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Items: 44

1.

Characterization of a protozoan Phosducin-like protein-3 (PhLP-3) reveals conserved redox activity.

Kooistra RL, David R, Ruiz AC, Powers SW, Haselton KJ, Kiernan K, Blagborough AM, Solamen L, Olsen KW, Putonti C, Kanzok SM.

PLoS One. 2018 Dec 31;13(12):e0209699. doi: 10.1371/journal.pone.0209699. eCollection 2018.

2.

Antimalarial Transmission-Blocking Interventions: Past, Present, and Future.

Delves MJ, Angrisano F, Blagborough AM.

Trends Parasitol. 2018 Sep;34(9):735-746. doi: 10.1016/j.pt.2018.07.001. Epub 2018 Aug 3. Review.

3.

Detection of Plasmodium berghei infected Anopheles stephensi using near-infrared spectroscopy.

Esperança PM, Blagborough AM, Da DF, Dowell FE, Churcher TS.

Parasit Vectors. 2018 Jun 28;11(1):377. doi: 10.1186/s13071-018-2960-z.

4.

Synergy in anti-malarial pre-erythrocytic and transmission-blocking antibodies is achieved by reducing parasite density.

Sherrard-Smith E, Sala KA, Betancourt M, Upton LM, Angrisano F, Morin MJ, Ghani AC, Churcher TS, Blagborough AM.

Elife. 2018 Jun 19;7. pii: e35213. doi: 10.7554/eLife.35213.

5.

Detection of malaria sporozoites expelled during mosquito sugar feeding.

Brugman VA, Kristan M, Gibbins MP, Angrisano F, Sala KA, Dessens JT, Blagborough AM, Walker T.

Sci Rep. 2018 May 15;8(1):7545. doi: 10.1038/s41598-018-26010-6.

6.

Understanding Human-Derived Antibodies Generated by Polymorphic Malaria Vaccine Against Merozoite Surface Protein 2.

Angrisano F, Blagborough AM.

J Infect Dis. 2018 Jun 5;218(1):5-6. doi: 10.1093/infdis/jiy171. No abstract available.

7.

Adenovirus-prime and baculovirus-boost heterologous immunization achieves sterile protection against malaria sporozoite challenge in a murine model.

Yoshida K, Iyori M, Blagborough AM, Salman AM, Dulal P, Sala KA, Yamamoto DS, Khan SM, Janse CJ, Biswas S, Yoshii T, Yusuf Y, Tokoro M, Hill AVS, Yoshida S.

Sci Rep. 2018 Mar 1;8(1):3896. doi: 10.1038/s41598-018-21369-y.

8.

Immunization with Transgenic Rodent Malaria Parasites Expressing Pfs25 Induces Potent Transmission-Blocking Activity.

Sala KA, Angrisano F, Da DF, Taylor IJ, Churcher TS, Blagborough AM.

Sci Rep. 2018 Jan 25;8(1):1573. doi: 10.1038/s41598-017-18831-8.

9.

Targeting the Conserved Fusion Loop of HAP2 Inhibits the Transmission of Plasmodium berghei and falciparum.

Angrisano F, Sala KA, Da DF, Liu Y, Pei J, Grishin NV, Snell WJ, Blagborough AM.

Cell Rep. 2017 Dec 5;21(10):2868-2878. doi: 10.1016/j.celrep.2017.11.024.

10.

Protective efficacy of an IL-12-expressing baculoviral malaria vaccine.

Iyori M, Blagborough AM, Sala KA, Nishiura H, Takagi K, Yoshida S.

Parasite Immunol. 2017 Dec;39(12). doi: 10.1111/pim.12498.

11.

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.

