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Items: 1 to 50 of 282

1.

Benzyloxycarbonyl-proline-prolinal (ZPP): Dual complementary roles for neutrophil inhibition.

Russell DW, Hardison M, Genschmer KR, Szul T, Bratcher PE, Abdul Roda M, Xu X, Viera L, Blalock JE, Gaggar A, Noerager BD.

Biochem Biophys Res Commun. 2019 Oct 1;517(4):691-696. doi: 10.1016/j.bbrc.2019.07.111. Epub 2019 Aug 7.

2.

Response to Comment on "An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness".

Patel DF, Gaggar A, Blalock JE, Gregory LG, Lloyd CM, Snelgrove RJ.

Sci Transl Med. 2019 Jun 19;11(497). pii: eaaw0462. doi: 10.1126/scitranslmed.aaw0462.

PMID:
31217333
3.

Abnormal pro-gly-pro pathway and airway neutrophilia in pediatric cystic fibrosis.

Turnbull AR, Pyle CJ, Patel DF, Jackson PL, Hilliard TN, Regamey N, Tan HL, Brown S, Thursfield R, Short C, Mc Fie M, Alton EWFW, Gaggar A, Blalock JE, Lloyd CM, Bush A, Davies JC, Snelgrove RJ.

J Cyst Fibros. 2019 Jun 5. pii: S1569-1993(19)30769-6. doi: 10.1016/j.jcf.2019.05.017. [Epub ahead of print]

4.

Proline-Glycine-Proline Peptides Are Critical in the Development of Smoke-Induced Emphysema.

Abdul Roda M, Xu X, Abdalla TH, Sadik M, Szul T, Bratcher PE, Viera L, Solomon GM, Wells JM, McNicholas CM, Redegeld FA, Folkerts G, Blalock JE, Gaggar A.

Am J Respir Cell Mol Biol. 2019 Apr 8. doi: 10.1165/rcmb.2018-0216OC. [Epub ahead of print]

PMID:
30958968
5.

Activated PMN Exosomes: Pathogenic Entities Causing Matrix Destruction and Disease in the Lung.

Genschmer KR, Russell DW, Lal C, Szul T, Bratcher PE, Noerager BD, Abdul Roda M, Xu X, Rezonzew G, Viera L, Dobosh BS, Margaroli C, Abdalla TH, King RW, McNicholas CM, Wells JM, Dransfield MT, Tirouvanziam R, Gaggar A, Blalock JE.

Cell. 2019 Jan 10;176(1-2):113-126.e15. doi: 10.1016/j.cell.2018.12.002.

PMID:
30633902
6.

Vaporized E-Cigarette Liquids Induce Ion Transport Dysfunction in Airway Epithelia.

Lin VY, Fain MD, Jackson PL, Berryhill TF, Wilson LS, Mazur M, Barnes SJ, Blalock JE, Raju SV, Rowe SM.

Am J Respir Cell Mol Biol. 2019 Aug;61(2):162-173. doi: 10.1165/rcmb.2017-0432OC.

PMID:
30576219
7.

An extracellular matrix fragment drives epithelial remodeling and airway hyperresponsiveness.

Patel DF, Peiró T, Shoemark A, Akthar S, Walker SA, Grabiec AM, Jackson PL, Hussell T, Gaggar A, Xu X, Trevor JL, Li J, Steele C, Tavernier G, Blalock JE, Niven RM, Gregory LG, Simpson A, Lloyd CM, Snelgrove RJ.

Sci Transl Med. 2018 Aug 22;10(455). pii: eaaq0693. doi: 10.1126/scitranslmed.aaq0693.

8.

Early airway microbial metagenomic and metabolomic signatures are associated with development of severe bronchopulmonary dysplasia.

Lal CV, Kandasamy J, Dolma K, Ramani M, Kumar R, Wilson L, Aghai Z, Barnes S, Blalock JE, Gaggar A, Bhandari V, Ambalavanan N.

Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L810-L815. doi: 10.1152/ajplung.00085.2018. Epub 2018 Aug 16.

PMID:
30113227
9.

The neutrophil chemoattractant peptide proline-glycine-proline is associated with acute respiratory distress syndrome.

