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Items: 1 to 20 of 140

1.

MAML1-dependent Notch responsive genes exhibit differing co-factor requirements for transcriptional activation.

Rogers JM, Guo B, Egan ED, Aster JC, Adelman K, Blacklow SC.

Mol Cell Biol. 2020 Mar 16. pii: MCB.00014-20. doi: 10.1128/MCB.00014-20. [Epub ahead of print]

PMID:
32179552
2.

Trib1 regulates T cell differentiation during chronic infection by restraining the effector program.

Rome KS, Stein SJ, Kurachi M, Petrovic J, Schwartz GW, Mack EA, Uljon S, Wu WW, DeHart AG, McClory SE, Xu L, Gimotty PA, Blacklow SC, Faryabi RB, Wherry EJ, Jordan MS, Pear WS.

J Exp Med. 2020 May 4;217(5). pii: e20190888. doi: 10.1084/jem.20190888.

PMID:
32150623
3.

Development of a covalent inhibitor of gut bacterial bile salt hydrolases.

Adhikari AA, Seegar TCM, Ficarro SB, McCurry MD, Ramachandran D, Yao L, Chaudhari SN, Ndousse-Fetter S, Banks AS, Marto JA, Blacklow SC, Devlin AS.

Nat Chem Biol. 2020 Mar;16(3):318-326. doi: 10.1038/s41589-020-0467-3. Epub 2020 Feb 10.

PMID:
32042200
4.

Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling.

Jarrett SM, Seegar TCM, Andrews M, Adelmant G, Marto JA, Aster JC, Blacklow SC.

Sci Signal. 2019 Nov 5;12(606). pii: eaay2369. doi: 10.1126/scisignal.aay2369.

PMID:
31690634
5.

Bioinspired mechanically active adhesive dressings to accelerate wound closure.

Blacklow SO, Li J, Freedman BR, Zeidi M, Chen C, Mooney DJ.

Sci Adv. 2019 Jul 24;5(7):eaaw3963. doi: 10.1126/sciadv.aaw3963. eCollection 2019 Jul.

6.

Domain integration of ADAM family proteins: Emerging themes from structural studies.

Seegar TC, Blacklow SC.

Exp Biol Med (Maywood). 2019 Dec;244(17):1510-1519. doi: 10.1177/1535370219865901. Epub 2019 Jul 23. No abstract available.

PMID:
31333048
7.

A Flow-Extension Tethered Particle Motion Assay for Single-Molecule Proteolysis.

Drabek AA, Loparo JJ, Blacklow SC.

Biochemistry. 2019 May 21;58(20):2509-2518. doi: 10.1021/acs.biochem.9b00106. Epub 2019 Apr 12.

8.

Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes.

Rogers JM, Waters CT, Seegar TCM, Jarrett SM, Hallworth AN, Blacklow SC, Bulyk ML.

Mol Cell. 2019 Apr 18;74(2):245-253.e6. doi: 10.1016/j.molcel.2019.01.019. Epub 2019 Feb 27.

PMID:
30826165
9.

Oncogenic Notch Promotes Long-Range Regulatory Interactions within Hyperconnected 3D Cliques.

Petrovic J, Zhou Y, Fasolino M, Goldman N, Schwartz GW, Mumbach MR, Nguyen SC, Rome KS, Sela Y, Zapataro Z, Blacklow SC, Kruhlak MJ, Shi J, Aster JC, Joyce EF, Little SC, Vahedi G, Pear WS, Faryabi RB.

Mol Cell. 2019 Mar 21;73(6):1174-1190.e12. doi: 10.1016/j.molcel.2019.01.006. Epub 2019 Feb 7.

10.

Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition.

LaRochelle JR, Fodor M, Vemulapalli V, Mohseni M, Wang P, Stams T, LaMarche MJ, Chopra R, Acker MG, Blacklow SC.

Nat Commun. 2018 Oct 30;9(1):4508. doi: 10.1038/s41467-018-06823-9.

11.

The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro.

Tveriakhina L, Schuster-Gossler K, Jarrett SM, Andrawes MB, Rohrbach M, Blacklow SC, Gossler A.

