Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 308

1.

Dopamine-dependent, swimming-induced paralysis arises as a consequence of loss of function mutations in the RUNX transcription factor RNT-1.

Robinson SB, Refai O, Hardaway JA, Sturgeon S, Popay T, Bermingham DP, Freeman P, Wright J, Blakely RD.

PLoS One. 2019 May 13;14(5):e0216417. doi: 10.1371/journal.pone.0216417. eCollection 2019.

2.

Repetitive mild concussion in subjects with a vulnerable cholinergic system: Lasting cholinergic-attentional impairments in CHT+/- mice.

Koshy Cherian A, Tronson NC, Parikh V, Kucinski A, Blakely RD, Sarter M.

Behav Neurosci. 2019 Aug;133(4):448-459. doi: 10.1037/bne0000310. Epub 2019 Mar 21.

PMID:
30896190
3.

Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.

Liu X, Nemeth DP, McKim DB, Zhu L, DiSabato DJ, Berdysz O, Gorantla G, Oliver B, Witcher KG, Wang Y, Negray CE, Vegesna RS, Sheridan JF, Godbout JP, Robson MJ, Blakely RD, Popovich PG, Bilbo SD, Quan N.

Immunity. 2019 Mar 19;50(3):764-766. doi: 10.1016/j.immuni.2019.02.012. No abstract available.

PMID:
30893590
4.

The SERT Met172 Mouse: An Engineered Model To Elucidate the Contributions of Serotonin Signaling to Cocaine Action.

Simmler LD, Blakely RD.

ACS Chem Neurosci. 2019 Jul 17;10(7):3053-3060. doi: 10.1021/acschemneuro.9b00005. Epub 2019 Mar 13.

PMID:
30817127
5.

Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities.

Liu X, Nemeth DP, McKim DB, Zhu L, DiSabato DJ, Berdysz O, Gorantla G, Oliver B, Witcher KG, Wang Y, Negray CE, Vegesna RS, Sheridan JF, Godbout JP, Robson MJ, Blakely RD, Popovich PG, Bilbo SD, Quan N.

Immunity. 2019 Feb 19;50(2):317-333.e6. doi: 10.1016/j.immuni.2018.12.012. Epub 2019 Jan 22. Erratum in: Immunity. 2019 Mar 19;50(3):764-766.

PMID:
30683620
6.

Human Serotonin Transporter Coding Variation Establishes Conformational Bias with Functional Consequences.

Quinlan MA, Krout D, Katamish RM, Robson MJ, Nettesheim C, Gresch PJ, Mash DC, Henry LK, Blakely RD.

ACS Chem Neurosci. 2019 Jul 17;10(7):3249-3260. doi: 10.1021/acschemneuro.8b00689. Epub 2019 Feb 5.

PMID:
30668912
7.

Serotonin transporter inhibition and 5-HT2C receptor activation drive loss of cocaine-induced locomotor activation in DAT Val559 mice.

Stewart A, Davis GL, Gresch PJ, Katamish RM, Peart R, Rabil MJ, Gowrishankar R, Carroll FI, Hahn MK, Blakely RD.

Neuropsychopharmacology. 2019 Apr;44(5):994-1006. doi: 10.1038/s41386-018-0301-8. Epub 2018 Dec 21.

8.

The brain in flux: Genetic, physiologic, and therapeutic perspectives on transporters in the CNS.

Blakely RD, El Mestikawy S, Robinson MB.

Neurochem Int. 2019 Feb;123:1-6. doi: 10.1016/j.neuint.2018.12.006. Epub 2018 Dec 17.

PMID:
30571999
9.

p38α MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse.

Robson MJ, Quinlan MA, Margolis KG, Gajewski-Kurdziel PA, Veenstra-VanderWeele J, Gershon MD, Watterson DM, Blakely RD.

Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10245-E10254. doi: 10.1073/pnas.1809137115. Epub 2018 Oct 8.

10.

Single Quantum Dot Imaging Reveals PKCβ-Dependent Alterations in Membrane Diffusion and Clustering of an Attention-Deficit Hyperactivity Disorder/Autism/Bipolar Disorder-Associated Dopamine Transporter Variant.

Thal LB, Tomlinson ID, Quinlan MA, Kovtun O, Blakely RD, Rosenthal SJ.

