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Macrophage MerTK Promotes Liver Fibrosis in Nonalcoholic Steatohepatitis.

Cai B, Dongiovanni P, Corey KE, Wang X, Shmarakov IO, Zheng Z, Kasikara C, Davra V, Meroni M, Chung RT, Rothlin CV, Schwabe RF, Blaner WS, Birge RB, Valenti L, Tabas I.

Cell Metab. 2019 Dec 12. pii: S1550-4131(19)30620-5. doi: 10.1016/j.cmet.2019.11.013. [Epub ahead of print]


Constitutive androstane receptor mediates PCB-induced disruption of retinoid homeostasis.

Shmarakov IO, Lee YJ, Jiang H, Blaner WS.

Toxicol Appl Pharmacol. 2019 Oct 15;381:114731. doi: 10.1016/j.taap.2019.114731. Epub 2019 Aug 23.


Adipocyte-specific expression of a retinoic acid receptor α dominant negative form causes glucose intolerance and hepatic steatosis in mice.

Lee SA, Jiang H, Feranil JB, Brun PJ, Blaner WS.

Biochem Biophys Res Commun. 2019 Jul 5;514(4):1231-1237. doi: 10.1016/j.bbrc.2019.05.075. Epub 2019 May 17.


Design, Synthesis, and Preclinical Efficacy of Novel Nonretinoid Antagonists of Retinol-Binding Protein 4 in the Mouse Model of Hepatic Steatosis.

Cioffi CL, Racz B, Varadi A, Freeman EE, Conlon MP, Chen P, Zhu L, Kitchen DB, Barnes KD, Martin WH, Pearson PG, Johnson G, Blaner WS, Petrukhin K.

J Med Chem. 2019 Jun 13;62(11):5470-5500. doi: 10.1021/acs.jmedchem.9b00352. Epub 2019 May 28.


Hepatic stellate cell activation: A source for bioactive lipids.

Shmarakov IO, Jiang H, Liu J, Fernandez EJ, Blaner WS.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 May;1864(5):629-642. doi: 10.1016/j.bbalip.2019.02.004. Epub 2019 Feb 5.


Abnormal Cannabidiol Modulates Vitamin A Metabolism by Acting as a Competitive Inhibitor of CRBP1.

Silvaroli JA, Widjaja-Adhi MAK, Trischman T, Chelstowska S, Horwitz S, Banerjee S, Kiser PD, Blaner WS, Golczak M.

ACS Chem Biol. 2019 Mar 15;14(3):434-448. doi: 10.1021/acschembio.8b01070. Epub 2019 Feb 18.


Vitamin A signaling and homeostasis in obesity, diabetes, and metabolic disorders.

Blaner WS.

Pharmacol Ther. 2019 May;197:153-178. doi: 10.1016/j.pharmthera.2019.01.006. Epub 2019 Jan 29. Review.


Hepatocyte and stellate cell deletion of liver fatty acid binding protein reveals distinct roles in fibrogenic injury.

Newberry EP, Xie Y, Lodeiro C, Solis R, Moritz W, Kennedy S, Barron L, Onufer E, Alpini G, Zhou T, Blaner WS, Chen A, Davidson NO.

FASEB J. 2019 Mar;33(3):4610-4625. doi: 10.1096/fj.201801976R. Epub 2018 Dec 21.


Hepatic Stellate Cells and Retinoids: Toward A Much More Defined Relationship.

Blaner WS.

Hepatology. 2019 Feb;69(2):484-486. doi: 10.1002/hep.30293. Epub 2019 Jan 3. No abstract available.


Dietary Macronutrient Composition Determines the Contribution of DGAT1 to Alcoholic Steatosis.

Huang LS, Yuen JJ, Trites MJ, Saha A, Epps CT, Hu Y, Kerolle S, Lee SA, Jiang H, Goldberg IJ, Blaner WS, Clugston RD.

