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Cargo adaptors regulate stepping and force generation of mammalian dynein-dynactin.

Elshenawy MM, Canty JT, Oster L, Ferro LS, Zhou Z, Blanchard SC, Yildiz A.

Nat Chem Biol. 2019 Sep 9. doi: 10.1038/s41589-019-0352-0. [Epub ahead of print]


A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS.

McMahon M, Contreras A, Holm M, Uechi T, Forester CM, Pang X, Jackson C, Calvert ME, Chen B, Quigley DA, Luk JM, Kelley RK, Gordan JD, Gill RM, Blanchard SC, Ruggero D.

Elife. 2019 Sep 3;8. pii: e48847. doi: 10.7554/eLife.48847.


The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor.

LeVine MV, Terry DS, Khelashvili G, Siegel ZS, Quick M, Javitch JA, Blanchard SC, Weinstein H.

Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15947-15956. doi: 10.1073/pnas.1903020116. Epub 2019 Jul 19.


Correction to: Implications of sequence variation on the evolution of rRNA.

Parks MM, Kurylo CM, Batchelder JE, Theresa Vincent C, Blanchard SC.

Chromosome Res. 2019 Sep;27(3):285. doi: 10.1007/s10577-019-09610-4.


Conformational dynamics between transmembrane domains and allosteric modulation of a metabotropic glutamate receptor.

Gutzeit VA, Thibado J, Stor DS, Zhou Z, Blanchard SC, Andersen OS, Levitz J.

Elife. 2019 Jun 7;8. pii: e45116. doi: 10.7554/eLife.45116.


Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease.

Prakash V, Carson BB, Feenstra JM, Dass RA, Sekyrova P, Hoshino A, Petersen J, Guo Y, Parks MM, Kurylo CM, Batchelder JE, Haller K, Hashimoto A, Rundqivst H, Condeelis JS, Allis CD, Drygin D, Nieto MA, Andäng M, Percipalle P, Bergh J, Adameyko I, Farrants AÖ, Hartman J, Lyden D, Pietras K, Blanchard SC, Vincent CT.

Nat Commun. 2019 May 8;10(1):2110. doi: 10.1038/s41467-019-10100-8.


Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET.

Lu M, Ma X, Castillo-Menendez LR, Gorman J, Alsahafi N, Ermel U, Terry DS, Chambers M, Peng D, Zhang B, Zhou T, Reichard N, Wang K, Grover JR, Carman BP, Gardner MR, Nikić-Spiegel I, Sugawara A, Arthos J, Lemke EA, Smith AB 3rd, Farzan M, Abrams C, Munro JB, McDermott AB, Finzi A, Kwong PD, Blanchard SC, Sodroski JG, Mothes W.

Nature. 2019 Apr;568(7752):415-419. doi: 10.1038/s41586-019-1101-y. Epub 2019 Apr 10.


Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome.

Pellegrino S, Meyer M, Könst ZA, Holm M, Voora VK, Kashinskaya D, Zanette C, Mobley DL, Yusupova G, Vanderwal CD, Blanchard SC, Yusupov M.

Nucleic Acids Res. 2019 Apr 8;47(6):3223-3232. doi: 10.1093/nar/gkz053.


Implications of sequence variation on the evolution of rRNA.

Parks MM, Kurylo CM, Batchelder JE, Theresa Vincent C, Blanchard SC.

Chromosome Res. 2019 Mar;27(1-2):89-93. doi: 10.1007/s10577-018-09602-w. Epub 2019 Feb 5. Review. Erratum in: Chromosome Res. 2019 Jun 28;:.


tRNA Translocation by the Eukaryotic 80S Ribosome and the Impact of GTP Hydrolysis.

Flis J, Holm M, Rundlet EJ, Loerke J, Hilal T, Dabrowski M, Bürger J, Mielke T, Blanchard SC, Spahn CMT, Budkevich TV.

Cell Rep. 2018 Dec 4;25(10):2676-2688.e7. doi: 10.1016/j.celrep.2018.11.040.


