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Dock5 is a new regulator of microtubule dynamic instability in osteoclasts.

Guimbal S, Morel A, Guérit D, Chardon M, Blangy A, Vives V.

Biol Cell. 2019 Nov;111(11):271-283. doi: 10.1111/boc.201900014. Epub 2019 Sep 6.


The atypical RhoU/Wrch1 Rho GTPase controls cell proliferation and apoptosis in the gut epithelium.

Slaymi C, Vignal E, Crès G, Roux P, Blangy A, Raynaud P, Fort P.

Biol Cell. 2019 May;111(5):121-141. doi: 10.1111/boc.201800062. Epub 2019 Mar 12.


Combined strategy of siRNA and osteoclast actin cytoskeleton automated imaging to identify novel regulators of bone resorption shows a non-mitotic function for anillin.

Maurin J, Morel A, Hassen-Khodja C, Vives V, Jurdic P, Machuca-Gayet I, Blangy A.

Eur J Cell Biol. 2018 Nov;97(8):568-579. doi: 10.1016/j.ejcb.2018.10.002. Epub 2018 Oct 31.


Methods to Investigate the Role of Rho GTPases in Osteoclast Function.

Morel A, Blangy A, Vives V.

Methods Mol Biol. 2018;1821:219-233. doi: 10.1007/978-1-4939-8612-5_15.


Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule.

Ferrandez Y, Zhang W, Peurois F, Akendengué L, Blangy A, Zeghouf M, Cherfils J.

Sci Rep. 2017 Oct 31;7(1):14409. doi: 10.1038/s41598-017-13619-2.


The Evolutionary Landscape of Dbl-Like RhoGEF Families: Adapting Eukaryotic Cells to Environmental Signals.

Fort P, Blangy A.

Genome Biol Evol. 2017 Jun 1;9(6):1471-1486. doi: 10.1093/gbe/evx100.


Tensins are versatile regulators of Rho GTPase signalling and cell adhesion.

Blangy A.

Biol Cell. 2017 Mar;109(3):115-126. doi: 10.1111/boc.201600053. Epub 2016 Nov 25. Review.


Tensin 3 is a new partner of Dock5 that controls osteoclast podosome organization and activity.

Touaitahuata H, Morel A, Urbach S, Mateos-Langerak J, de Rossi S, Blangy A.

J Cell Sci. 2016 Sep 15;129(18):3449-61. doi: 10.1242/jcs.184622. Epub 2016 Aug 2.


The RhoE/ROCK/ARHGAP25 signaling pathway controls cell invasion by inhibition of Rac activity.

Thuault S, Comunale F, Hasna J, Fortier M, Planchon D, Elarouci N, De Reynies A, Bodin S, Blangy A, Gauthier-Rouvière C.

Mol Biol Cell. 2016 Sep 1;27(17):2653-61. doi: 10.1091/mbc.E16-01-0041. Epub 2016 Jul 13.


[A novel therapeutic approach to fight osteoporosis: disrupt osteoclast activity without affecting bone formation].

Blangy A.

Med Sci (Paris). 2015 Jun-Jul;31(6-7):584-6. doi: 10.1051/medsci/20153106003. Epub 2015 Jul 7. French. No abstract available.


Pharmacological inhibition of Dock5 prevents osteolysis by affecting osteoclast podosome organization while preserving bone formation.

Vives V, Cres G, Richard C, Busson M, Ferrandez Y, Planson AG, Zeghouf M, Cherfils J, Malaval L, Blangy A.

Nat Commun. 2015 Feb 3;6:6218. doi: 10.1038/ncomms7218.


Dock-family exchange factors in cell migration and disease.

Gadea G, Blangy A.

Eur J Cell Biol. 2014 Oct;93(10-12):466-77. doi: 10.1016/j.ejcb.2014.06.003. Epub 2014 Jun 24. Review.


The mineral dissolution function of osteoclasts is dispensable for hypertrophic cartilage degradation during long bone development and growth.

Touaitahuata H, Cres G, de Rossi S, Vives V, Blangy A.

Dev Biol. 2014 Sep 1;393(1):57-70. doi: 10.1016/j.ydbio.2014.06.020. Epub 2014 Jun 30.


Podosome organization drives osteoclast-mediated bone resorption.

Georgess D, Machuca-Gayet I, Blangy A, Jurdic P.

Cell Adh Migr. 2014;8(3):191-204. Review.


Modulation of osteoclast differentiation and bone resorption by Rho GTPases.