Alcohol Clin Exp Res. 2018 Dec;42(12):2298-2312. doi: 10.1111/acer.13881. Epub 2018 Oct 3.


Perilipin 5 and liver fatty acid binding protein function to restore quiescence in mouse hepatic stellate cells.

Lin J, Zheng S, Attie AD, Keller MP, Bernlohr DA, Blaner WS, Newberry EP, Davidson NO, Chen A.

J Lipid Res. 2018 Mar;59(3):416-428. doi: 10.1194/jlr.M077487. Epub 2018 Jan 9.


Non-alcoholic steatohepatitis-related liver tumorigenesis is suppressed in mice lacking hepatic retinoid storage.

Ideta T, Shirakami Y, Ohnishi M, Maruta A, Obara K, Miyazaki T, Kochi T, Sakai H, Tomita H, Tanaka T, Blaner WS, Shimizu M.

Oncotarget. 2017 Aug 7;8(41):70695-70706. doi: 10.18632/oncotarget.19978. eCollection 2017 Sep 19.


Retinoid Actions: A New Horizon.

Blaner WS.

Endocrinology. 2017 Sep 1;158(9):2719-2721. doi: 10.1210/en.2017-00622. No abstract available.


Chronic alcohol consumption decreases brown adipose tissue mass and disrupts thermoregulation: a possible role for altered retinoid signaling.

Blaner WS, Gao MA, Jiang H, Dalmer TR, Hu XJ, Ginsberg HN, Clugston RD.

Sci Rep. 2017 Mar 6;7:43474. doi: 10.1038/srep43474.


Acyl-CoA wax alcohol acyltransferase 2: its regulation and actions in support of color vision.

Blaner WS.

J Lipid Res. 2017 Apr;58(4):633-635. doi: 10.1194/jlr.C075838. Epub 2017 Feb 23. No abstract available.


Hepatic Detoxification of Bisphenol A is Retinoid-Dependent.

Shmarakov IO, Borschovetska VL, Blaner WS.

Toxicol Sci. 2017 May 1;157(1):141-155. doi: 10.1093/toxsci/kfx022.


Vitamin A Absorption, Storage and Mobilization.

Blaner WS, Li Y, Brun PJ, Yuen JJ, Lee SA, Clugston RD.

Subcell Biochem. 2016;81:95-125. Review.


Long-term Diet and Biomarker Changes after a Short-term Intervention among Hispanic Breast Cancer Survivors: The ¡Cocinar Para Su Salud! Randomized Controlled Trial.

Greenlee H, Ogden Gaffney A, Aycinena AC, Koch P, Contento I, Karmally W, Richardson JM, Shi Z, Lim E, Tsai WY, Santella RM, Blaner WS, Clugston RD, Cremers S, Pollak S, Sirosh I, Crew KD, Maurer M, Kalinsky K, Hershman DL.

Cancer Epidemiol Biomarkers Prev. 2016 Nov;25(11):1491-1502. Epub 2016 Jul 26.


Hepatocytes Are the Principal Source of Circulating RBP4 in Mice.

Thompson SJ, Sargsyan A, Lee SA, Yuen JJ, Cai J, Smalling R, Ghyselinck N, Mark M, Blaner WS, Graham TE.

Diabetes. 2017 Jan;66(1):58-63. doi: 10.2337/db16-0286. Epub 2016 Oct 19.


Adipocyte-specific overexpression of retinol-binding protein 4 causes hepatic steatosis in mice.

Lee SA, Yuen JJ, Jiang H, Kahn BB, Blaner WS.

Hepatology. 2016 Nov;64(5):1534-1546. doi: 10.1002/hep.28659. Epub 2016 Jul 4.


Aldehyde dehydrogenase 1a3 defines a subset of failing pancreatic β cells in diabetic mice.

Kim-Muller JY, Fan J, Kim YJ, Lee SA, Ishida E, Blaner WS, Accili D.

Nat Commun. 2016 Aug 30;7:12631. doi: 10.1038/ncomms12631.


