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Items: 31

1.

Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist.

Shi Y, Li J, Kennedy LJ, Tao S, Hernández AS, Lai Z, Chen S, Wong H, Zhu J, Trehan A, Lim NK, Zhang H, Chen BC, Locke KT, O'Malley KM, Zhang L, Srivastava RA, Miao B, Meyers DS, Monshizadegan H, Search D, Grimm D, Zhang R, Harrity T, Kunselman LK, Cap M, Muckelbauer J, Chang C, Krystek SR, Li YX, Hosagrahara V, Zhang L, Kadiyala P, Xu C, Blanar MA, Zahler R, Mukherjee R, Cheng PT, Tino JA.

ACS Med Chem Lett. 2016 Apr 4;7(6):590-4. doi: 10.1021/acsmedchemlett.6b00033. eCollection 2016 Jun 9.

2.

Triazolo and imidazo dihydropyrazolopyrimidine potassium channel antagonists.

Finlay HJ, Jiang J, Caringal Y, Kover A, Conder ML, Xing D, Levesque P, Harper T, Hsueh MM, Atwal K, Blanar M, Wexler R, Lloyd J.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1743-7. doi: 10.1016/j.bmcl.2013.01.064. Epub 2013 Jan 26.

PMID:
23414837
3.

Discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1H-indol-2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S)-2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone as a potent and selective I(Kur) inhibitor.

Finlay HJ, Lloyd J, Vaccaro W, Kover A, Yan L, Bhave G, Prol J, Huynh T, Bhandaru R, Caringal Y, DiMarco J, Gan J, Harper T, Huang C, Conder ML, Sun H, Levesque P, Blanar M, Atwal K, Wexler R.

J Med Chem. 2012 Apr 12;55(7):3036-48. doi: 10.1021/jm201386u. Epub 2012 Mar 21. Erratum in: J Med Chem. 2013 Sep 12;56(17):7133.

PMID:
22409629
4.

Discovery of an oxybenzylglycine based peroxisome proliferator activated receptor alpha selective agonist 2-((3-((2-(4-chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic acid (BMS-687453).

Li J, Kennedy LJ, Shi Y, Tao S, Ye XY, Chen SY, Wang Y, Hernández AS, Wang W, Devasthale PV, Chen S, Lai Z, Zhang H, Wu S, Smirk RA, Bolton SA, Ryono DE, Zhang H, Lim NK, Chen BC, Locke KT, O'Malley KM, Zhang L, Srivastava RA, Miao B, Meyers DS, Monshizadegan H, Search D, Grimm D, Zhang R, Harrity T, Kunselman LK, Cap M, Kadiyala P, Hosagrahara V, Zhang L, Xu C, Li YX, Muckelbauer JK, Chang C, An Y, Krystek SR, Blanar MA, Zahler R, Mukherjee R, Cheng PT, Tino JA.

J Med Chem. 2010 Apr 8;53(7):2854-64. doi: 10.1021/jm9016812.

PMID:
20218621
5.

Novel peroxisome proliferator-activated receptor alpha agonists lower low-density lipoprotein and triglycerides, raise high-density lipoprotein, and synergistically increase cholesterol excretion with a liver X receptor agonist.

Mukherjee R, Locke KT, Miao B, Meyers D, Monshizadegan H, Zhang R, Search D, Grimm D, Flynn M, O'Malley KM, Zhang L, Li J, Shi Y, Kennedy LJ, Blanar M, Cheng PT, Tino J, Srivastava RA.

J Pharmacol Exp Ther. 2008 Dec;327(3):716-26. doi: 10.1124/jpet.108.143271. Epub 2008 Sep 17.

PMID:
18799592
6.

(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor with reduced myotoxicity potential.

Ahmad S, Madsen CS, Stein PD, Janovitz E, Huang C, Ngu K, Bisaha S, Kennedy LJ, Chen BC, Zhao R, Sitkoff D, Monshizadegan H, Yin X, Ryan CS, Zhang R, Giancarli M, Bird E, Chang M, Chen X, Setters R, Search D, Zhuang S, Nguyen-Tran V, Cuff CA, Harrity T, Darienzo CJ, Li T, Reeves RA, Blanar MA, Barrish JC, Zahler R, Robl JA.

J Med Chem. 2008 May 8;51(9):2722-33. doi: 10.1021/jm800001n. Epub 2008 Apr 15.

PMID:
18412317
7.

The Guinea pig as a preclinical model for demonstrating the efficacy and safety of statins.

Madsen CS, Janovitz E, Zhang R, Nguyen-Tran V, Ryan CS, Yin X, Monshizadegan H, Chang M, D'Arienzo C, Scheer S, Setters R, Search D, Chen X, Zhuang S, Kunselman L, Peters A, Harrity T, Apedo A, Huang C, Cuff CA, Kowala MC, Blanar MA, Sun CQ, Robl JA, Stein PD.

J Pharmacol Exp Ther. 2008 Feb;324(2):576-86. Epub 2007 Nov 6.

PMID:
17986646
8.

Expression and characterization of human transient receptor potential melastatin 3 (hTRPM3).