Sharma NS, Lal CV, Li JD, Lou XY, Viera L, Abdallah T, King RW, Sethi J, Kanagarajah P, Restrepo-Jaramillo R, Sales-Conniff A, Wei S, Jackson PL, Blalock JE, Gaggar A, Xu X.

Am J Physiol Lung Cell Mol Physiol. 2018 Nov 1;315(5):L653-L661. doi: 10.1152/ajplung.00308.2017. Epub 2018 Aug 9.

PMID:
30091378
10.

Macrophage Rac2 Is Required to Reduce the Severity of Cigarette Smoke-induced Pneumonia.

Larson-Casey JL, Gu L, Jackson PL, Briles DE, Hale JY, Blalock JE, Wells JM, Deshane JS, Wang Y, Davis D, Antony VB, Massicano AVF, Lapi SE, Carter AB.

Am J Respir Crit Care Med. 2018 Nov 15;198(10):1288-1301. doi: 10.1164/rccm.201712-2388OC.

PMID:
29897791
11.

Exosomal microRNA predicts and protects against severe bronchopulmonary dysplasia in extremely premature infants.

Lal CV, Olave N, Travers C, Rezonzew G, Dolma K, Simpson A, Halloran B, Aghai Z, Das P, Sharma N, Xu X, Genschmer K, Russell D, Szul T, Yi N, Blalock JE, Gaggar A, Bhandari V, Ambalavanan N.

JCI Insight. 2018 Mar 8;3(5). pii: 93994. doi: 10.1172/jci.insight.93994.

12.

Angiotensin-converting enzyme defines matrikine-regulated inflammation and fibrosis.

O'Reilly PJ, Ding Q, Akthar S, Cai G, Genschmer KR, Patel DF, Jackson PL, Viera L, Roda M, Locy ML, Bernstein EA, Lloyd CM, Bernstein KE, Snelgrove RJ, Blalock JE.

JCI Insight. 2017 Nov 16;2(22). pii: 91923. doi: 10.1172/jci.insight.91923. eCollection 2017 Nov 16.

13.

The Matrikine Acetylated Proline-Glycine-Proline Couples Vascular Inflammation and Acute Cardiac Rejection.

Payne GA, Li J, Xu X, Jackson P, Qin H, Pollock DM, Wells JM, Oparil S, Leesar M, Patel RP, Blalock JE, Gaggar A.

Sci Rep. 2017 Aug 8;7(1):7563. doi: 10.1038/s41598-017-07610-0.

14.

Doxycycline improves clinical outcomes during cystic fibrosis exacerbations.

Xu X, Abdalla T, Bratcher PE, Jackson PL, Sabbatini G, Wells JM, Lou XY, Quinn R, Blalock JE, Clancy JP, Gaggar A.

Eur Respir J. 2017 Apr 5;49(4). pii: 1601102. doi: 10.1183/13993003.01102-2016. Print 2017 Apr.

15.

The development of novel LTA4H modulators to selectively target LTB4 generation.

Low CM, Akthar S, Patel DF, Löser S, Wong CT, Jackson PL, Blalock JE, Hare SA, Lloyd CM, Snelgrove RJ.

Sci Rep. 2017 Mar 17;7:44449. doi: 10.1038/srep44449.

16.

Tristetraprolin Down-Regulation Contributes to Persistent TNF-Alpha Expression Induced by Cigarette Smoke Extract through a Post-Transcriptional Mechanism.

Zhao XK, Che P, Cheng ML, Zhang Q, Mu M, Li H, Luo Y, Liang YD, Luo XH, Gao CQ, Jackson PL, Wells JM, Zhou Y, Hu M, Cai G, Thannickal VJ, Steele C, Blalock JE, Han X, Chen CY, Ding Q.

PLoS One. 2016 Dec 2;11(12):e0167451. doi: 10.1371/journal.pone.0167451. eCollection 2016.

17.

Genetic regulation of expression of leukotriene A4 hydrolase.

Szul T, Castaldi P, Cho MH, Blalock JE, Gaggar A.

ERJ Open Res. 2016 Feb 9;2(1). pii: 00058-2015. eCollection 2016 Jan.

18.

