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Solvent-dependent segmental dynamics in intrinsically disordered proteins.

Salvi N, Abyzov A, Blackledge M.

Sci Adv. 2019 Jun 28;5(6):eaax2348. doi: 10.1126/sciadv.aax2348. eCollection 2019 Jun.


relax: the analysis of biomolecular kinetics and thermodynamics using NMR relaxation dispersion data.

Morin S, Linnet TE, Lescanne M, Schanda P, Thompson GS, Tollinger M, Teilum K, Gagné S, Marion D, Griesinger C, Blackledge M, d'Auvergne EJ.

Bioinformatics. 2019 Jun 4. pii: btz397. doi: 10.1093/bioinformatics/btz397. [Epub ahead of print] No abstract available.


From Antihistamine to Anti-infective: Loratadine Inhibition of Regulatory PASTA Kinases in Staphylococci Reduces Biofilm Formation and Potentiates β-Lactam Antibiotics and Vancomycin in Resistant Strains of Staphylococcus aureus.

Cutrona N, Gillard K, Ulrich R, Seemann M, Miller HB, Blackledge MS.

ACS Infect Dis. 2019 Jun 7. doi: 10.1021/acsinfecdis.9b00096. [Epub ahead of print]


Structure and Functions of Microtubule Associated Proteins Tau and MAP2c: Similarities and Differences.

Melková K, Zapletal V, Narasimhan S, Jansen S, Hritz J, Škrabana R, Zweckstetter M, Ringkjøbing Jensen M, Blackledge M, Žídek L.

Biomolecules. 2019 Mar 16;9(3). pii: E105. doi: 10.3390/biom9030105. Review.


MRI Imaging of the Hemodynamic Vasculature of Neuroblastoma Predicts Response to Antiangiogenic Treatment.

Zormpas-Petridis K, Jerome NP, Blackledge MD, Carceller F, Poon E, Clarke M, McErlean CM, Barone G, Koers A, Vaidya SJ, Marshall LV, Pearson ADJ, Moreno L, Anderson J, Sebire N, McHugh K, Koh DM, Yuan Y, Chesler L, Robinson SP, Jamin Y.

Cancer Res. 2019 Jun 1;79(11):2978-2991. doi: 10.1158/0008-5472.CAN-18-3412. Epub 2019 Mar 15.


Guidelines for Acquisition, Interpretation, and Reporting of Whole-Body MRI in Myeloma: Myeloma Response Assessment and Diagnosis System (MY-RADS).

Messiou C, Hillengass J, Delorme S, Lecouvet FE, Moulopoulos LA, Collins DJ, Blackledge MD, Abildgaard N, Østergaard B, Schlemmer HP, Landgren O, Asmussen JT, Kaiser MF, Padhani A.

Radiology. 2019 Apr;291(1):5-13. doi: 10.1148/radiol.2019181949. Epub 2019 Feb 26.


Assembly and cryo-EM structures of RNA-specific measles virus nucleocapsids provide mechanistic insight into paramyxoviral replication.

Desfosses A, Milles S, Jensen MR, Guseva S, Colletier JP, Maurin D, Schoehn G, Gutsche I, Ruigrok RWH, Blackledge M.

Proc Natl Acad Sci U S A. 2019 Feb 20. pii: 201816417. doi: 10.1073/pnas.1816417116. [Epub ahead of print]


Characterization of intrinsically disordered proteins and their dynamic complexes: From in vitro to cell-like environments.

Milles S, Salvi N, Blackledge M, Jensen MR.

Prog Nucl Magn Reson Spectrosc. 2018 Dec;109:79-100. doi: 10.1016/j.pnmrs.2018.07.001. Epub 2018 Jul 31. Review.


Electrochemical Detection of Small Molecule Induced Pseudomonas aeruginosa Biofilm Dispersion.

Robb AJ, Vinogradov S, Danell AS, Anderson E, Blackledge MS, Melander C, Hvastkovs EG.

Electrochim Acta. 2018 Apr 1;268:276-282. doi: 10.1016/j.electacta.2018.02.113. Epub 2018 Mar 2.


Quantitative Whole-Body Diffusion-Weighted MR Imaging.

Donners R, Blackledge M, Tunariu N, Messiou C, Merkle EM, Koh DM.

Magn Reson Imaging Clin N Am. 2018 Nov;26(4):479-494. doi: 10.1016/j.mric.2018.06.002. Epub 2018 Sep 15. Review.


Elucidating binding mechanisms and dynamics of intrinsically disordered protein complexes using NMR spectroscopy.

Schneider R, Blackledge M, Jensen MR.

Curr Opin Struct Biol. 2019 Feb;54:10-18. doi: 10.1016/ Epub 2018 Oct 11. Review.


Probing Protein Dynamics Using Multifield Variable Temperature NMR Relaxation and Molecular Dynamics Simulation.

