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Items: 1 to 50 of 255

1.

Epithelial Injury and Dysfunction in the Pathogenesis of Idiopathic PulmonaryFibrosis.

Winters NI, Burman A, Kropski JA, Blackwell TS.

Am J Med Sci. 2019 May;357(5):374-378. doi: 10.1016/j.amjms.2019.01.010. Epub 2019 Jan 22. Review.

PMID:
31010463
2.

Correction: Electrophilic cyclopentenone neuroprostanes are anti-inflammatory mediators formed from the peroxidation of the ω -3 polyunsaturated fatty acid docosahexaenoic acid.

Musiek ES, Brooks JD, Joo M, Brunoldi E, Porta A, Zanoni G, Vidari G, Blackwell TS, Montine TJ, Milne GL, McLaughlin B, Morrow JD.

J Biol Chem. 2019 Apr 19;294(16):6657. doi: 10.1074/jbc.AAC119.008639. No abstract available.

3.

p73 Is Required for pIgR Expression in the Respiratory Epithelium.

Richmond BW, Du RH, Marshall C, Pietenpol J, Polosukhin VV, Blackwell TS.

Ann Am Thorac Soc. 2018 Dec;15(Supplement_4):S290. doi: 10.1513/AnnalsATS.201806-410MG.

PMID:
30759000
4.

Progress in Understanding and Treating Idiopathic Pulmonary Fibrosis.

Kropski JA, Blackwell TS.

Annu Rev Med. 2019 Jan 27;70:211-224. doi: 10.1146/annurev-med-041317-102715.

PMID:
30691371
5.

Bone Marrow-Derived Proangiogenic Cells Mediate Pulmonary Arteriole Stiffening via Serotonin 2B Receptor Dependent Mechanism.

Bloodworth NC, Clark CR, West JD, Snider JC, Gaskill C, Shay S, Scott C, Bastarache J, Gladson S, Moore C, D'Amico R, Brittain EL, Tanjore H, Blackwell TS, Majka SM, Merryman WD.

Circ Res. 2018 Dec 7;123(12):e51-e64. doi: 10.1161/CIRCRESAHA.118.313397.

PMID:
30566041
6.

lncITPF Promotes Pulmonary Fibrosis by Targeting hnRNP-L Depending on Its Host Gene ITGBL1.

Song X, Xu P, Meng C, Song C, Blackwell TS, Li R, Li H, Zhang J, Lv C.

Mol Ther. 2019 Feb 6;27(2):380-393. doi: 10.1016/j.ymthe.2018.08.026. Epub 2018 Sep 6.

PMID:
30528088
7.

Pathologic Fibroblasts in Idiopathic Subglottic Stenosis Amplify Local Inflammatory Signals.

Morrison RJ, Katsantonis NG, Motz KM, Hillel AT, Garrett CG, Netterville JL, Wootten CT, Majka SM, Blackwell TS, Drake WP, Gelbard A.

Otolaryngol Head Neck Surg. 2019 Jan;160(1):107-115. doi: 10.1177/0194599818803584. Epub 2018 Oct 16.

8.

PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production.

Celada LJ, Kropski JA, Herazo-Maya JD, Luo W, Creecy A, Abad AT, Chioma OS, Lee G, Hassell NE, Shaginurova GI, Wang Y, Johnson JE, Kerrigan A, Mason WR, Baughman RP, Ayers GD, Bernard GR, Culver DA, Montgomery CG, Maher TM, Molyneaux PL, Noth I, Mutsaers SE, Prele CM, Peebles RS Jr, Newcomb DC, Kaminski N, Blackwell TS, Van Kaer L, Drake WP.

Sci Transl Med. 2018 Sep 26;10(460). pii: eaar8356. doi: 10.1126/scitranslmed.aar8356.

9.

Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein.

Burman A, Kropski JA, Calvi CL, Serezani AP, Pascoalino BD, Han W, Sherrill T, Gleaves L, Lawson WE, Young LR, Blackwell TS, Tanjore H.