ACS Chem Neurosci. 2019 Jan 16;10(1):460-471. doi: 10.1021/acschemneuro.8b00350. Epub 2018 Sep 11.

PMID:
30153408
11.

Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits.

Muntean BS, Zucca S, MacMullen CM, Dao MT, Johnston C, Iwamoto H, Blakely RD, Davis RL, Martemyanov KA.

Cell Rep. 2018 Jul 24;24(4):1081-1084. doi: 10.1016/j.celrep.2018.07.031. No abstract available.

12.

Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation.

Burke SJ, Batdorf HM, Burk DH, Martin TM, Mendoza T, Stadler K, Alami W, Karlstad MD, Robson MJ, Blakely RD, Mynatt RL, Collier JJ.

Mol Metab. 2018 Aug;14:95-107. doi: 10.1016/j.molmet.2018.06.003. Epub 2018 Jun 6.

13.

Adrenal serotonin derives from accumulation by the antidepressant-sensitive serotonin transporter.

Brindley RL, Bauer MB, Walker LA, Quinlan MA, Carneiro AMD, Sze JY, Blakely RD, Currie KPM.

Pharmacol Res. 2019 Feb;140:56-66. doi: 10.1016/j.phrs.2018.06.008. Epub 2018 Jun 9.

PMID:
29894763
14.

Global untargeted serum metabolomic analyses nominate metabolic pathways responsive to loss of expression of the orphan metallo β-lactamase, MBLAC1.

Gibson CL, Codreanu SG, Schrimpe-Rutledge AC, Retzlaff CL, Wright J, Mortlock DP, Sherrod SD, McLean JA, Blakely RD.

Mol Omics. 2018 Jun 12;14(3):142-155. doi: 10.1039/c7mo00022g.

15.

Blockade and reversal of swimming-induced paralysis in C. elegans by the antipsychotic and D2-type dopamine receptor antagonist azaperone.

Refai O, Blakely RD.

Neurochem Int. 2019 Feb;123:59-68. doi: 10.1016/j.neuint.2018.05.013. Epub 2018 May 22.

PMID:
29800604
16.

Region-Specific Regulation of Presynaptic Dopamine Homeostasis by D2 Autoreceptors Shapes the In Vivo Impact of the Neuropsychiatric Disease-Associated DAT Variant Val559.

Gowrishankar R, Gresch PJ, Davis GL, Katamish RM, Riele JR, Stewart AM, Vaughan RA, Hahn MK, Blakely RD.

J Neurosci. 2018 Jun 6;38(23):5302-5312. doi: 10.1523/JNEUROSCI.0055-18.2018. Epub 2018 May 8.

17.

Analysis of neuroanatomical differences in mice with genetically modified serotonin transporters assessed by structural magnetic resonance imaging.

Ellegood J, Yee Y, Kerr TM, Muller CL, Blakely RD, Henkelman RM, Veenstra-VanderWeele J, Lerch JP.

Mol Autism. 2018 Apr 10;9:24. doi: 10.1186/s13229-018-0210-z. eCollection 2018.

18.

Glial loss of the metallo β-lactamase domain containing protein, SWIP-10, induces age- and glutamate-signaling dependent, dopamine neuron degeneration.

Gibson CL, Balbona JT, Niedzwiecki A, Rodriguez P, Nguyen KCQ, Hall DH, Blakely RD.

PLoS Genet. 2018 Mar 28;14(3):e1007269. doi: 10.1371/journal.pgen.1007269. eCollection 2018 Mar.

19.

Truncating SLC5A7 mutations underlie a spectrum of dominant hereditary motor neuropathies.

Salter CG, Beijer D, Hardy H, Barwick KES, Bower M, Mademan I, De Jonghe P, Deconinck T, Russell MA, McEntagart MM, Chioza BA, Blakely RD, Chilton JK, De Bleecker J, Baets J, Baple EL, Walk D, Crosby AH.

Neurol Genet. 2018 Mar 23;4(2):e222. doi: 10.1212/NXG.0000000000000222. eCollection 2018 Apr.

20.

Interrogating the Spatiotemporal Landscape of Neuromodulatory GPCR Signaling by Real-Time Imaging of cAMP in Intact Neurons and Circuits.

Muntean BS, Zucca S, MacMullen CM, Dao MT, Johnston C, Iwamoto H, Blakely RD, Davis RL, Martemyanov KA.