Paquet T, Le Manach C, Cabrera DG, Younis Y, Henrich PP, Abraham TS, Lee MCS, Basak R, Ghidelli-Disse S, Lafuente-Monasterio MJ, Bantscheff M, Ruecker A, Blagborough AM, Zakutansky SE, Zeeman AM, White KL, Shackleford DM, Mannila J, Morizzi J, Scheurer C, Angulo-Barturen I, Martínez MS, Ferrer S, Sanz LM, Gamo FJ, Reader J, Botha M, Dechering KJ, Sauerwein RW, Tungtaeng A, Vanachayangkul P, Lim CS, Burrows J, Witty MJ, Marsh KC, Bodenreider C, Rochford R, Solapure SM, Jiménez-Díaz MB, Wittlin S, Charman SA, Donini C, Campo B, Birkholtz LM, Hanson KK, Drewes G, Kocken CHM, Delves MJ, Leroy D, Fidock DA, Waterson D, Street LJ, Chibale K.

Sci Transl Med. 2017 Apr 26;9(387). pii: eaad9735. doi: 10.1126/scitranslmed.aad9735.

12.

A novel model fitted to multiple life stages of malaria for assessing efficacy of transmission-blocking interventions.

Sherrard-Smith E, Churcher TS, Upton LM, Sala KA, Zakutansky SE, Slater HC, Blagborough AM, Betancourt M.

Malar J. 2017 Apr 4;16(1):137. doi: 10.1186/s12936-017-1782-3.

13.

Probability of Transmission of Malaria from Mosquito to Human Is Regulated by Mosquito Parasite Density in Naïve and Vaccinated Hosts.

Churcher TS, Sinden RE, Edwards NJ, Poulton ID, Rampling TW, Brock PM, Griffin JT, Upton LM, Zakutansky SE, Sala KA, Angrisano F, Hill AV, Blagborough AM.

PLoS Pathog. 2017 Jan 12;13(1):e1006108. doi: 10.1371/journal.ppat.1006108. eCollection 2017 Jan.

14.

Systematic tracking of altered haematopoiesis during sporozoite-mediated malaria development reveals multiple response points.

Vainieri ML, Blagborough AM, MacLean AL, Haltalli ML, Ruivo N, Fletcher HA, Stumpf MP, Sinden RE, Celso CL.

Open Biol. 2016 Jun;6(6). pii: 160038. doi: 10.1098/rsob.160038.

15.

Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis.

Baragaña B, Hallyburton I, Lee MC, Norcross NR, Grimaldi R, Otto TD, Proto WR, Blagborough AM, Meister S, Wirjanata G, Ruecker A, Upton LM, Abraham TS, Almeida MJ, Pradhan A, Porzelle A, Martínez MS, Bolscher JM, Woodland A, Luksch T, Norval S, Zuccotto F, Thomas J, Simeons F, Stojanovski L, Osuna-Cabello M, Brock PM, Churcher TS, Sala KA, Zakutansky SE, Jiménez-Díaz MB, Sanz LM, Riley J, Basak R, Campbell M, Avery VM, Sauerwein RW, Dechering KJ, Noviyanti R, Campo B, Frearson JA, Angulo-Barturen I, Ferrer-Bazaga S, Gamo FJ, Wyatt PG, Leroy D, Siegl P, Delves MJ, Kyle DE, Wittlin S, Marfurt J, Price RN, Sinden RE, Winzeler EA, Charman SA, Bebrevska L, Gray DW, Campbell S, Fairlamb AH, Willis PA, Rayner JC, Fidock DA, Read KD, Gilbert IH.

Nature. 2016 Sep 1;537(7618):122. doi: 10.1038/nature18280. Epub 2016 May 25. No abstract available.

16.

Transmission blocking potency and immunogenicity of a plant-produced Pvs25-based subunit vaccine against Plasmodium vivax.

Blagborough AM, Musiychuk K, Bi H, Jones RM, Chichester JA, Streatfield S, Sala KA, Zakutansky SE, Upton LM, Sinden RE, Brian I, Biswas S, Sattabonkot J, Yusibov V.

Vaccine. 2016 Jun 14;34(28):3252-9. doi: 10.1016/j.vaccine.2016.05.007. Epub 2016 May 10.

