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Clinical benefit of methotrexate plus vinorelbine chemotherapy for desmoid fibromatosis (DF) and correlation of treatment response with MRI.

Ingley KM, Burtenshaw SM, Theobalds NC, White LM, Blackstein ME, Gladdy RA, Thipphavong S, Gupta AA.

Cancer Med. 2019 Sep;8(11):5047-5057. doi: 10.1002/cam4.2374. Epub 2019 Jul 13.


Clinical outcomes in breast angiosarcoma patients: A rare tumor with unique challenges.

Gervais MK, Burtenshaw SM, Maxwell J, Dickson BC, Catton CN, Blackstein M, McCready D, Escallon J, Gladdy RA.

J Surg Oncol. 2017 Dec;116(8):1056-1061. doi: 10.1002/jso.24780. Epub 2017 Dec 4.


Correlation of Long-term Results of Imatinib in Advanced Gastrointestinal Stromal Tumors With Next-Generation Sequencing Results: Analysis of Phase 3 SWOG Intergroup Trial S0033.

Heinrich MC, Rankin C, Blanke CD, Demetri GD, Borden EC, Ryan CW, von Mehren M, Blackstein ME, Priebat DA, Tap WD, Maki RG, Corless CL, Fletcher JA, Owzar K, Crowley JJ, Benjamin RS, Baker LH.

JAMA Oncol. 2017 Jul 1;3(7):944-952. doi: 10.1001/jamaoncol.2016.6728. Erratum in: JAMA Oncol. 2017 Jul 1;3(7):1002.


Clinical features and outcomes of 20 patients with abdominopelvic desmoplastic small round cell tumor.

Angarita FA, Hassan S, Cannell AJ, Dickson BC, Gladdy RA, Swallow CJ, Gupta A, Blackstein ME, McCart JA.

Eur J Surg Oncol. 2017 Feb;43(2):423-431. doi: 10.1016/j.ejso.2016.08.017. Epub 2016 Oct 4.


Results of Resection for Recurrent or Residual Retroperitoneal Sarcoma After Failed Primary Treatment.

Hamilton TD, Cannell AJ, Kim M, Catton CN, Blackstein ME, Dickson BC, Gladdy RA, Swallow CJ.

Ann Surg Oncol. 2017 Jan;24(1):211-218. doi: 10.1245/s10434-016-5523-6. Epub 2016 Aug 23.


Histopathologic Features of Prognostic Significance in High-Grade Osteosarcoma.

Chui MH, Kandel RA, Wong M, Griffin AM, Bell RS, Blackstein ME, Wunder JS, Dickson BC.

Arch Pathol Lab Med. 2016 Aug 23. [Epub ahead of print]


Toward Observation as First-line Management in Abdominal Desmoid Tumors.

Burtenshaw SM, Cannell AJ, McAlister ED, Siddique S, Kandel R, Blackstein ME, Swallow CJ, Gladdy RA.

Ann Surg Oncol. 2016 Jul;23(7):2212-9. doi: 10.1245/s10434-016-5159-6. Epub 2016 Mar 28.


Efficacy of denosumab in joint preservation for patients with giant cell tumour of the bone.

Traub F, Singh J, Dickson BC, Leung S, Mohankumar R, Blackstein ME, Razak AR, Griffin AM, Ferguson PC, Wunder JS.

Eur J Cancer. 2016 May;59:1-12. doi: 10.1016/j.ejca.2016.01.006. Epub 2016 Mar 15.


Trabectedin for inoperable or recurrent soft tissue sarcoma in adult patients: a retrospective cohort study.

Angarita FA, Cannell AJ, Abdul Razak AR, Dickson BC, Blackstein ME.

BMC Cancer. 2016 Jan 19;16:30. doi: 10.1186/s12885-016-2054-2.


The GOLD ReGISTry: a Global, Prospective, Observational Registry Collecting Longitudinal Data on Patients with Advanced and Localised Gastrointestinal Stromal Tumours.

Barrios CH, Blackstein ME, Blay JY, Casali PG, Chacon M, Gu J, Kang YK, Nishida T, Purkayastha D, Woodman RC, Reichardt P.

Eur J Cancer. 2015 Nov;51(16):2423-33. doi: 10.1016/j.ejca.2015.07.010. Epub 2015 Aug 3.


Pathologic and molecular features correlate with long-term outcome after adjuvant therapy of resected primary GI stromal tumor: the ACOSOG Z9001 trial.

Corless CL, Ballman KV, Antonescu CR, Kolesnikova V, Maki RG, Pisters PW, Blackstein ME, Blanke CD, Demetri GD, Heinrich MC, von Mehren M, Patel S, McCarter MD, Owzar K, DeMatteo RP.

