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Updated results from MONALEESA-2, a phase III trial of first-line ribociclib plus letrozole versus placebo plus letrozole in hormone receptor-positive, HER2-negative advanced breast cancer.

Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Mondal S, Su F, Miller M, Elmeliegy M, Germa C, O'Shaughnessy J.

Ann Oncol. 2019 Aug 13. pii: mdz215. doi: 10.1093/annonc/mdz215. [Epub ahead of print] No abstract available.


Efficacy and Safety of Ribociclib With Letrozole in US Patients Enrolled in the MONALEESA-2 Study.

Yardley DA, Hart L, Favret A, Blau S, Diab S, Richards D, Sparano J, Beck JT, Richards P, Ward P, Ramaswamy B, Tsai M, Blackwell K, Pluard T, Tolaney SM, Esteva FJ, Truica CI, Alemany C, Volas-Redd G, Shtivelband M, Purkayastha D, Dalal AA, Miller M, Hortobagyi GN.

Clin Breast Cancer. 2019 Aug;19(4):268-277.e1. doi: 10.1016/j.clbc.2019.02.007. Epub 2019 Feb 28.


Invasive Oral Tongue Mucormycosis Rapidly Presenting After Orthotopic Liver Transplant.

Vahabzadeh-Hagh AM, Chao KY, Blackwell KE.

Ear Nose Throat J. 2019 Jun;98(5):268-270. doi: 10.1177/0145561319840535. Epub 2019 May 13. No abstract available.


Examination and prognostic implications of the unique microenvironment of breast cancer brain metastases.

Sambade MJ, Prince G, Deal AM, Trembath D, McKee M, Garrett A, Keith K, Ramirez J, Midkiff B, Blackwell K, Sammons S, Leone JP, Brufsky A, Morikawa A, Brogi E, Seidman A, Ewend M, Carey LA, Moschos SJ, Hamilton RL, Vincent B, Anders C.

Breast Cancer Res Treat. 2019 Jul;176(2):321-328. doi: 10.1007/s10549-019-05211-1. Epub 2019 Apr 23.


TBCRC 022: A Phase II Trial of Neratinib and Capecitabine for Patients With Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases.

Freedman RA, Gelman RS, Anders CK, Melisko ME, Parsons HA, Cropp AM, Silvestri K, Cotter CM, Componeschi KP, Marte JM, Connolly RM, Moy B, Van Poznak CH, Blackwell KL, Puhalla SL, Jankowitz RC, Smith KL, Ibrahim N, Moynihan TJ, O'Sullivan CC, Nangia J, Niravath P, Tung N, Pohlmann PR, Burns R, Rimawi MF, Krop IE, Wolff AC, Winer EP, Lin NU; Translational Breast Cancer Research Consortium.

J Clin Oncol. 2019 May 1;37(13):1081-1089. doi: 10.1200/JCO.18.01511. Epub 2019 Mar 12.


Total Glossectomy With Free Flap Reconstruction: Twenty-Year Experience at a Tertiary Medical Center.

Han AY, Kuan EC, Mallen-St Clair J, Badran KW, Palma Diaz MF, Blackwell KE, St John MA.

Laryngoscope. 2019 May;129(5):1087-1092. doi: 10.1002/lary.27579. Epub 2019 Jan 22.


Neratinib in Combination With Trastuzumab for the Treatment of Patients With Advanced HER2-positive Breast Cancer: A Phase I/II Study.

Blackwell KL, Zaman K, Qin S, Tkaczuk KHR, Campone M, Hunt D, Bryce R, Goldstein LJ; 202 Study Group.

Clin Breast Cancer. 2019 Apr;19(2):97-104.e4. doi: 10.1016/j.clbc.2018.12.011. Epub 2018 Dec 20.


Vaccine-Induced Memory CD8+ T Cells Provide Clinical Benefit in HER2 Expressing Breast Cancer: A Mouse to Human Translational Study.

Crosby EJ, Gwin W, Blackwell K, Marcom PK, Chang S, Maecker HT, Broadwater G, Hyslop T, Kim S, Rogatko A, Lubkov V, Snyder JC, Osada T, Hobeika AC, Morse MA, Lyerly HK, Hartman ZC.

