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Items: 25


Leukotriene B4 receptor BLT1 signaling is critical for neutrophil apoptosis and resolution of experimental Lyme arthritis.

Hilliard KA, Blaho VA, Jackson CD, Brown CR.

FASEB J. 2020 Feb;34(2):2840-2852. doi: 10.1096/fj.201902014R. Epub 2019 Dec 24.


LPA1/3 overactivation induces neonatal posthemorrhagic hydrocephalus through ependymal loss and ciliary dysfunction.

Lummis NC, Sánchez-Pavón P, Kennedy G, Frantz AJ, Kihara Y, Blaho VA, Chun J.

Sci Adv. 2019 Oct 9;5(10):eaax2011. doi: 10.1126/sciadv.aax2011. eCollection 2019 Oct.


Identification of ApoA4 as a sphingosine 1-phosphate chaperone in ApoM- and albumin-deficient mice.

Obinata H, Kuo A, Wada Y, Swendeman S, Liu CH, Blaho VA, Nagumo R, Satoh K, Izumi T, Hla T.

J Lipid Res. 2019 Nov;60(11):1912-1921. doi: 10.1194/jlr.RA119000277. Epub 2019 Aug 28.


Abrogation of Endogenous Glycolipid Antigen Presentation on Myelin-Laden Macrophages by D-Sphingosine Ameliorates the Pathogenesis of Experimental Autoimmune Encephalomyelitis.

Ban Y, Dong W, Zhang L, Zhou T, Altiti AS, Ali K, Mootoo DR, Blaho VA, Hla T, Ren Y, Ma X.

Front Immunol. 2019 Mar 19;10:404. doi: 10.3389/fimmu.2019.00404. eCollection 2019.


Fingolimod: Lessons Learned and New Opportunities for Treating Multiple Sclerosis and Other Disorders.

Chun J, Kihara Y, Jonnalagadda D, Blaho VA.

Annu Rev Pharmacol Toxicol. 2019 Jan 6;59:149-170. doi: 10.1146/annurev-pharmtox-010818-021358.


'Crystal' Clear? Lysophospholipid Receptor Structure Insights and Controversies.

Blaho VA, Chun J.

Trends Pharmacol Sci. 2018 Nov;39(11):953-966. doi: 10.1016/ Review.


HDL-bound sphingosine 1-phosphate acts as a biased agonist for the endothelial cell receptor S1P1 to limit vascular inflammation.

Galvani S, Sanson M, Blaho VA, Swendeman SL, Obinata H, Conger H, Dahlbäck B, Kono M, Proia RL, Smith JD, Hla T.

Sci Signal. 2015 Aug 11;8(389):ra79. doi: 10.1126/scisignal.aaa2581. Erratum in: Sci Signal. 2015 Oct 27;8(400):er8. Obinata, Hideru [added].


HDL-bound sphingosine-1-phosphate restrains lymphopoiesis and neuroinflammation.

Blaho VA, Galvani S, Engelbrecht E, Liu C, Swendeman SL, Kono M, Proia RL, Steinman L, Han MH, Hla T.

Nature. 2015 Jul 16;523(7560):342-6. doi: 10.1038/nature14462. Epub 2015 Jun 8.


Sphingosine-1-phosphate receptor 1 signalling in T cells: trafficking and beyond.

Garris CS, Blaho VA, Hla T, Han MH.

Immunology. 2014 Jul;142(3):347-53. doi: 10.1111/imm.12272. Review.


An update on the biology of sphingosine 1-phosphate receptors.

Blaho VA, Hla T.

J Lipid Res. 2014 Aug;55(8):1596-608. doi: 10.1194/jlr.R046300. Epub 2014 Jan 23. Review.


Defective sphingosine 1-phosphate receptor 1 (S1P1) phosphorylation exacerbates TH17-mediated autoimmune neuroinflammation.

Garris CS, Wu L, Acharya S, Arac A, Blaho VA, Huang Y, Moon BS, Axtell RC, Ho PP, Steinberg GK, Lewis DB, Sobel RA, Han DK, Steinman L, Snyder MP, Hla T, Han MH.