A ferret model of COPD-related chronic bronchitis.

Raju SV, Kim H, Byzek SA, Tang LP, Trombley JE, Jackson P, Rasmussen L, Wells JM, Libby EF, Dohm E, Winter L, Samuel SL, Zinn KR, Blalock JE, Schoeb TR, Dransfield MT, Rowe SM.

JCI Insight. 2016 Sep 22;1(15):e87536. doi: 10.1172/jci.insight.87536.

19.

Disease phenotyping in chronic obstructive pulmonary disease: the neutrophilic endotype.

Russell DW, Wells JM, Blalock JE.

Curr Opin Pulm Med. 2016 Mar;22(2):91-9. doi: 10.1097/MCP.0000000000000238. Review.

PMID:
26717512
20.
21.

The soot of all evil.

Russell DW, Blalock JE.

Elife. 2015 Oct 21;4:e11709. doi: 10.7554/eLife.11709.

22.

Matrikines are key regulators in modulating the amplitude of lung inflammation in acute pulmonary infection.

Akthar S, Patel DF, Beale RC, Peiró T, Xu X, Gaggar A, Jackson PL, Blalock JE, Lloyd CM, Snelgrove RJ.

Nat Commun. 2015 Sep 24;6:8423. doi: 10.1038/ncomms9423.

23.

Matrix Metalloproteinase-9 Mediates RSV Infection in Vitro and in Vivo.

Kong MY, Whitley RJ, Peng N, Oster R, Schoeb TR, Sullender W, Ambalavanan N, Clancy JP, Gaggar A, Blalock JE.

Viruses. 2015 Jul 30;7(8):4230-53. doi: 10.3390/v7082817. Erratum in: Viruses. 2015 Oct;7(10):5609.

24.

The matrikine N-α-PGP couples extracellular matrix fragmentation to endothelial permeability.

Hahn CS, Scott DW, Xu X, Roda MA, Payne GA, Wells JM, Viera L, Winstead CJ, Bratcher P, Sparidans RW, Redegeld FA, Jackson PL, Folkerts G, Blalock JE, Patel RP, Gaggar A.

Sci Adv. 2015;1(3). pii: e1500175.

25.

Toll-Like Receptor 4 Engagement Mediates Prolyl Endopeptidase Release from Airway Epithelia via Exosomes.

Szul T, Bratcher PE, Fraser KB, Kong M, Tirouvanziam R, Ingersoll S, Sztul E, Rangarajan S, Blalock JE, Xu X, Gaggar A.

Am J Respir Cell Mol Biol. 2016 Mar;54(3):359-69. doi: 10.1165/rcmb.2015-0108OC.

26.

A Potential Role for Acrolein in Neutrophil-Mediated Chronic Inflammation.

Noerager BD, Xu X, Davis VA, Jones CW, Okafor S, Whitehead A, Blalock JE, Jackson PL.

Inflammation. 2015 Dec;38(6):2279-87. doi: 10.1007/s10753-015-0213-2.

PMID:
26208604
27.

A Randomized, Placebo-controlled Trial of Roflumilast. Effect on Proline-Glycine-Proline and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease.

Wells JM, Jackson PL, Viera L, Bhatt SP, Gautney J, Handley G, King RW, Xu X, Gaggar A, Bailey WC, Dransfield MT, Blalock JE.

Am J Respir Crit Care Med. 2015 Oct 15;192(8):934-42. doi: 10.1164/rccm.201503-0543OC.

28.

The matrikine PGP as a potential biomarker in COPD.

Abdul Roda M, Fernstrand AM, Redegeld FA, Blalock JE, Gaggar A, Folkerts G.

Am J Physiol Lung Cell Mol Physiol. 2015 Jun 1;308(11):L1095-101. doi: 10.1152/ajplung.00040.2015. Epub 2015 Apr 10. Review.

29.

MMP generated matrikines.

Wells JM, Gaggar A, Blalock JE.

Matrix Biol. 2015 May-Jul;44-46:122-9. doi: 10.1016/j.matbio.2015.01.016. Epub 2015 Jan 28. Review.

30.

An aberrant leukotriene A4 hydrolase-proline-glycine-proline pathway in the pathogenesis of chronic obstructive pulmonary disease.

