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Items: 1 to 50 of 81

1.

Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors.

Craig AT, Gavrilova O, Dwyer NK, Jou W, Pack S, Liu E, Pechhold K, Schmidt M, McAlister VJ, Chiorini JA, Blanchette-Mackie EJ, Harlan DM, Owens RA.

Virol J. 2009 May 18;6:61. doi: 10.1186/1743-422X-6-61.

2.

Differential trafficking of the Niemann-Pick C1 and 2 proteins highlights distinct roles in late endocytic lipid trafficking.

Zhang M, Sun M, Dwyer NK, Comly ME, Patel SC, Sundaram R, Hanover JA, Blanchette-Mackie EJ.

Acta Paediatr Suppl. 2003 Dec;92(443):63-73; discussion 45.

PMID:
14989468
3.

Targeted mutation of the MLN64 START domain causes only modest alterations in cellular sterol metabolism.

Kishida T, Kostetskii I, Zhang Z, Martinez F, Liu P, Walkley SU, Dwyer NK, Blanchette-Mackie EJ, Radice GL, Strauss JF 3rd.

J Biol Chem. 2004 Apr 30;279(18):19276-85. Epub 2004 Feb 12.

4.

A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell growth and its expression is decreased in prostate and renal tumors.

Sun M, Ma L, Xu L, Li J, Zhang W, Petrovics G, Makarem M, Sesterhenn I, Zhang M, Blanchette-Mackie EJ, Moul J, Srivastava S, Zou Z.

Mol Med. 2002 Oct;8(10):655-63.

5.

A sperm-associated WD repeat protein orthologous to Chlamydomonas PF20 associates with Spag6, the mammalian orthologue of Chlamydomonas PF16.

Zhang Z, Sapiro R, Kapfhamer D, Bucan M, Bray J, Chennathukuzhi V, McNamara P, Curtis A, Zhang M, Blanchette-Mackie EJ, Strauss JF 3rd.

Mol Cell Biol. 2002 Nov;22(22):7993-8004.

6.

MLN64 mediates mobilization of lysosomal cholesterol to steroidogenic mitochondria.

Zhang M, Liu P, Dwyer NK, Christenson LK, Fujimoto T, Martinez F, Comly M, Hanover JA, Blanchette-Mackie EJ, Strauss JF 3rd.

J Biol Chem. 2002 Sep 6;277(36):33300-10. Epub 2002 Jun 17.

7.

Cessation of rapid late endosomal tubulovesicular trafficking in Niemann-Pick type C1 disease.

Zhang M, Dwyer NK, Love DC, Cooney A, Comly M, Neufeld E, Pentchev PG, Blanchette-Mackie EJ, Hanover JA.

Proc Natl Acad Sci U S A. 2001 Apr 10;98(8):4466-71.

8.

Sterol-modulated glycolipid sorting occurs in niemann-pick C1 late endosomes.

Zhang M, Dwyer NK, Neufeld EB, Love DC, Cooney A, Comly M, Patel S, Watari H, Strauss JF 3rd, Pentchev PG, Hanover JA, Blanchette-Mackie EJ.

J Biol Chem. 2001 Feb 2;276(5):3417-25. Epub 2000 Oct 13.

9.

Determinants of NPC1 expression and action: key promoter regions, posttranscriptional control, and the importance of a "cysteine-rich" loop.

Watari H, Blanchette-Mackie EJ, Dwyer NK, Watari M, Burd CG, Patel S, Pentchev PG, Strauss JF 3rd.

Exp Cell Res. 2000 Aug 25;259(1):247-56.

PMID:
10942596
10.

Intracellular cholesterol trafficking: role of the NPC1 protein.

Blanchette-Mackie EJ.

Biochim Biophys Acta. 2000 Jun 26;1486(1):171-83. Review. No abstract available.

PMID:
10856720
11.
12.

NPC1-containing compartment of human granulosa-lutein cells: a role in the intracellular trafficking of cholesterol supporting steroidogenesis.

Watari H, Blanchette-Mackie EJ, Dwyer NK, Sun G, Glick JM, Patel S, Neufeld EB, Pentchev PG, Strauss JF 3rd.

Exp Cell Res. 2000 Feb 25;255(1):56-66.

PMID:
10666334
13.

Mutations in the leucine zipper motif and sterol-sensing domain inactivate the Niemann-Pick C1 glycoprotein.

Watari H, Blanchette-Mackie EJ, Dwyer NK, Watari M, Neufeld EB, Patel S, Pentchev PG, Strauss JF 3rd.

J Biol Chem. 1999 Jul 30;274(31):21861-6.

14.

Induction of endocytic vesicles by exogenous C(6)-ceramide.

Li R, Blanchette-Mackie EJ, Ladisch S.

J Biol Chem. 1999 Jul 23;274(30):21121-7.

15.

The Niemann-Pick C1 protein resides in a vesicular compartment linked to retrograde transport of multiple lysosomal cargo.

