Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 136

1.

Deletion of Plasmodium falciparum Protein RON3 Affects the Functional Translocation of Exported Proteins and Glucose Uptake.

Low LM, Azasi Y, Sherling ES, Garten M, Zimmerberg J, Tsuboi T, Brzostowski J, Mu J, Blackman MJ, Miller LH.

MBio. 2019 Jul 9;10(4). pii: e01460-19. doi: 10.1128/mBio.01460-19.

2.

Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.

El Bakkouri M, Kouidmi I, Wernimont AK, Amani M, Hutchinson A, Loppnau P, Kim JJ, Flueck C, Walker JR, Seitova A, Senisterra G, Kakihara Y, Kim C, Blackman MJ, Calmettes C, Baker DA, Hui R.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14164-14173. doi: 10.1073/pnas.1905558116. Epub 2019 Jun 25.

3.

Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery.

Patel A, Perrin AJ, Flynn HR, Bisson C, Withers-Martinez C, Treeck M, Flueck C, Nicastro G, Martin SR, Ramos A, Gilberger TW, Snijders AP, Blackman MJ, Baker DA.

PLoS Biol. 2019 May 10;17(5):e3000264. doi: 10.1371/journal.pbio.3000264. eCollection 2019 May.

4.

The Plasmodium berghei serine protease PbSUB1 plays an important role in male gamete egress.

Pace T, Grasso F, Camarda G, Suarez C, Blackman MJ, Ponzi M, Olivieri A.

Cell Microbiol. 2019 Jul;21(7):e13028. doi: 10.1111/cmi.13028. Epub 2019 Apr 29.

5.

Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion.

Flueck C, Drought LG, Jones A, Patel A, Perrin AJ, Walker EM, Nofal SD, Snijders AP, Blackman MJ, Baker DA.

PLoS Biol. 2019 Feb 22;17(2):e3000154. doi: 10.1371/journal.pbio.3000154. eCollection 2019 Feb.

6.

Peptidomimetic plasmepsin inhibitors with potent anti-malarial activity and selectivity against cathepsin D.

Zogota R, Kinena L, Withers-Martinez C, Blackman MJ, Bobrovs R, Pantelejevs T, Kanepe-Lapsa I, Ozola V, Jaudzems K, Suna E, Jirgensons A.

Eur J Med Chem. 2019 Feb 1;163:344-352. doi: 10.1016/j.ejmech.2018.11.068. Epub 2018 Nov 29.

7.

Essentiality of Plasmodium falciparum plasmepsin V.

Boonyalai N, Collins CR, Hackett F, Withers-Martinez C, Blackman MJ.

PLoS One. 2018 Dec 5;13(12):e0207621. doi: 10.1371/journal.pone.0207621. eCollection 2018.

8.

Correction: Essential role of Plasmodium perforin-like protein 4 in ookinete midgut passage.

Deligianni E, Silmon de Monerri NC, McMillan PJ, Bertuccini L, Superti F, Manola M, Spanos L, Louis C, Blackman MJ, Tilley L, Siden-Kiamos I.

PLoS One. 2018 Sep 12;13(9):e0204083. doi: 10.1371/journal.pone.0204083. eCollection 2018.

9.

Essential role of Plasmodium perforin-like protein 4 in ookinete midgut passage.

Deligianni E, Silmon de Monerri NC, McMillan PJ, Bertuccini L, Superti F, Manola M, Spanos L, Louis C, Blackman MJ, Tilley L, Siden-Kiamos I.

PLoS One. 2018 Aug 13;13(8):e0201651. doi: 10.1371/journal.pone.0201651. eCollection 2018. Erratum in: PLoS One. 2018 Sep 12;13(9):e0204083.

10.

The Actinomyosin Motor Drives Malaria Parasite Red Blood Cell Invasion but Not Egress.

Perrin AJ, Collins CR, Russell MRG, Collinson LM, Baker DA, Blackman MJ.

MBio. 2018 Jul 3;9(4). pii: e00905-18. doi: 10.1128/mBio.00905-18.

