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Items: 28

1.

Biotherapeutics in non-clinical development: Strengthening the interface between safety, pharmacokinetics-pharmacodynamics and manufacturing.

Ulrich P, Blaich G, Baumann A, Fagg R, Hey A, Kiessling A, Kronenberg S, Lindecrona RH, Mohl S, Richter WF, Tibbitts J, Crameri F, Weir L.

Regul Toxicol Pharmacol. 2018 Apr;94:91-100. doi: 10.1016/j.yrtph.2018.01.013. Epub 2018 Jan 28.

PMID:
29355662
2.

Dual Blockade of Interleukin-1β and Interleukin-17A Reduces Murine Arthritis Pathogenesis but Also Leads to Spontaneous Skin Infections in Nonhuman Primates.

Ruzek MC, Huang L, Zhang TT, Bryant S, Slivka PF, Cuff CA, Tripp C, Blaich G.

J Pharmacol Exp Ther. 2018 Mar;364(3):474-484. doi: 10.1124/jpet.117.243493. Epub 2018 Jan 8.

PMID:
29311111
3.

Leverage nonclinical development of bispecifics by translational science.

Baumann A, Fischmann S, Blaich G, Friedrich M.

Drug Discov Today Technol. 2016 Sep - Dec;21-22:95-102. doi: 10.1016/j.ddtec.2016.08.001. Epub 2016 Oct 27. Review.

PMID:
27978993
4.

Non-clinical Safety Evaluation of Biotherapeutics - Challenges, Opportunities and new Insights.

Blaich G, Baumann A, Kronenberg S, de Haan L, Ulrich P, Richter WF, Tibbitts J, Chivers S, Tarcsa E, Caldwell R, Crameri F.

Regul Toxicol Pharmacol. 2016 Oct;80S:S1-S14. doi: 10.1016/j.yrtph.2016.08.012. Epub 2016 Aug 27.

PMID:
27578450
5.

Nonclinical safety testing of biopharmaceuticals--Addressing current challenges of these novel and emerging therapies.

Brennan FR, Baumann A, Blaich G, de Haan L, Fagg R, Kiessling A, Kronenberg S, Locher M, Milton M, Tibbitts J, Ulrich P, Weir L.

Regul Toxicol Pharmacol. 2015 Oct;73(1):265-75. doi: 10.1016/j.yrtph.2015.07.019. Epub 2015 Jul 26.

PMID:
26219199
6.

Male and female fertility assessment in the cynomolgus monkey following administration of ABT-874, a human Anti-IL-12/23p40 monoclonal antibody.

Enright BP, Tornesi B, Weinbauer GF, Blaich G.

Birth Defects Res B Dev Reprod Toxicol. 2012 Dec;95(6):421-30. doi: 10.1002/bdrb.21031. Epub 2012 Dec 4.

PMID:
23213064
7.

Pre- and postnatal development in the cynomolgus monkey following administration of ABT-874, a human anti-IL-12/23p40 monoclonal antibody.

Enright BP, Tornesi B, Weinbauer GF, Blaich G.

Birth Defects Res B Dev Reprod Toxicol. 2012 Dec;95(6):431-43. doi: 10.1002/bdrb.21034. Epub 2012 Dec 4.

PMID:
23212752
8.

N-vinylpyrrolidone dimer (VPD), a novel excipient for oral drugs: repeat-dose oral toxicity in Sprague-Dawley rats.

Weber S, Halm S, Du Vall M, Whitney K, Blaich G, Bury D.

Toxicol Lett. 2012 May 5;210(3):324-31. doi: 10.1016/j.toxlet.2012.02.002. Epub 2012 Feb 11.

PMID:
22343116
9.

Developmental and reproductive toxicology studies in IL-12p40 knockout mice.

Enright BP, Davila DR, Tornesi BM, Blaich G, Hoberman AM, Gallenberg LA.

Birth Defects Res B Dev Reprod Toxicol. 2011 Apr;92(2):102-10. doi: 10.1002/bdrb.20287. Epub 2011 Mar 2.

PMID:
21370397
10.

Comparison of haematology, coagulation and clinical chemistry parameters in blood samples from the sublingual vein and vena cava in Sprague-Dawley rats.

Seibel J, Bodié K, Weber S, Bury D, Kron M, Blaich G.

Lab Anim. 2010 Oct;44(4):344-51. doi: 10.1258/la.2010.009049. Epub 2010 Aug 2.

PMID:
20679324
11.

Role of metabolic activation in the carcinogenicity of estrogens: studies in an animal liver tumor model.

Metzler M, Blaich G, Tritscher AM.

Environ Health Perspect. 1990 Aug;88:117-21. Review.

13.
14.

Multiple pathways for the oxidative metabolism of estrogens in Syrian hamster and rabbit kidney.

Degen GH, Blaich G, Metzler M.

J Biochem Toxicol. 1990 Summer;5(2):91-7.

PMID:
2126561
15.

Metabolic activation of diethylstilbestrol and 7,8-benzoflavone in hamster hepatocytes.

Blaich G, Metzler M.

Arch Toxicol Suppl. 1989;13:203-5. No abstract available.

PMID:
2774930
19.
20.

Role of a rapidly dischargeable pool of calcium in the transition of isolated mitochondria.

Krell H, Blaich G, Fromm H, Pfaff E.

Prog Clin Biol Res. 1988;252:171-6. No abstract available.

PMID:
2450363
21.

Metabolism of diethylstilbestrol in hamster hepatocytes.

Blaich G, Pfaff E, Metzler M.

Biochem Pharmacol. 1987 Oct 1;36(19):3135-40.

PMID:
3663230
22.
24.

Reference values for free amino acids and other biochemical constituents in serum of male rabbits.

Bauer B, Blaich G, Metzler B, Schmahl FW.

J Clin Chem Clin Biochem. 1986 Nov;24(11):861-2.

PMID:
3806014
26.
27.
28.

On the state of calcium ions in isolated rat liver mitochondria. II. Effects of phosphate and pH on Ca2+-induced Ca2+ release.

Blaich G, Krell H, Täfler M, Pfaff E.

Hoppe Seylers Z Physiol Chem. 1984 Jan;365(1):73-82.

PMID:
6201430

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