Touaitahuata H, Blangy A, Vives V.

Small GTPases. 2014;5:e28119. doi: 10.4161/sgtp.28119. Epub 2014 Mar 10. Review.


Promyelocytic leukemia zinc-finger induction signs mesenchymal stem cell commitment: identification of a key marker for stemness maintenance?

Djouad F, Tejedor G, Toupet K, Maumus M, Bony C, Blangy A, Chuchana P, Jorgensen C, Noël D.

Stem Cell Res Ther. 2014 Feb 24;5(1):27. doi: 10.1186/scrt416.


Podosomes are dispensable for osteoclast differentiation and migration.

Touaitahuata H, Planus E, Albiges-Rizo C, Blangy A, Pawlak G.

Eur J Cell Biol. 2013 Apr-May;92(4-5):139-49. doi: 10.1016/j.ejcb.2013.03.001. Epub 2013 Mar 26.


Targeting the Dbl and dock-family RhoGEFs: a yeast-based assay to identify cell-active inhibitors of Rho-controlled pathways.

Blangy A, Fort P.

Enzymes. 2013;33 Pt A:169-91. doi: 10.1016/B978-0-12-416749-0.00008-7. Epub 2013 Aug 8. Review.


Cofilin activation during podosome belt formation in osteoclasts.

Blangy A, Touaitahuata H, Cres G, Pawlak G.

PLoS One. 2012;7(9):e45909. doi: 10.1371/journal.pone.0045909. Epub 2012 Sep 25.


Using a modified yeast two-hybrid system to screen for chemical GEF inhibitors.

Blangy A, Fort P.

Methods Mol Biol. 2012;928:81-95. doi: 10.1007/978-1-62703-008-3_7.


The Rac1 exchange factor Dock5 is essential for bone resorption by osteoclasts.

Vives V, Laurin M, Cres G, Larrousse P, Morichaud Z, Noel D, Côté JF, Blangy A.

J Bone Miner Res. 2011 May;26(5):1099-110. doi: 10.1002/jbmr.282.


A cell active chemical GEF inhibitor selectively targets the Trio/RhoG/Rac1 signaling pathway.

Bouquier N, Vignal E, Charrasse S, Weill M, Schmidt S, Léonetti JP, Blangy A, Fort P.

Chem Biol. 2009 Jun 26;16(6):657-66. doi: 10.1016/j.chembiol.2009.04.012.


The Rho GTPase Wrch1 regulates osteoclast precursor adhesion and migration.

Brazier H, Pawlak G, Vives V, Blangy A.

Int J Biochem Cell Biol. 2009 Jun;41(6):1391-401. doi: 10.1016/j.biocel.2008.12.007. Epub 2008 Dec 24.


The atypical Rac activator Dock180 (Dock1) regulates myoblast fusion in vivo.

Laurin M, Fradet N, Blangy A, Hall A, Vuori K, Côté JF.

Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15446-51. doi: 10.1073/pnas.0805546105. Epub 2008 Sep 26.


The DH-PH region of the giant protein UNC-89 activates RHO-1 GTPase in Caenorhabditis elegans body wall muscle.

Qadota H, Blangy A, Xiong G, Benian GM.

J Mol Biol. 2008 Nov 21;383(4):747-52. doi: 10.1016/j.jmb.2008.08.083. Epub 2008 Sep 9.


Rho GTPases in osteoclasts: orchestrators of podosome arrangement.

Ory S, Brazier H, Pawlak G, Blangy A.

Eur J Cell Biol. 2008 Sep;87(8-9):469-77. doi: 10.1016/j.ejcb.2008.03.002. Epub 2008 Apr 23. Review.


RhoE controls myoblast alignment prior fusion through RhoA and ROCK.

Fortier M, Comunale F, Kucharczak J, Blangy A, Charrasse S, Gauthier-Rouvière C.

Cell Death Differ. 2008 Aug;15(8):1221-31. doi: 10.1038/cdd.2008.34. Epub 2008 Mar 28.


Interaction of ezrin with the novel guanine nucleotide exchange factor PLEKHG6 promotes RhoG-dependent apical cytoskeleton rearrangements in epithelial cells.

D'Angelo R, Aresta S, Blangy A, Del Maestro L, Louvard D, Arpin M.

Mol Biol Cell. 2007 Dec;18(12):4780-93. Epub 2007 Sep 19.


Expression profile of RhoGTPases and RhoGEFs during RANKL-stimulated osteoclastogenesis: identification of essential genes in osteoclasts.