11.

Identification and validation of a novel panel of Plasmodium knowlesi biomarkers of serological exposure.

Herman LS, Fornace K, Phelan J, Grigg MJ, Anstey NM, William T, Moon RW, Blackman MJ, Drakeley CJ, Tetteh KKA.

PLoS Negl Trop Dis. 2018 Jun 14;12(6):e0006457. doi: 10.1371/journal.pntd.0006457. eCollection 2018 Jun.

12.

Publisher Correction: A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells.

Thomas JA, Tan MSY, Bisson C, Borg A, Umrekar TR, Hackett F, Hale VL, Vizcay-Barrena G, Fleck RA, Snijders AP, Saibil HR, Blackman MJ.

Nat Microbiol. 2018 Apr;3(4):523. doi: 10.1038/s41564-018-0134-6.

PMID:
29511275
13.

A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells.

Thomas JA, Tan MSY, Bisson C, Borg A, Umrekar TR, Hackett F, Hale VL, Vizcay-Barrena G, Fleck RA, Snijders AP, Saibil HR, Blackman MJ.

Nat Microbiol. 2018 Apr;3(4):447-455. doi: 10.1038/s41564-018-0111-0. Epub 2018 Feb 19. Erratum in: Nat Microbiol. 2018 Mar 6;:.

14.

A reference genome and methylome for the Plasmodium knowlesi A1-H.1 line.

Benavente ED, de Sessions PF, Moon RW, Grainger M, Holder AA, Blackman MJ, Roper C, Drakeley CJ, Pain A, Sutherland CJ, Hibberd ML, Campino S, Clark TG.

Int J Parasitol. 2018 Mar;48(3-4):191-196. doi: 10.1016/j.ijpara.2017.09.008. Epub 2017 Dec 16.

15.

A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress.

Pino P, Caldelari R, Mukherjee B, Vahokoski J, Klages N, Maco B, Collins CR, Blackman MJ, Kursula I, Heussler V, Brochet M, Soldati-Favre D.

Science. 2017 Oct 27;358(6362):522-528. doi: 10.1126/science.aaf8675.

16.

Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations.

Diez Benavente E, Florez de Sessions P, Moon RW, Holder AA, Blackman MJ, Roper C, Drakeley CJ, Pain A, Sutherland CJ, Hibberd ML, Campino S, Clark TG.

PLoS Genet. 2017 Sep 18;13(9):e1007008. doi: 10.1371/journal.pgen.1007008. eCollection 2017 Sep.

17.

The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes.

Collins CR, Hackett F, Atid J, Tan MSY, Blackman MJ.

PLoS Pathog. 2017 Jul 6;13(7):e1006453. doi: 10.1371/journal.ppat.1006453. eCollection 2017 Jul.

18.

Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress.

Hale VL, Watermeyer JM, Hackett F, Vizcay-Barrena G, van Ooij C, Thomas JA, Spink MC, Harkiolaki M, Duke E, Fleck RA, Blackman MJ, Saibil HR.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3439-3444. doi: 10.1073/pnas.1619441114. Epub 2017 Mar 14.

19.

The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake.

Sherling ES, Knuepfer E, Brzostowski JA, Miller LH, Blackman MJ, van Ooij C.

Elife. 2017 Mar 2;6. pii: e23239. doi: 10.7554/eLife.23239.

20.

Regulation and Essentiality of the StAR-related Lipid Transfer (START) Domain-containing Phospholipid Transfer Protein PFA0210c in Malaria Parasites.

Hill RJ, Ringel A, Knuepfer E, Moon RW, Blackman MJ, van Ooij C.

J Biol Chem. 2016 Nov 11;291(46):24280-24292. Epub 2016 Oct 2.

21.

Development and Application of a Simple Plaque Assay for the Human Malaria Parasite Plasmodium falciparum.

Thomas JA, Collins CR, Das S, Hackett F, Graindorge A, Bell D, Deu E, Blackman MJ.

