago maydis enable enhanced production.

Geiser E, Przybilla SK, Engel M, Kleineberg W, Büttner L, Sarikaya E, Hartog TD, Klankermayer J, Leitner W, Bölker M, Blank LM, Wierckx N.

Metab Eng. 2016 Nov;38:427-435. doi: 10.1016/j.ymben.2016.10.006. Epub 2016 Oct 14.


Activation of the Glutamic Acid-Dependent Acid Resistance System in Escherichia coli BL21(DE3) Leads to Increase of the Fatty Acid Biotransformation Activity.

Woo JM, Kim JW, Song JW, Blank LM, Park JB.

PLoS One. 2016 Sep 28;11(9):e0163265. doi: 10.1371/journal.pone.0163265. eCollection 2016.


A rapid method to estimate NADH regeneration rates in living cells.

Kuepper J, Zobel S, Wierckx N, Blank LM.

J Microbiol Methods. 2016 Nov;130:92-94. doi: 10.1016/j.mimet.2016.09.001. Epub 2016 Sep 2.


Rhamnolipid biosurfactant analysis using online turbulent flow chromatography-liquid chromatography-tandem mass spectrometry.

Behrens B, Helmer PO, Tiso T, Blank LM, Hayen H.

J Chromatogr A. 2016 Sep 23;1465:90-7. doi: 10.1016/j.chroma.2016.08.044. Epub 2016 Aug 21.


Elucidation of the regulatory role of the fructose operon reveals a novel target for enhancing the NADPH supply in Corynebacterium glutamicum.

Wang Z, Chan SHJ, Sudarsan S, Blank LM, Jensen PR, Solem C.

Metab Eng. 2016 Nov;38:344-357. doi: 10.1016/j.ymben.2016.08.004. Epub 2016 Aug 20.


Creating metabolic demand as an engineering strategy in Pseudomonas putida - Rhamnolipid synthesis as an example.

Tiso T, Sabelhaus P, Behrens B, Wittgens A, Rosenau F, Hayen H, Blank LM.

Metab Eng Commun. 2016 Aug 8;3:234-244. doi: 10.1016/j.meteno.2016.08.002. eCollection 2016 Dec.


A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy.

Cordes H, Thiel C, Aschmann HE, Baier V, Blank LM, Kuepfer L.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):6134-45. doi: 10.1128/AAC.00508-16. Print 2016 Oct.


Draft Genome Sequence of Ustilago trichophora RK089, a Promising Malic Acid Producer.

Zambanini T, Buescher JM, Meurer G, Wierckx N, Blank LM.

Genome Announc. 2016 Jul 28;4(4). pii: e00749-16. doi: 10.1128/genomeA.00749-16.


Enhanced malic acid production from glycerol with high-cell density Ustilago trichophora TZ1 cultivations.

Zambanini T, Kleineberg W, Sarikaya E, Buescher JM, Meurer G, Wierckx N, Blank LM.

Biotechnol Biofuels. 2016 Jul 2;9:135. doi: 10.1186/s13068-016-0553-7. eCollection 2016.


Activating Intrinsic Carbohydrate-Active Enzymes of the Smut Fungus Ustilago maydis for the Degradation of Plant Cell Wall Components.

Geiser E, Reindl M, Blank LM, Feldbrügge M, Wierckx N, Schipper K.

Appl Environ Microbiol. 2016 Aug 15;82(17):5174-85. doi: 10.1128/AEM.00713-16. Print 2016 Sep 1.


Strain- and Substrate-Dependent Redox Mediator and Electricity Production by Pseudomonas aeruginosa.

Bosire EM, Blank LM, Rosenbaum MA.

Appl Environ Microbiol. 2016 Jul 29;82(16):5026-38. doi: 10.1128/AEM.01342-16. Print 2016 Aug 15.


High performance liquid chromatography-charged aerosol detection applying an inverse gradient for quantification of rhamnolipid biosurfactants.

Behrens B, Baune M, Jungkeit J, Tiso T, Blank LM, Hayen H.

J Chromatogr A. 2016 Jul 15;1455:125-132. doi: 10.1016/j.chroma.2016.05.079. Epub 2016 May 25.


Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients.

Thiel C, Cordes H, Conde I, Castell JV, Blank LM, Kuepfer L.

Arch Toxicol. 2017 Feb;91(2):865-883. doi: 10.1007/s00204-016-1723-x. Epub 2016 May 9.


Efficient malic acid production from glycerol with Ustilago trichophora TZ1.

Zambanini T, Sarikaya E, Kleineberg W, Buescher JM, Meurer G, Wierckx N, Blank LM.

Biotechnol Biofuels. 2016 Mar 17;9:67. doi: 10.1186/s13068-016-0483-4. eCollection 2016.


Engineering and systems-level analysis of Saccharomyces cerevisiae for production of 3-hydroxypropionic acid via malonyl-CoA reductase-dependent pathway.

Kildegaard KR, Jensen NB, Schneider K, Czarnotta E, Özdemir E, Klein T, Maury J, Ebert BE, Christensen HB, Chen Y, Kim IK, Herrgård MJ, Blank LM, Forster J, Nielsen J, Borodina I.

Microb Cell Fact. 2016 Mar 15;15:53. doi: 10.1186/s12934-016-0451-5.

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