Clin Cancer Res. 2019 May 1;25(9):2725-2736. doi: 10.1158/1078-0432.CCR-18-3102. Epub 2019 Jan 11.


From membrane receptors to protein synthesis and actin cytoskeleton: Mechanisms underlying long lasting forms of synaptic plasticity.

Jędrzejewska-Szmek J, Blackwell KT.

Semin Cell Dev Biol. 2019 Jan 11. pii: S1084-9521(18)30058-2. doi: 10.1016/j.semcdb.2019.01.006. [Epub ahead of print] Review.


Impact of lapatinib plus trastuzumab versus single-agent lapatinib on quality of life of patients with trastuzumab-refractory HER2+ metastatic breast cancer.

Wu Y, Amonkar MM, Sherrill BH, O'Shaughnessy J, Ellis C, Baselga J, Blackwell KL, Burstein HJ.

Ann Oncol. 2019 Jan 9. doi: 10.1093/annonc/mdy531. [Epub ahead of print] No abstract available.


Correction to: Fulvestrant-Based Combination Therapy for Second-Line Treatment of Hormone Receptor-Positive Advanced Breast Cancer.

Sammons S, Kornblum NS, Blackwell KL.

Target Oncol. 2019 Feb;14(1):13. doi: 10.1007/s11523-018-0614-x.


Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model.

Dorman DB, Jędrzejewska-Szmek J, Blackwell KT.

Elife. 2018 Oct 25;7. pii: e38588. doi: 10.7554/eLife.38588.


Readmission after surgery for oropharyngeal cancer: An analysis of rates, causes, and risk factors.

Goel AN, Badran KW, Mendelsohn AH, Chhetri DK, Sercarz JA, Blackwell KE, John MAS, Long JL.

Laryngoscope. 2019 Apr;129(4):910-918. doi: 10.1002/lary.27461. Epub 2018 Sep 19.


Fulvestrant-Based Combination Therapy for Second-Line Treatment of Hormone Receptor-Positive Advanced Breast Cancer.

Sammons S, Kornblum NS, Blackwell KL.

Target Oncol. 2019 Feb;14(1):1-12. doi: 10.1007/s11523-018-0587-9. Erratum in: Target Oncol. 2018 Dec 8;:.


Parameter Optimization Using Covariance Matrix Adaptation-Evolutionary Strategy (CMA-ES), an Approach to Investigate Differences in Channel Properties Between Neuron Subtypes.

Jȩdrzejewski-Szmek Z, Abrahao KP, Jȩdrzejewska-Szmek J, Lovinger DM, Blackwell KT.

Front Neuroinform. 2018 Jul 31;12:47. doi: 10.3389/fninf.2018.00047. eCollection 2018.


Modulation of Spike-Timing Dependent Plasticity: Towards the Inclusion of a Third Factor in Computational Models.

Foncelle A, Mendes A, Jędrzejewska-Szmek J, Valtcheva S, Berry H, Blackwell KT, Venance L.

Front Comput Neurosci. 2018 Jul 3;12:49. doi: 10.3389/fncom.2018.00049. eCollection 2018. Review.


Endobronchial Ultrasound-guided Transbronchial Needle Aspiration in the Diagnosis of Breast Cancer Thoracic Metastases and Detection of Receptor Discordance.

Argento AC, Gilstrap DL, Shofer S, Mahmood K, Blackwell K, Wahidi MM.

J Bronchology Interv Pulmonol. 2018 Jul;25(3):176-180. doi: 10.1097/LBR.0000000000000476.


Sentinel lymph node biopsy in cutaneous melanoma of the head and neck using the indocyanine green SPY Elite system.

Vahabzadeh-Hagh AM, Blackwell KE, Abemayor E, St John MA.

Am J Otolaryngol. 2018 Sep - Oct;39(5):485-488. doi: 10.1016/j.amjoto.2018.05.006. Epub 2018 May 17.


Phase 1 study of seviteronel, a selective CYP17 lyase and androgen receptor inhibitor, in women with estrogen receptor-positive or triple-negative breast cancer.

Bardia A, Gucalp A, DaCosta N, Gabrail N, Danso M, Ali H, Blackwell KL, Carey LA, Eisner JR, Baskin-Bey ES, Traina TA.

Breast Cancer Res Treat. 2018 Aug;171(1):111-120. doi: 10.1007/s10549-018-4813-z. Epub 2018 May 9.