PLoS One. 2016 Jun 22;11(6):e0157873. doi: 10.1371/journal.pone.0157873. eCollection 2016.

22.

Normocyte-binding protein required for human erythrocyte invasion by the zoonotic malaria parasite Plasmodium knowlesi.

Moon RW, Sharaf H, Hastings CH, Ho YS, Nair MB, Rchiad Z, Knuepfer E, Ramaprasad A, Mohring F, Amir A, Yusuf NA, Hall J, Almond N, Lau YL, Pain A, Blackman MJ, Holder AA.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7231-6. doi: 10.1073/pnas.1522469113. Epub 2016 Jun 14.

23.

A versatile strategy for rapid conditional genome engineering using loxP sites in a small synthetic intron in Plasmodium falciparum.

Jones ML, Das S, Belda H, Collins CR, Blackman MJ, Treeck M.

Sci Rep. 2016 Feb 19;6:21800. doi: 10.1038/srep21800.

24.

In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors.

Brogi S, Giovani S, Brindisi M, Gemma S, Novellino E, Campiani G, Blackman MJ, Butini S.

J Mol Graph Model. 2016 Mar;64:121-130. doi: 10.1016/j.jmgm.2016.01.005. Epub 2016 Jan 19.

25.

Fragment-Based Discovery of 2-Aminoquinazolin-4(3H)-ones As Novel Class Nonpeptidomimetic Inhibitors of the Plasmepsins I, II, and IV.

Rasina D, Otikovs M, Leitans J, Recacha R, Borysov OV, Kanepe-Lapsa I, Domraceva I, Pantelejevs T, Tars K, Blackman MJ, Jaudzems K, Jirgensons A.

J Med Chem. 2016 Jan 14;59(1):374-87. doi: 10.1021/acs.jmedchem.5b01558. Epub 2015 Dec 23.

PMID:
26670264
26.

A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum-infected erythrocytes.

Watermeyer JM, Hale VL, Hackett F, Clare DK, Cutts EE, Vakonakis I, Fleck RA, Blackman MJ, Saibil HR.

Blood. 2016 Jan 21;127(3):343-51. doi: 10.1182/blood-2015-10-674002. Epub 2015 Dec 4.

27.

Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs.

Das S, Hertrich N, Perrin AJ, Withers-Martinez C, Collins CR, Jones ML, Watermeyer JM, Fobes ET, Martin SR, Saibil HR, Wright GJ, Treeck M, Epp C, Blackman MJ.

Cell Host Microbe. 2015 Oct 14;18(4):433-44. doi: 10.1016/j.chom.2015.09.007.

28.

Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.

McConville M, Fernández J, Angulo-Barturen Í, Bahamontes-Rosa N, Ballell-Pages L, Castañeda P, de Cózar C, Crespo B, Guijarro L, Jiménez-Díaz MB, Martínez-Martínez MS, de Mercado J, Santos-Villarejo Á, Sanz LM, Frigerio M, Washbourn G, Ward SA, Nixon GL, Biagini GA, Berry NG, Blackman MJ, Calderón F, O'Neill PM.

J Med Chem. 2015 Aug 27;58(16):6448-55. doi: 10.1021/acs.jmedchem.5b00434. Epub 2015 Aug 17.

PMID:
26222445
29.

Conditional U1 Gene Silencing in Toxoplasma gondii.

Pieperhoff MS, Pall GS, Jiménez-Ruiz E, Das S, Melatti C, Gow M, Wong EH, Heng J, Müller S, Blackman MJ, Meissner M.

PLoS One. 2015 Jun 19;10(6):e0130356. doi: 10.1371/journal.pone.0130356. eCollection 2015.

30.

Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle.

Stallmach R, Kavishwar M, Withers-Martinez C, Hackett F, Collins CR, Howell SA, Yeoh S, Knuepfer E, Atid AJ, Holder AA, Blackman MJ.

Mol Microbiol. 2015 Apr;96(2):368-87. doi: 10.1111/mmi.12941. Epub 2015 Feb 11.

