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Items: 36


Blocking NMDAR Disrupts Spike Timing and Decouples Monkey Prefrontal Circuits: Implications for Activity-Dependent Disconnection in Schizophrenia.

Zick JL, Blackman RK, Crowe DA, Amirikian B, DeNicola AL, Netoff TI, Chafee MV.

Neuron. 2018 Jun 27;98(6):1243-1255.e5. doi: 10.1016/j.neuron.2018.05.010. Epub 2018 May 31.


Monkey Prefrontal Neurons Reflect Logical Operations for Cognitive Control in a Variant of the AX Continuous Performance Task (AX-CPT).

Blackman RK, Crowe DA, DeNicola AL, Sakellaridi S, MacDonald AW 3rd, Chafee MV.

J Neurosci. 2016 Apr 6;36(14):4067-79. doi: 10.1523/JNEUROSCI.3578-15.2016.


Prefrontal neurons transmit signals to parietal neurons that reflect executive control of cognition.

Crowe DA, Goodwin SJ, Blackman RK, Sakellaridi S, Sponheim SR, MacDonald AW 3rd, Chafee MV.

Nat Neurosci. 2013 Oct;16(10):1484-91. doi: 10.1038/nn.3509. Epub 2013 Sep 1.


Effects of ketamine on context-processing performance in monkeys: a new animal model of cognitive deficits in schizophrenia.

Blackman RK, Macdonald AW 3rd, Chafee MV.

Neuropsychopharmacology. 2013 Oct;38(11):2090-100. doi: 10.1038/npp.2013.118. Epub 2013 May 10.


The 3rd Schizophrenia International Research Society Conference, 14-18 April 2012, Florence, Italy: summaries of oral sessions.

Abbs B, Achalia RM, Adelufosi AO, Aktener AY, Beveridge NJ, Bhakta SG, Blackman RK, Bora E, Byun MS, Cabanis M, Carrion R, Castellani CA, Chow TJ, Dmitrzak-Weglarz M, Gayer-Anderson C, Gomes FV, Haut K, Hori H, Kantrowitz JT, Kishimoto T, Lee FH, Lin A, Palaniyappan L, Quan M, Rubio MD, Ruiz de Azúa S, Sahoo S, Strauss GP, Szczepankiewicz A, Thompson AD, Trotta A, Tully LM, Uchida H, Velthorst E, Young JW, O'Shea A, Delisi LE.

Schizophr Res. 2012 Oct;141(1):e1-e24. doi: 10.1016/j.schres.2012.07.024. Epub 2012 Aug 19.


The oncology drug elesclomol selectively transports copper to the mitochondria to induce oxidative stress in cancer cells.

Nagai M, Vo NH, Shin Ogawa L, Chimmanamada D, Inoue T, Chu J, Beaudette-Zlatanova BC, Lu R, Blackman RK, Barsoum J, Koya K, Wada Y.

Free Radic Biol Med. 2012 May 15;52(10):2142-50. doi: 10.1016/j.freeradbiomed.2012.03.017. Epub 2012 Apr 17.


Executive control over cognition: stronger and earlier rule-based modulation of spatial category signals in prefrontal cortex relative to parietal cortex.

Goodwin SJ, Blackman RK, Sakellaridi S, Chafee MV.

J Neurosci. 2012 Mar 7;32(10):3499-515. doi: 10.1523/JNEUROSCI.3585-11.2012.


Mitochondrial electron transport is the cellular target of the oncology drug elesclomol.

Blackman RK, Cheung-Ong K, Gebbia M, Proia DA, He S, Kepros J, Jonneaux A, Marchetti P, Kluza J, Rao PE, Wada Y, Giaever G, Nislow C.

PLoS One. 2012;7(1):e29798. doi: 10.1371/journal.pone.0029798. Epub 2012 Jan 11.


Synergistic activity of the Hsp90 inhibitor ganetespib with taxanes in non-small cell lung cancer models.

Proia DA, Sang J, He S, Smith DL, Sequeira M, Zhang C, Liu Y, Ye S, Zhou D, Blackman RK, Foley KP, Koya K, Wada Y.

Invest New Drugs. 2012 Dec;30(6):2201-9. doi: 10.1007/s10637-011-9790-6. Epub 2012 Jan 10.