Updated results from MONALEESA-2, a phase III trial of first-line ribociclib plus letrozole versus placebo plus letrozole in hormone receptor-positive, HER2-negative advanced breast cancer.

Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Petrakova K, Blackwell KL, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Mondal S, Su F, Miller M, Elmeliegy M, Germa C, O'Shaughnessy J.

Ann Oncol. 2018 Jul 1;29(7):1541-1547. doi: 10.1093/annonc/mdy155.


Clinical Trial Results Summary for Laypersons: A User Testing Study.

Raynor DK, Myers L, Blackwell K, Kress B, Dubost A, Joos A.

Ther Innov Regul Sci. 2018 Sep;52(5):606-628. doi: 10.1177/2168479017753129. Epub 2018 Feb 5.


Early Stage HER2-Positive Breast Cancers Not Achieving a pCR From Neoadjuvant Trastuzumab- or Pertuzumab-Based Regimens Have an Immunosuppressive Phenotype.

Force J, Howie LJ, Abbott SE, Bentley R, Marcom PK, Kimmick G, Westbrook K, Sammons SL, Parks M, Topping DL, Emerson R, Broadwater G, Hyslop T, Blackwell KL, Nair SK.

Clin Breast Cancer. 2018 Oct;18(5):410-417. doi: 10.1016/j.clbc.2018.02.010. Epub 2018 Feb 24.


Molecular mechanisms underlying striatal synaptic plasticity: relevance to chronic alcohol consumption and seeking.

Blackwell KT, Salinas AG, Tewatia P, English B, Hellgren Kotaleski J, Lovinger DM.

Eur J Neurosci. 2019 Mar;49(6):768-783. doi: 10.1111/ejn.13919. Epub 2018 Apr 20.


The Global Need for a Trastuzumab Biosimilar for Patients With HER2-Positive Breast Cancer.

Blackwell K, Gligorov J, Jacobs I, Twelves C.

Clin Breast Cancer. 2018 Apr;18(2):95-113. doi: 10.1016/j.clbc.2018.01.006. Epub 2018 Feb 2. Review.


Safety Profile of Biosimilar Filgrastim (Zarzio/Zarxio): A Combined Analysis of Phase III Studies.

Harbeck N, Gascón P, Krendyukov A, Hoebel N, Gattu S, Blackwell K.

Oncologist. 2018 Apr;23(4):403-409. doi: 10.1634/theoncologist.2017-0348. Epub 2018 Jan 9.


Leptomeningeal disease: current diagnostic and therapeutic strategies.

Nayar G, Ejikeme T, Chongsathidkiet P, Elsamadicy AA, Blackwell KL, Clarke JM, Lad SP, Fecci PE.

Oncotarget. 2017 Aug 16;8(42):73312-73328. doi: 10.18632/oncotarget.20272. eCollection 2017 Sep 22. Review.


Association Between Targeted HER-2 Therapy and Breast Reconstruction Outcomes: A Propensity Score-Matched Analysis.

Shammas RL, Cho EH, Glener AD, Poveromo LP, Mundy LR, Greenup RA, Blackwell KL, Hollenbeck ST.

J Am Coll Surg. 2017 Dec;225(6):731-739.e1. doi: 10.1016/j.jamcollsurg.2017.08.023. Epub 2017 Oct 3.


Is lecture dead? A preliminary study of medical students' evaluation of teaching methods in the preclinical curriculum.

Zinski A, Blackwell KTCPW, Belue FM, Brooks WS.

Int J Med Educ. 2017 Sep 22;8:326-333. doi: 10.5116/ijme.59b9.5f40.


Intraosseous mucoepidermoid carcinoma: Outcome review.

Merna C, Kita A, Wester J, Diaz-Aguilar D, Goldstein JD, Palma Diaz F, Blackwell K, St John MA.

Laryngoscope. 2018 May;128(5):1083-1092. doi: 10.1002/lary.26832. Epub 2017 Aug 22. Review.


β-adrenergic signaling broadly contributes to LTP induction.

Jȩdrzejewska-Szmek J, Luczak V, Abel T, Blackwell KT.

PLoS Comput Biol. 2017 Jul 24;13(7):e1005657. doi: 10.1371/journal.pcbi.1005657. eCollection 2017 Jul.