JCI Insight. 2018 Aug 23;3(16). pii: 99543. doi: 10.1172/jci.insight.99543. eCollection 2018 Aug 23.

10.

Lung injury and fibrosis induced by a mutant form of surfactant protein C.

Blackwell TS.

J Clin Invest. 2018 Aug 31;128(9):3745-3746. doi: 10.1172/JCI122727. Epub 2018 Aug 13.

11.

Interstitial Pneumonia With Autoimmune Features: An Emerging Challenge at the Intersection of Rheumatology and Pulmonology.

Wilfong EM, Lentz RJ, Guttentag A, Tolle JJ, Johnson JE, Kropski JA, Kendall PL, Blackwell TS, Crofford LJ.

Arthritis Rheumatol. 2018 Dec;70(12):1901-1913. doi: 10.1002/art.40679. Epub 2018 Oct 27. Review.

PMID:
30058242
12.

MUC5B Promoter Polymorphism and Development of Acute Respiratory Distress Syndrome.

Rogers AJ, Solus JF, Hunninghake GM, Baron RM, Meyer NJ, Janz DR, Schwartz DA, May AK, Lawson WE, Blackwell TS, Ware LB.

Am J Respir Crit Care Med. 2018 Nov 15;198(10):1342-1345. doi: 10.1164/rccm.201801-0140LE. No abstract available.

PMID:
30025215
13.

Analysis of protein-altering variants in telomerase genes and their association with MUC5B common variant status in patients with idiopathic pulmonary fibrosis: a candidate gene sequencing study.

Dressen A, Abbas AR, Cabanski C, Reeder J, Ramalingam TR, Neighbors M, Bhangale TR, Brauer MJ, Hunkapiller J, Reeder J, Mukhyala K, Cuenco K, Tom J, Cowgill A, Vogel J, Forrest WF, Collard HR, Wolters PJ, Kropski JA, Lancaster LH, Blackwell TS, Arron JR, Yaspan BL.

Lancet Respir Med. 2018 Aug;6(8):603-614. doi: 10.1016/S2213-2600(18)30135-8. Epub 2018 Jun 18.

PMID:
29891356
14.

Lung Dendritic Cells Drive Natural Killer Cytotoxicity in Chronic Obstructive Pulmonary Disease via IL-15Rα.

Finch DK, Stolberg VR, Ferguson J, Alikaj H, Kady MR, Richmond BW, Polosukhin VV, Blackwell TS, McCloskey L, Curtis JL, Freeman CM.

Am J Respir Crit Care Med. 2018 Nov 1;198(9):1140-1150. doi: 10.1164/rccm.201712-2513OC.

PMID:
29676596
15.

p52 expression enhances lung cancer progression.

Saxon JA, Yu H, Polosukhin VV, Stathopoulos GT, Gleaves LA, McLoed AG, Massion PP, Yull FE, Zhao Z, Blackwell TS.

Sci Rep. 2018 Apr 17;8(1):6078. doi: 10.1038/s41598-018-24488-8.

16.

Idiopathic pulmonary fibrosis: Epithelial-mesenchymal interactions and emerging therapeutic targets.

Hewlett JC, Kropski JA, Blackwell TS.

Matrix Biol. 2018 Oct;71-72:112-127. doi: 10.1016/j.matbio.2018.03.021. Epub 2018 Apr 3. Review.

PMID:
29625182
17.

Successful Establishment of Primary Type II Alveolar Epithelium with 3D Organotypic Coculture.

Sucre JMS, Jetter CS, Loomans H, Williams J, Plosa EJ, Benjamin JT, Young LR, Kropski JA, Calvi CL, Kook S, Wang P, Gleaves L, Eskaros A, Goetzl L, Blackwell TS, Guttentag SH, Zijlstra A.

