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Items: 1 to 50 of 131

1.

A Flow-Extension Tethered Particle Motion Assay for Single-Molecule Proteolysis.

Drabek AA, Loparo JJ, Blacklow SC.

Biochemistry. 2019 May 21;58(20):2509-2518. doi: 10.1021/acs.biochem.9b00106. Epub 2019 Apr 12.

PMID:
30946563
2.

Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes.

Rogers JM, Waters CT, Seegar TCM, Jarrett SM, Hallworth AN, Blacklow SC, Bulyk ML.

Mol Cell. 2019 Apr 18;74(2):245-253.e6. doi: 10.1016/j.molcel.2019.01.019. Epub 2019 Feb 27.

PMID:
30826165
3.

Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques.

Petrovic J, Zhou Y, Fasolino M, Goldman N, Schwartz GW, Mumbach MR, Nguyen SC, Rome KS, Sela Y, Zapataro Z, Blacklow SC, Kruhlak MJ, Shi J, Aster JC, Joyce EF, Little SC, Vahedi G, Pear WS, Faryabi RB.

Mol Cell. 2019 Mar 21;73(6):1174-1190.e12. doi: 10.1016/j.molcel.2019.01.006. Epub 2019 Feb 7.

PMID:
30745086
4.

Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition.

LaRochelle JR, Fodor M, Vemulapalli V, Mohseni M, Wang P, Stams T, LaMarche MJ, Chopra R, Acker MG, Blacklow SC.

Nat Commun. 2018 Oct 30;9(1):4508. doi: 10.1038/s41467-018-06823-9.

5.

The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro.

Tveriakhina L, Schuster-Gossler K, Jarrett SM, Andrawes MB, Rohrbach M, Blacklow SC, Gossler A.

Elife. 2018 Oct 5;7. pii: e40045. doi: 10.7554/eLife.40045.

6.

Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.

Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS.

ACS Chem Biol. 2018 Sep 21;13(9):2438-2448. doi: 10.1021/acschembio.7b00638. Epub 2018 Aug 31.

PMID:
30102854
7.

The Molecular Mechanism of Notch Activation.

Lovendahl KN, Blacklow SC, Gordon WR.

Adv Exp Med Biol. 2018;1066:47-58. doi: 10.1007/978-3-319-89512-3_3. Review.

PMID:
30030821
8.

Dual Allosteric Inhibition of SHP2 Phosphatase.

Fodor M, Price E, Wang P, Lu H, Argintaru A, Chen Z, Glick M, Hao HX, Kato M, Koenig R, LaRochelle JR, Liu G, McNeill E, Majumdar D, Nishiguchi GA, Perez LB, Paris G, Quinn CM, Ramsey T, Sendzik M, Shultz MD, Williams SL, Stams T, Blacklow SC, Acker MG, LaMarche MJ.

ACS Chem Biol. 2018 Mar 16;13(3):647-656. doi: 10.1021/acschembio.7b00980. Epub 2018 Jan 18.

PMID:
29304282
9.

Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10.

Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC.

Cell. 2017 Dec 14;171(7):1638-1648.e7. doi: 10.1016/j.cell.2017.11.014. Epub 2017 Dec 7.

10.

MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia.

Pajcini KV, Xu L, Shao L, Petrovic J, Palasiewicz K, Ohtani Y, Bailis W, Lee C, Wertheim GB, Mani R, Muthusamy N, Li Y, Meijerink JPP, Blacklow SC, Faryabi RB, Cherry S, Pear WS.

Sci Signal. 2017 Nov 14;10(505). pii: eaam6846. doi: 10.1126/scisignal.aam6846.

11.

Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.

LaRochelle JR, Fodor M, Ellegast JM, Liu X, Vemulapalli V, Mohseni M, Stams T, Buhrlage SJ, Stegmaier K, LaMarche MJ, Acker MG, Blacklow SC.

Bioorg Med Chem. 2017 Dec 15;25(24):6479-6485. doi: 10.1016/j.bmc.2017.10.025. Epub 2017 Oct 20.

PMID:
29089257
12.

A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas.

Ryan RJH, Petrovic J, Rausch DM, Zhou Y, Lareau CA, Kluk MJ, Christie AL, Lee WY, Tarjan DR, Guo B, Donohue LKH, Gillespie SM, Nardi V, Hochberg EP, Blacklow SC, Weinstock DM, Faryabi RB, Bernstein BE, Aster JC, Pear WS.

Cell Rep. 2017 Oct 17;21(3):784-797. doi: 10.1016/j.celrep.2017.09.066.

13.

The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.

