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Items: 1 to 50 of 93

1.

Dietary Restriction Extends Lifespan through Metabolic Regulation of Innate Immunity.

Wu Z, Isik M, Moroz N, Steinbaugh MJ, Zhang P, Blackwell TK.

Cell Metab. 2019 May 7;29(5):1192-1205.e8. doi: 10.1016/j.cmet.2019.02.013. Epub 2019 Mar 21.

PMID:
30905669
2.

Mitochondrial unfolded protein response transcription factor ATFS-1 promotes longevity in a long-lived mitochondrial mutant through activation of stress response pathways.

Wu Z, Senchuk MM, Dues DJ, Johnson BK, Cooper JF, Lew L, Machiela E, Schaar CE, DeJonge H, Blackwell TK, Van Raamsdonk JM.

BMC Biol. 2018 Dec 18;16(1):147. doi: 10.1186/s12915-018-0615-3.

3.

Oxidative Stress Assays (arsenite and tBHP) in Caenorhabditis elegans.

Ewald CY, Hourihan JM, Blackwell TK.

Bio Protoc. 2017 Jul 5;7(13). pii: e2365. doi: 10.21769/BioProtoc.2365.

4.

Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling.

Lee G, Zheng Y, Cho S, Jang C, England C, Dempsey JM, Yu Y, Liu X, He L, Cavaliere PM, Chavez A, Zhang E, Isik M, Couvillon A, Dephoure NE, Blackwell TK, Yu JJ, Rabinowitz JD, Cantley LC, Blenis J.

Cell. 2017 Dec 14;171(7):1545-1558.e18. doi: 10.1016/j.cell.2017.10.037. Epub 2017 Nov 16.

5.

Triclosan Disrupts SKN-1/Nrf2-Mediated Oxidative Stress Response in C. elegans and Human Mesenchymal Stem Cells.

Yoon DS, Choi Y, Cha DS, Zhang P, Choi SM, Alfhili MA, Polli JR, Pendergrass D, Taki FA, Kapalavavi B, Pan X, Zhang B, Blackwell TK, Lee JW, Lee MH.

Sci Rep. 2017 Oct 3;7(1):12592. doi: 10.1038/s41598-017-12719-3.

6.

Untangling Longevity, Dauer, and Healthspan in Caenorhabditis elegans Insulin/IGF-1-Signalling.

Ewald CY, Castillo-Quan JI, Blackwell TK.

Gerontology. 2018;64(1):96-104. doi: 10.1159/000480504. Epub 2017 Sep 22.

7.

NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans.

Ewald CY, Hourihan JM, Bland MS, Obieglo C, Katic I, Moronetti Mazzeo LE, Alcedo J, Blackwell TK, Hynes NE.

Elife. 2017 Jan 13;6. pii: e19493. doi: 10.7554/eLife.19493.

8.

Metformin: Restraining Nucleocytoplasmic Shuttling to Fight Cancer and Aging.

Castillo-Quan JI, Blackwell TK.

Cell. 2016 Dec 15;167(7):1670-1671. doi: 10.1016/j.cell.2016.11.058.

9.

MicroRNA mir-34 provides robustness to environmental stress response via the DAF-16 network in C. elegans.

Isik M, Blackwell TK, Berezikov E.

Sci Rep. 2016 Dec 1;6:36766. doi: 10.1038/srep36766.

10.

Cysteine Sulfenylation Directs IRE-1 to Activate the SKN-1/Nrf2 Antioxidant Response.

Hourihan JM, Moronetti Mazzeo LE, Fernández-Cárdenas LP, Blackwell TK.

Mol Cell. 2016 Aug 18;63(4):553-566. doi: 10.1016/j.molcel.2016.07.019.

11.

Natural thioallyl compounds increase oxidative stress resistance and lifespan in Caenorhabditis elegans by modulating SKN-1/Nrf.

Ogawa T, Kodera Y, Hirata D, Blackwell TK, Mizunuma M.

Sci Rep. 2016 Feb 22;6:21611. doi: 10.1038/srep21611.

12.

SKN-1/Nrf, stress responses, and aging in Caenorhabditis elegans.

Blackwell TK, Steinbaugh MJ, Hourihan JM, Ewald CY, Isik M.

Free Radic Biol Med. 2015 Nov;88(Pt B):290-301. doi: 10.1016/j.freeradbiomed.2015.06.008. Epub 2015 Aug 5. Review.

13.

Lipid-mediated regulation of SKN-1/Nrf in response to germ cell absence.

Steinbaugh MJ, Narasimhan SD, Robida-Stubbs S, Moronetti Mazzeo LE, Dreyfuss JM, Hourihan JM, Raghavan P, Operaña TN, Esmaillie R, Blackwell TK.

Elife. 2015 Aug 24;4. doi: 10.7554/eLife.07836.

14.

Dauer-independent insulin/IGF-1-signalling implicates collagen remodelling in longevity.

Ewald CY, Landis JN, Porter Abate J, Murphy CT, Blackwell TK.