17.

Tailoring a Combination Preerythrocytic Malaria Vaccine.

Bauza K, Atcheson E, Malinauskas T, Blagborough AM, Reyes-Sandoval A.

Infect Immun. 2015 Dec 14;84(3):622-34. doi: 10.1128/IAI.01063-15.

18.

A novel multiple-stage antimalarial agent that inhibits protein synthesis.

Baragaña B, Hallyburton I, Lee MC, Norcross NR, Grimaldi R, Otto TD, Proto WR, Blagborough AM, Meister S, Wirjanata G, Ruecker A, Upton LM, Abraham TS, Almeida MJ, Pradhan A, Porzelle A, Luksch T, Martínez MS, Luksch T, Bolscher JM, Woodland A, Norval S, Zuccotto F, Thomas J, Simeons F, Stojanovski L, Osuna-Cabello M, Brock PM, Churcher TS, Sala KA, Zakutansky SE, Jiménez-Díaz MB, Sanz LM, Riley J, Basak R, Campbell M, Avery VM, Sauerwein RW, Dechering KJ, Noviyanti R, Campo B, Frearson JA, Angulo-Barturen I, Ferrer-Bazaga S, Gamo FJ, Wyatt PG, Leroy D, Siegl P, Delves MJ, Kyle DE, Wittlin S, Marfurt J, Price RN, Sinden RE, Winzeler EA, Charman SA, Bebrevska L, Gray DW, Campbell S, Fairlamb AH, Willis PA, Rayner JC, Fidock DA, Read KD, Gilbert IH.

Nature. 2015 Jun 18;522(7556):315-20. doi: 10.1038/nature14451. Erratum in: Nature. 2016 Sep 1;537(7618):122.

19.

Comparative assessment of transmission-blocking vaccine candidates against Plasmodium falciparum.

Kapulu MC, Da DF, Miura K, Li Y, Blagborough AM, Churcher TS, Nikolaeva D, Williams AR, Goodman AL, Sangare I, Turner AV, Cottingham MG, Nicosia A, Straschil U, Tsuboi T, Gilbert SC, Long CA, Sinden RE, Draper SJ, Hill AV, Cohuet A, Biswas S.

Sci Rep. 2015 Jun 11;5:11193. doi: 10.1038/srep11193.

20.

Experimental study of the relationship between Plasmodium gametocyte density and infection success in mosquitoes; implications for the evaluation of malaria transmission-reducing interventions.

Da DF, Churcher TS, Yerbanga RS, Yaméogo B, Sangaré I, Ouedraogo JB, Sinden RE, Blagborough AM, Cohuet A.

Exp Parasitol. 2015 Feb;149:74-83. doi: 10.1016/j.exppara.2014.12.010. Epub 2014 Dec 23.

21.

The Plasmodium berghei sexual stage antigen PSOP12 induces anti-malarial transmission blocking immunity both in vivo and in vitro.

Sala KA, Nishiura H, Upton LM, Zakutansky SE, Delves MJ, Iyori M, Mizutani M, Sinden RE, Yoshida S, Blagborough AM.

Vaccine. 2015 Jan 9;33(3):437-45. doi: 10.1016/j.vaccine.2014.11.038. Epub 2014 Nov 30.

22.

Lead clinical and preclinical antimalarial drugs can significantly reduce sporozoite transmission to vertebrate populations.

Upton LM, Brock PM, Churcher TS, Ghani AC, Gething PW, Delves MJ, Sala KA, Leroy D, Sinden RE, Blagborough AM.

Antimicrob Agents Chemother. 2015 Jan;59(1):490-7. doi: 10.1128/AAC.03942-14. Epub 2014 Nov 10.

23.

An essential role of the basal body protein SAS-6 in Plasmodium male gamete development and malaria transmission.

Marques SR, Ramakrishnan C, Carzaniga R, Blagborough AM, Delves MJ, Talman AM, Sinden RE.