31.

Substrate derived peptidic α-ketoamides as inhibitors of the malarial protease PfSUB1.

Kher SS, Penzo M, Fulle S, Finn PW, Blackman MJ, Jirgensons A.

Bioorg Med Chem Lett. 2014 Sep 15;24(18):4486-4489. doi: 10.1016/j.bmcl.2014.07.086. Epub 2014 Aug 7.

32.

Rational design of the first difluorostatone-based PfSUB1 inhibitors.

Giovani S, Penzo M, Brogi S, Brindisi M, Gemma S, Novellino E, Savini L, Blackman MJ, Campiani G, Butini S.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3582-6. doi: 10.1016/j.bmcl.2014.05.044. Epub 2014 May 23.

PMID:
24909083
33.

Plasmepsin inhibitory activity and structure-guided optimization of a potent hydroxyethylamine-based antimalarial hit.

Jaudzems K, Tars K, Maurops G, Ivdra N, Otikovs M, Leitans J, Kanepe-Lapsa I, Domraceva I, Mutule I, Trapencieris P, Blackman MJ, Jirgensons A.

ACS Med Chem Lett. 2014 Jan 13;5(4):373-7. doi: 10.1021/ml4004952. eCollection 2014 Apr 10.

34.

The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin.

Withers-Martinez C, Strath M, Hackett F, Haire LF, Howell SA, Walker PA, Christodoulou E, Dodson GG, Blackman MJ.

Nat Commun. 2014 May 2;5:3726. doi: 10.1038/ncomms4726. Erratum in: Nat Commun. 2014;5:4031. Evangelos, Christodoulou [corrected to Christodoulou, Evangelos].

35.

Cyclic Nucleotide (cAMP and cGMP) Assays and Capture ELISA for Quantitative Analysis of Plasmodium falciparum Blood-stage Egress.

Hackett F, Collins CR, Strath M, Blackman MJ.

Bio Protoc. 2014 Mar 5;4(5). pii: e1055. doi: 10.21769/BioProtoc.1055.

36.

Human red blood cell-adapted Plasmodium knowlesi parasites: a new model system for malaria research.

Grüring C, Moon RW, Lim C, Holder AA, Blackman MJ, Duraisingh MT.

Cell Microbiol. 2014 May;16(5):612-20. doi: 10.1111/cmi.12275. Epub 2014 Mar 12. Review.

37.

The malarial serine protease SUB1 plays an essential role in parasite liver stage development.

Suarez C, Volkmann K, Gomes AR, Billker O, Blackman MJ.

PLoS Pathog. 2013;9(12):e1003811. doi: 10.1371/journal.ppat.1003811. Epub 2013 Dec 12.

38.

Identification of a Plasmodium falciparum phospholipid transfer protein.

van Ooij C, Withers-Martinez C, Ringel A, Cockcroft S, Haldar K, Blackman MJ.

J Biol Chem. 2013 Nov 1;288(44):31971-83. doi: 10.1074/jbc.M113.474189. Epub 2013 Sep 16.

39.

Molecular determinants for subcellular trafficking of the malarial sheddase PfSUB2.

Child MA, Harris PK, Collins CR, Withers-Martinez C, Yeoh S, Blackman MJ.

Traffic. 2013 Oct;14(10):1053-64. doi: 10.1111/tra.12092. Epub 2013 Jul 30.

40.

Recent insights into apicomplexan parasite egress provide new views to a kill.

Blackman MJ, Carruthers VB.

Curr Opin Microbiol. 2013 Aug;16(4):459-64. doi: 10.1016/j.mib.2013.04.008. Epub 2013 May 28. Review.

41.

Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress.

Collins CR, Hackett F, Strath M, Penzo M, Withers-Martinez C, Baker DA, Blackman MJ.

PLoS Pathog. 2013 May;9(5):e1003344. doi: 10.1371/journal.ppat.1003344. Epub 2013 May 9.