J Clin Oncol. 2014 May 20;32(15):1563-70. doi: 10.1200/JCO.2013.51.2046. Epub 2014 Mar 17. Erratum in: J Clin Oncol. 2014 Oct 20;32(30):3462.


Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial.

Demetri GD, Reichardt P, Kang YK, Blay JY, Rutkowski P, Gelderblom H, Hohenberger P, Leahy M, von Mehren M, Joensuu H, Badalamenti G, Blackstein M, Le Cesne A, Schöffski P, Maki RG, Bauer S, Nguyen BB, Xu J, Nishida T, Chung J, Kappeler C, Kuss I, Laurent D, Casali PG; GRID study investigators.

Lancet. 2013 Jan 26;381(9863):295-302. doi: 10.1016/S0140-6736(12)61857-1. Epub 2012 Nov 22.


Topotecan and cyclophosphamide in adults with relapsed sarcoma.

Blanchette P, Hogg D, Ferguson P, Wunder JS, Swallow C, Gladdy R, Chung P, O'Sullivan B, Blackstein ME, Catton C, Gupta AA.

Sarcoma. 2012;2012:749067. doi: 10.1155/2012/749067. Epub 2012 Jul 18.


A thematic review of scientific and family interests in Canavan Disease: where are the developmentalists?

Glicksman S, Borgen C, Blackstein M, Gordon A, Hanon I, Kusin D, Leibowitz B, Halle J.

J Intellect Disabil Res. 2013 Sep;57(9):815-25. doi: 10.1111/j.1365-2788.2012.01576.x. Epub 2012 Jun 8. Review.


Axial Skeletal Location Predicts Poor Outcome in Ewing's Sarcoma: A Single Institution Experience.

Weiss KR, Biau DJ, Bhumbra R, Griffin AM, Blackstein ME, Chung P, Catton C, O'Sullivan B, Ferguson PC, Wunder JS.

Sarcoma. 2011;2011:395180. doi: 10.1155/2011/395180. Epub 2011 Nov 24.


Clinical features, treatment, and outcome in 102 adult and pediatric patients with localized high-grade synovial sarcoma.

Al-Hussaini H, Hogg D, Blackstein ME, O'Sullivan B, Catton CN, Chung PW, Griffin AM, Hodgson D, Hopyan S, Kandel R, Ferguson PC, Wunder JS, Gupta AA.

Sarcoma. 2011;2011:231789. doi: 10.1155/2011/231789. Epub 2011 Apr 14.


Perspective on updated treatment guidelines for patients with gastrointestinal stromal tumors.

Blay JY, von Mehren M, Blackstein ME.

Cancer. 2010 Nov 15;116(22):5126-37. doi: 10.1002/cncr.25267. Review.


Clinical outcome of children and adults with localized Ewing sarcoma: impact of chemotherapy dose and timing of local therapy.

Gupta AA, Pappo A, Saunders N, Hopyan S, Ferguson P, Wunder J, O'Sullivan B, Catton C, Greenberg M, Blackstein M.

Cancer. 2010 Jul 1;116(13):3189-94. doi: 10.1002/cncr.25144.


Painful palatal swelling.

Klieb HB, Duchnay M, Skeete D, Leong IT, Blackstein ME.

Lancet. 2010 Apr 3;375(9721):1224. doi: 10.1016/S0140-6736(10)60053-0. No abstract available.


Circulating levels of soluble KIT serve as a biomarker for clinical outcome in gastrointestinal stromal tumor patients receiving sunitinib following imatinib failure.

Deprimo SE, Huang X, Blackstein ME, Garrett CR, Harmon CS, Schöffski P, Shah MH, Verweij J, Baum CM, Demetri GD.

Clin Cancer Res. 2009 Sep 15;15(18):5869-77. doi: 10.1158/1078-0432.CCR-08-2480. Epub 2009 Sep 8.


Limitations of single slice dynamic contrast enhanced MR in pharmacokinetic modeling of bone sarcomas.

Toms AP, White LM, Kandel R, Bleakney RR, Noseworthy M, Lee S, Blackstein ME, Wunder J.

Acta Radiol. 2009 Jun;50(5):512-20. doi: 10.1080/02841850902922761.


Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial.

Dematteo RP, Ballman KV, Antonescu CR, Maki RG, Pisters PW, Demetri GD, Blackstein ME, Blanke CD, von Mehren M, Brennan MF, Patel S, McCarter MD, Polikoff JA, Tan BR, Owzar K; American College of Surgeons Oncology Group (ACOSOG) Intergroup Adjuvant GIST Study Team.

Lancet. 2009 Mar 28;373(9669):1097-104. doi: 10.1016/S0140-6736(09)60500-6. Epub 2009 Mar 18. Erratum in: Lancet. 2009 Aug 8;374(9688):450.


