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Items: 9

1.

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation.

Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Gómez-Suaga P, Waschbüsch D, Lobbestael E, Baekelandt V, Nairn AC, Ruiz-Martínez J, Aiastui A, López de Munain A, Lis P, Comptdaer T, Taymans JM, Chartier-Harlin MC, Beilina A, Gonnelli A, Cookson MR, Greggio E, Hilfiker S.

Mol Neurodegener. 2018 Jan 23;13(1):3. doi: 10.1186/s13024-018-0235-y.

2.

GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2.

Blanca Ramírez M, Lara Ordóñez AJ, Fdez E, Madero-Pérez J, Gonnelli A, Drouyer M, Chartier-Harlin MC, Taymans JM, Bubacco L, Greggio E, Hilfiker S.

Hum Mol Genet. 2017 Jul 15;26(14):2747-2767. doi: 10.1093/hmg/ddx161.

3.

Cellular effects mediated by pathogenic LRRK2: homing in on Rab-mediated processes.

Madero-Pérez J, Fdez E, Fernández B, Lara Ordóñez AJ, Blanca Ramírez M, Romo Lozano M, Rivero-Ríos P, Hilfiker S.

Biochem Soc Trans. 2017 Feb 8;45(1):147-154. doi: 10.1042/BST20160392. Review.

PMID:
28202668
4.

LRRK2: from kinase to GTPase to microtubules and back.

Blanca Ramírez M, Lara Ordóñez AJ, Fdez E, Hilfiker S.

Biochem Soc Trans. 2017 Feb 8;45(1):141-146. doi: 10.1042/BST20160333. Review.

PMID:
28202667
5.

LRRK2 and Parkinson's Disease: From Lack of Structure to Gain of Function.

Blanca Ramírez M, Madero-Perez J, Rivero-Rios P, Martinez-Salvador M, Lara Ordonez AJ, Fernandez B, Fdez E, Hilfiker S.

Curr Protein Pept Sci. 2017;18(7):677-686. doi: 10.2174/1389203717666160311121748. Review.

PMID:
26965688
6.

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity.

Gómez-Suaga P, Rivero-Ríos P, Fdez E, Blanca Ramírez M, Ferrer I, Aiastui A, López De Munain A, Hilfiker S.

Hum Mol Genet. 2014 Dec 20;23(25):6779-96. doi: 10.1093/hmg/ddu395. Epub 2014 Jul 30.

PMID:
25080504
7.

Novel insights into the neurobiology underlying LRRK2-linked Parkinson's disease.

Gómez-Suaga P, Fdez E, Fernández B, Martínez-Salvador M, Blanca Ramírez M, Madero-Pérez J, Rivero-Ríos P, Fuentes JM, Hilfiker S.

Neuropharmacology. 2014 Oct;85:45-56. doi: 10.1016/j.neuropharm.2014.05.020. Epub 2014 May 24. Review.

PMID:
24863040
8.

A direct interaction between leucine-rich repeat kinase 2 and specific β-tubulin isoforms regulates tubulin acetylation.

Law BM, Spain VA, Leinster VH, Chia R, Beilina A, Cho HJ, Taymans JM, Urban MK, Sancho RM, Blanca Ramírez M, Biskup S, Baekelandt V, Cai H, Cookson MR, Berwick DC, Harvey K.

J Biol Chem. 2014 Jan 10;289(2):895-908. doi: 10.1074/jbc.M113.507913. Epub 2013 Nov 25.

9.

A Link between Autophagy and the Pathophysiology of LRRK2 in Parkinson's Disease.

Gómez-Suaga P, Fdez E, Blanca Ramírez M, Hilfiker S.

Parkinsons Dis. 2012;2012:324521. doi: 10.1155/2012/324521. Epub 2012 Dec 3.

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