Structure of the STRA6 receptor for retinol uptake.

Chen Y, Clarke OB, Kim J, Stowe S, Kim YK, Assur Z, Cavalier M, Godoy-Ruiz R, von Alpen DC, Manzini C, Blaner WS, Frank J, Quadro L, Weber DJ, Shapiro L, Hendrickson WA, Mancia F.

Science. 2016 Aug 26;353(6302). pii: aad8266. doi: 10.1126/science.aad8266.


Erratum. Retinoic Acid Mediates Visceral-Specific Adipogenic Defects of Human Adipose-Derived Stem Cells. Diabetes 2016;65:1164-1178.

Takeda K, Sriram S, Chan XH, Ong WK, Yeo CR, Tan B, Lee SA, Kong KV, Hoon S, Jiang H, Yuen JJ, Perumal J, Agrawal M, Vaz C, So J, Shabbir A, Blaner WS, Olivo M, Han W, Tanavde V, Toh SA, Sugii S.

Diabetes. 2016 Sep;65(9):2816. doi: 10.2337/db16-er09. No abstract available.


Lipocalin 2, a Regulator of Retinoid Homeostasis and Retinoid-mediated Thermogenic Activation in Adipose Tissue.

Guo H, Foncea R, O'Byrne SM, Jiang H, Zhang Y, Deis JA, Blaner WS, Bernlohr DA, Chen X.

J Biol Chem. 2016 May 20;291(21):11216-29. doi: 10.1074/jbc.M115.711556. Epub 2016 Mar 22.


Retinoic Acid Mediates Visceral-Specific Adipogenic Defects of Human Adipose-Derived Stem Cells.

Takeda K, Sriram S, Chan XH, Ong WK, Yeo CR, Tan B, Lee SA, Kong KV, Hoon S, Jiang H, Yuen JJ, Perumal J, Agrawal M, Vaz C, So J, Shabbir A, Blaner WS, Olivo M, Han W, Tanavde V, Toh SA, Sugii S.

Diabetes. 2016 May;65(5):1164-78. doi: 10.2337/db15-1315. Epub 2016 Mar 2. Erratum in: Diabetes. 2016 Sep;65(9):2816.


Retinoids in the pancreas.

Brun PJ, Wongsiriroj N, Blaner WS.

Hepatobiliary Surg Nutr. 2016 Feb;5(1):1-14. doi: 10.3978/j.issn.2304-3881.2015.09.03. Review.


Serial scanning with technetium pyrophosphate (99mTc-PYP) in advanced ATTR cardiac amyloidosis.

Castaño A, DeLuca A, Weinberg R, Pozniakoff T, Blaner WS, Pirmohamed A, Bettencourt B, Gollob J, Karsten V, Vest JA, Chiuzan C, Maurer MS, Bokhari S.

J Nucl Cardiol. 2016 Dec;23(6):1355-1363. Epub 2015 Oct 9.


The diversity of retinoid biology.

Wongsiriroj N, Blaner WS.

Hepatobiliary Surg Nutr. 2015 Aug;4(4):220-1. doi: 10.3978/j.issn.2304-3881.2015.07.06. No abstract available.


The Hepatic Lipidome: A Gateway to Understanding the Pathogenes is of Alcohol-Induced Fatty Liver.

Clugston RD, Gao MA, Blaner WS.

Curr Mol Pharmacol. 2017;10(3):195-206. doi: 10.2174/1874467208666150817111419. Review.


DGAT1-deficiency affects the cellular distribution of hepatic retinoid and attenuates the progression of CCl4-induced liver fibrosis.

Yuen JJ, Lee SA, Jiang H, Brun PJ, Blaner WS.

Hepatobiliary Surg Nutr. 2015 Jun;4(3):184-96. doi: 10.3978/j.issn.2304-3881.2014.12.02.


Chronic alcohol consumption has a biphasic effect on hepatic retinoid loss.

Clugston RD, Huang LS, Blaner WS.