Wells JM, O'Reilly PJ, Szul T, Sullivan DI, Handley G, Garrett C, McNicholas CM, Roda MA, Miller BE, Tal-Singer R, Gaggar A, Rennard SI, Jackson PL, Blalock JE.

Am J Respir Crit Care Med. 2014 Jul 1;190(1):51-61. doi: 10.1164/rccm.201401-0145OC.

31.

Targeting prolyl endopeptidase with valproic acid as a potential modulator of neutrophilic inflammation.

Abdul Roda M, Sadik M, Gaggar A, Hardison MT, Jablonsky MJ, Braber S, Blalock JE, Redegeld FA, Folkerts G, Jackson PL.

PLoS One. 2014 May 16;9(5):e97594. doi: 10.1371/journal.pone.0097594. eCollection 2014.

32.

Sputum PGP is reduced by azithromycin treatment in patients with COPD and correlates with exacerbations.

O'Reilly PJ, Jackson PL, Wells JM, Dransfield MT, Scanlon PD, Blalock JE.

BMJ Open. 2013 Dec 23;3(12):e004140. doi: 10.1136/bmjopen-2013-004140.

33.

Pulmonary matrix metalloproteinase-9 activity in mechanically ventilated children with respiratory syncytial virus.

Kong MY, Clancy JP, Peng N, Li Y, Szul TJ, Xu X, Oster R, Sullender W, Ambalavanan N, Blalock JE, Gaggar A.

Eur Respir J. 2014 Apr;43(4):1086-96. doi: 10.1183/09031936.00105613. Epub 2013 Dec 5.

34.

Cigarette smoke induces systemic defects in cystic fibrosis transmembrane conductance regulator function.

Raju SV, Jackson PL, Courville CA, McNicholas CM, Sloane PA, Sabbatini G, Tidwell S, Tang LP, Liu B, Fortenberry JA, Jones CW, Boydston JA, Clancy JP, Bowen LE, Accurso FJ, Blalock JE, Dransfield MT, Rowe SM.

Am J Respir Crit Care Med. 2013 Dec 1;188(11):1321-30. doi: 10.1164/rccm.201304-0733OC.

35.

Collagen degradation and neutrophilic infiltration: a vicious circle in inflammatory bowel disease.

Koelink PJ, Overbeek SA, Braber S, Morgan ME, Henricks PA, Abdul Roda M, Verspaget HW, Wolfkamp SC, te Velde AA, Jones CW, Jackson PL, Blalock JE, Sparidans RW, Kruijtzer JA, Garssen J, Folkerts G, Kraneveld AD.

Gut. 2014 Apr;63(4):578-87. doi: 10.1136/gutjnl-2012-303252. Epub 2013 Mar 23.

36.

Cigarette smoke-induced collagen destruction; key to chronic neutrophilic airway inflammation?

Overbeek SA, Braber S, Koelink PJ, Henricks PA, Mortaz E, LoTam Loi AT, Jackson PL, Garssen J, Wagenaar GT, Timens W, Koenderman L, Blalock JE, Kraneveld AD, Folkerts G.

PLoS One. 2013;8(1):e55612. doi: 10.1371/journal.pone.0055612. Epub 2013 Jan 31. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/0faf4c12-4fd4-474c-b5a4-16e49370aff3.

37.

Cigarette smoke enhances chemotaxis via acetylation of proline-glycine-proline.

Hardison MT, Brown MD, Snelgrove RJ, Blalock JE, Jackson P.

Front Biosci (Elite Ed). 2012 Jun 1;4:2402-9.

38.

Proline-glycine-proline as a potential biomarker in chronic obstructive pulmonary disease and cystic fibrosis.

Ten Hoeve AL, Roda MA, Redegeld F, Folkerts G, Blalock JE, Gaggar A.

Tanaffos. 2012;11(2):12-5. Review.

39.

Molecular recognition theory and sense-antisense interaction: therapeutic applications in autoimmunity.

Hardison MT, Blalock JE.

Front Biosci (Elite Ed). 2012 Jan 1;4:1864-70. Review.

40.

A CXCL8 receptor antagonist based on the structure of N-acetyl-proline-glycine-proline.