Ganetespib, a unique triazolone-containing Hsp90 inhibitor, exhibits potent antitumor activity and a superior safety profile for cancer therapy.

Ying W, Du Z, Sun L, Foley KP, Proia DA, Blackman RK, Zhou D, Inoue T, Tatsuta N, Sang J, Ye S, Acquaviva J, Ogawa LS, Wada Y, Barsoum J, Koya K.

Mol Cancer Ther. 2012 Feb;11(2):475-84. doi: 10.1158/1535-7163.MCT-11-0755. Epub 2011 Dec 5.


Multifaceted intervention by the Hsp90 inhibitor ganetespib (STA-9090) in cancer cells with activated JAK/STAT signaling.

Proia DA, Foley KP, Korbut T, Sang J, Smith D, Bates RC, Liu Y, Rosenberg AF, Zhou D, Koya K, Barsoum J, Blackman RK.

PLoS One. 2011 Apr 14;6(4):e18552. doi: 10.1371/journal.pone.0018552.


Heat shock protein 90 regulates the expression of Wilms tumor 1 protein in myeloid leukemias.

Bansal H, Bansal S, Rao M, Foley KP, Sang J, Proia DA, Blackman RK, Ying W, Barsoum J, Baer MR, Kelly K, Swords R, Tomlinson GE, Battiwalla M, Giles FJ, Lee KP, Padmanabhan S.

Blood. 2010 Nov 25;116(22):4591-9. doi: 10.1182/blood-2009-10-247239. Epub 2010 Jul 22.


Repeatability and reproducibility in proteomic identifications by liquid chromatography-tandem mass spectrometry.

Tabb DL, Vega-Montoto L, Rudnick PA, Variyath AM, Ham AJ, Bunk DM, Kilpatrick LE, Billheimer DD, Blackman RK, Cardasis HL, Carr SA, Clauser KR, Jaffe JD, Kowalski KA, Neubert TA, Regnier FE, Schilling B, Tegeler TJ, Wang M, Wang P, Whiteaker JR, Zimmerman LJ, Fisher SJ, Gibson BW, Kinsinger CR, Mesri M, Rodriguez H, Stein SE, Tempst P, Paulovich AG, Liebler DC, Spiegelman C.

J Proteome Res. 2010 Feb 5;9(2):761-76. doi: 10.1021/pr9006365.


Interlaboratory study characterizing a yeast performance standard for benchmarking LC-MS platform performance.

Paulovich AG, Billheimer D, Ham AJ, Vega-Montoto L, Rudnick PA, Tabb DL, Wang P, Blackman RK, Bunk DM, Cardasis HL, Clauser KR, Kinsinger CR, Schilling B, Tegeler TJ, Variyath AM, Wang M, Whiteaker JR, Zimmerman LJ, Fenyo D, Carr SA, Fisher SJ, Gibson BW, Mesri M, Neubert TA, Regnier FE, Rodriguez H, Spiegelman C, Stein SE, Tempst P, Liebler DC.

Mol Cell Proteomics. 2010 Feb;9(2):242-54. doi: 10.1074/mcp.M900222-MCP200. Epub 2009 Oct 26.


Performance metrics for liquid chromatography-tandem mass spectrometry systems in proteomics analyses.

Rudnick PA, Clauser KR, Kilpatrick LE, Tchekhovskoi DV, Neta P, Blonder N, Billheimer DD, Blackman RK, Bunk DM, Cardasis HL, Ham AJ, Jaffe JD, Kinsinger CR, Mesri M, Neubert TA, Schilling B, Tabb DL, Tegeler TJ, Vega-Montoto L, Variyath AM, Wang M, Wang P, Whiteaker JR, Zimmerman LJ, Carr SA, Fisher SJ, Gibson BW, Paulovich AG, Regnier FE, Rodriguez H, Spiegelman C, Tempst P, Liebler DC, Stein SE.

Mol Cell Proteomics. 2010 Feb;9(2):225-41. doi: 10.1074/mcp.M900223-MCP200. Epub 2009 Oct 16.


Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma.