ERASE: a novel surface reconditioning strategy for single-molecule experiments.

Broadwater DWB, Altman RB, Blanchard SC, Kim HD.

Nucleic Acids Res. 2019 Feb 20;47(3):e14. doi: 10.1093/nar/gky1168.


ADAM10 controls the differentiation of the coronary arterial endothelium.

Farber G, Parks MM, Lustgarten Guahmich N, Zhang Y, Monette S, Blanchard SC, Di Lorenzo A, Blobel CP.

Angiogenesis. 2019 May;22(2):237-250. doi: 10.1007/s10456-018-9653-2. Epub 2018 Nov 16.


Endogenous rRNA Sequence Variation Can Regulate Stress Response Gene Expression and Phenotype.

Kurylo CM, Parks MM, Juette MF, Zinshteyn B, Altman RB, Thibado JK, Vincent CT, Blanchard SC.

Cell Rep. 2018 Oct 2;25(1):236-248.e6. doi: 10.1016/j.celrep.2018.08.093.


A facile approach for the in vitro assembly of multimeric membrane transport proteins.

Riederer EA, Focke PJ, Georgieva ER, Akyuz N, Matulef K, Borbat PP, Freed JH, Blanchard SC, Boudker O, Valiyaveetil FI.

Elife. 2018 Jun 11;7. pii: e36478. doi: 10.7554/eLife.36478.


A Much-Needed Boost for the Dwindling Antibiotic Pipeline.

Blanchard SC.

Mol Cell. 2018 Apr 5;70(1):3-5. doi: 10.1016/j.molcel.2018.03.023.


HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations.

Ma X, Lu M, Gorman J, Terry DS, Hong X, Zhou Z, Zhao H, Altman RB, Arthos J, Blanchard SC, Kwong PD, Munro JB, Mothes W.

Elife. 2018 Mar 21;7. pii: e34271. doi: 10.7554/eLife.34271.


Variant ribosomal RNA alleles are conserved and exhibit tissue-specific expression.

Parks MM, Kurylo CM, Dass RA, Bojmar L, Lyden D, Vincent CT, Blanchard SC.

Sci Adv. 2018 Feb 28;4(2):eaao0665. doi: 10.1126/sciadv.aao0665. eCollection 2018 Feb.


A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport.

Terry DS, Kolster RA, Quick M, LeVine MV, Khelashvili G, Zhou Z, Weinstein H, Javitch JA, Blanchard SC.

Nat Commun. 2018 Jan 15;9(1):230. doi: 10.1038/s41467-017-02202-y.


Publisher Correction: The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.

Herschhorn A, Gu C, Moraca F, Ma X, Farrell M, Smith AB 3rd, Pancera M, Kwong PD, Schön A, Freire E, Abrams C, Blanchard SC, Mothes W, Sodroski JG.

Nat Commun. 2018 Jan 8;9(1):158. doi: 10.1038/s41467-017-02463-7.


Aminoglycoside interactions and impacts on the eukaryotic ribosome.

Prokhorova I, Altman RB, Djumagulov M, Shrestha JP, Urzhumtsev A, Ferguson A, Chang CT, Yusupov M, Blanchard SC, Yusupova G.

Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):E10899-E10908. doi: 10.1073/pnas.1715501114. Epub 2017 Dec 5.


Dynamics of P-type ATPase transport revealed by single-molecule FRET.

Dyla M, Terry DS, Kjaergaard M, Sørensen TL, Lauwring Andersen J, Andersen JP, Rohde Knudsen C, Altman RB, Nissen P, Blanchard SC.

Nature. 2017 Nov 16;551(7680):346-351. doi: 10.1038/nature24296. Epub 2017 Nov 8.


The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.

Herschhorn A, Gu C, Moraca F, Ma X, Farrell M, Smith AB 3rd, Pancera M, Kwong PD, Schön A, Freire E, Abrams C, Blanchard SC, Mothes W, Sodroski JG.