Lee N, Chen J, Sun L, Wu S, Gray KR, Rich A, Huang M, Lin JH, Feder JN, Janovitz EB, Levesque PC, Blanar MA.

J Biol Chem. 2003 Jun 6;278(23):20890-7. Epub 2003 Apr 2.

9.

HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity.

Huang L, Sankar S, Lin C, Kontos CD, Schroff AD, Cha EH, Feng SM, Li SF, Yu Z, Van Etten RL, Blanar MA, Peters KG.

J Biol Chem. 1999 Dec 31;274(53):38183-8.

10.

Functional expression of two KvLQT1-related potassium channels responsible for an inherited idiopathic epilepsy.

Yang WP, Levesque PC, Little WA, Conder ML, Ramakrishnan P, Neubauer MG, Blanar MA.

J Biol Chem. 1998 Jul 31;273(31):19419-23.

11.

Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt.

Kontos CD, Stauffer TP, Yang WP, York JD, Huang L, Blanar MA, Meyer T, Peters KG.

Mol Cell Biol. 1998 Jul;18(7):4131-40.

12.

Aortic carboxypeptidase-like protein, a novel protein with discoidin and carboxypeptidase-like domains, is up-regulated during vascular smooth muscle cell differentiation.

Layne MD, Endege WO, Jain MK, Yet SF, Hsieh CM, Chin MT, Perrella MA, Blanar MA, Haber E, Lee ME.

J Biol Chem. 1998 Jun 19;273(25):15654-60.

13.
14.

Dominant-negative KvLQT1 mutations underlie the LQT1 form of long QT syndrome.

Shalaby FY, Levesque PC, Yang WP, Little WA, Conder ML, Jenkins-West T, Blanar MA.

Circulation. 1997 Sep 16;96(6):1733-6.

PMID:
9323054
15.

KvLQT1, a voltage-gated potassium channel responsible for human cardiac arrhythmias.

Yang WP, Levesque PC, Little WA, Conder ML, Shalaby FY, Blanar MA.

Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4017-21.

16.

Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development.

Cross JC, Flannery ML, Blanar MA, Steingrimsson E, Jenkins NA, Copeland NG, Rutter WJ, Werb Z.

Development. 1995 Aug;121(8):2513-23.

17.

Murine chromosomal location of five bHLH-Zip transcription factor genes.

Steingrímsson E, Sawadogo M, Gilbert DJ, Zervos AS, Brent R, Blanar MA, Fisher DE, Copeland NG, Jenkins NA.

Genomics. 1995 Jul 20;28(2):179-83.

PMID:
8530024
18.

Meso1, a basic-helix-loop-helix protein involved in mammalian presomitic mesoderm development.

Blanar MA, Crossley PH, Peters KG, Steingrímsson E, Copeland NG, Jenkins NA, Martin GR, Rutter WJ.

Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):5870-4.

19.

Cloning and characterization of a basic helix-loop-helix protein expressed in early mesoderm and the developing somites.

Quertermous EE, Hidai H, Blanar MA, Quertermous T.

Proc Natl Acad Sci U S A. 1994 Jul 19;91(15):7066-70.

20.

The bZIP transactivator of Epstein-Barr virus, BZLF1, functionally and physically interacts with the p65 subunit of NF-kappa B.

Gutsch DE, Holley-Guthrie EA, Zhang Q, Stein B, Blanar MA, Baldwin AS, Kenney SC.

Mol Cell Biol. 1994 Mar;14(3):1939-48.

21.

The p50 subunit of NF-kappa B associates with the NF-IL6 transcription factor.

LeClair KP, Blanar MA, Sharp PA.

Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):8145-9.

22.

Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties.

Kaelin WG Jr, Krek W, Sellers WR, DeCaprio JA, Ajchenbaum F, Fuchs CS, Chittenden T, Li Y, Farnham PJ, Blanar MA, et al.

Cell. 1992 Jul 24;70(2):351-64.

PMID:
1638635
23.
24.

Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind the insulin enhancer.

German MS, Blanar MA, Nelson C, Moss LG, Rutter WJ.

Mol Endocrinol. 1991 Feb;5(2):292-9.

PMID:
1710033
25.
27.

Transcriptional activation of HLA-DR alpha by interferon gamma requires a trans-acting protein.

Blanar MA, Boettger EC, Flavell RA.

Proc Natl Acad Sci U S A. 1988 Jul;85(13):4672-6.

28.
29.

Molecular analysis of the recF gene of Escherichia coli.

Blanar MA, Sandler SJ, Armengod ME, Ream LW, Clark AJ.

Proc Natl Acad Sci U S A. 1984 Aug;81(15):4622-6.

30.

A model for the core structure of the Escherichia coli RecA protein.

Blanar MA, Kneller D, Clark AJ, Karu AE, Cohen FE, Langridge R, Kuntz ID.

Cold Spring Harb Symp Quant Biol. 1984;49:507-11. No abstract available.

PMID:
6397305
31.

Genes of the RecE and RecF pathways of conjugational recombination in Escherichia coli.

Clark AJ, Sandler SJ, Willis DK, Chu CC, Blanar MA, Lovett ST.

Cold Spring Harb Symp Quant Biol. 1984;49:453-62. No abstract available.

PMID:
6397300

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