Nat Immunol. 2013 Nov;14(11):1166-72. doi: 10.1038/ni.2730. Epub 2013 Sep 29.


Dietary fish oil substitution alters the eicosanoid profile in ankle joints of mice during Lyme infection.

Dumlao DS, Cunningham AM, Wax LE, Norris PC, Hanks JH, Halpin R, Lett KM, Blaho VA, Mitchell WJ, Fritsche KL, Dennis EA, Brown CR.

J Nutr. 2012 Aug;142(8):1582-9. doi: 10.3945/jn.112.157883. Epub 2012 Jun 13.


Regulation of mammalian physiology, development, and disease by the sphingosine 1-phosphate and lysophosphatidic acid receptors.

Blaho VA, Hla T.

Chem Rev. 2011 Oct 12;111(10):6299-320. doi: 10.1021/cr200273u. Epub 2011 Sep 22. Review. No abstract available.


Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland.

Subbaramaiah K, Howe LR, Bhardwaj P, Du B, Gravaghi C, Yantiss RK, Zhou XK, Blaho VA, Hla T, Yang P, Kopelovich L, Hudis CA, Dannenberg AJ.

Cancer Prev Res (Phila). 2011 Mar;4(3):329-46. doi: 10.1158/1940-6207.CAPR-10-0381.


5-Lipoxygenase-deficient mice infected with Borrelia burgdorferi develop persistent arthritis.

Blaho VA, Zhang Y, Hughes-Hanks JM, Brown CR.

J Immunol. 2011 Mar 1;186(5):3076-84. doi: 10.4049/jimmunol.1003473. Epub 2011 Jan 26.


The chemokine receptor CXCR2 ligand KC (CXCL1) mediates neutrophil recruitment and is critical for development of experimental Lyme arthritis and carditis.

Ritzman AM, Hughes-Hanks JM, Blaho VA, Wax LE, Mitchell WJ, Brown CR.

Infect Immun. 2010 Nov;78(11):4593-600. doi: 10.1128/IAI.00798-10. Epub 2010 Sep 7.


Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics.

Thangada S, Khanna KM, Blaho VA, Oo ML, Im DS, Guo C, Lefrancois L, Hla T.

J Exp Med. 2010 Jul 5;207(7):1475-83. doi: 10.1084/jem.20091343. Epub 2010 Jun 28.


Cyclooxygenase-1 orchestrates germinal center formation and antibody class-switch via regulation of IL-17.

Blaho VA, Buczynski MW, Dennis EA, Brown CR.

J Immunol. 2009 Nov 1;183(9):5644-53. doi: 10.4049/jimmunol.0901499.


Lipidomic analysis of dynamic eicosanoid responses during the induction and resolution of Lyme arthritis.

Blaho VA, Buczynski MW, Brown CR, Dennis EA.

J Biol Chem. 2009 Aug 7;284(32):21599-612. doi: 10.1074/jbc.M109.003822. Epub 2009 Jun 1.


Adenoviral delivery of interleukin-10 fails to attenuate experimental Lyme disease.

Brown CR, Lai AY, Callen ST, Blaho VA, Hughes JM, Mitchell WJ.

Infect Immun. 2008 Dec;76(12):5500-7. doi: 10.1128/IAI.00808-08. Epub 2008 Sep 29.


Arthritis develops but fails to resolve during inhibition of cyclooxygenase 2 in a murine model of Lyme disease.

Blaho VA, Mitchell WJ, Brown CR.

Arthritis Rheum. 2008 May;58(5):1485-95. doi: 10.1002/art.23371.


Recruitment of macrophages and polymorphonuclear leukocytes in Lyme carditis.

Montgomery RR, Booth CJ, Wang X, Blaho VA, Malawista SE, Brown CR.

Infect Immun. 2007 Feb;75(2):613-20. Epub 2006 Nov 13.


Stat1 deficiency exacerbates carditis but not arthritis during experimental lyme borreliosis.

Brown CR, Blaho VA, Fritsche KL, Loiacono CM.

J Interferon Cytokine Res. 2006 Jun;26(6):390-9.


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