Nat Commun. 2017 Oct 19;8(1):1049. doi: 10.1038/s41467-017-01119-w. Erratum in: Nat Commun. 2018 Jan 8;9(1):158.


Miscoding-induced stalling of substrate translocation on the bacterial ribosome.

Alejo JL, Blanchard SC.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8603-E8610. doi: 10.1073/pnas.1707539114. Epub 2017 Sep 25.


Single-molecule analysis of ligand efficacy in β2AR-G-protein activation.

Gregorio GG, Masureel M, Hilger D, Terry DS, Juette M, Zhao H, Zhou Z, Perez-Aguilar JM, Hauge M, Mathiasen S, Javitch JA, Weinstein H, Kobilka BK, Blanchard SC.

Nature. 2017 Jul 6;547(7661):68-73. doi: 10.1038/nature22354. Epub 2017 Jun 7.


Pseudoknot Formation Seeds the Twister Ribozyme Cleavage Reaction Coordinate.

Vušurović N, Altman RB, Terry DS, Micura R, Blanchard SC.

J Am Chem Soc. 2017 Jun 21;139(24):8186-8193. doi: 10.1021/jacs.7b01549. Epub 2017 Jun 9.


Electronic tuning of self-healing fluorophores for live-cell and single-molecule imaging.

Zheng Q, Jockusch S, Zhou Z, Altman RB, Zhao H, Asher W, Holsey M, Mathiasen S, Geggier P, Javitch JA, Blanchard SC.

Chem Sci. 2017 Jan 1;8(1):755-762. doi: 10.1039/C6SC02976K. Epub 2016 Sep 7.


Release of gp120 Restraints Leads to an Entry-Competent Intermediate State of the HIV-1 Envelope Glycoproteins.

Herschhorn A, Ma X, Gu C, Ventura JD, Castillo-Menendez L, Melillo B, Terry DS, Smith AB 3rd, Blanchard SC, Munro JB, Mothes W, Finzi A, Sodroski J.

MBio. 2016 Oct 25;7(5). pii: e01598-16. doi: 10.1128/mBio.01598-16.


Engineering a Prototypic P-type ATPase Listeria monocytogenes Ca(2+)-ATPase 1 for Single-Molecule FRET Studies.

Dyla M, Andersen JL, Kjaergaard M, Birkedal V, Terry DS, Altman RB, Blanchard SC, Nissen P, Knudsen CR.

Bioconjug Chem. 2016 Sep 21;27(9):2176-87. doi: 10.1021/acs.bioconjchem.6b00387. Epub 2016 Aug 24.


Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I.

Dass RA, Sarshad AA, Carson BB, Feenstra JM, Kaur A, Obrdlik A, Parks MM, Prakash V, Love DK, Pietras K, Serra R, Blanchard SC, Percipalle P, Brown AM, Vincent CT.

PLoS Genet. 2016 Aug 8;12(8):e1006217. doi: 10.1371/journal.pgen.1006217. eCollection 2016 Aug.


Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors.

Cocozaki AI, Altman RB, Huang J, Buurman ET, Kazmirski SL, Doig P, Prince DB, Blanchard SC, Cate JH, Ferguson AD.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8188-93. doi: 10.1073/pnas.1605127113. Epub 2016 Jul 5.


Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome.

Arenz S, Juette MF, Graf M, Nguyen F, Huter P, Polikanov YS, Blanchard SC, Wilson DN.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7527-32. doi: 10.1073/pnas.1604790113. Epub 2016 Jun 21.


Effect of acidic pH on the stability of α-synuclein dimers.

Lv Z, Krasnoslobodtsev AV, Zhang Y, Ysselstein D, Rochet JC, Blanchard SC, Lyubchenko YL.

Biopolymers. 2016 Oct;105(10):715-24. doi: 10.1002/bip.22874.


Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody.