Neratinib Efficacy and Circulating Tumor DNA Detection of HER2 Mutations in HER2 Nonamplified Metastatic Breast Cancer.

Ma CX, Bose R, Gao F, Freedman RA, Telli ML, Kimmick G, Winer E, Naughton M, Goetz MP, Russell C, Tripathy D, Cobleigh M, Forero A, Pluard TJ, Anders C, Niravath PA, Thomas S, Anderson J, Bumb C, Banks KC, Lanman RB, Bryce R, Lalani AS, Pfeifer J, Hayes DF, Pegram M, Blackwell K, Bedard PL, Al-Kateb H, Ellis MJC.

Clin Cancer Res. 2017 Oct 1;23(19):5687-5695. doi: 10.1158/1078-0432.CCR-17-0900. Epub 2017 Jul 5.


Pooled analysis of two randomized, double-blind trials comparing proposed biosimilar LA-EP2006 with reference pegfilgrastim in breast cancer.

Blackwell K, Gascon P, Jones CM, Nixon A, Krendyukov A, Nakov R, Li Y, Harbeck N.

Ann Oncol. 2017 Sep 1;28(9):2272-2277. doi: 10.1093/annonc/mdx303.


Trastuzumab emtansine versus capecitabine plus lapatinib in patients with previously treated HER2-positive advanced breast cancer (EMILIA): a descriptive analysis of final overall survival results from a randomised, open-label, phase 3 trial.

Diéras V, Miles D, Verma S, Pegram M, Welslau M, Baselga J, Krop IE, Blackwell K, Hoersch S, Xu J, Green M, Gianni L.

Lancet Oncol. 2017 Jun;18(6):732-742. doi: 10.1016/S1470-2045(17)30312-1. Epub 2017 May 16. Erratum in: Lancet Oncol. 2017 Aug;18(8):e433. Erratum in: Lancet Oncol. 2018 Dec;19(12):e667.


Education and training of clinical and translational study investigators and research coordinators: A competency-based approach.

Calvin-Naylor NA, Jones CT, Wartak MM, Blackwell K, Davis JM, Divecha R, Ellerbeck EF, Kieburtz K, Koziel MJ, Luzuriaga K, Maddox J, Needler NA, Murphy S, Pemberton K, Radovich C, Rubinstein EP, Selker HP, Tenaerts P, Unsworth K, Wilson K, Wright JE, Barohn R, Shanley TP.

J Clin Transl Sci. 2017 Feb;1(1):16-25. doi: 10.1017/cts.2016.2. Epub 2017 Jan 13.


Biopsy of enlarging lesions after stereotactic radiosurgery for brain metastases frequently reveals radiation necrosis.

Narloch JL, Farber SH, Sammons S, McSherry F, Herndon JE, Hoang JK, Yin FF, Sampson JH, Fecci PE, Blackwell KL, Kirkpatrick JP, Kim GJ.

Neuro Oncol. 2017 Oct 1;19(10):1391-1397. doi: 10.1093/neuonc/nox090.


Proposed biosimilar pegfilgrastim (LA-EP2006) compared with reference pegfilgrastim in Asian patients with breast cancer: an exploratory comparison from two Phase III trials.

Harbeck N, Gascon P, Jones CM, Nixon A, Krendyukov A, Nakov R, Li Y, Blackwell K.

Future Oncol. 2017 Jul;13(16):1385-1393. doi: 10.2217/fon-2017-0041. Epub 2017 Apr 28.


Long-term plasticity of corticostriatal synapses is modulated by pathway-specific co-release of opioids through κ-opioid receptors.

Hawes SL, Salinas AG, Lovinger DM, Blackwell KT.

J Physiol. 2017 Aug 15;595(16):5637-5652. doi: 10.1113/JP274190. Epub 2017 May 26.


HR+, HER2- Advanced Breast Cancer and CDK4/6 Inhibitors: Mode of Action, Clinical Activity, and Safety Profiles.

Sammons SL, Topping DL, Blackwell KL.

Curr Cancer Drug Targets. 2017;17(7):637-649. doi: 10.2174/1568009617666170330120452. Review.


