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Items: 46


Repeated repeat problems: Combinatorial effect of C9orf72-derived dipeptide repeat proteins.

Darling AL, Breydo L, Rivas EG, Gebru NT, Zheng D, Baker JD, Blair LJ, Dickey CA, Koren J 3rd, Uversky VN.

Int J Biol Macromol. 2019 Apr 15;127:136-145. doi: 10.1016/j.ijbiomac.2019.01.035. Epub 2019 Jan 9.


The multiple facets of the Hsp90 machine.

Blair LJ, Genest O, Mollapour M.

Nat Struct Mol Biol. 2019 Feb;26(2):92-95. doi: 10.1038/s41594-018-0177-7. No abstract available.


Hsp90 Heterocomplexes Regulate Steroid Hormone Receptors: From Stress Response to Psychiatric Disease.

Baker JD, Ozsan I, Rodriguez Ospina S, Gulick D, Blair LJ.

Int J Mol Sci. 2018 Dec 25;20(1). pii: E79. doi: 10.3390/ijms20010079. Review.


Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex.

Oroz J, Chang BJ, Wysoczanski P, Lee CT, Pérez-Lara Á, Chakraborty P, Hofele RV, Baker JD, Blair LJ, Biernat J, Urlaub H, Mandelkow E, Dickey CA, Zweckstetter M.

Nat Commun. 2018 Oct 31;9(1):4532. doi: 10.1038/s41467-018-06880-0.


Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD.

Sabbagh JJ, Cordova RA, Zheng D, Criado-Marrero M, Lemus A, Li P, Baker JD, Nordhues BA, Darling AL, Martinez-Licha C, Rutz DA, Patel S, Buchner J, Leahy JW, Koren J 3rd, Dickey CA, Blair LJ.

ACS Chem Biol. 2018 Aug 17;13(8):2288-2299. doi: 10.1021/acschembio.8b00454. Epub 2018 Jun 19.


Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies.

Shelton LB, Koren J 3rd, Blair LJ.

Front Neurosci. 2017 Dec 22;11:724. doi: 10.3389/fnins.2017.00724. eCollection 2017. Review.


Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma.

Stothert AR, Suntharalingam A, Tang X, Crowley VM, Mishra SJ, Webster JM, Nordhues BA, Huard DJE, Passaglia CL, Lieberman RL, Blagg BSJ, Blair LJ, Koren J 3rd, Dickey CA.

Sci Rep. 2017 Dec 20;7(1):17951. doi: 10.1038/s41598-017-18344-4.


Hsp90 and FKBP51: complex regulators of psychiatric diseases.

Criado-Marrero M, Rein T, Binder EB, Porter JT, Koren J 3rd, Blair LJ.

Philos Trans R Soc Lond B Biol Sci. 2018 Jan 19;373(1738). pii: 20160532. doi: 10.1098/rstb.2016.0532. Review.


Hsp90 activator Aha1 drives production of pathological tau aggregates.

Shelton LB, Baker JD, Zheng D, Sullivan LE, Solanki PK, Webster JM, Sun Z, Sabbagh JJ, Nordhues BA, Koren J 3rd, Ghosh S, Blagg BSJ, Blair LJ, Dickey CA.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):9707-9712. doi: 10.1073/pnas.1707039114. Epub 2017 Aug 21.


Human cyclophilin 40 unravels neurotoxic amyloids.

Baker JD, Shelton LB, Zheng D, Favretto F, Nordhues BA, Darling A, Sullivan LE, Sun Z, Solanki PK, Martin MD, Suntharalingam A, Sabbagh JJ, Becker S, Mandelkow E, Uversky VN, Zweckstetter M, Dickey CA, Koren J 3rd, Blair LJ.

PLoS Biol. 2017 Jun 27;15(6):e2001336. doi: 10.1371/journal.pbio.2001336. eCollection 2017 Jun.


The effect of component separation technique on quality of life (QOL) and surgical outcomes in complex open ventral hernia repair (OVHR).

Blair LJ, Cox TC, Huntington CR, Groene SA, Prasad T, Lincourt AE, Kercher KW, Heniford BT, Augenstein VA.

Surg Endosc. 2017 Sep;31(9):3539-3546. doi: 10.1007/s00464-016-5382-z. Epub 2016 Dec 30.


The cost of preventable comorbidities on wound complications in open ventral hernia repair.