Osteosarcoma in adolescents and adults: survival analysis with and without lung metastases.

Aljubran AH, Griffin A, Pintilie M, Blackstein M.

Ann Oncol. 2009 Jun;20(6):1136-41. doi: 10.1093/annonc/mdn731. Epub 2009 Jan 19.


Rectal gastrointestinal stromal tumor mimicking a primary prostatic lesion.

Dickson BC, Srigley JR, Pollett AF, Blackstein ME, Honey JD, Juco JW.

Can J Urol. 2008 Jun;15(3):4112-4.


A Phase II Study of Docetaxel in Chemotherapy-Naïve Patients With Recurrent or Metastatic Adult Soft Tissue Sarcoma.

Bramwell V, Blackstein M, Belanger K, Verma S, Beare S, Eisenhauer E.

Sarcoma. 1998;2(1):29-33. doi: 10.1080/13577149878136.


Dose-intensive chemotherapy with growth factor or autologous bone marrow or stem-cell transplant support in first-line treatment of advanced or metastatic adult soft tissue sarcoma: a clinical practice guideline.

Verma S, Younus J, Haynes AE, Stys-Norman D, Blackstein M; Sarcoma Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care.

Curr Oncol. 2008 Apr;15(2):80-4.


The challenge of conducting pharmacoeconomic evaluations in oncology using crossover trials: the example of sunitinib for gastrointestinal stromal tumour.

Chabot I, LeLorier J, Blackstein ME.

Eur J Cancer. 2008 May;44(7):972-7. doi: 10.1016/j.ejca.2008.02.041. Epub 2008 Mar 26.


Meta-analysis of ifosfamide-based combination chemotherapy in advanced soft tissue sarcoma.

Verma S, Younus J, Stys-Norman D, Haynes AE, Blackstein M; Members of the Sarcoma Disease Site Group of Cancer Care Ontario's Program in Evidence-Based Care.

Cancer Treat Rev. 2008 Jun;34(4):339-47. doi: 10.1016/j.ctrv.2008.01.005. Epub 2008 Mar 3.


Dose-intensive chemotherapy with growth factor or autologous bone marrow/stem cell transplant support in first-line treatment of advanced or metastatic adult soft tissue sarcoma: a systematic review.

Verma S, Younus J, Stys-Norman D, Haynes AE, Blackstein M; Sarcoma Disease Site Group of Cancer Care Ontario's Program in Evidence-based Care.

Cancer. 2008 Mar 15;112(6):1197-205. doi: 10.1002/cncr.23302. Review.


Spontaneous atherosclerosis in aged lipoprotein lipase-deficient mice with severe hypertriglyceridemia on a normal chow diet.

Zhang X, Qi R, Xian X, Yang F, Blackstein M, Deng X, Fan J, Ross C, Karasinska J, Hayden MR, Liu G.

Circ Res. 2008 Feb 1;102(2):250-6. Epub 2007 Nov 21.


A dose escalation trial of adjuvant cyclophosphamide and epirubicin in combination with 5-fluorouracil using G-CSF support for premenopausal women with breast cancer involving four or more positive nodes.

Findlay B, Tonkin K, Crump M, Norris B, Trudeau M, Blackstein M, Burnell M, Skillings J, Bowman D, Walde D, Levine M, Pritchard KI, Palmer MJ, Tu D, Shepherd L.

Ann Oncol. 2007 Oct;18(10):1646-51. Epub 2007 Aug 22.


Ifosfamide-based combination chemotherapy in advanced soft-tissue sarcoma: a practice guideline.

Verma S, Younus J, Stys-Norman D, Haynes AE, Blackstein M.

Curr Oncol. 2007 Aug;14(4):144-8.


A Phase II Study of Flavopiridol in Patients With Previously Untreated Advanced Soft Tissue Sarcoma.

Morris DG, Bramwell VH, Turcotte R, Figueredo AT, Blackstein ME, Verma S, Matthews S, Eisenhauer EA.

Sarcoma. 2006;2006:64374.


Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial.

Demetri GD, van Oosterom AT, Garrett CR, Blackstein ME, Shah MH, Verweij J, McArthur G, Judson IR, Heinrich MC, Morgan JA, Desai J, Fletcher CD, George S, Bello CL, Huang X, Baum CM, Casali PG.

Lancet. 2006 Oct 14;368(9544):1329-38.


Gastrointestinal stromal tumours: consensus statement on diagnosis and treatment.

Blackstein ME, Blay JY, Corless C, Driman DK, Riddell R, Soulières D, Swallow CJ, Verma S; Canadian Advisory Committee on GIST.

Can J Gastroenterol. 2006 Mar;20(3):157-63.