Cell Rep. 2018 Jan 2;22(1):255-268. doi: 10.1016/j.celrep.2017.12.022. Erratum in: Cell Rep. 2018 Jul 24;24(4):1081-1084.

22.

Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localization.

Wang H, Salter CG, Refai O, Hardy H, Barwick KES, Akpulat U, Kvarnung M, Chioza BA, Harlalka G, Taylan F, Sejersen T, Wright J, Zimmerman HH, Karakaya M, Stüve B, Weis J, Schara U, Russell MA, Abdul-Rahman OA, Chilton J, Blakely RD, Baple EL, Cirak S, Crosby AH.

Brain. 2017 Nov 1;140(11):2838-2850. doi: 10.1093/brain/awx249.

23.

Functional coding variation in the presynaptic dopamine transporter associated with neuropsychiatric disorders drives enhanced motivation and context-dependent impulsivity in mice.

Davis GL, Stewart A, Stanwood GD, Gowrishankar R, Hahn MK, Blakely RD.

Behav Brain Res. 2018 Jan 30;337:61-69. doi: 10.1016/j.bbr.2017.09.043. Epub 2017 Sep 28.

24.

Spatial gene expression analysis of neuroanatomical differences in mouse models.

Fernandes DJ, Ellegood J, Askalan R, Blakely RD, Dicicco-Bloom E, Egan SE, Osborne LR, Powell CM, Raznahan A, Robins DM, Salter MW, Sengar AS, Veenstra-VanderWeele J, Henkelman RM, Lerch JP.

Neuroimage. 2017 Dec;163:220-230. doi: 10.1016/j.neuroimage.2017.08.065. Epub 2017 Sep 4.

PMID:
28882630
25.

The Atypical MAP Kinase SWIP-13/ERK8 Regulates Dopamine Transporters through a Rho-Dependent Mechanism.

Bermingham DP, Hardaway JA, Refai O, Marks CR, Snider SL, Sturgeon SM, Spencer WC, Colbran RJ, Miller DM 3rd, Blakely RD.

J Neurosci. 2017 Sep 20;37(38):9288-9304. doi: 10.1523/JNEUROSCI.1582-17.2017. Epub 2017 Aug 21.

26.

Metallo-β-lactamase Domain-Containing Protein 1 (MBLAC1) Is a Specific, High-Affinity Target for the Glutamate Transporter Inducer Ceftriaxone.

Retzlaff CL, Kussrow A, Schorkopf T, Saetear P, Bornhop DJ, Hardaway JA, Sturgeon SM, Wright J, Blakely RD.

ACS Chem Neurosci. 2017 Oct 18;8(10):2132-2138. doi: 10.1021/acschemneuro.7b00232. Epub 2017 Aug 14.

PMID:
28783953
27.

Length of axons expressing the serotonin transporter in orbitofrontal cortex is lower with age in depression.

Rajkowska G, Mahajan G, Legutko B, Challagundla L, Griswold M, Albert PR, Daigle M, Miguel-Hidalgo JJ, Austin MC, Blakely RD, Steffens DC, Stockmeier CA.

Neuroscience. 2017 Sep 17;359:30-39. doi: 10.1016/j.neuroscience.2017.07.006. Epub 2017 Jul 13.

28.

Blockade of the 5-HT transporter contributes to the behavioural, neuronal and molecular effects of cocaine.

Simmler LD, Anacker AMJ, Levin MH, Vaswani NM, Gresch PJ, Nackenoff AG, Anastasio NC, Stutz SJ, Cunningham KA, Wang J, Zhang B, Henry LK, Stewart A, Veenstra-VanderWeele J, Blakely RD.

Br J Pharmacol. 2017 Aug;174(16):2716-2738. doi: 10.1111/bph.13899. Epub 2017 Jul 11.

29.

Hemicholinium-3 sensitive choline transport in human T lymphocytes: Evidence for use as a proxy for brain choline transporter (CHT) capacity.

Koshy Cherian A, Parikh V, Wu Q, Mao-Draayer Y, Wang Q, Blakely RD, Sarter M.

Neurochem Int. 2017 Sep;108:410-416. doi: 10.1016/j.neuint.2017.05.022. Epub 2017 May 31.

30.