Cox TC, Blair LJ, Huntington CR, Colavita PD, Prasad T, Lincourt AE, Heniford BT, Augenstein VA.

J Surg Res. 2016 Nov;206(1):214-222. doi: 10.1016/j.jss.2016.08.009. Epub 2016 Aug 9.


Biologic mesh in ventral hernia repair: Outcomes, recurrence, and charge analysis.

Huntington CR, Cox TC, Blair LJ, Schell S, Randolph D, Prasad T, Lincourt A, Heniford BT, Augenstein VA.

Surgery. 2016 Dec;160(6):1517-1527. doi: 10.1016/j.surg.2016.07.008. Epub 2016 Aug 12.


Predictive modeling for chronic pain after ventral hernia repair.

Cox TC, Huntington CR, Blair LJ, Prasad T, Lincourt AE, Heniford BT, Augenstein VA.

Am J Surg. 2016 Sep;212(3):501-10. doi: 10.1016/j.amjsurg.2016.02.021. Epub 2016 May 12.


MicroRNA-511 Binds to FKBP5 mRNA, Which Encodes a Chaperone Protein, and Regulates Neuronal Differentiation.

Zheng D, Sabbagh JJ, Blair LJ, Darling AL, Wen X, Dickey CA.

J Biol Chem. 2016 Aug 19;291(34):17897-906. doi: 10.1074/jbc.M116.727941. Epub 2016 Jun 21.


DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins.

Fontaine SN, Zheng D, Sabbagh JJ, Martin MD, Chaput D, Darling A, Trotter JH, Stothert AR, Nordhues BA, Lussier A, Baker J, Shelton L, Kahn M, Blair LJ, Stevens SM Jr, Dickey CA.

EMBO J. 2016 Jul 15;35(14):1537-49. doi: 10.15252/embj.201593489. Epub 2016 Jun 3.


Quality of life and outcomes for femoral hernia repair: does laparoscopy have an advantage?

Cox TC, Huntington CR, Blair LJ, Prasad T, Heniford BT, Augenstein VA.

Hernia. 2017 Feb;21(1):79-88. doi: 10.1007/s10029-016-1502-x. Epub 2016 May 21.


Noncontact Rotational Head Injury Produces Transient Cognitive Deficits but Lasting Neuropathological Changes.

Sabbagh JJ, Fontaine SN, Shelton LB, Blair LJ, Hunt JB Jr, Zhang B, Gutmann JM, Lee DC, Lloyd JD, Dickey CA.

J Neurotrauma. 2016 Oct 1;33(19):1751-1760. Epub 2016 Mar 16.


Indocyanine Green: Historical Context, Current Applications, and Future Considerations.

Reinhart MB, Huntington CR, Blair LJ, Heniford BT, Augenstein VA.

Surg Innov. 2016 Apr;23(2):166-75. doi: 10.1177/1553350615604053. Epub 2015 Sep 10. Review.


Computed tomographic measurements predict component separation in ventral hernia repair.

Blair LJ, Ross SW, Huntington CR, Watkins JD, Prasad T, Lincourt AE, Augenstein VA, Heniford BT.

J Surg Res. 2015 Dec;199(2):420-7. doi: 10.1016/j.jss.2015.06.033. Epub 2015 Jun 18.


Local Anesthesia in Open Inguinal Hernia Repair Improves Postoperative Quality of Life Compared to General Anesthesia: A Prospective, International Study.

Huntington CR, Wormer BA, Cox TC, Blair LJ, Lincourt AE, Augenstein VA, Heniford BT.

Am Surg. 2015 Jul;81(7):704-9.


Bone Anchor Fixation in Abdominal Wall Reconstruction: A Useful Adjunct in Suprapubic and Para-iliac Hernia Repair.

Blair LJ, Cox TC, Huntington CR, Ross SW, Kneisl JS, Augenstein VA, Heniford BT.

Am Surg. 2015 Jul;81(7):693-7.


Acuity, outcomes, and trends in the transfer of surgical patients: a national study.

Huntington CR, Cox TC, Blair LJ, Prasad T, Lincourt AE, Matthews BD, Heniford BT, Augenstein VA.

Surg Endosc. 2016 Apr;30(4):1301-9. doi: 10.1007/s00464-015-4361-0. Epub 2015 Jul 3.