Neufeld EB, Wastney M, Patel S, Suresh S, Cooney AM, Dwyer NK, Roff CF, Ohno K, Morris JA, Carstea ED, Incardona JP, Strauss JF 3rd, Vanier MT, Patterson MC, Brady RO, Pentchev PG, Blanchette-Mackie EJ.

J Biol Chem. 1999 Apr 2;274(14):9627-35.

16.

Localization of Niemann-Pick C1 protein in astrocytes: implications for neuronal degeneration in Niemann- Pick type C disease.

Patel SC, Suresh S, Kumar U, Hu CY, Cooney A, Blanchette-Mackie EJ, Neufeld EB, Patel RC, Brady RO, Patel YC, Pentchev PG, Ong WY.

Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1657-62.

17.

Niemann-Pick C1 protein: obligatory roles for N-terminal domains and lysosomal targeting in cholesterol mobilization.

Watari H, Blanchette-Mackie EJ, Dwyer NK, Glick JM, Patel S, Neufeld EB, Brady RO, Pentchev PG, Strauss JF 3rd.

Proc Natl Acad Sci U S A. 1999 Feb 2;96(3):805-10.

18.

Combined lipase deficiency (cld/cld) in mice affects differently post-translational processing of lipoprotein lipase, hepatic lipase and pancreatic lipase.

Scow RO, Schultz CJ, Park JW, Blanchette-Mackie EJ.

Chem Phys Lipids. 1998 Jun;93(1-2):149-55. Review.

PMID:
9720257
19.

Sickling of nucleated erythroid precursors from patients with sickle cell anemia.

Hasegawa S, Rodgers GP, Dwyer N, Noguchi CT, Blanchette-Mackie EJ, Uyesaka N, Schechter AN, Fibach E.

Exp Hematol. 1998 Apr;26(4):314-9.

PMID:
9546314
20.

Constitutive achlorhydria in mucolipidosis type IV.

Schiffmann R, Dwyer NK, Lubensky IA, Tsokos M, Sutliff VE, Latimer JS, Frei KP, Brady RO, Barton NW, Blanchette-Mackie EJ, Goldin E.

Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):1207-12.

21.

Adipose differentiation-related protein is an ubiquitously expressed lipid storage droplet-associated protein.

Brasaemle DL, Barber T, Wolins NE, Serrero G, Blanchette-Mackie EJ, Londos C.

J Lipid Res. 1997 Nov;38(11):2249-63.

22.
23.

Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.

Carstea ED, Morris JA, Coleman KG, Loftus SK, Zhang D, Cummings C, Gu J, Rosenfeld MA, Pavan WJ, Krizman DB, Nagle J, Polymeropoulos MH, Sturley SL, Ioannou YA, Higgins ME, Comly M, Cooney A, Brown A, Kaneski CR, Blanchette-Mackie EJ, Dwyer NK, Neufeld EB, Chang TY, Liscum L, Strauss JF 3rd, Ohno K, Zeigler M, Carmi R, Sokol J, Markie D, O'Neill RR, van Diggelen OP, Elleder M, Patterson MC, Brady RO, Vanier MT, Pentchev PG, Tagle DA.

Science. 1997 Jul 11;277(5323):228-31.

24.

Biological implications of the Niemann-Pick C mutation.

Pentchev PG, Blanchette-Mackie EJ, Liscum L.

Subcell Biochem. 1997;28:437-51. Review. No abstract available.

PMID:
9090302
25.

Intracellular trafficking of cholesterol monitored with a cyclodextrin.

Neufeld EB, Cooney AM, Pitha J, Dawidowicz EA, Dwyer NK, Pentchev PG, Blanchette-Mackie EJ.

J Biol Chem. 1996 Aug 30;271(35):21604-13.

27.

Perilipin: possible roles in structure and metabolism of intracellular neutral lipids in adipocytes and steroidogenic cells.

Londos C, Gruia-Gray J, Brasaemle DL, Rondinone CM, Takeda T, Dwyer NK, Barber T, Kimmel AR, Blanchette-Mackie EJ.

Int J Obes Relat Metab Disord. 1996 Mar;20 Suppl 3:S97-101. Review.

PMID:
8680486
28.

Perilipin is located on the surface layer of intracellular lipid droplets in adipocytes.

Blanchette-Mackie EJ, Dwyer NK, Barber T, Coxey RA, Takeda T, Rondinone CM, Theodorakis JL, Greenberg AS, Londos C.

J Lipid Res. 1995 Jun;36(6):1211-26.

29.

Cultured skin fibroblasts derived from patients with mucolipidosis 4 are auto-fluorescent.

Goldin E, Blanchette-Mackie EJ, Dwyer NK, Pentchev PG, Brady RO.

Pediatr Res. 1995 Jun;37(6):687-92.

PMID:
7651750
30.

Sickle cell rheology is determined by polymer fraction--not cell morphology.

Hiruma H, Noguchi CT, Uyesaka N, Hasegawa S, Blanchette-Mackie EJ, Schechter AN, Rodgers GP.

Am J Hematol. 1995 Jan;48(1):19-28.