Brazier H, Stephens S, Ory S, Fort P, Morrison N, Blangy A.

J Bone Miner Res. 2006 Sep;21(9):1387-98.


Identification of TRIO-GEFD1 chemical inhibitors using the yeast exchange assay.

Blangy A, Bouquier N, Gauthier-Rouvière C, Schmidt S, Debant A, Leonetti JP, Fort P.

Biol Cell. 2006 Sep;98(9):511-22.


RhoA GTPase regulates M-cadherin activity and myoblast fusion.

Charrasse S, Comunale F, Grumbach Y, Poulat F, Blangy A, Gauthier-Rouvière C.

Mol Biol Cell. 2006 Feb;17(2):749-59. Epub 2005 Nov 16.


Interferon-alpha and -beta differentially regulate osteoclastogenesis: role of differential induction of chemokine CXCL11 expression.

Coelho LF, Magno de Freitas Almeida G, Mennechet FJ, Blangy A, Uzé G.

Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11917-22. Epub 2005 Aug 4.


Induction of lamellipodia by Kalirin does not require its guanine nucleotide exchange factor activity.

Schiller MR, Blangy A, Huang J, Mains RE, Eipper BA.

Exp Cell Res. 2005 Jul 15;307(2):402-17. Epub 2005 Apr 21.


Phagocytosis of apoptotic cells is regulated by a UNC-73/TRIO-MIG-2/RhoG signaling module and armadillo repeats of CED-12/ELMO.

deBakker CD, Haney LB, Kinchen JM, Grimsley C, Lu M, Klingele D, Hsu PK, Chou BK, Cheng LC, Blangy A, Sondek J, Hengartner MO, Wu YC, Ravichandran KS.

Curr Biol. 2004 Dec 29;14(24):2208-16.


The GTP/GDP cycling of rho GTPase TCL is an essential regulator of the early endocytic pathway.

de Toledo M, Senic-Matuglia F, Salamero J, Uze G, Comunale F, Fort P, Blangy A.

Mol Biol Cell. 2003 Dec;14(12):4846-56. Epub 2003 Sep 5. Erratum in: Mol Biol Cell. 2004 Apr;15(4):preceding table of contents.


Interaction of the mitotic inhibitor monastrol with human kinesin Eg5.

DeBonis S, Simorre JP, Crevel I, Lebeau L, Skoufias DA, Blangy A, Ebel C, Gans P, Cross R, Hackney DD, Wade RH, Kozielski F.

Biochemistry. 2003 Jan 21;42(2):338-49.


N-cadherin-dependent cell-cell contact regulates Rho GTPases and beta-catenin localization in mouse C2C12 myoblasts.

Charrasse S, Meriane M, Comunale F, Blangy A, Gauthier-Rouvière C.

J Cell Biol. 2002 Sep 2;158(5):953-65. Epub 2002 Sep 3.


The Human Rho-GEF trio and its target GTPase RhoG are involved in the NGF pathway, leading to neurite outgrowth.

Estrach S, Schmidt S, Diriong S, Penna A, Blangy A, Fort P, Debant A.

Curr Biol. 2002 Feb 19;12(4):307-12.


Biogenesis of N-cadherin-dependent cell-cell contacts in living fibroblasts is a microtubule-dependent kinesin-driven mechanism.

Mary S, Charrasse S, Meriane M, Comunale F, Travo P, Blangy A, Gauthier-Rouvière C.

Mol Biol Cell. 2002 Jan;13(1):285-301.


The gene for a new brain specific RhoA exchange factor maps to the highly unstable chromosomal region 1p36.2-1p36.3.

De Toledo M, Coulon V, Schmidt S, Fort P, Blangy A.

Oncogene. 2001 Nov 1;20(50):7307-17.


Kinectin is a key effector of RhoG microtubule-dependent cellular activity.

Vignal E, Blangy A, Martin M, Gauthier-Rouvière C, Fort P.

Mol Cell Biol. 2001 Dec;21(23):8022-34.


Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42.

Vignal E, De Toledo M, Comunale F, Ladopoulou A, Gauthier-Rouvière C, Blangy A, Fort P.

J Biol Chem. 2000 Nov 17;275(46):36457-64.


TrioGEF1 controls Rac- and Cdc42-dependent cell structures through the direct activation of rhoG.

Blangy A, Vignal E, Schmidt S, Debant A, Gauthier-Rouvière C, Fort P.

J Cell Sci. 2000 Feb;113 ( Pt 4):729-39.


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