Elife. 2018 Oct 5;7. pii: e40045. doi: 10.7554/eLife.40045.

12.

Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains.

Wang J, Erazo T, Ferguson FM, Buckley DL, Gomez N, Muñoz-Guardiola P, Diéguez-Martínez N, Deng X, Hao M, Massefski W, Fedorov O, Offei-Addo NK, Park PM, Dai L, DiBona A, Becht K, Kim ND, McKeown MR, Roberts JM, Zhang J, Sim T, Alessi DR, Bradner JE, Lizcano JM, Blacklow SC, Qi J, Xu X, Gray NS.

ACS Chem Biol. 2018 Sep 21;13(9):2438-2448. doi: 10.1021/acschembio.7b00638. Epub 2018 Aug 31.

13.

The Molecular Mechanism of Notch Activation.

Lovendahl KN, Blacklow SC, Gordon WR.

Adv Exp Med Biol. 2018;1066:47-58. doi: 10.1007/978-3-319-89512-3_3. Review.

PMID:
30030821
14.

Injectable, Tough Alginate Cryogels as Cancer Vaccines.

Shih TY, Blacklow SO, Li AW, Freedman BR, Bencherif S, Koshy ST, Darnell MC, Mooney DJ.

Adv Healthc Mater. 2018 May;7(10):e1701469. doi: 10.1002/adhm.201701469. Epub 2018 Feb 14.

15.

Dual Allosteric Inhibition of SHP2 Phosphatase.

Fodor M, Price E, Wang P, Lu H, Argintaru A, Chen Z, Glick M, Hao HX, Kato M, Koenig R, LaRochelle JR, Liu G, McNeill E, Majumdar D, Nishiguchi GA, Perez LB, Paris G, Quinn CM, Ramsey T, Sendzik M, Shultz MD, Williams SL, Stams T, Blacklow SC, Acker MG, LaMarche MJ.

ACS Chem Biol. 2018 Mar 16;13(3):647-656. doi: 10.1021/acschembio.7b00980. Epub 2018 Jan 18.

PMID:
29304282
16.

Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10.

Seegar TCM, Killingsworth LB, Saha N, Meyer PA, Patra D, Zimmerman B, Janes PW, Rubinstein E, Nikolov DB, Skiniotis G, Kruse AC, Blacklow SC.

Cell. 2017 Dec 14;171(7):1638-1648.e7. doi: 10.1016/j.cell.2017.11.014. Epub 2017 Dec 7.

17.

MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia.

Pajcini KV, Xu L, Shao L, Petrovic J, Palasiewicz K, Ohtani Y, Bailis W, Lee C, Wertheim GB, Mani R, Muthusamy N, Li Y, Meijerink JPP, Blacklow SC, Faryabi RB, Cherry S, Pear WS.

Sci Signal. 2017 Nov 14;10(505). pii: eaam6846. doi: 10.1126/scisignal.aam6846.

18.

Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2.

LaRochelle JR, Fodor M, Ellegast JM, Liu X, Vemulapalli V, Mohseni M, Stams T, Buhrlage SJ, Stegmaier K, LaMarche MJ, Acker MG, Blacklow SC.

Bioorg Med Chem. 2017 Dec 15;25(24):6479-6485. doi: 10.1016/j.bmc.2017.10.025. Epub 2017 Oct 20.

PMID:
29089257
19.

A B Cell Regulome Links Notch to Downstream Oncogenic Pathways in Small B Cell Lymphomas.

Ryan RJH, Petrovic J, Rausch DM, Zhou Y, Lareau CA, Kluk MJ, Christie AL, Lee WY, Tarjan DR, Guo B, Donohue LKH, Gillespie SM, Nardi V, Hochberg EP, Blacklow SC, Weinstock DM, Faryabi RB, Bernstein BE, Aster JC, Pear WS.

Cell Rep. 2017 Oct 17;21(3):784-797. doi: 10.1016/j.celrep.2017.09.066.

20.

The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia.

Choi SH, Severson E, Pear WS, Liu XS, Aster JC, Blacklow SC.

PLoS One. 2017 Oct 12;12(10):e0185762. doi: 10.1371/journal.pone.0185762. eCollection 2017.

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