42.

Robust inducible Cre recombinase activity in the human malaria parasite Plasmodium falciparum enables efficient gene deletion within a single asexual erythrocytic growth cycle.

Collins CR, Das S, Wong EH, Andenmatten N, Stallmach R, Hackett F, Herman JP, Müller S, Meissner M, Blackman MJ.

Mol Microbiol. 2013 May;88(4):687-701. doi: 10.1111/mmi.12206. Epub 2013 Mar 26.

43.

A perforin-like protein mediates disruption of the erythrocyte membrane during egress of Plasmodium berghei male gametocytes.

Deligianni E, Morgan RN, Bertuccini L, Wirth CC, Silmon de Monerri NC, Spanos L, Blackman MJ, Louis C, Pradel G, Siden-Kiamos I.

Cell Microbiol. 2013 Aug;15(8):1438-55. doi: 10.1111/cmi.12131. Epub 2013 Mar 20.

PMID:
23461714
44.

Molecular determinants of binding to the Plasmodium subtilisin-like protease 1.

Fulle S, Withers-Martinez C, Blackman MJ, Morris GM, Finn PW.

J Chem Inf Model. 2013 Mar 25;53(3):573-83. doi: 10.1021/ci300581z. Epub 2013 Mar 4.

45.

Adaptation of the genetically tractable malaria pathogen Plasmodium knowlesi to continuous culture in human erythrocytes.

Moon RW, Hall J, Rangkuti F, Ho YS, Almond N, Mitchell GH, Pain A, Holder AA, Blackman MJ.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):531-6. doi: 10.1073/pnas.1216457110. Epub 2012 Dec 24.

46.

Proteolytic activation of the essential parasitophorous vacuole cysteine protease SERA6 accompanies malaria parasite egress from its host erythrocyte.

Ruecker A, Shea M, Hackett F, Suarez C, Hirst EM, Milutinovic K, Withers-Martinez C, Blackman MJ.

J Biol Chem. 2012 Nov 2;287(45):37949-63. doi: 10.1074/jbc.M112.400820. Epub 2012 Sep 14.

47.

Quinolylhydrazones as novel inhibitors of Plasmodium falciparum serine protease PfSUB1.

Gemma S, Giovani S, Brindisi M, Tripaldi P, Brogi S, Savini L, Fiorini I, Novellino E, Butini S, Campiani G, Penzo M, Blackman MJ.

Bioorg Med Chem Lett. 2012 Aug 15;22(16):5317-21. doi: 10.1016/j.bmcl.2012.06.023. Epub 2012 Jun 23.

PMID:
22796182
48.

Plasmodium subtilisin-like protease 1 (SUB1): insights into the active-site structure, specificity and function of a pan-malaria drug target.

Withers-Martinez C, Suarez C, Fulle S, Kher S, Penzo M, Ebejer JP, Koussis K, Hackett F, Jirgensons A, Finn P, Blackman MJ.

Int J Parasitol. 2012 May 15;42(6):597-612. doi: 10.1016/j.ijpara.2012.04.005. Epub 2012 Apr 27.

49.

Extracellular ATP triggers proteolysis and cytosolic Ca²⁺ rise in Plasmodium berghei and Plasmodium yoelii malaria parasites.

Cruz LN, Juliano MA, Budu A, Juliano L, Holder AA, Blackman MJ, Garcia CR.

Malar J. 2012 Mar 15;11:69. doi: 10.1186/1475-2875-11-69.

50.

Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies.

Olivieri A, Collins CR, Hackett F, Withers-Martinez C, Marshall J, Flynn HR, Skehel JM, Blackman MJ.

PLoS Pathog. 2011 Dec;7(12):e1002448. doi: 10.1371/journal.ppat.1002448. Epub 2011 Dec 15. Erratum in: PLoS Pathog. 2012 Feb;8(2). doi:10.1371/annotation/72b02b2e-460a-44f4-bc87-067cfe76bfdb.

Supplemental Content

Loading ...
Support Center