Kong R, Xu K, Zhou T, Acharya P, Lemmin T, Liu K, Ozorowski G, Soto C, Taft JD, Bailer RT, Cale EM, Chen L, Choi CW, Chuang GY, Doria-Rose NA, Druz A, Georgiev IS, Gorman J, Huang J, Joyce MG, Louder MK, Ma X, McKee K, O'Dell S, Pancera M, Yang Y, Blanchard SC, Mothes W, Burton DR, Koff WC, Connors M, Ward AB, Kwong PD, Mascola JR.

Science. 2016 May 13;352(6287):828-33. doi: 10.1126/science.aae0474.


Multiperspective smFRET reveals rate-determining late intermediates of ribosomal translocation.

Wasserman MR, Alejo JL, Altman RB, Blanchard SC.

Nat Struct Mol Biol. 2016 Apr;23(4):333-41. doi: 10.1038/nsmb.3177. Epub 2016 Feb 29.


Single-molecule imaging of non-equilibrium molecular ensembles on the millisecond timescale.

Juette MF, Terry DS, Wasserman MR, Altman RB, Zhou Z, Zhao H, Blanchard SC.

Nat Methods. 2016 Apr;13(4):341-4. doi: 10.1038/nmeth.3769. Epub 2016 Feb 15.


Genome Sequence and Analysis of Escherichia coli MRE600, a Colicinogenic, Nonmotile Strain that Lacks RNase I and the Type I Methyltransferase, EcoKI.

Kurylo CM, Alexander N, Dass RA, Parks MM, Altman RA, Vincent CT, Mason CE, Blanchard SC.

Genome Biol Evol. 2016 Jan 22;8(3):742-52. doi: 10.1093/gbe/evw008.


Intra-molecular triplet energy transfer is a general approach to improve organic fluorophore photostability.

Zheng Q, Jockusch S, Rodríguez-Calero GG, Zhou Z, Zhao H, Altman RB, Abruña HD, Blanchard SC.

Photochem Photobiol Sci. 2016 Feb;15(2):196-203. doi: 10.1039/c5pp00400d. Epub 2015 Dec 23.


Functional Dynamics within the Human Ribosome Regulate the Rate of Active Protein Synthesis.

Ferguson A, Wang L, Altman RB, Terry DS, Juette MF, Burnett BJ, Alejo JL, Dass RA, Parks MM, Vincent CT, Blanchard SC.

Mol Cell. 2015 Nov 5;60(3):475-86. doi: 10.1016/j.molcel.2015.09.013. Epub 2015 Oct 22.


Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions.

Wasserman MR, Pulk A, Zhou Z, Altman RB, Zinder JC, Green KD, Garneau-Tsodikova S, Cate JH, Blanchard SC.

Nat Commun. 2015 Jul 30;6:7896. doi: 10.1038/ncomms8896.


Assembly and diploid architecture of an individual human genome via single-molecule technologies.

Pendleton M, Sebra R, Pang AW, Ummat A, Franzen O, Rausch T, Stütz AM, Stedman W, Anantharaman T, Hastie A, Dai H, Fritz MH, Cao H, Cohain A, Deikus G, Durrett RE, Blanchard SC, Altman R, Chin CS, Guo Y, Paxinos EE, Korbel JO, Darnell RB, McCombie WR, Kwok PY, Mason CE, Schadt EE, Bashir A.

Nat Methods. 2015 Aug;12(8):780-6. doi: 10.1038/nmeth.3454. Epub 2015 Jun 29.


Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env.

Kwon YD, Pancera M, Acharya P, Georgiev IS, Crooks ET, Gorman J, Joyce MG, Guttman M, Ma X, Narpala S, Soto C, Terry DS, Yang Y, Zhou T, Ahlsen G, Bailer RT, Chambers M, Chuang GY, Doria-Rose NA, Druz A, Hallen MA, Harned A, Kirys T, Louder MK, O'Dell S, Ofek G, Osawa K, Prabhakaran M, Sastry M, Stewart-Jones GB, Stuckey J, Thomas PV, Tittley T, Williams C, Zhang B, Zhao H, Zhou Z, Donald BR, Lee LK, Zolla-Pazner S, Baxa U, Schön A, Freire E, Shapiro L, Lee KK, Arthos J, Munro JB, Blanchard SC, Mothes W, Binley JM, McDermott AB, Mascola JR, Kwong PD.