Am J Respir Cell Mol Biol. 2018 Aug;59(2):158-166. doi: 10.1165/rcmb.2017-0442MA.

PMID:
29625013
18.

IκB Kinase α Is Required for Development and Progression of KRAS-Mutant Lung Adenocarcinoma.

Vreka M, Lilis I, Papageorgopoulou M, Giotopoulou GA, Lianou M, Giopanou I, Kanellakis NI, Spella M, Agalioti T, Armenis V, Goldmann T, Marwitz S, Yull FE, Blackwell TS, Pasparakis M, Marazioti A, Stathopoulos GT.

Cancer Res. 2018 Jun 1;78(11):2939-2951. doi: 10.1158/0008-5472.CAN-17-1944. Epub 2018 Mar 27.

19.

Endoplasmic reticulum stress in pulmonary fibrosis.

Burman A, Tanjore H, Blackwell TS.

Matrix Biol. 2018 Aug;68-69:355-365. doi: 10.1016/j.matbio.2018.03.015. Epub 2018 Mar 19. Review.

20.

NF-κB is weakly activated in the NOD mouse model of type 1 diabetes.

Irvin AE, Jhala G, Zhao Y, Blackwell TS, Krishnamurthy B, Thomas HE, Kay TWH.

Sci Rep. 2018 Mar 9;8(1):4217. doi: 10.1038/s41598-018-22738-3.

21.

Myeloid-derived interleukin-1β drives oncogenic KRAS-NF-κΒ addiction in malignant pleural effusion.

Marazioti A, Lilis I, Vreka M, Apostolopoulou H, Kalogeropoulou A, Giopanou I, Giotopoulou GA, Krontira AC, Iliopoulou M, Kanellakis NI, Agalioti T, Giannou AD, Jones-Paris C, Iwakura Y, Kardamakis D, Blackwell TS, Taraviras S, Spella M, Stathopoulos GT.

Nat Commun. 2018 Feb 14;9(1):672. doi: 10.1038/s41467-018-03051-z.

22.

Salt-bridge modulates differential calcium-mediated ligand binding to integrin α1- and α2-I domains.

Brown KL, Banerjee S, Feigley A, Abe H, Blackwell TS, Pozzi A, Hudson BG, Zent R.

Sci Rep. 2018 Feb 13;8(1):2916. doi: 10.1038/s41598-018-21231-1.

23.

Time for a change: is idiopathic pulmonary fibrosis still idiopathic and only fibrotic?

Wolters PJ, Blackwell TS, Eickelberg O, Loyd JE, Kaminski N, Jenkins G, Maher TM, Molina-Molina M, Noble PW, Raghu G, Richeldi L, Schwarz MI, Selman M, Wuyts WA, Schwartz DA.

Lancet Respir Med. 2018 Feb;6(2):154-160. doi: 10.1016/S2213-2600(18)30007-9. Review.

24.

Three-dimensional spatial analysis of missense variants in RTEL1 identifies pathogenic variants in patients with Familial Interstitial Pneumonia.

Sivley RM, Sheehan JH, Kropski JA, Cogan J, Blackwell TS, Phillips JA, Bush WS, Meiler J, Capra JA.

BMC Bioinformatics. 2018 Jan 23;19(1):18. doi: 10.1186/s12859-018-2010-z.

25.

A Shared Pattern of β-Catenin Activation in Bronchopulmonary Dysplasia and Idiopathic Pulmonary Fibrosis.

Sucre JMS, Deutsch GH, Jetter CS, Ambalavanan N, Benjamin JT, Gleaves LA, Millis BA, Young LR, Blackwell TS, Kropski JA, Guttentag SH.

Am J Pathol. 2018 Apr;188(4):853-862. doi: 10.1016/j.ajpath.2017.12.004. Epub 2018 Jan 31.

26.

Bacterial-derived Neutrophilic Inflammation Drives Lung Remodeling in a Mouse Model of Chronic Obstructive Pulmonary Disease.