A phase II study of perifosine (D-21226) in patients with previously untreated metastatic or locally advanced soft tissue sarcoma: A National Cancer Institute of Canada Clinical Trials Group trial.

Knowling M, Blackstein M, Tozer R, Bramwell V, Dancey J, Dore N, Matthews S, Eisenhauer E.

Invest New Drugs. 2006 Sep;24(5):435-9.


Histologic assessment of peritumoral edema in soft tissue sarcoma.

White LM, Wunder JS, Bell RS, O'Sullivan B, Catton C, Ferguson P, Blackstein M, Kandel RA.

Int J Radiat Oncol Biol Phys. 2005 Apr 1;61(5):1439-45.


Induction chemotherapy with mitomycin, vindesine, and cisplatin for stage IIIA (T1-3, N2) unresectable non-small-cell lung cancer: final results of the Toronto phase II trial.

Burkes RL, Shepherd FA, Blackstein ME, Goldberg ME, Waters PF, Patterson GA, Todd T, Pearson FG, Jones D, Farooq S, McGlaughlin J, Ginsberg RJ.

Lung Cancer. 2005 Jan;47(1):103-9.


Bone marrow metastasis of angiosarcoma.

Wang C, Rabah R, Blackstein M, Riddell RH.

Pathol Res Pract. 2004;200(7-8):551-5. Review.


Gastrointestinal stromal tumours: etiology, pathology and clinical management.

Blackstein ME, Dubé P, Fletcher JA, Keller OR, Knowling M, Létourneau R, Morris D, Riddell R, Rorke S, Swallow CJ; Canadian Advisory Committee on GIST.

Can J Gastroenterol. 2004 Sep;18 Suppl B:3B-8B. Review.


Lymph node metastasis in soft tissue sarcoma in an extremity.

Riad S, Griffin AM, Liberman B, Blackstein ME, Catton CN, Kandel RA, O'Sullivan B, White LM, Bell RS, Ferguson PC, Wunder JS.

Clin Orthop Relat Res. 2004 Sep;(426):129-34.


The combination of p53 mutation and neu/erbB-2 amplification is associated with poor survival in node-negative breast cancer.

Bull SB, Ozcelik H, Pinnaduwage D, Blackstein ME, Sutherland DA, Pritchard KI, Tzontcheva AT, Sidlofsky S, Hanna WM, Qizilbash AH, Tweeddale ME, Fine S, McCready DR, Andrulis IL.

J Clin Oncol. 2004 Jan 1;22(1):86-96.


Safety and efficacy of the multidrug-resistance inhibitor biricodar (VX-710) with concurrent doxorubicin in patients with anthracycline-resistant advanced soft tissue sarcoma.

Bramwell VH, Morris D, Ernst DS, Hings I, Blackstein M, Venner PM, Ette EI, Harding MW, Waxman A, Demetri GD.

Clin Cancer Res. 2002 Feb;8(2):383-93.


Gemcitabine as first-line therapy in patients with metastatic breast cancer: a phase II trial.

Blackstein M, Vogel CL, Ambinder R, Cowan J, Iglesias J, Melemed A.

Oncology. 2002;62(1):2-8.


Extended follow-up of patients treated with cytotoxic chemotherapy for intra-abdominal desmoid tumors.

Poritz LS, Blackstein M, Berk T, Gallinger S, McLeod RS, Cohen Z.

Dis Colon Rectum. 2001 Sep;44(9):1268-73.


Comparison of HER2/neu status assessed by quantitative polymerase chain reaction and immunohistochemistry.

O'Malley FP, Parkes R, Latta E, Tjan S, Zadro T, Mueller R, Arneson N, Blackstein M, Andrulis I.

Am J Clin Pathol. 2001 Apr;115(4):504-11.


Liarozole fumarate (R85246): in the treatment of ER negative, tamoxifen refractory or chemotherapy resistant postmenopausal metastatic breast cancer.

Goss PE, Strasser K, Marques R, Clemons M, Oza A, Goel R, Blackstein M, Kaizer L, Sterns EE, Nabholtz JM, De Coster R, Crump M, Abdolell M, Qi S.

Breast Cancer Res Treat. 2000 Nov;64(2):177-88.


Development of tertiary hyperparathyroidism after phosphate supplementation in oncogenic osteomalacia.

Huang QL, Feig DS, Blackstein ME.

J Endocrinol Invest. 2000 Apr;23(4):263-7.


Randomized phase II study of high-dose paclitaxel with or without amifostine in patients with metastatic breast cancer.

Gelmon K, Eisenhauer E, Bryce C, Tolcher A, Mayer L, Tomlinson E, Zee B, Blackstein M, Tomiak E, Yau J, Batist G, Fisher B, Iglesias J.

J Clin Oncol. 1999 Oct;17(10):3038-47.


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