Serotonin and Serotonin Transporters in the Adrenal Medulla: A Potential Hub for Modulation of the Sympathetic Stress Response.

Brindley RL, Bauer MB, Blakely RD, Currie KPM.

ACS Chem Neurosci. 2017 May 17;8(5):943-954. doi: 10.1021/acschemneuro.7b00026. Epub 2017 Apr 13. Review.

31.

Immune System Activation and Depression: Roles of Serotonin in the Central Nervous System and Periphery.

Robson MJ, Quinlan MA, Blakely RD.

ACS Chem Neurosci. 2017 May 17;8(5):932-942. doi: 10.1021/acschemneuro.6b00412. Epub 2017 Apr 3. Review.

PMID:
28345868
32.

An autism-associated serotonin transporter variant disrupts multisensory processing.

Siemann JK, Muller CL, Forsberg CG, Blakely RD, Veenstra-VanderWeele J, Wallace MT.

Transl Psychiatry. 2017 Mar 21;7(3):e1067. doi: 10.1038/tp.2017.17.

33.

Serotonin Transporter-Independent Actions of the Antidepressant Vortioxetine As Revealed Using the SERT Met172 Mouse.

Nackenoff AG, Simmler LD, Baganz NL, Pehrson AL, Sánchez C, Blakely RD.

ACS Chem Neurosci. 2017 May 17;8(5):1092-1100. doi: 10.1021/acschemneuro.7b00038. Epub 2017 Mar 20.

PMID:
28272863
34.

Unresponsive Choline Transporter as a Trait Neuromarker and a Causal Mediator of Bottom-Up Attentional Biases.

Koshy Cherian A, Kucinski A, Pitchers K, Yegla B, Parikh V, Kim Y, Valuskova P, Gurnani S, Lindsley CW, Blakely RD, Sarter M.

J Neurosci. 2017 Mar 15;37(11):2947-2959. doi: 10.1523/JNEUROSCI.3499-16.2017. Epub 2017 Feb 13.

35.

Sequence determinants of the Caenhorhabditis elegans dopamine transporter dictating in vivo axonal export and synaptic localization.

Robinson SB, Hardaway JA, Hardie SL, Wright J, Glynn RM, Bermingham DP, Han Q, Sturgeon SM, Freeman P, Blakely RD.

Mol Cell Neurosci. 2017 Jan;78:41-51. doi: 10.1016/j.mcn.2016.11.011. Epub 2016 Nov 30.

36.

Kinase-dependent Regulation of Monoamine Neurotransmitter Transporters.

Bermingham DP, Blakely RD.

Pharmacol Rev. 2016 Oct;68(4):888-953. doi: 10.1124/pr.115.012260. Review.

37.

Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound.

Bertron JL, Ennis EA, Tarr CJ, Wright J, Dickerson JW, Locuson CW, Blobaum AL, Rook JM, Blakely RD, Lindsley CW.

Bioorg Med Chem Lett. 2016 Oct 1;26(19):4637-4640. doi: 10.1016/j.bmcl.2016.08.062. Epub 2016 Aug 21.

PMID:
27575469
38.

Impact of Maternal Serotonin Transporter Genotype on Placental Serotonin, Fetal Forebrain Serotonin, and Neurodevelopment.

Muller CL, Anacker AM, Rogers TD, Goeden N, Keller EH, Forsberg CG, Kerr TM, Wender C, Anderson GM, Stanwood GD, Blakely RD, Bonnin A, Veenstra-VanderWeele J.

Neuropsychopharmacology. 2017 Jan;42(2):427-436. doi: 10.1038/npp.2016.166. Epub 2016 Aug 23.

39.

An interplay between the serotonin transporter (SERT) and 5-HT receptors controls stimulus-secretion coupling in sympathoadrenal chromaffin cells.

Brindley RL, Bauer MB, Blakely RD, Currie KPM.

Neuropharmacology. 2016 Nov;110(Pt A):438-448. doi: 10.1016/j.neuropharm.2016.08.015. Epub 2016 Aug 18.

40.

Cholinergic genetics of visual attention: Human and mouse choline transporter capacity variants influence distractibility.

Sarter M, Lustig C, Blakely RD, Koshy Cherian A.

J Physiol Paris. 2016 Sep;110(1-2):10-18. doi: 10.1016/j.jphysparis.2016.07.001. Epub 2016 Jul 9. Review.