Richmond BW, Du RH, Han W, Benjamin JT, van der Meer R, Gleaves L, Guo M, McKissack A, Zhang Y, Cheng DS, Polosukhin VV, Blackwell TS.

Am J Respir Cell Mol Biol. 2018 Jun;58(6):736-744. doi: 10.1165/rcmb.2017-0329OC.

27.

Endoplasmic reticulum stress in the pathogenesis of fibrotic disease.

Kropski JA, Blackwell TS.

J Clin Invest. 2018 Jan 2;128(1):64-73. doi: 10.1172/JCI93560. Epub 2018 Jan 2. Review.

28.

Inverse Relationship between Soluble RAGE and Risk for Bronchopulmonary Dysplasia.

Benjamin JT, van der Meer R, Slaughter JC, Steele S, Plosa EJ, Sucre JM, Moore PE, Aschner JL, Blackwell TS, Young LR.

Am J Respir Crit Care Med. 2018 Apr 15;197(8):1083-1086. doi: 10.1164/rccm.201707-1445LE. No abstract available.

29.

Suppressed ubiquitination of Nrf2 by p47phox contributes to Nrf2 activation.

Ha Kim K, Sadikot RT, Yeon Lee J, Jeong HS, Oh YK, Blackwell TS, Joo M.

Free Radic Biol Med. 2017 Dec;113:48-58. doi: 10.1016/j.freeradbiomed.2017.09.011. Epub 2017 Sep 19.

30.

IKKβ Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis.

McCoy AM, Herington JL, Stouch AN, Mukherjee AB, Lakhdari O, Blackwell TS, Prince LS.

Am J Pathol. 2017 Dec;187(12):2635-2644. doi: 10.1016/j.ajpath.2017.08.013. Epub 2017 Sep 18.

31.

Utility of Flexible Bronchoscopic Cryobiopsy for Diagnosis of Diffuse Parenchymal Lung Diseases.

Lentz RJ, Taylor TM, Kropski JA, Sandler KL, Johnson JE, Blackwell TS, Maldonado F, Rickman OB.

J Bronchology Interv Pulmonol. 2018 Apr;25(2):88-96. doi: 10.1097/LBR.0000000000000401.

32.

Reply: The Genetic Diagnosis of Interstitial Lung Disease: A Need for an International Consensus.

Kropski JA, Young LR, Blackwell TS, Loyd JE.

Am J Respir Crit Care Med. 2017 Jun 1;195(11):1539-1540. doi: 10.1164/rccm.201612-2520LE. No abstract available.

33.

Disruption of lineage specification in adult pulmonary mesenchymal progenitor cells promotes microvascular dysfunction.

Gaskill CF, Carrier EJ, Kropski JA, Bloodworth NC, Menon S, Foronjy RF, Taketo MM, Hong CC, Austin ED, West JD, Means AL, Loyd JE, Merryman WD, Hemnes AR, De Langhe S, Blackwell TS, Klemm DJ, Majka SM.

J Clin Invest. 2017 Jun 1;127(6):2262-2276. doi: 10.1172/JCI88629. Epub 2017 May 2.

34.

Rare Genetic Variants in PARN Are Associated with Pulmonary Fibrosis in Families.

Kropski JA, Reiss S, Markin C, Brown KK, Schwartz DA, Schwarz MI, Loyd JE, Phillips JA 3rd, Blackwell TS, Cogan JD.

Am J Respir Crit Care Med. 2017 Dec 1;196(11):1481-1484. doi: 10.1164/rccm.201703-0635LE. No abstract available.

35.

The innate immune response in fetal lung mesenchymal cells targets VEGFR2 expression and activity.

Medal RM, Im AM, Yamamoto Y, Lakhdari O, Blackwell TS, Hoffman HM, Sahoo D, Prince LS.