FASEB J. 2015 Sep;29(9):3654-67. doi: 10.1096/fj.14-266296. Epub 2015 May 18.


Actions of β-apo-carotenoids in differentiating cells: differential effects in P19 cells and 3T3-L1 adipocytes.

Wang CX, Jiang H, Yuen JJ, Lee SA, Narayanasamy S, Curley RW Jr, Harrison EH, Blaner WS.

Arch Biochem Biophys. 2015 Apr 15;572:2-10. doi: 10.1016/ Epub 2015 Jan 17.


Cellular localization of β-carotene 15,15' oxygenase-1 (BCO1) and β-carotene 9',10' oxygenase-2 (BCO2) in rat liver and intestine.

Raghuvanshi S, Reed V, Blaner WS, Harrison EH.

Arch Biochem Biophys. 2015 Apr 15;572:19-27. doi: 10.1016/ Epub 2015 Jan 6.


Liver X receptors balance lipid stores in hepatic stellate cells through Rab18, a retinoid responsive lipid droplet protein.

O'Mahony F, Wroblewski K, O'Byrne SM, Jiang H, Clerkin K, Benhammou J, Blaner WS, Beaven SW.

Hepatology. 2015 Aug;62(2):615-26. doi: 10.1002/hep.27645. Epub 2015 Mar 23.


Retinoic acid receptor signaling is required to maintain glucose-stimulated insulin secretion and β-cell mass.

Brun PJ, Grijalva A, Rausch R, Watson E, Yuen JJ, Das BC, Shudo K, Kagechika H, Leibel RL, Blaner WS.

FASEB J. 2015 Feb;29(2):671-83. doi: 10.1096/fj.14-256743. Epub 2014 Nov 11.


Nutrition and health in amphibian husbandry.

Ferrie GM, Alford VC, Atkinson J, Baitchman E, Barber D, Blaner WS, Crawshaw G, Daneault A, Dierenfeld E, Finke M, Fleming G, Gagliardo R, Hoffman EA, Karasov W, Klasing K, Koutsos E, Lankton J, Lavin SR, Lentini A, Livingston S, Lock B, Mason T, McComb A, Morris C, Pessier AP, Olea-Popelka F, Probst T, Rodriguez C, Schad K, Semmen K, Sincage J, Stamper MA, Steinmetz J, Sullivan K, Terrell S, Wertan N, Wheaton CJ, Wilson B, Valdes EV.

Zoo Biol. 2014 Nov-Dec;33(6):485-501. doi: 10.1002/zoo.21180. Epub 2014 Oct 8. Review.


Cardiac dysfunction in β-carotene-15,15'-dioxygenase-deficient mice is associated with altered retinoid and lipid metabolism.

Lee SA, Jiang H, Trent CM, Yuen JJ, Narayanasamy S, Curley RW Jr, Harrison EH, Goldberg IJ, Maurer MS, Blaner WS.

Am J Physiol Heart Circ Physiol. 2014 Dec 1;307(11):H1675-84. doi: 10.1152/ajpheart.00548.2014. Epub 2014 Sep 26.


Cardiomyocyte-specific loss of diacylglycerol acyltransferase 1 (DGAT1) reproduces the abnormalities in lipids found in severe heart failure.

Liu L, Trent CM, Fang X, Son NH, Jiang H, Blaner WS, Hu Y, Yin YX, Farese RV Jr, Homma S, Turnbull AV, Eriksson JW, Hu SL, Ginsberg HN, Huang LS, Goldberg IJ.

J Biol Chem. 2014 Oct 24;289(43):29881-91. doi: 10.1074/jbc.M114.601864. Epub 2014 Aug 25.


Retinoid acid-related orphan receptor γ, RORγ, participates in diurnal transcriptional regulation of lipid metabolic genes.

Takeda Y, Kang HS, Lih FB, Jiang H, Blaner WS, Jetten AM.