PMID:
7832188
31.

Microtubules are not required for glucocorticoid receptor mediated gene induction.

Szapary D, Barber T, Dwyer NK, Blanchette-Mackie EJ, Simons SS Jr.

J Steroid Biochem Mol Biol. 1994 Nov;51(3-4):143-8.

PMID:
7981123
32.

The NP-C gene: a key to pathways of intracellular cholesterol transport.

Pentchev PG, Blanchette-Mackie EJ, Dawidowicz EA.

Trends Cell Biol. 1994 Oct;4(10):365-9.

PMID:
14731625
33.

The Niemann-Pick C lesion and its relationship to the intracellular distribution and utilization of LDL cholesterol.

Pentchev PG, Brady RO, Blanchette-Mackie EJ, Vanier MT, Carstea ED, Parker CC, Goldin E, Roff CF.

Biochim Biophys Acta. 1994 Feb 22;1225(3):235-43. Review. No abstract available.

PMID:
8312368
34.

Development of unesterified cholesterol-rich lipid particles in atherosclerotic lesions of WHHL and cholesterol-fed NZW rabbits.

Chao FF, Blanchette-Mackie EJ, Dickens BF, Gamble W, Kruth HS.

J Lipid Res. 1994 Jan;35(1):71-83.

36.

Cholesterol deprivation affects the fluorescence properties of a ceramide analog at the Golgi apparatus of living cells.

Martin OC, Comly ME, Blanchette-Mackie EJ, Pentchev PG, Pagano RE.

Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2661-5.

37.

Endothelium, the dynamic interface in cardiac lipid transport.

Scow RO, Blanchette-Mackie EJ.

Mol Cell Biochem. 1992 Oct 21;116(1-2):181-91. Review.

PMID:
1480147
38.

Retention of glucose by N-linked oligosaccharide chains impedes expression of lipoprotein lipase activity: effect of castanospermine.

Masuno H, Blanchette-Mackie EJ, Schultz CJ, Spaeth AE, Scow RO, Okuda H.

J Lipid Res. 1992 Sep;33(9):1343-9.

39.

Hydrolysis of cholesteryl ester in low density lipoprotein converts this lipoprotein to a liposome.

Chao FF, Blanchette-Mackie EJ, Tertov VV, Skarlatos SI, Chen YJ, Kruth HS.

J Biol Chem. 1992 Mar 5;267(7):4992-8.

40.

Transport of fatty acids and monoacylglycerols in white and brown adipose tissues.

Scow RO, Blanchette-Mackie EJ.

Brain Res Bull. 1991 Sep-Oct;27(3-4):487-91. Review.

PMID:
1959050
41.
42.

Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets.

Greenberg AS, Egan JJ, Wek SA, Garty NB, Blanchette-Mackie EJ, Londos C.

J Biol Chem. 1991 Jun 15;266(17):11341-6.

43.
44.

Type C Niemann-Pick disease: documentation of abnormal LDL processing in lymphocytes.

Argoff CE, Kaneski CR, Blanchette-Mackie EJ, Comly M, Dwyer NK, Brown A, Brady RO, Pentchev PG.

Biochem Biophys Res Commun. 1990 Aug 31;171(1):38-45.

PMID:
2393397
45.
46.

Characterization of two unique cholesterol-rich lipid particles isolated from human atherosclerotic lesions.

Chao FF, Blanchette-Mackie EJ, Chen YJ, Dickens BF, Berlin E, Amende LM, Skarlatos SI, Gamble W, Resau JH, Mergner WT, et al.

Am J Pathol. 1990 Jan;136(1):169-79.

47.

Type C Niemann-Pick disease: dimethyl sulfoxide moderates abnormal LDL-cholesterol processing in mutant fibroblasts.

Blanchette Mackie EJ, Dwyer NK, Vanier MT, Sokol J, Merrick HF, Comly ME, Argoff CE, Pentchev PG.

Biochim Biophys Acta. 1989 Nov 28;1006(2):219-26.

PMID:
2688743
48.

Lipoprotein lipase in myocytes and capillary endothelium of heart: immunocytochemical study.

Blanchette-Mackie EJ, Masuno H, Dwyer NK, Olivecrona T, Scow RO.

Am J Physiol. 1989 Jun;256(6 Pt 1):E818-28.

PMID:
2735404
49.

Cytochemical studies of lipid metabolism: immunogold probes for lipoprotein lipase and cholesterol.

Blanchette-Mackie EJ, Dwyer NK, Amende LA.

Am J Anat. 1989 Jun-Jul;185(2-3):255-63. Review.

PMID:
2476020
50.

Type-C Niemann-Pick disease: low density lipoprotein uptake is associated with premature cholesterol accumulation in the Golgi complex and excessive cholesterol storage in lysosomes.

Blanchette-Mackie EJ, Dwyer NK, Amende LM, Kruth HS, Butler JD, Sokol J, Comly ME, Vanier MT, August JT, Brady RO, et al.

Proc Natl Acad Sci U S A. 1988 Nov;85(21):8022-6.

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