Nature. 2015 Mar 5;519(7541):97-101. doi: 10.1038/nature14021. Epub 2014 Dec 15.

15.

Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism.

Moroz N, Carmona JJ, Anderson E, Hart AC, Sinclair DA, Blackwell TK.

Aging Cell. 2014 Dec;13(6):1075-85. doi: 10.1111/acel.12273. Epub 2014 Sep 25.

16.

mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity.

Mizunuma M, Neumann-Haefelin E, Moroz N, Li Y, Blackwell TK.

Aging Cell. 2014 Oct;13(5):869-78. doi: 10.1111/acel.12248. Epub 2014 Jul 9.

17.

GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.

Yoon JC, Ling AJ, Isik M, Lee DY, Steinbaugh MJ, Sack LM, Boduch AN, Blackwell TK, Sinclair DA, Elledge SJ.

Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3781-6. doi: 10.1073/pnas.1400705111. Epub 2014 Feb 20.

18.

Integration of the unfolded protein and oxidative stress responses through SKN-1/Nrf.

Glover-Cutter KM, Lin S, Blackwell TK.

PLoS Genet. 2013;9(9):e1003701. doi: 10.1371/journal.pgen.1003701. Epub 2013 Sep 12.

19.

TORC2 signaling antagonizes SKN-1 to induce C. elegans mesendodermal embryonic development.

Ruf V, Holzem C, Peyman T, Walz G, Blackwell TK, Neumann-Haefelin E.

Dev Biol. 2013 Dec 15;384(2):214-27. doi: 10.1016/j.ydbio.2013.08.011. Epub 2013 Aug 20.

20.

Mitochondrial SKN-1/Nrf mediates a conserved starvation response.

Paek J, Lo JY, Narasimhan SD, Nguyen TN, Glover-Cutter K, Robida-Stubbs S, Suzuki T, Yamamoto M, Blackwell TK, Curran SP.

Cell Metab. 2012 Oct 3;16(4):526-37. doi: 10.1016/j.cmet.2012.09.007.

21.

Role of microRNA processing in adipose tissue in stress defense and longevity.

Mori MA, Raghavan P, Thomou T, Boucher J, Robida-Stubbs S, Macotela Y, Russell SJ, Kirkland JL, Blackwell TK, Kahn CR.

Cell Metab. 2012 Sep 5;16(3):336-47. doi: 10.1016/j.cmet.2012.07.017.

22.

TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO.

Robida-Stubbs S, Glover-Cutter K, Lamming DW, Mizunuma M, Narasimhan SD, Neumann-Haefelin E, Sabatini DM, Blackwell TK.

Cell Metab. 2012 May 2;15(5):713-24. doi: 10.1016/j.cmet.2012.04.007.

23.

Specific SKN-1/Nrf stress responses to perturbations in translation elongation and proteasome activity.

Li X, Matilainen O, Jin C, Glover-Cutter KM, Holmberg CI, Blackwell TK.

PLoS Genet. 2011 Jun;7(6):e1002119. doi: 10.1371/journal.pgen.1002119. Epub 2011 Jun 9.

24.

RNAi screening implicates a SKN-1-dependent transcriptional response in stress resistance and longevity deriving from translation inhibition.

Wang J, Robida-Stubbs S, Tullet JM, Rual JF, Vidal M, Blackwell TK.

PLoS Genet. 2010 Aug 5;6(8). pii: e1001048. doi: 10.1371/journal.pgen.1001048.

25.

Life is short, if sweet.

Porter Abate J, Blackwell TK.

Cell Metab. 2009 Nov;10(5):338-9. doi: 10.1016/j.cmet.2009.10.006.

26.

Condition-adapted stress and longevity gene regulation by Caenorhabditis elegans SKN-1/Nrf.

Oliveira RP, Porter Abate J, Dilks K, Landis J, Ashraf J, Murphy CT, Blackwell TK.

Aging Cell. 2009 Sep;8(5):524-41. doi: 10.1111/j.1474-9726.2009.00501.x. Epub 2009 Jul 3.

27.

nhl-2 Modulates microRNA activity in Caenorhabditis elegans.

Hammell CM, Lubin I, Boag PR, Blackwell TK, Ambros V.

Cell. 2009 Mar 6;136(5):926-38. doi: 10.1016/j.cell.2009.01.053.

28.

A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance.

Oláhová M, Taylor SR, Khazaipoul S, Wang J, Morgan BA, Matsumoto K, Blackwell TK, Veal EA.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19839-44. doi: 10.1073/pnas.0805507105. Epub 2008 Dec 8.

29.

OMA-gosh, where's that TAF?

Blackwell TK, Walker AK.

Cell. 2008 Oct 3;135(1):18-20. doi: 10.1016/j.cell.2008.09.021.

30.

Germline survival and apoptosis.

Gartner A, Boag PR, Blackwell TK.

WormBook. 2008 Sep 4:1-20. doi: 10.1895/wormbook.1.145.1. Review.

31.

Protection of specific maternal messenger RNAs by the P body protein CGH-1 (Dhh1/RCK) during Caenorhabditis elegans oogenesis.

