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Items: 9


Cryptococcus neoformans ADS lyase is an enzyme essential for virulence whose crystal structure reveals features exploitable in antifungal drug design.

Chitty JL, Blake KL, Blundell RD, Koh YQAE, Thompson M, Robertson AAB, Butler MS, Cooper MA, Kappler U, Williams SJ, Kobe B, Fraser JA.

J Biol Chem. 2017 Jul 14;292(28):11829-11839. doi: 10.1074/jbc.M117.787994. Epub 2017 May 30.


Disruption of de Novo Adenosine Triphosphate (ATP) Biosynthesis Abolishes Virulence in Cryptococcus neoformans.

Blundell RD, Williams SJ, Arras SD, Chitty JL, Blake KL, Ericsson DJ, Tibrewal N, Rohr J, Koh YQ, Kappler U, Robertson AA, Butler MS, Cooper MA, Kobe B, Fraser JA.

ACS Infect Dis. 2016 Sep 9;2(9):651-663. Epub 2016 Aug 17.


A genomic safe haven for mutant complementation in Cryptococcus neoformans.

Arras SD, Chitty JL, Blake KL, Schulz BL, Fraser JA.

PLoS One. 2015 Apr 9;10(4):e0122916. doi: 10.1371/journal.pone.0122916. eCollection 2015.


Transposon library screening for identification of genetic loci participating in intrinsic susceptibility and acquired resistance to antistaphylococcal agents.

Blake KL, O'Neill AJ.

J Antimicrob Chemother. 2013 Jan;68(1):12-6. doi: 10.1093/jac/dks373. Epub 2012 Oct 7.


In vitro studies indicate a high resistance potential for the lantibiotic nisin in Staphylococcus aureus and define a genetic basis for nisin resistance.

Blake KL, Randall CP, O'Neill AJ.

Antimicrob Agents Chemother. 2011 May;55(5):2362-8. doi: 10.1128/AAC.01077-10. Epub 2011 Feb 7.


Benzothioxalone derivatives as novel inhibitors of UDP-N-acetylglucosamine enolpyruvyl transferases (MurA and MurZ).

Miller K, Dunsmore CJ, Leeds JA, Patching SG, Sachdeva M, Blake KL, Stubbings WJ, Simmons KJ, Henderson PJ, De Los Angeles J, Fishwick CW, Chopra I.

J Antimicrob Chemother. 2010 Dec;65(12):2566-73. doi: 10.1093/jac/dkq349. Epub 2010 Sep 22.


The nature of Staphylococcus aureus MurA and MurZ and approaches for detection of peptidoglycan biosynthesis inhibitors.

Blake KL, O'Neill AJ, Mengin-Lecreulx D, Henderson PJ, Bostock JM, Dunsmore CJ, Simmons KJ, Fishwick CW, Leeds JA, Chopra I.

Mol Microbiol. 2009 Apr;72(2):335-43. doi: 10.1111/j.1365-2958.2009.06648.x. Epub 2009 Mar 3.


2-Aminotetralones: novel inhibitors of MurA and MurZ.

Dunsmore CJ, Miller K, Blake KL, Patching SG, Henderson PJ, Garnett JA, Stubbings WJ, Phillips SE, Palestrant DJ, Angeles Jde L, Leeds JA, Chopra I, Fishwick CW.

Bioorg Med Chem Lett. 2008 Mar 1;18(5):1730-4. doi: 10.1016/j.bmcl.2008.01.089. Epub 2008 Jan 30.


Randomized comparison of ultrasonic aspiration versus conventional electrocautery for dissection of the human internal thoracic artery.

Blake KL, Watt PA, Smith JM, De Souza AC, Spyt TJ, Thurston H.

J Thorac Cardiovasc Surg. 1996 Jun;111(6):1194-9.

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