Nucleic Acids Res. 2014;42(16):10448-59. doi: 10.1093/nar/gku766. Epub 2014 Aug 20.


The multifaceted nature of retinoid transport and metabolism.

Li Y, Wongsiriroj N, Blaner WS.

Hepatobiliary Surg Nutr. 2014 Jun;3(3):126-39. doi: 10.3978/j.issn.2304-3881.2014.05.04. Review.


Vitamin A (retinoid) metabolism and actions: What we know and what we need to know about amphibians.

Clugston RD, Blaner WS.

Zoo Biol. 2014 Nov-Dec;33(6):527-35. doi: 10.1002/zoo.21140. Epub 2014 Jun 24. Review.


Null mutation in hormone-sensitive lipase gene and risk of type 2 diabetes.

Albert JS, Yerges-Armstrong LM, Horenstein RB, Pollin TI, Sreenivasan UT, Chai S, Blaner WS, Snitker S, O'Connell JR, Gong DW, Breyer RJ 3rd, Ryan AS, McLenithan JC, Shuldiner AR, Sztalryd C, Damcott CM.

N Engl J Med. 2014 Jun 12;370(24):2307-2315. doi: 10.1056/NEJMoa1315496. Epub 2014 May 21.


Bone-specific insulin resistance disrupts whole-body glucose homeostasis via decreased osteocalcin activation.

Wei J, Ferron M, Clarke CJ, Hannun YA, Jiang H, Blaner WS, Karsenty G.

J Clin Invest. 2014 Apr;124(4):1-13. doi: 10.1172/JCI72323. Epub 2014 Mar 18.


Retinoids modulate thioacetamide-induced acute hepatotoxicity.

Shmarakov IO, Borschovetska VL, Marchenko MM, Blaner WS.

Toxicol Sci. 2014 Jun;139(2):284-92. doi: 10.1093/toxsci/kfu045. Epub 2014 Mar 10.


CD36-deficient mice are resistant to alcohol- and high-carbohydrate-induced hepatic steatosis.

Clugston RD, Yuen JJ, Hu Y, Abumrad NA, Berk PD, Goldberg IJ, Blaner WS, Huang LS.

J Lipid Res. 2014 Feb;55(2):239-46. doi: 10.1194/jlr.M041863. Epub 2013 Nov 26.


Genetic dissection of retinoid esterification and accumulation in the liver and adipose tissue.

Wongsiriroj N, Jiang H, Piantedosi R, Yang KJ, Kluwe J, Schwabe RF, Ginsberg H, Goldberg IJ, Blaner WS.

J Lipid Res. 2014 Jan;55(1):104-14. doi: 10.1194/jlr.M043844. Epub 2013 Nov 1.


Altered hepatic retinyl ester concentration and acyl composition in response to alcohol consumption.

Clugston RD, Jiang H, Lee MX, Berk PD, Goldberg IJ, Huang LS, Blaner WS.

Biochim Biophys Acta. 2013 Jul;1831(7):1276-86.


The retina rapidly incorporates ingested C20-D₃-vitamin A in a swine model.

Mihai DM, Jiang H, Blaner WS, Romanov A, Washington I.

Mol Vis. 2013 Jul 25;19:1677-83. Print 2013.


Vitamin E: the enigmatic one!

Blaner WS.

J Lipid Res. 2013 Sep;54(9):2293-4. doi: 10.1194/jlr.E042267. Epub 2013 Jul 11. No abstract available.


The STRA6 receptor is essential for retinol-binding protein-induced insulin resistance but not for maintaining vitamin A homeostasis in tissues other than the eye.

Berry DC, Jacobs H, Marwarha G, Gely-Pernot A, O'Byrne SM, DeSantis D, Klopfenstein M, Feret B, Dennefeld C, Blaner WS, Croniger CM, Mark M, Noy N, Ghyselinck NB.

J Biol Chem. 2013 Aug 23;288(34):24528-39. doi: 10.1074/jbc.M113.484014. Epub 2013 Jul 9.

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