Boag PR, Atalay A, Robida S, Reinke V, Blackwell TK.

J Cell Biol. 2008 Aug 11;182(3):543-57. doi: 10.1083/jcb.200801183.

32.

Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans.

Tullet JM, Hertweck M, An JH, Baker J, Hwang JY, Liu S, Oliveira RP, Baumeister R, Blackwell TK.

Cell. 2008 Mar 21;132(6):1025-38. doi: 10.1016/j.cell.2008.01.030.

33.

Transcription mechanisms.

Blackwell TK, Walker AK.

WormBook. 2006 Sep 5:1-16. Review.

34.

The DEAD box RNA helicase VBH-1 is required for germ cell function in C. elegans.

Salinas LS, Maldonado E, Macías-Silva M, Blackwell TK, Navarro RE.

Genesis. 2007 Sep;45(9):533-46.

PMID:
17868112
35.

Transcription reactivation steps stimulated by oocyte maturation in C. elegans.

Walker AK, Boag PR, Blackwell TK.

Dev Biol. 2007 Apr 1;304(1):382-93. Epub 2006 Dec 23.

36.

A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.

Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villén J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A.

Cell. 2006 Jun 2;125(5):987-1001.

37.

Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3.

An JH, Vranas K, Lucke M, Inoue H, Hisamoto N, Matsumoto K, Blackwell TK.

Proc Natl Acad Sci U S A. 2005 Nov 8;102(45):16275-80. Epub 2005 Oct 26.

38.

A conserved RNA-protein complex component involved in physiological germline apoptosis regulation in C. elegans.

Boag PR, Nakamura A, Blackwell TK.

Development. 2005 Nov;132(22):4975-86. Epub 2005 Oct 12.

39.

The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response.

Inoue H, Hisamoto N, An JH, Oliveira RP, Nishida E, Blackwell TK, Matsumoto K.

Genes Dev. 2005 Oct 1;19(19):2278-83. Epub 2005 Sep 15.

40.

Requirement for P granules and meiosis for accumulation of the germline RNA helicase CGH-1.

Navarro RE, Blackwell TK.

Genesis. 2005 Jul;42(3):172-80.

PMID:
15986473
41.

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

Bourbon HM, Aguilera A, Ansari AZ, Asturias FJ, Berk AJ, Bjorklund S, Blackwell TK, Borggrefe T, Carey M, Carlson M, Conaway JW, Conaway RC, Emmons SW, Fondell JD, Freedman LP, Fukasawa T, Gustafsson CM, Han M, He X, Herman PK, Hinnebusch AG, Holmberg S, Holstege FC, Jaehning JA, Kim YJ, Kuras L, Leutz A, Lis JT, Meisterernest M, Naar AM, Nasmyth K, Parvin JD, Ptashne M, Reinberg D, Ronne H, Sadowski I, Sakurai H, Sipiczki M, Sternberg PW, Stillman DJ, Strich R, Struhl K, Svejstrup JQ, Tuck S, Winston F, Roeder RG, Kornberg RD.

Mol Cell. 2004 Jun 4;14(5):553-7. No abstract available.

42.

The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis.

Wang JC, Walker A, Blackwell TK, Yamamoto KR.

J Biol Chem. 2004 Jul 9;279(28):29270-7. Epub 2004 Apr 8.

43.

Germ cells: finding programs of mass repression.

Blackwell TK.

Curr Biol. 2004 Mar 23;14(6):R229-30. Review.

44.

MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay.

Stoecklin G, Stubbs T, Kedersha N, Wax S, Rigby WF, Blackwell TK, Anderson P.

EMBO J. 2004 Mar 24;23(6):1313-24. Epub 2004 Mar 11.

45.

An extensive requirement for transcription factor IID-specific TAF-1 in Caenorhabditis elegans embryonic transcription.

Walker AK, Shi Y, Blackwell TK.

J Biol Chem. 2004 Apr 9;279(15):15339-47. Epub 2004 Jan 15.

46.

Transcription elongation: TLKing to chromatin?

Blackwell TK, Walker AK.

Curr Biol. 2003 Dec 2;13(23):R915-6. Review. No abstract available.

47.

A two-tiered transcription regulation mechanism that protects germ cell identity.

Shi Y, Blackwell TK.

Mol Cell. 2003 Nov;12(5):1062-4. No abstract available.

48.

SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response.

An JH, Blackwell TK.

Genes Dev. 2003 Aug 1;17(15):1882-93. Epub 2003 Jul 17.

49.

A model of repression: CTD analogs and PIE-1 inhibit transcriptional elongation by P-TEFb.

Zhang F, Barboric M, Blackwell TK, Peterlin BM.

Genes Dev. 2003 Mar 15;17(6):748-58.

50.

The Caenorhabditis elegans mRNA 5'-capping enzyme. In vitro and in vivo characterization.

Takagi T, Walker AK, Sawa C, Diehn F, Takase Y, Blackwell TK, Buratowski S.

J Biol Chem. 2003 Apr 18;278(16):14174-84. Epub 2003 Feb 7.

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