41.

Choline on the Move: Perspectives on the Molecular Physiology and Pharmacology of the Presynaptic Choline Transporter.

Ennis EA, Blakely RD.

Adv Pharmacol. 2016;76:175-213. doi: 10.1016/bs.apha.2016.03.001. Epub 2016 Apr 7. Review.

PMID:
27288078
42.

Serotonin transporter variant drives preventable gastrointestinal abnormalities in development and function.

Margolis KG, Li Z, Stevanovic K, Saurman V, Israelyan N, Anderson GM, Snyder I, Veenstra-VanderWeele J, Blakely RD, Gershon MD.

J Clin Invest. 2016 Jun 1;126(6):2221-35. doi: 10.1172/JCI84877. Epub 2016 Apr 25.

43.

Differential impact of genetically modulated choline transporter expression on the release of endogenous versus newly synthesized acetylcholine.

Iwamoto H, Calcutt MW, Blakely RD.

Neurochem Int. 2016 Sep;98:138-45. doi: 10.1016/j.neuint.2016.03.012. Epub 2016 Mar 22.

44.

Generation and Characterization of Mice Expressing a Conditional Allele of the Interleukin-1 Receptor Type 1.

Robson MJ, Zhu CB, Quinlan MA, Botschner DA, Baganz NL, Lindler KM, Thome JG, Hewlett WA, Blakely RD.

PLoS One. 2016 Mar 1;11(3):e0150068. doi: 10.1371/journal.pone.0150068. eCollection 2016.

45.

Acute blockade of the Caenorhabditis elegans dopamine transporter DAT-1 by the mammalian norepinephrine transporter inhibitor nisoxetine reveals the influence of genetic modifications of dopamine signaling in vivo.

Bermingham DP, Hardaway JA, Snarrenberg CL, Robinson SB, Folkes OM, Salimando GJ, Jinnah H, Blakely RD.

Neurochem Int. 2016 Sep;98:122-8. doi: 10.1016/j.neuint.2016.01.008. Epub 2016 Feb 3.

46.

Physical Interactions and Functional Relationships of Neuroligin 2 and Midbrain Serotonin Transporters.

Ye R, Quinlan MA, Iwamoto H, Wu HH, Green NH, Jetter CS, McMahon DG, Veestra-VanderWeele J, Levitt P, Blakely RD.

Front Synaptic Neurosci. 2016 Jan 11;7:20. doi: 10.3389/fnsyn.2015.00020. eCollection 2015.

47.

A requirement of serotonergic p38α mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors.

Baganz NL, Lindler KM, Zhu CB, Smith JT, Robson MJ, Iwamoto H, Deneris ES, Hewlett WA, Blakely RD.

Transl Psychiatry. 2015 Nov 3;5:e671. doi: 10.1038/tp.2015.168.

48.

Essential Contributions of Serotonin Transporter Inhibition to the Acute and Chronic Actions of Fluoxetine and Citalopram in the SERT Met172 Mouse.

Nackenoff AG, Moussa-Tooks AB, McMeekin AM, Veenstra-VanderWeele J, Blakely RD.

Neuropsychopharmacology. 2016 Jun;41(7):1733-41. doi: 10.1038/npp.2015.335. Epub 2015 Oct 30.

49.

Glial Expression of the Caenorhabditis elegans Gene swip-10 Supports Glutamate Dependent Control of Extrasynaptic Dopamine Signaling.

Hardaway JA, Sturgeon SM, Snarrenberg CL, Li Z, Xu XZ, Bermingham DP, Odiase P, Spencer WC, Miller DM 3rd, Carvelli L, Hardie SL, Blakely RD.

J Neurosci. 2015 Jun 24;35(25):9409-23. doi: 10.1523/JNEUROSCI.0800-15.2015.

50.

Genetic variation in alpha2-adrenoreceptors and heart rate recovery after exercise.

Kohli U, Diedrich A, Kannankeril PJ, Muszkat M, Sofowora GG, Hahn MK, English BA, Blakely RD, Stein CM, Kurnik D.

Physiol Genomics. 2015 Sep;47(9):400-6. doi: 10.1152/physiolgenomics.00124.2014. Epub 2015 Jun 9.

Supplemental Content

Loading ...
Support Center