Am J Physiol Lung Cell Mol Physiol. 2017 Jun 1;312(6):L861-L872. doi: 10.1152/ajplung.00554.2016. Epub 2017 Mar 23.

36.

Identification of a novel series of anti-inflammatory and anti-oxidative phospholipid oxidation products containing the cyclopentenone moiety in vitro and in vivo: Implication in atherosclerosis.

Lu J, Guo S, Xue X, Chen Q, Ge J, Zhuo Y, Zhong H, Chen B, Zhao M, Han W, Suzuki T, Zhu M, Xia L, Schneider C, Blackwell TS, Porter NA, Zheng L, Tsimikas S, Yin H.

J Biol Chem. 2017 Mar 31;292(13):5378-5391. doi: 10.1074/jbc.M116.751909. Epub 2017 Feb 15.

37.

PET-based Imaging of Chemokine Receptor 2 in Experimental and Disease-related Lung Inflammation.

Liu Y, Gunsten SP, Sultan DH, Luehmann HP, Zhao Y, Blackwell TS, Bollermann-Nowlis Z, Pan JH, Byers DE, Atkinson JJ, Kreisel D, Holtzman MJ, Gropler RJ, Combadiere C, Brody SL.

Radiology. 2017 Jun;283(3):758-768. doi: 10.1148/radiol.2016161409. Epub 2017 Jan 3.

38.

Secretory IgA Deficiency in Individual Small Airways Is Associated with Persistent Inflammation and Remodeling.

Polosukhin VV, Richmond BW, Du RH, Cates JM, Wu P, Nian H, Massion PP, Ware LB, Lee JW, Kononov AV, Lawson WE, Blackwell TS.

Am J Respir Crit Care Med. 2017 Apr 15;195(8):1010-1021. doi: 10.1164/rccm.201604-0759OC.

39.

Genetic Evaluation and Testing of Patients and Families with Idiopathic Pulmonary Fibrosis.

Kropski JA, Young LR, Cogan JD, Mitchell DB, Lancaster LH, Worrell JA, Markin C, Liu N, Mason WR, Fingerlin TE, Schwartz DA, Lawson WE, Blackwell TS, Phillips JA 3rd, Loyd JE.

Am J Respir Crit Care Med. 2017 Jun 1;195(11):1423-1428. doi: 10.1164/rccm.201609-1820PP. No abstract available.

40.

Epithelial-macrophage interactions determine pulmonary fibrosis susceptibility in Hermansky-Pudlak syndrome.

Young LR, Gulleman PM, Short CW, Tanjore H, Sherrill T, Qi A, McBride AP, Zaynagetdinov R, Benjamin JT, Lawson WE, Novitskiy SV, Blackwell TS.

JCI Insight. 2016 Oct 20;1(17):e88947. doi: 10.1172/jci.insight.88947.

41.

Idiopathic subglottic stenosis is associated with activation of the inflammatory IL-17A/IL-23 axis.

Gelbard A, Katsantonis NG, Mizuta M, Newcomb D, Rotsinger J, Rousseau B, Daniero JJ, Edell ES, Ekbom DC, Kasperbauer JL, Hillel AT, Yang L, Garrett CG, Netterville JL, Wootten CT, Francis DO, Stratton C, Jenkins K, McGregor TL, Gaddy JA, Blackwell TS, Drake WP.

Laryngoscope. 2016 Nov;126(11):E356-E361. doi: 10.1002/lary.26098. Epub 2016 Jun 14.

42.

Epithelial NF-κB signaling promotes EGFR-driven lung carcinogenesis via macrophage recruitment.

Saxon JA, Sherrill TP, Polosukhin VV, Sai J, Zaynagetdinov R, McLoed AG, Gulleman PM, Barham W, Cheng DS, Hunt RP, Gleaves LA, Richmond A, Young LR, Yull FE, Blackwell TS.

Oncoimmunology. 2016 Mar 30;5(6):e1168549. doi: 10.1080/2162402X.2016.1168549. eCollection 2016 Jun.