Phase II, randomized, placebo-controlled study of dovitinib in combination with fulvestrant in postmenopausal patients with HR+, HER2- breast cancer that had progressed during or after prior endocrine therapy.

Musolino A, Campone M, Neven P, Denduluri N, Barrios CH, Cortes J, Blackwell K, Soliman H, Kahan Z, Bonnefoi H, Squires M, Zhang Y, Deudon S, Shi MM, André F.

Breast Cancer Res. 2017 Feb 10;19(1):18. doi: 10.1186/s13058-017-0807-8.


Three novel ANO5 missense mutations in Caucasian and Chinese families and sporadic cases with gnathodiaphyseal dysplasia.

Jin L, Liu Y, Sun F, Collins MT, Blackwell K, Woo AS, Reichenberger EJ, Hu Y.

Sci Rep. 2017 Feb 8;7:40935. doi: 10.1038/srep40935.


PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.

Anderson GR, Wardell SE, Cakir M, Crawford L, Leeds JC, Nussbaum DP, Shankar PS, Soderquist RS, Stein EM, Tingley JP, Winter PS, Zieser-Misenheimer EK, Alley HM, Yllanes A, Haney V, Blackwell KL, McCall SJ, McDonnell DP, Wood KC.

Sci Transl Med. 2016 Dec 14;8(369):369ra175.


Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer.

Hortobagyi GN, Stemmer SM, Burris HA, Yap YS, Sonke GS, Paluch-Shimon S, Campone M, Blackwell KL, André F, Winer EP, Janni W, Verma S, Conte P, Arteaga CL, Cameron DA, Petrakova K, Hart LL, Villanueva C, Chan A, Jakobsen E, Nusch A, Burdaeva O, Grischke EM, Alba E, Wist E, Marschner N, Favret AM, Yardley D, Bachelot T, Tseng LM, Blau S, Xuan F, Souami F, Miller M, Germa C, Hirawat S, O'Shaughnessy J.

N Engl J Med. 2016 Nov 3;375(18):1738-1748. Epub 2016 Oct 7. Erratum in: N Engl J Med. 2018 Dec 27;379(26):2582.


Stop! border ahead: Automatic detection of subthalamic exit during deep brain stimulation surgery.

Valsky D, Marmor-Levin O, Deffains M, Eitan R, Blackwell KT, Bergman H, Israel Z.

Mov Disord. 2017 Jan;32(1):70-79. doi: 10.1002/mds.26806. Epub 2016 Oct 6.


Embracing rejection: Immunologic trends in brain metastasis.

Farber SH, Tsvankin V, Narloch JL, Kim GJ, Salama AK, Vlahovic G, Blackwell KL, Kirkpatrick JP, Fecci PE.

Oncoimmunology. 2016 Apr 11;5(7):e1172153. doi: 10.1080/2162402X.2016.1172153. eCollection 2016 Jul. Review.


Dendritic diameter influences the rate and magnitude of hippocampal cAMP and PKA transients during β-adrenergic receptor activation.

Luczak V, Blackwell KT, Abel T, Girault JA, Gervasi N.

Neurobiol Learn Mem. 2017 Feb;138:10-20. doi: 10.1016/j.nlm.2016.08.006. Epub 2016 Aug 12.


Calcium dynamics predict direction of synaptic plasticity in striatal spiny projection neurons.

Jędrzejewska-Szmek J, Damodaran S, Dorman DB, Blackwell KT.

Eur J Neurosci. 2017 Apr;45(8):1044-1056. doi: 10.1111/ejn.13287. Epub 2016 Jun 15.


TBCRC-010: Phase I/II Study of Dasatinib in Combination with Zoledronic Acid for the Treatment of Breast Cancer Bone Metastasis.

Mitri Z, Nanda R, Blackwell K, Costelloe CM, Hood I, Wei C, Brewster AM, Ibrahim NK, Koenig KB, Hortobagyi GN, Van Poznak C, Rimawi MF, Moulder-Thompson S; Translational Breast Cancer Research Consortium.

Clin Cancer Res. 2016 Dec 1;22(23):5706-5712. Epub 2016 May 10.


Crowdsourcing medical education.

Blackwell KA, Travis MJ, Arbuckle MR, Ross DA.

Med Educ. 2016 May;50(5):576. doi: 10.1111/medu.13010. No abstract available.

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