Choi SH, Severson E, Pear WS, Liu XS, Aster JC, Blacklow SC.

PLoS One. 2017 Oct 12;12(10):e0185762. doi: 10.1371/journal.pone.0185762. eCollection 2017.

14.

Diffuse Staining for Activated NOTCH1 Correlates With NOTCH1 Mutation Status and Is Associated With Worse Outcome in Adenoid Cystic Carcinoma.

Sajed DP, Faquin WC, Carey C, Severson EA, H Afrogheh A, A Johnson C, Blacklow SC, Chau NG, Lin DT, Krane JF, Jo VY, Garcia JJ, Sholl LM, Aster JC.

Am J Surg Pathol. 2017 Nov;41(11):1473-1482. doi: 10.1097/PAS.0000000000000945.

15.

Structural Basis for Regulation of ESCRT-III Complexes by Lgd.

McMillan BJ, Tibbe C, Drabek AA, Seegar TCM, Blacklow SC, Klein T.

Cell Rep. 2017 May 30;19(9):1750-1757. doi: 10.1016/j.celrep.2017.05.026.

16.

Signal Transduction: Notch catches a Jagged edge.

Blacklow SC.

Nat Chem Biol. 2017 May 17;13(6):570-571. doi: 10.1038/nchembio.2379. No abstract available.

17.

Genome-wide identification and characterization of Notch transcription complex-binding sequence-paired sites in leukemia cells.

Severson E, Arnett KL, Wang H, Zang C, Taing L, Liu H, Pear WS, Shirley Liu X, Blacklow SC, Aster JC.

Sci Signal. 2017 May 2;10(477). pii: eaag1598. doi: 10.1126/scisignal.aag1598.

18.

Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations.

McMillan BJ, Zimmerman B, Egan ED, Lofgren M, Xu X, Hesser A, Blacklow SC.

Glycobiology. 2017 Aug 1;27(8):777-786. doi: 10.1093/glycob/cwx020.

19.

STK40 Is a Pseudokinase that Binds the E3 Ubiquitin Ligase COP1.

Durzynska I, Xu X, Adelmant G, Ficarro SB, Marto JA, Sliz P, Uljon S, Blacklow SC.

Structure. 2017 Feb 7;25(2):287-294. doi: 10.1016/j.str.2016.12.008. Epub 2017 Jan 12.

20.

The Varied Roles of Notch in Cancer.

Aster JC, Pear WS, Blacklow SC.

Annu Rev Pathol. 2017 Jan 24;12:245-275. doi: 10.1146/annurev-pathol-052016-100127. Epub 2016 Dec 5. Review.

21.

Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket.

Zimmerman B, Kelly B, McMillan BJ, Seegar TCM, Dror RO, Kruse AC, Blacklow SC.

Cell. 2016 Nov 3;167(4):1041-1051.e11. doi: 10.1016/j.cell.2016.09.056. Epub 2016 Oct 27.

22.

Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan ESCRT-III Protein.

McMillan BJ, Tibbe C, Jeon H, Drabek AA, Klein T, Blacklow SC.

Cell Rep. 2016 Aug 2;16(5):1211-1217. doi: 10.1016/j.celrep.2016.06.093. Epub 2016 Jul 21.

23.

Structure and function of the Mind bomb E3 ligase in the context of Notch signal transduction.

Guo B, McMillan BJ, Blacklow SC.

Curr Opin Struct Biol. 2016 Dec;41:38-45. doi: 10.1016/j.sbi.2016.05.012. Epub 2016 Jun 7. Review.

24.

Characterization of activating mutations of NOTCH3 in T-cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies.

Bernasconi-Elias P, Hu T, Jenkins D, Firestone B, Gans S, Kurth E, Capodieci P, Deplazes-Lauber J, Petropoulos K, Thiel P, Ponsel D, Hee Choi S, LeMotte P, London A, Goetcshkes M, Nolin E, Jones MD, Slocum K, Kluk MJ, Weinstock DM, Christodoulou A, Weinberg O, Jaehrling J, Ettenberg SA, Buckler A, Blacklow SC, Aster JC, Fryer CJ.

Oncogene. 2016 Nov 24;35(47):6077-6086. doi: 10.1038/onc.2016.133. Epub 2016 May 9.

25.

Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case.

Knoechel B, Bhatt A, Pan L, Pedamallu CS, Severson E, Gutierrez A, Dorfman DM, Kuo FC, Kluk M, Kung AL, Zweidler-McKay P, Meyerson M, Blacklow SC, DeAngelo DJ, Aster JC.

Cold Spring Harb Mol Case Stud. 2015 Oct;1(1):a000539. doi: 10.1101/mcs.a000539.

