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Items: 24


Synergy between Variant PRC1 Complexes Defines Polycomb-Mediated Gene Repression.

Fursova NA, Blackledge NP, Nakayama M, Ito S, Koseki Y, Farcas AM, King HW, Koseki H, Klose RJ.

Mol Cell. 2019 Jun 6;74(5):1020-1036.e8. doi: 10.1016/j.molcel.2019.03.024. Epub 2019 Apr 24.


Polycomb repressive complex 1 shapes the nucleosome landscape but not accessibility at target genes.

King HW, Fursova NA, Blackledge NP, Klose RJ.

Genome Res. 2018 Oct;28(10):1494-1507. doi: 10.1101/gr.237180.118. Epub 2018 Aug 28.


Biochemical Identification of Nonmethylated DNA by BioCAP-Seq.

Long HK, Rose NR, Blackledge NP, Klose RJ.

Methods Mol Biol. 2018;1766:15-29. doi: 10.1007/978-1-4939-7768-0_2.


The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin.

Brown DA, Di Cerbo V, Feldmann A, Ahn J, Ito S, Blackledge NP, Nakayama M, McClellan M, Dimitrova E, Turberfield AH, Long HK, King HW, Kriaucionis S, Schermelleh L, Kutateladze TG, Koseki H, Klose RJ.

Cell Rep. 2017 Sep 5;20(10):2313-2327. doi: 10.1016/j.celrep.2017.08.030.


MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia.

Kerry J, Godfrey L, Repapi E, Tapia M, Blackledge NP, Ma H, Ballabio E, O'Byrne S, Ponthan F, Heidenreich O, Roy A, Roberts I, Konopleva M, Klose RJ, Geng H, Milne TA.

Cell Rep. 2017 Jan 10;18(2):482-495. doi: 10.1016/j.celrep.2016.12.054.


RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes.

Rose NR, King HW, Blackledge NP, Fursova NA, Ember KJ, Fischer R, Kessler BM, Klose RJ.

Elife. 2016 Oct 5;5. pii: e18591. doi: 10.7554/eLife.18591.


Targeting Polycomb systems to regulate gene expression: modifications to a complex story.

Blackledge NP, Rose NR, Klose RJ.

Nat Rev Mol Cell Biol. 2015 Nov;16(11):643-649. doi: 10.1038/nrm4067. Epub 2015 Sep 30. Review.


Targeting polycomb to pericentric heterochromatin in embryonic stem cells reveals a role for H2AK119u1 in PRC2 recruitment.

Cooper S, Dienstbier M, Hassan R, Schermelleh L, Sharif J, Blackledge NP, De Marco V, Elderkin S, Koseki H, Klose R, Heger A, Brockdorff N.

Cell Rep. 2014 Jun 12;7(5):1456-1470. doi: 10.1016/j.celrep.2014.04.012. Epub 2014 May 22.


Variant PRC1 complex-dependent H2A ubiquitylation drives PRC2 recruitment and polycomb domain formation.

Blackledge NP, Farcas AM, Kondo T, King HW, McGouran JF, Hanssen LL, Ito S, Cooper S, Kondo K, Koseki Y, Ishikura T, Long HK, Sheahan TW, Brockdorff N, Kessler BM, Koseki H, Klose RJ.

Cell. 2014 Jun 5;157(6):1445-59. doi: 10.1016/j.cell.2014.05.004. Epub 2014 May 22.


CpG island chromatin is shaped by recruitment of ZF-CxxC proteins.

Blackledge NP, Thomson JP, Skene PJ.

Cold Spring Harb Perspect Biol. 2013 Nov 1;5(11):a018648. doi: 10.1101/cshperspect.a018648. Review.


Chromatin sampling--an emerging perspective on targeting polycomb repressor proteins.

Klose RJ, Cooper S, Farcas AM, Blackledge NP, Brockdorff N.

PLoS Genet. 2013;9(8):e1003717. doi: 10.1371/journal.pgen.1003717. Epub 2013 Aug 22. No abstract available.


ZF-CxxC domain-containing proteins, CpG islands and the chromatin connection.

Long HK, Blackledge NP, Klose RJ.

Biochem Soc Trans. 2013 Jun;41(3):727-40. doi: 10.1042/BST20130028. Review.


Epigenetic conservation at gene regulatory elements revealed by non-methylated DNA profiling in seven vertebrates.

Long HK, Sims D, Heger A, Blackledge NP, Kutter C, Wright ML, Gr├╝tzner F, Odom DT, Patient R, Ponting CP, Klose RJ.

Elife. 2013 Feb 26;2:e00348. doi: 10.7554/eLife.00348.


KDM2B links the Polycomb Repressive Complex 1 (PRC1) to recognition of CpG islands.

Farcas AM, Blackledge NP, Sudbery I, Long HK, McGouran JF, Rose NR, Lee S, Sims D, Cerase A, Sheahan TW, Koseki H, Brockdorff N, Ponting CP, Kessler BM, Klose RJ.

Elife. 2012 Dec 18;1:e00205. doi: 10.7554/eLife.00205.


Bio-CAP: a versatile and highly sensitive technique to purify and characterise regions of non-methylated DNA.

Blackledge NP, Long HK, Zhou JC, Kriaucionis S, Patient R, Klose RJ.

Nucleic Acids Res. 2012 Feb;40(4):e32. doi: 10.1093/nar/gkr1207. Epub 2011 Dec 10.


Recognition of CpG island chromatin by KDM2A requires direct and specific interaction with linker DNA.

Zhou JC, Blackledge NP, Farcas AM, Klose RJ.

Mol Cell Biol. 2012 Jan;32(2):479-89. doi: 10.1128/MCB.06332-11. Epub 2011 Nov 14.


CpG island chromatin: a platform for gene regulation.

Blackledge NP, Klose R.

Epigenetics. 2011 Feb;6(2):147-52. Epub 2011 Feb 1.


CpG islands recruit a histone H3 lysine 36 demethylase.

Blackledge NP, Zhou JC, Tolstorukov MY, Farcas AM, Park PJ, Klose RJ.

Mol Cell. 2010 Apr 23;38(2):179-90. doi: 10.1016/j.molcel.2010.04.009.


Histone lysine methylation: an epigenetic modification?

Blackledge NP, Klose RJ.

Epigenomics. 2010 Feb;2(1):151-61. doi: 10.2217/epi.09.42. Review.


Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus.

Ott CJ, Blackledge NP, Kerschner JL, Leir SH, Crawford GE, Cotton CU, Harris A.

Proc Natl Acad Sci U S A. 2009 Nov 24;106(47):19934-9. doi: 10.1073/pnas.0900946106. Epub 2009 Nov 6.


Novel regulatory mechanisms for the CFTR gene.

Ott CJ, Blackledge NP, Leir SH, Harris A.

Biochem Soc Trans. 2009 Aug;37(Pt 4):843-8. doi: 10.1042/BST0370843. Review.


A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter.

Ott CJ, Suszko M, Blackledge NP, Wright JE, Crawford GE, Harris A.

J Cell Mol Med. 2009 Apr;13(4):680-92.


An insulator element 3' to the CFTR gene binds CTCF and reveals an active chromatin hub in primary cells.

Blackledge NP, Ott CJ, Gillen AE, Harris A.

Nucleic Acids Res. 2009 Mar;37(4):1086-94. doi: 10.1093/nar/gkn1056. Epub 2009 Jan 7.


CTCF mediates insulator function at the CFTR locus.

Blackledge NP, Carter EJ, Evans JR, Lawson V, Rowntree RK, Harris A.

Biochem J. 2007 Dec 1;408(2):267-75.

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