Addona TA, Abbatiello SE, Schilling B, Skates SJ, Mani DR, Bunk DM, Spiegelman CH, Zimmerman LJ, Ham AJ, Keshishian H, Hall SC, Allen S, Blackman RK, Borchers CH, Buck C, Cardasis HL, Cusack MP, Dodder NG, Gibson BW, Held JM, Hiltke T, Jackson A, Johansen EB, Kinsinger CR, Li J, Mesri M, Neubert TA, Niles RK, Pulsipher TC, Ransohoff D, Rodriguez H, Rudnick PA, Smith D, Tabb DL, Tegeler TJ, Variyath AM, Vega-Montoto LJ, Wahlander A, Waldemarson S, Wang M, Whiteaker JR, Zhao L, Anderson NL, Fisher SJ, Liebler DC, Paulovich AG, Regnier FE, Tempst P, Carr SA.

Nat Biotechnol. 2009 Jul;27(7):633-41. doi: 10.1038/nbt.1546. Epub 2009 Jun 28. Erratum in: Nat Biotechnol. 2009 Sep;27(9):864.


Microarray approach for cloned library quality assessment and the comprehensive identification of positives from library screens.

Blackman RK, Amidon BS.

Biotechniques. 2004 Oct;37(4):536, 538, 540. No abstract available.


Biological characterization of MLN944: a potent DNA binding agent.

Sappal DS, McClendon AK, Fleming JA, Thoroddsen V, Connolly K, Reimer C, Blackman RK, Bulawa CE, Osheroff N, Charlton P, Rudolph-Owen LA.

Mol Cancer Ther. 2004 Jan;3(1):47-58.


Novel small-molecule inhibitors of RNA polymerase III.

Wu L, Pan J, Thoroddsen V, Wysong DR, Blackman RK, Bulawa CE, Gould AE, Ocain TD, Dick LR, Errada P, Dorr PK, Parkinson T, Wood T, Kornitzer D, Weissman Z, Willis IM, McGovern K.

Eukaryot Cell. 2003 Apr;2(2):256-64.


Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341.

Fleming JA, Lightcap ES, Sadis S, Thoroddsen V, Bulawa CE, Blackman RK.

Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1461-6.


The Drosophila decapentaplegic and short gastrulation genes function antagonistically during adult wing vein development.

Yu K, Sturtevant MA, Biehs B, François V, Padgett RW, Blackman RK, Bier E.

Development. 1996 Dec;122(12):4033-44.


Streamlined protocol for polytene chromosome in situ hybridization.

Blackman RK.

Biotechniques. 1996 Aug;21(2):226-228, 230. No abstract available.


Promoter specificity mediates the independent regulation of neighboring genes.

Merli C, Bergstrom DE, Cygan JA, Blackman RK.

Genes Dev. 1996 May 15;10(10):1260-70.


The TGF-beta signaling pathway is essential for Drosophila oogenesis.

Twombly V, Blackman RK, Jin H, Graff JM, Padgett RW, Gelbart WM.

Development. 1996 May;122(5):1555-65.


The tolkin gene is a tolloid/BMP-1 homologue that is essential for Drosophila development.

Finelli AL, Xie T, Bossie CA, Blackman RK, Padgett RW.

Genetics. 1995 Sep;141(1):271-81.


Regulatory autonomy and molecular characterization of the Drosophila out at first gene.

Bergstrom DE, Merli CA, Cygan JA, Shelby R, Blackman RK.

Genetics. 1995 Mar;139(3):1331-46.


Molecular organization of the decapentaplegic gene in Drosophila melanogaster.

St Johnston RD, Hoffmann FM, Blackman RK, Segal D, Grimaila R, Padgett RW, Irick HA, Gelbart WM.

Genes Dev. 1990 Jul;4(7):1114-27.


The hobo element of Drosophila melanogaster.

Gelbart WM, Blackman RK.

Prog Nucleic Acid Res Mol Biol. 1989;36:37-46. Review. No abstract available.


The decapentaplegic gene complex in Drosophila melanogaster.

Gelbart WM, Irish VF, St Johnston RD, Hoffmann FM, Blackman RK, Segal D, Posakony LM, Grimaila R.

Cold Spring Harb Symp Quant Biol. 1985;50:119-25. No abstract available.


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