26.

Structural Basis for Substrate Selectivity of the E3 Ligase COP1.

Uljon S, Xu X, Durzynska I, Stein S, Adelmant G, Marto JA, Pear WS, Blacklow SC.

Structure. 2016 May 3;24(5):687-696. doi: 10.1016/j.str.2016.03.002. Epub 2016 Mar 31.

27.

Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2.

LaRochelle JR, Fodor M, Xu X, Durzynska I, Fan L, Stams T, Chan HM, LaMarche MJ, Chopra R, Wang P, Fortin PD, Acker MG, Blacklow SC.

Biochemistry. 2016 Apr 19;55(15):2269-77. doi: 10.1021/acs.biochem.5b01287. Epub 2016 Apr 11.

28.

Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.

29.

Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region.

Xu X, Choi SH, Hu T, Tiyanont K, Habets R, Groot AJ, Vooijs M, Aster JC, Chopra R, Fryer C, Blacklow SC.

Structure. 2015 Jul 7;23(7):1227-35. doi: 10.1016/j.str.2015.05.001. Epub 2015 Jun 4.

30.

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch.

Gordon WR, Zimmerman B, He L, Miles LJ, Huang J, Tiyanont K, McArthur DG, Aster JC, Perrimon N, Loparo JJ, Blacklow SC.

Dev Cell. 2015 Jun 22;33(6):729-36. doi: 10.1016/j.devcel.2015.05.004. Epub 2015 Jun 4.

31.

Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17.

Habets RA, Groot AJ, Yahyanejad S, Tiyanont K, Blacklow SC, Vooijs M.

J Biol Chem. 2015 Jun 5;290(23):14705-16. doi: 10.1074/jbc.M115.643676. Epub 2015 Apr 27.

32.

A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb E3 ligases.

McMillan BJ, Schnute B, Ohlenhard N, Zimmerman B, Miles L, Beglova N, Klein T, Blacklow SC.

Mol Cell. 2015 Mar 5;57(5):912-924. doi: 10.1016/j.molcel.2015.01.019. Erratum in: Mol Cell. 2015 Apr 16;58(2):387.

33.

Long-range enhancer activity determines Myc sensitivity to Notch inhibitors in T cell leukemia.

Yashiro-Ohtani Y, Wang H, Zang C, Arnett KL, Bailis W, Ho Y, Knoechel B, Lanauze C, Louis L, Forsyth KS, Chen S, Chung Y, Schug J, Blobel GA, Liebhaber SA, Bernstein BE, Blacklow SC, Liu XS, Aster JC, Pear WS.

Proc Natl Acad Sci U S A. 2014 Nov 18;111(46):E4946-53. doi: 10.1073/pnas.1407079111. Epub 2014 Nov 4.

34.

Biased multicomponent reactions to develop novel bromodomain inhibitors.

McKeown MR, Shaw DL, Fu H, Liu S, Xu X, Marineau JJ, Huang Y, Zhang X, Buckley DL, Kadam A, Zhang Z, Blacklow SC, Qi J, Zhang W, Bradner JE.

J Med Chem. 2014 Nov 13;57(21):9019-27. doi: 10.1021/jm501120z. Epub 2014 Oct 31.

35.

Analyzing the nuclear complexes of Notch signaling by electrophoretic mobility shift assay.

Arnett KL, Blacklow SC.

Methods Mol Biol. 2014;1187:231-45. doi: 10.1007/978-1-4939-1139-4_18.

36.

NOTCH1-RBPJ complexes drive target gene expression through dynamic interactions with superenhancers.

Wang H, Zang C, Taing L, Arnett KL, Wong YJ, Pear WS, Blacklow SC, Liu XS, Aster JC.

Proc Natl Acad Sci U S A. 2014 Jan 14;111(2):705-10. doi: 10.1073/pnas.1315023111. Epub 2013 Dec 27.

37.

Refining a Jagged edge.

Blacklow SC.

Structure. 2013 Dec 3;21(12):2100-1. doi: 10.1016/j.str.2013.11.001.

38.

Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.

Andrawes MB, Xu X, Liu H, Ficarro SB, Marto JA, Aster JC, Blacklow SC.

J Biol Chem. 2013 Aug 30;288(35):25477-89. doi: 10.1074/jbc.M113.454850. Epub 2013 Jul 9.

39.

Insights into Notch3 activation and inhibition mediated by antibodies directed against its negative regulatory region.

Tiyanont K, Wales TE, Siebel CW, Engen JR, Blacklow SC.