43.

Neutrophil-Derived IL-1β Impairs the Efficacy of NF-κB Inhibitors against Lung Cancer.

McLoed AG, Sherrill TP, Cheng DS, Han W, Saxon JA, Gleaves LA, Wu P, Polosukhin VV, Karin M, Yull FE, Stathopoulos GT, Georgoulias V, Zaynagetdinov R, Blackwell TS.

Cell Rep. 2016 Jun 28;16(1):120-132. doi: 10.1016/j.celrep.2016.05.085. Epub 2016 Jun 16.

44.

Molecular analysis of idiopathic subglottic stenosis for Mycobacterium species.

Gelbard A, Katsantonis NG, Mizuta M, Newcomb D, Rotsinger J, Rousseau B, Daniero JJ, Edell ES, Ekbom DC, Kasperbauer JL, Hillel AT, Yang L, Garrett CG, Netterville JL, Wootten CT, Francis DO, Stratton C, Jenkins K, McGregor TL, Gaddy JA, Blackwell TS, Drake WP.

Laryngoscope. 2017 Jan;127(1):179-185. doi: 10.1002/lary.26097. Epub 2016 Jun 14.

45.

Extracellular chloride signals collagen IV network assembly during basement membrane formation.

Cummings CF, Pedchenko V, Brown KL, Colon S, Rafi M, Jones-Paris C, Pokydeshava E, Liu M, Pastor-Pareja JC, Stothers C, Ero-Tolliver IA, McCall AS, Vanacore R, Bhave G, Santoro S, Blackwell TS, Zent R, Pozzi A, Hudson BG.

J Cell Biol. 2016 May 23;213(4):479-94. doi: 10.1083/jcb.201510065.

46.

Persistent Lung Disease in Adults with NKX2.1 Mutation and Familial Neuroendocrine Cell Hyperplasia of Infancy.

Nevel RJ, Garnett ET, Worrell JA, Morton RL, Nogee LM, Blackwell TS, Young LR.

Ann Am Thorac Soc. 2016 Aug;13(8):1299-304. doi: 10.1513/AnnalsATS.201603-155BC.

47.

Epithelial-Derived Inflammation Disrupts Elastin Assembly and Alters Saccular Stage Lung Development.

Benjamin JT, van der Meer R, Im AM, Plosa EJ, Zaynagetdinov R, Burman A, Havrilla ME, Gleaves LA, Polosukhin VV, Deutsch GH, Yanagisawa H, Davidson JM, Prince LS, Young LR, Blackwell TS.

Am J Pathol. 2016 Jul;186(7):1786-1800. doi: 10.1016/j.ajpath.2016.02.016. Epub 2016 May 12.

48.

Accumulation of isolevuglandin-modified protein in normal and fibrotic lung.

Mont S, Davies SS, Roberts Second LJ, Mernaugh RL, McDonald WH, Segal BH, Zackert W, Kropski JA, Blackwell TS, Sekhar KR, Galligan JJ, Massion PP, Marnett LJ, Travis EL, Freeman ML.

Sci Rep. 2016 Apr 27;6:24919. doi: 10.1038/srep24919.

49.

Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.

Richmond BW, Brucker RM, Han W, Du RH, Zhang Y, Cheng DS, Gleaves L, Abdolrasulnia R, Polosukhina D, Clark PE, Bordenstein SR, Blackwell TS, Polosukhin VV.

Nat Commun. 2016 Apr 5;7:11240. doi: 10.1038/ncomms11240.

50.

IL-1β and Inflammasome Activity Link Inflammation to Abnormal Fetal Airway Development.

Stouch AN, McCoy AM, Greer RM, Lakhdari O, Yull FE, Blackwell TS, Hoffman HM, Prince LS.

J Immunol. 2016 Apr 15;196(8):3411-20. doi: 10.4049/jimmunol.1500906. Epub 2016 Mar 7.

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