Jackson PL, Noerager BD, Jablonsky MJ, Hardison MT, Cox BD, Patterson JC, Dhanapal B, Blalock JE, Muccio DD.

Eur J Pharmacol. 2011 Oct 15;668(3):435-42. doi: 10.1016/j.ejphar.2011.02.045. Epub 2011 Mar 31.

41.

CD14 signaling reciprocally controls collagen deposition and turnover to regulate the development of lyme arthritis.

Sahay B, Singh A, Gnanamani A, Patsey RL, Blalock JE, Sellati TJ.

Am J Pathol. 2011 Feb;178(2):724-34. doi: 10.1016/j.ajpath.2010.10.025.

42.

A self-propagating matrix metalloprotease-9 (MMP-9) dependent cycle of chronic neutrophilic inflammation.

Xu X, Jackson PL, Tanner S, Hardison MT, Abdul Roda M, Blalock JE, Gaggar A.

PLoS One. 2011 Jan 13;6(1):e15781. doi: 10.1371/journal.pone.0015781.

43.

Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown.

Braber S, Koelink PJ, Henricks PA, Jackson PL, Nijkamp FP, Garssen J, Kraneveld AD, Blalock JE, Folkerts G.

Am J Physiol Lung Cell Mol Physiol. 2011 Feb;300(2):L255-65. doi: 10.1152/ajplung.00304.2010. Epub 2010 Nov 26.

44.

A critical role for LTA4H in limiting chronic pulmonary neutrophilic inflammation.

Snelgrove RJ, Jackson PL, Hardison MT, Noerager BD, Kinloch A, Gaggar A, Shastry S, Rowe SM, Shim YM, Hussell T, Blalock JE.

Science. 2010 Oct 1;330(6000):90-4. doi: 10.1126/science.1190594. Epub 2010 Sep 2.

45.

Proline-Glycine-Proline (PGP) and High Mobility Group Box Protein-1 (HMGB1): Potential Mediators of Cystic Fibrosis Airway Inflammation.

Gaggar A, Rowe SM, Matthew H, Blalock JE.

Open Respir Med J. 2010 Mar 30;4:32-8. doi: 10.2174/1874306401004020032.

46.

Human neutrophil elastase-mediated cleavage sites of MMP-9 and TIMP-1: implications to cystic fibrosis proteolytic dysfunction.

Jackson PL, Xu X, Wilson L, Weathington NM, Clancy JP, Blalock JE, Gaggar A.

Mol Med. 2010 May-Jun;16(5-6):159-66. doi: 10.2119/molmed.2009.00109. Epub 2010 Jan 22.

47.

Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen.

O'Reilly PJ, Hardison MT, Jackson PL, Xu X, Snelgrove RJ, Gaggar A, Galin FS, Blalock JE.

J Neuroimmunol. 2009 Dec 10;217(1-2):51-4. doi: 10.1016/j.jneuroim.2009.09.020. Epub 2009 Oct 28.

48.

Investigating bacterial sources of toxicity as an environmental contributor to dopaminergic neurodegeneration.

Caldwell KA, Tucci ML, Armagost J, Hodges TW, Chen J, Memon SB, Blalock JE, DeLeon SM, Findlay RH, Ruan Q, Webber PJ, Standaert DG, Olson JB, Caldwell GA.

PLoS One. 2009 Oct 6;4(10):e7227. doi: 10.1371/journal.pone.0007227.

49.

N-alpha-PGP and PGP, potential biomarkers and therapeutic targets for COPD.

O'Reilly P, Jackson PL, Noerager B, Parker S, Dransfield M, Gaggar A, Blalock JE.

Respir Res. 2009 May 18;10:38. doi: 10.1186/1465-9921-10-38.

50.

The presence of a matrix-derived neutrophil chemoattractant in bronchiolitis obliterans syndrome after lung transplantation.

Hardison MT, Galin FS, Calderon CE, Djekic UV, Parker SB, Wille KM, Jackson PL, Oster RA, Young KR, Blalock JE, Gaggar A.

J Immunol. 2009 Apr 1;182(7):4423-31. doi: 10.4049/jimmunol.0802457.

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