Nat Struct Mol Biol. 2015 Jul;22(7):522-31. doi: 10.1038/nsmb.3051. Epub 2015 Jun 22.


Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A.

Polikanov YS, Starosta AL, Juette MF, Altman RB, Terry DS, Lu W, Burnett BJ, Dinos G, Reynolds KA, Blanchard SC, Steitz TA, Wilson DN.

Mol Cell. 2015 Jun 4;58(5):832-44. doi: 10.1016/j.molcel.2015.04.014. Epub 2015 May 28.


Direct Detection of α-Synuclein Dimerization Dynamics: Single-Molecule Fluorescence Analysis.

Lv Z, Krasnoslobodtsev AV, Zhang Y, Ysselstein D, Rochet JC, Blanchard SC, Lyubchenko YL.

Biophys J. 2015 Apr 21;108(8):2038-47. doi: 10.1016/j.bpj.2015.03.010.


High-resolution structure of the Escherichia coli ribosome.

Noeske J, Wasserman MR, Terry DS, Altman RB, Blanchard SC, Cate JH.

Nat Struct Mol Biol. 2015 Apr;22(4):336-41. doi: 10.1038/nsmb.2994. Epub 2015 Mar 16.


Transport domain unlocking sets the uptake rate of an aspartate transporter.

Akyuz N, Georgieva ER, Zhou Z, Stolzenberg S, Cuendet MA, Khelashvili G, Altman RB, Terry DS, Freed JH, Weinstein H, Boudker O, Blanchard SC.

Nature. 2015 Feb 5;518(7537):68-73. doi: 10.1038/nature14158.


Negamycin induces translational stalling and miscoding by binding to the small subunit head domain of the Escherichia coli ribosome.

Olivier NB, Altman RB, Noeske J, Basarab GS, Code E, Ferguson AD, Gao N, Huang J, Juette MF, Livchak S, Miller MD, Prince DB, Cate JH, Buurman ET, Blanchard SC.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):16274-9. doi: 10.1073/pnas.1414401111. Epub 2014 Nov 3.


Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions.

Munro JB, Gorman J, Ma X, Zhou Z, Arthos J, Burton DR, Koff WC, Courter JR, Smith AB 3rd, Kwong PD, Blanchard SC, Mothes W.

Science. 2014 Nov 7;346(6210):759-63. doi: 10.1126/science.1254426. Epub 2014 Oct 8.


Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

Pancera M, Zhou T, Druz A, Georgiev IS, Soto C, Gorman J, Huang J, Acharya P, Chuang GY, Ofek G, Stewart-Jones GB, Stuckey J, Bailer RT, Joyce MG, Louder MK, Tumba N, Yang Y, Zhang B, Cohen MS, Haynes BF, Mascola JR, Morris L, Munro JB, Blanchard SC, Mothes W, Connors M, Kwong PD.

Nature. 2014 Oct 23;514(7523):455-61. doi: 10.1038/nature13808. Epub 2014 Oct 8.


Direct evidence of an elongation factor-Tu/Ts·GTP·Aminoacyl-tRNA quaternary complex.

Burnett BJ, Altman RB, Ferguson A, Wasserman MR, Zhou Z, Blanchard SC.

J Biol Chem. 2014 Aug 22;289(34):23917-27. doi: 10.1074/jbc.M114.583385. Epub 2014 Jul 2.


The bright future of single-molecule fluorescence imaging.

Juette MF, Terry DS, Wasserman MR, Zhou Z, Altman RB, Zheng Q, Blanchard SC.

Curr Opin Chem Biol. 2014 Jun;20:103-11. doi: 10.1016/j.cbpa.2014.05.010. Epub 2014 Jun 21. Review.

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