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Items: 10


In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease.

Lin BL, Matera D, Doerner JF, Zheng N, Del Camino D, Mishra S, Bian H, Zeveleva S, Zhen X, Blair NT, Chong JA, Hessler DP, Bedja D, Zhu G, Muller GK, Ranek MJ, Pantages L, McFarland M, Netherton MR, Berry A, Wong D, Rast G, Qian HS, Weldon SM, Kuo JJ, Sauer A, Sarko C, Moran MM, Kass DA, Pullen SS.

Proc Natl Acad Sci U S A. 2019 May 14;116(20):10156-10161. doi: 10.1073/pnas.1815354116. Epub 2019 Apr 26.


Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice.

Just S, Chenard BL, Ceci A, Strassmaier T, Chong JA, Blair NT, Gallaschun RJ, Del Camino D, Cantin S, D'Amours M, Eickmeier C, Fanger CM, Hecker C, Hessler DP, Hengerer B, Kroker KS, Malekiani S, Mihalek R, McLaughlin J, Rast G, Witek J, Sauer A, Pryce CR, Moran MM.

PLoS One. 2018 Jan 31;13(1):e0191225. doi: 10.1371/journal.pone.0191225. eCollection 2018.


Action Potential Broadening in Capsaicin-Sensitive DRG Neurons from Frequency-Dependent Reduction of Kv3 Current.

Liu PW, Blair NT, Bean BP.

J Neurosci. 2017 Oct 4;37(40):9705-9714. doi: 10.1523/JNEUROSCI.1703-17.2017. Epub 2017 Sep 6.


Naturally Produced Defensive Alkenal Compounds Activate TRPA1.

Blair NT, Philipson BI, Richards PM, Doerner JF, Segura A, Silver WL, Clapham DE.

Chem Senses. 2016 May;41(4):281-92. doi: 10.1093/chemse/bjv071. Epub 2016 Feb 3.


Benzoquinone reveals a cysteine-dependent desensitization mechanism of TRPA1.

Ibarra Y, Blair NT.

Mol Pharmacol. 2013 May;83(5):1120-32. doi: 10.1124/mol.112.084194. Epub 2013 Mar 11.


Intracellular calcium strongly potentiates agonist-activated TRPC5 channels.

Blair NT, Kaczmarek JS, Clapham DE.

J Gen Physiol. 2009 May;133(5):525-46. doi: 10.1085/jgp.200810153.


Characterization of a Ca2+ release-activated nonselective cation current regulating membrane potential and [Ca2+]i oscillations in transgenically derived beta-cells.

Roe MW, Worley JF 3rd, Qian F, Tamarina N, Mittal AA, Dralyuk F, Blair NT, Mertz RJ, Philipson LH, Dukes ID.

J Biol Chem. 1998 Apr 24;273(17):10402-10.

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