Nationwide variation in outcomes and cost of laparoscopic procedures.

Huntington CR, Cox TC, Blair LJ, Prasad T, Lincourt AE, Heniford BT, Augenstein VA.

Surg Endosc. 2016 Mar;30(3):934-46. doi: 10.1007/s00464-015-4328-1. Epub 2015 Jul 3.


Risk factors for postoperative sepsis in laparoscopic gastric bypass.

Blair LJ, Huntington CR, Cox TC, Prasad T, Lincourt AE, Gersin KS, Heniford BT, Augenstein VA.

Surg Endosc. 2016 Apr;30(4):1287-93. doi: 10.1007/s00464-015-4349-9. Epub 2015 Jul 1.


Laparoscopic versus open peritoneal dialysis catheter placement.

Cox TC, Blair LJ, Huntington CR, Prasad T, Kercher KW, Heniford BT, Augenstein VA.

Surg Endosc. 2016 Mar;30(3):899-905. doi: 10.1007/s00464-015-4297-4. Epub 2015 Jun 20.


The Centers for Medicare and Medicaid Services (CMS) two midnight rule: policy at odds with reality.

Huntington CR, Blair LJ, Cox TC, Prasad T, Kercher KW, Augenstein VA, Heniford BT.

Surg Endosc. 2016 Feb;30(2):751-755. doi: 10.1007/s00464-015-4271-1. Epub 2015 Jun 20.


Laparoscopic appendectomy and cholecystectomy versus open: a study in 1999 pregnant patients.

Cox TC, Huntington CR, Blair LJ, Prasad T, Lincourt AE, Augenstein VA, Heniford BT.

Surg Endosc. 2016 Feb;30(2):593-602. doi: 10.1007/s00464-015-4244-4. Epub 2015 Jun 20.


Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy.

Blair LJ, Frauen HD, Zhang B, Nordhues BA, Bijan S, Lin YC, Zamudio F, Hernandez LD, Sabbagh JJ, Selenica ML, Dickey CA.

Acta Neuropathol Commun. 2015 Jan 31;3:8. doi: 10.1186/s40478-015-0186-2.


The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease.

Blair LJ, Baker JD, Sabbagh JJ, Dickey CA.

J Neurochem. 2015 Apr;133(1):1-13. doi: 10.1111/jnc.13033. Epub 2015 Feb 24. Review.


Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency.

Sabbagh JJ, O'Leary JC 3rd, Blair LJ, Klengel T, Nordhues BA, Fontaine SN, Binder EB, Dickey CA.

PLoS One. 2014 Sep 5;9(9):e107241. doi: 10.1371/journal.pone.0107241. eCollection 2014.


Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis.

Selenica ML, Davtyan H, Housley SB, Blair LJ, Gillies A, Nordhues BA, Zhang B, Liu J, Gestwicki JE, Lee DC, Gordon MN, Morgan D, Dickey CA.

J Neuroinflammation. 2014 Sep 3;11:152. doi: 10.1186/s12974-014-0152-0.


Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease.

Blair LJ, Sabbagh JJ, Dickey CA.

Expert Opin Ther Targets. 2014 Oct;18(10):1219-32. doi: 10.1517/14728222.2014.943185. Epub 2014 Jul 29. Review.


Potential synergy between tau aggregation inhibitors and tau chaperone modulators.

Blair LJ, Zhang B, Dickey CA.

Alzheimers Res Ther. 2013 Sep 16;5(5):41. doi: 10.1186/alzrt207. eCollection 2013. Review.


Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O'Leary JC 3rd, Fontaine SN, Breydo L, Zhang B, Li P, Wang L, Cotman C, Paulson HL, Muschol M, Uversky VN, Klengel T, Binder EB, Kayed R, Golde TE, Berchtold N, Dickey CA.

J Clin Invest. 2013 Oct;123(10):4158-69. doi: 10.1172/JCI69003. Epub 2013 Sep 3.


Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation.

Abisambra JF, Jinwal UK, Blair LJ, O'Leary JC 3rd, Li Q, Brady S, Wang L, Guidi CE, Zhang B, Nordhues BA, Cockman M, Suntharalingham A, Li P, Jin Y, Atkins CA, Dickey CA.

J Neurosci. 2013 May 29;33(22):9498-507. doi: 10.1523/JNEUROSCI.5397-12.2013.