Cell Microbiol. 2015 Feb;17(2):191-206. doi: 10.1111/cmi.12355. Epub 2014 Sep 24.

24.

Baculovirus-vectored multistage Plasmodium vivax vaccine induces both protective and transmission-blocking immunities against transgenic rodent malaria parasites.

Mizutani M, Iyori M, Blagborough AM, Fukumoto S, Funatsu T, Sinden RE, Yoshida S.

Infect Immun. 2014 Oct;82(10):4348-57. doi: 10.1128/IAI.02040-14. Epub 2014 Aug 4.

25.

Protective CD8+ T-cell immunity to human malaria induced by chimpanzee adenovirus-MVA immunisation.

Ewer KJ, O'Hara GA, Duncan CJ, Collins KA, Sheehy SH, Reyes-Sandoval A, Goodman AL, Edwards NJ, Elias SC, Halstead FD, Longley RJ, Rowland R, Poulton ID, Draper SJ, Blagborough AM, Berrie E, Moyle S, Williams N, Siani L, Folgori A, Colloca S, Sinden RE, Lawrie AM, Cortese R, Gilbert SC, Nicosia A, Hill AV.

Nat Commun. 2013;4:2836. doi: 10.1038/ncomms3836.

26.

Transmission-blocking interventions eliminate malaria from laboratory populations.

Blagborough AM, Churcher TS, Upton LM, Ghani AC, Gething PW, Sinden RE.

Nat Commun. 2013;4:1812. doi: 10.1038/ncomms2840.

27.

Measuring the blockade of malaria transmission--an analysis of the Standard Membrane Feeding Assay.

Churcher TS, Blagborough AM, Delves M, Ramakrishnan C, Kapulu MC, Williams AR, Biswas S, Da DF, Cohuet A, Sinden RE.

Int J Parasitol. 2012 Oct;42(11):1037-44. doi: 10.1016/j.ijpara.2012.09.002. Epub 2012 Sep 27.

28.

A high-throughput assay for the identification of malarial transmission-blocking drugs and vaccines.

Delves MJ, Ramakrishnan C, Blagborough AM, Leroy D, Wells TN, Sinden RE.

Int J Parasitol. 2012 Oct;42(11):999-1006. doi: 10.1016/j.ijpara.2012.08.009. Epub 2012 Sep 27.

PMID:
23023046
29.

Assessing transmission blockade in Plasmodium spp.

Blagborough AM, Delves MJ, Ramakrishnan C, Lal K, Butcher G, Sinden RE.

Methods Mol Biol. 2013;923:577-600.

PMID:
22990806
30.

Laboratory maintenance of rodent malaria parasites.

Ramakrishnan C, Delves MJ, Lal K, Blagborough AM, Butcher G, Baker KW, Sinden RE.

Methods Mol Biol. 2013;923:51-72.

PMID:
22990771
31.

The design and interpretation of laboratory assays measuring mosquito transmission of Plasmodium.

Sinden RE, Blagborough AM, Churcher T, Ramakrishnan C, Biswas S, Delves MJ.

Trends Parasitol. 2012 Nov;28(11):457-65. doi: 10.1016/j.pt.2012.07.005. Epub 2012 Sep 11.

PMID:
22980759
32.

Proteomic analysis of Plasmodium in the mosquito: progress and pitfalls.

Wass MN, Stanway R, Blagborough AM, Lal K, Prieto JH, Raine D, Sternberg MJ, Talman AM, Tomley F, Yates J 3rd, Sinden RE.

Parasitology. 2012 Aug;139(9):1131-45. doi: 10.1017/S0031182012000133. Epub 2012 Feb 16.

33.

A viral vectored prime-boost immunization regime targeting the malaria Pfs25 antigen induces transmission-blocking activity.

Goodman AL, Blagborough AM, Biswas S, Wu Y, Hill AV, Sinden RE, Draper SJ.