J Mol Biol. 2013 Sep 9;425(17):3192-204. doi: 10.1016/j.jmb.2013.05.025. Epub 2013 Jun 6.

40.

Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer.

Roti G, Carlton A, Ross KN, Markstein M, Pajcini K, Su AH, Perrimon N, Pear WS, Kung AL, Blacklow SC, Aster JC, Stegmaier K.

Cancer Cell. 2013 Mar 18;23(3):390-405. doi: 10.1016/j.ccr.2013.01.015. Epub 2013 Feb 21.

41.

Targeting the Notch pathway: twists and turns on the road to rational therapeutics.

Aster JC, Blacklow SC.

J Clin Oncol. 2012 Jul 1;30(19):2418-20. doi: 10.1200/JCO.2012.42.0992. Epub 2012 May 14. Review. No abstract available.

PMID:
22585704
42.

A grid-enabled web service for low-resolution crystal structure refinement.

O'Donovan DJ, Stokes-Rees I, Nam Y, Blacklow SC, Schröder GF, Brunger AT, Sliz P.

Acta Crystallogr D Biol Crystallogr. 2012 Mar;68(Pt 3):261-7. doi: 10.1107/S0907444912001163. Epub 2012 Feb 14.

43.

Conformational locking upon cooperative assembly of notch transcription complexes.

Choi SH, Wales TE, Nam Y, O'Donovan DJ, Sliz P, Engen JR, Blacklow SC.

Structure. 2012 Feb 8;20(2):340-9. doi: 10.1016/j.str.2011.12.011.

44.

T-cell factor 1 is a gatekeeper for T-cell specification in response to Notch signaling.

Germar K, Dose M, Konstantinou T, Zhang J, Wang H, Lobry C, Arnett KL, Blacklow SC, Aifantis I, Aster JC, Gounari F.

Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20060-5. doi: 10.1073/pnas.1110230108. Epub 2011 Nov 22.

45.

Notch ankyrin repeat domain variation influences leukemogenesis and Myc transactivation.

Aster JC, Bodnar N, Xu L, Karnell F, Milholland JM, Maillard I, Histen G, Nam Y, Blacklow SC, Pear WS.

PLoS One. 2011;6(10):e25645. doi: 10.1371/journal.pone.0025645. Epub 2011 Oct 13.

46.

Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma.

Wang NJ, Sanborn Z, Arnett KL, Bayston LJ, Liao W, Proby CM, Leigh IM, Collisson EA, Gordon PB, Jakkula L, Pennypacker S, Zou Y, Sharma M, North JP, Vemula SS, Mauro TM, Neuhaus IM, Leboit PE, Hur JS, Park K, Huh N, Kwok PY, Arron ST, Massion PP, Bale AE, Haussler D, Cleaver JE, Gray JW, Spellman PT, South AP, Aster JC, Blacklow SC, Cho RJ.

Proc Natl Acad Sci U S A. 2011 Oct 25;108(43):17761-6. doi: 10.1073/pnas.1114669108. Epub 2011 Oct 17.

47.

Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth.

Zhao B, Zou J, Wang H, Johannsen E, Peng CW, Quackenbush J, Mar JC, Morton CC, Freedman ML, Blacklow SC, Aster JC, Bernstein BE, Kieff E.

Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14902-7. doi: 10.1073/pnas.1108892108. Epub 2011 Jul 11.

48.

Genome-wide analysis reveals conserved and divergent features of Notch1/RBPJ binding in human and murine T-lymphoblastic leukemia cells.

Wang H, Zou J, Zhao B, Johannsen E, Ashworth T, Wong H, Pear WS, Schug J, Blacklow SC, Arnett KL, Bernstein BE, Kieff E, Aster JC.

Proc Natl Acad Sci U S A. 2011 Sep 6;108(36):14908-13. doi: 10.1073/pnas.1109023108. Epub 2011 Jul 7.

49.

Evidence for increased exposure of the Notch1 metalloprotease cleavage site upon conversion to an activated conformation.

Tiyanont K, Wales TE, Aste-Amezaga M, Aster JC, Engen JR, Blacklow SC.

Structure. 2011 Apr 13;19(4):546-54. doi: 10.1016/j.str.2011.01.016.

50.

Epstein-Barr virus nuclear protein 3C binds to the N-terminal (NTD) and beta trefoil domains (BTD) of RBP/CSL; only the NTD interaction is essential for lymphoblastoid cell growth.

Calderwood MA, Lee S, Holthaus AM, Blacklow SC, Kieff E, Johannsen E.

Virology. 2011 May 25;414(1):19-25. doi: 10.1016/j.virol.2011.02.018. Epub 2011 Mar 26.

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