Imbalance of Hsp70 family variants fosters tau accumulation.

Jinwal UK, Akoury E, Abisambra JF, O'Leary JC 3rd, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, Biernat J, Mandelkow E, Gestwicki JE, Zweckstetter M, Dickey CA.

FASEB J. 2013 Apr;27(4):1450-9. doi: 10.1096/fj.12-220889. Epub 2012 Dec 27.


Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism.

Suntharalingam A, Abisambra JF, O'Leary JC 3rd, Koren J 3rd, Zhang B, Joe MK, Blair LJ, Hill SE, Jinwal UK, Cockman M, Duerfeldt AS, Tomarev S, Blagg BS, Lieberman RL, Dickey CA.

J Biol Chem. 2012 Nov 23;287(48):40661-9. doi: 10.1074/jbc.M112.384800. Epub 2012 Oct 3.


Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics.

Abisambra JF, Jinwal UK, Jones JR, Blair LJ, Koren J 3rd, Dickey CA.

Curr Neuropharmacol. 2011 Dec;9(4):623-31. doi: 10.2174/157015911798376226.


Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance.

Koren J 3rd, Miyata Y, Kiray J, O'Leary JC 3rd, Nguyen L, Guo J, Blair LJ, Li X, Jinwal UK, Cheng JQ, Gestwicki JE, Dickey CA.

PLoS One. 2012;7(4):e35566. doi: 10.1371/journal.pone.0035566. Epub 2012 Apr 26. Erratum in: PLoS One. 2012;7(7). doi:.1371/annotation/7493e5d2-4c1a-43eb-a83f-16814861ff13. Li, Xiokai [corrected to Li, Xiaokai].


A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.

O'Leary JC 3rd, Dharia S, Blair LJ, Brady S, Johnson AG, Peters M, Cheung-Flynn J, Cox MB, de Erausquin G, Weeber EJ, Jinwal UK, Dickey CA.

PLoS One. 2011;6(9):e24840. doi: 10.1371/journal.pone.0024840. Epub 2011 Sep 15.


Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.

Abisambra JF, Blair LJ, Hill SE, Jones JR, Kraft C, Rogers J, Koren J 3rd, Jinwal UK, Lawson L, Johnson AG, Wilcock D, O'Leary JC, Jansen-West K, Muschol M, Golde TE, Weeber EJ, Banko J, Dickey CA.

J Neurosci. 2010 Nov 17;30(46):15374-82. doi: 10.1523/JNEUROSCI.3155-10.2010.


Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden.

O'Leary JC 3rd, Li Q, Marinec P, Blair LJ, Congdon EE, Johnson AG, Jinwal UK, Koren J 3rd, Jones JR, Kraft C, Peters M, Abisambra JF, Duff KE, Weeber EJ, Gestwicki JE, Dickey CA.

Mol Neurodegener. 2010 Nov 1;5:45. doi: 10.1186/1750-1326-5-45.


Hsc70 rapidly engages tau after microtubule destabilization.

Jinwal UK, O'Leary JC 3rd, Borysov SI, Jones JR, Li Q, Koren J 3rd, Abisambra JF, Vestal GD, Lawson LY, Johnson AG, Blair LJ, Jin Y, Miyata Y, Gestwicki JE, Dickey CA.

J Biol Chem. 2010 May 28;285(22):16798-805. doi: 10.1074/jbc.M110.113753. Epub 2010 Mar 22.


The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.

Jinwal UK, Koren J 3rd, Borysov SI, Schmid AB, Abisambra JF, Blair LJ, Johnson AG, Jones JR, Shults CL, O'Leary JC 3rd, Jin Y, Buchner J, Cox MB, Dickey CA.

J Neurosci. 2010 Jan 13;30(2):591-9. doi: 10.1523/JNEUROSCI.4815-09.2010.


Facilitating Akt clearance via manipulation of Hsp70 activity and levels.

Koren J 3rd, Jinwal UK, Jin Y, O'Leary J, Jones JR, Johnson AG, Blair LJ, Abisambra JF, Chang L, Miyata Y, Cheng AM, Guo J, Cheng JQ, Gestwicki JE, Dickey CA.

J Biol Chem. 2010 Jan 22;285(4):2498-505. doi: 10.1074/jbc.M109.057208. Epub 2009 Nov 4.

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