PLoS One. 2011;6(12):e29428. doi: 10.1371/journal.pone.0029428. Epub 2011 Dec 28.

34.

PbGEST mediates malaria transmission to both mosquito and vertebrate host.

Talman AM, Lacroix C, Marques SR, Blagborough AM, Carzaniga R, Ménard R, Sinden RE.

Mol Microbiol. 2011 Oct;82(2):462-74. doi: 10.1111/j.1365-2958.2011.07823.x. Epub 2011 Sep 30.

35.

Vital functions of the malarial ookinete protein, CTRP, reside in the A domains.

Ramakrishnan C, Dessens JT, Armson R, Pinto SB, Talman AM, Blagborough AM, Sinden RE.

Int J Parasitol. 2011 Aug 15;41(10):1029-39. doi: 10.1016/j.ijpara.2011.05.007. Epub 2011 Jun 22.

36.

Wolbachia stimulates immune gene expression and inhibits plasmodium development in Anopheles gambiae.

Kambris Z, Blagborough AM, Pinto SB, Blagrove MS, Godfray HC, Sinden RE, Sinkins SP.

PLoS Pathog. 2010 Oct 7;6(10):e1001143. doi: 10.1371/journal.ppat.1001143.

37.

Intranasal and intramuscular immunization with Baculovirus Dual Expression System-based Pvs25 vaccine substantially blocks Plasmodium vivax transmission.

Blagborough AM, Yoshida S, Sattabongkot J, Tsuboi T, Sinden RE.

Vaccine. 2010 Aug 23;28(37):6014-20. doi: 10.1016/j.vaccine.2010.06.100. Epub 2010 Jul 14.

PMID:
20637303
38.

A Plasmodium falciparum strain expressing GFP throughout the parasite's life-cycle.

Talman AM, Blagborough AM, Sinden RE.

PLoS One. 2010 Feb 10;5(2):e9156. doi: 10.1371/journal.pone.0009156.

39.

Plasmodium berghei HAP2 induces strong malaria transmission-blocking immunity in vivo and in vitro.

Blagborough AM, Sinden RE.

Vaccine. 2009 Aug 20;27(38):5187-94. doi: 10.1016/j.vaccine.2009.06.069. Epub 2009 Jul 9. Review.

PMID:
19596419
40.

PCR-based detection of Plasmodium in Anopheles mosquitoes: a comparison of a new high-throughput assay with existing methods.

Bass C, Nikou D, Blagborough AM, Vontas J, Sinden RE, Williamson MS, Field LM.

Malar J. 2008 Sep 15;7:177. doi: 10.1186/1475-2875-7-177.

41.

Transmission blocking immunity in the malaria non-vector mosquito Anopheles quadriannulatus species A.

Habtewold T, Povelones M, Blagborough AM, Christophides GK.

PLoS Pathog. 2008 May 23;4(5):e1000070. doi: 10.1371/journal.ppat.1000070.

42.

The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes.

Liu Y, Tewari R, Ning J, Blagborough AM, Garbom S, Pei J, Grishin NV, Steele RE, Sinden RE, Snell WJ, Billker O.

Genes Dev. 2008 Apr 15;22(8):1051-68. doi: 10.1101/gad.1656508. Epub 2008 Mar 26.

43.

An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites.

Dittrich S, Mitchell SL, Blagborough AM, Wang Q, Wang P, Sims PF, Hyde JE.

Mol Microbiol. 2008 Feb;67(3):609-18. Epub 2007 Dec 18.

44.

The use of transgenic Plasmodium berghei expressing the Plasmodium vivax antigen P25 to determine the transmission-blocking activity of sera from malaria vaccine trials.

Ramjanee S, Robertson JS, Franke-Fayard B, Sinha R, Waters AP, Janse CJ, Wu Y, Blagborough AM, Saul A, Sinden RE.

Vaccine. 2007 Jan 15;25(5):886-94. Epub 2006 Sep 20.

PMID:
17049690

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