Busi B, Yarava JR, Hofstetter A, Salvi N, Cala-De Paepe D, Lewandowski JR, Blackledge M, Emsley L.

J Phys Chem B. 2018 Oct 25;122(42):9697-9702. doi: 10.1021/acs.jpcb.8b08578. Epub 2018 Oct 10.


An ultraweak interaction in the intrinsically disordered replication machinery is essential for measles virus function.

Milles S, Jensen MR, Lazert C, Guseva S, Ivashchenko S, Communie G, Maurin D, Gerlier D, Ruigrok RWH, Blackledge M.

Sci Adv. 2018 Aug 22;4(8):eaat7778. doi: 10.1126/sciadv.aat7778. eCollection 2018 Aug.


Tricyclic amine antidepressants suppress β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) by repressing mRNA levels of key resistance genes.

Gillard K, Miller HB, Blackledge MS.

Chem Biol Drug Des. 2018 Nov;92(5):1822-1829. doi: 10.1111/cbdd.13361. Epub 2018 Jul 18.


Functionally specific binding regions of microtubule-associated protein 2c exhibit distinct conformations and dynamics.

Melková K, Zapletal V, Jansen S, Nomilner E, Zachrdla M, Hritz J, Nováček J, Zweckstetter M, Jensen MR, Blackledge M, Žídek L.

J Biol Chem. 2018 Aug 24;293(34):13297-13309. doi: 10.1074/jbc.RA118.001769. Epub 2018 Jun 20.


Conformational dynamics in crystals reveal the molecular bases for D76N beta-2 microglobulin aggregation propensity.

Le Marchand T, de Rosa M, Salvi N, Sala BM, Andreas LB, Barbet-Massin E, Sormanni P, Barbiroli A, Porcari R, Sousa Mota C, de Sanctis D, Bolognesi M, Emsley L, Bellotti V, Blackledge M, Camilloni C, Pintacuda G, Ricagno S.

Nat Commun. 2018 Apr 25;9(1):1658. doi: 10.1038/s41467-018-04078-y.


Characterizing Protein-Protein Interactions Using Solution NMR Spectroscopy.

Ortega-Roldan JL, Blackledge M, Jensen MR.

Methods Mol Biol. 2018;1764:73-85. doi: 10.1007/978-1-4939-7759-8_5.


Resensitization of methicillin-resistant Staphylococcus aureus by amoxapine, an FDA-approved antidepressant.

Wilson TJ, Blackledge MS, Vigueira PA.

Heliyon. 2018 Jan 12;4(1):e00501. doi: 10.1016/j.heliyon.2017.e00501. eCollection 2018 Jan.


Deciphering the Dynamic Interaction Profile of an Intrinsically Disordered Protein by NMR Exchange Spectroscopy.

Delaforge E, Kragelj J, Tengo L, Palencia A, Milles S, Bouvignies G, Salvi N, Blackledge M, Jensen MR.

J Am Chem Soc. 2018 Jan 24;140(3):1148-1158. doi: 10.1021/jacs.7b12407. Epub 2018 Jan 11.


Non-Invasive Prostate Cancer Characterization with Diffusion-Weighted MRI: Insight from In silico Studies of a Transgenic Mouse Model.

Hill DK, Heindl A, Zormpas-Petridis K, Collins DJ, Euceda LR, Rodrigues DN, Moestue SA, Jamin Y, Koh DM, Yuan Y, Bathen TF, Leach MO, Blackledge MD.

Front Oncol. 2017 Dec 1;7:290. doi: 10.3389/fonc.2017.00290. eCollection 2017.


Structural analysis of the complex between influenza B nucleoprotein and human importin-α.

Labaronne A, Milles S, Donchet A, Jensen MR, Blackledge M, Bourhis JM, Ruigrok RWH, Crépin T.

Sci Rep. 2017 Dec 7;7(1):17164. doi: 10.1038/s41598-017-17458-z.


Atomic resolution conformational dynamics of intrinsically disordered proteins from NMR spin relaxation.

Salvi N, Abyzov A, Blackledge M.

Prog Nucl Magn Reson Spectrosc. 2017 Nov;102-103:43-60. doi: 10.1016/j.pnmrs.2017.06.001. Epub 2017 Jul 10. Review.


Apparent diffusion coefficient of vertebral haemangiomas allows differentiation from malignant focal deposits in whole-body diffusion-weighted MRI.

Winfield JM, Poillucci G, Blackledge MD, Collins DJ, Shah V, Tunariu N, Kaiser MF, Messiou C.

Eur Radiol. 2018 Apr;28(4):1687-1691. doi: 10.1007/s00330-017-5079-2. Epub 2017 Nov 13.


UK quantitative WB-DWI technical workgroup: consensus meeting recommendations on optimisation, quality control, processing and analysis of quantitative whole-body diffusion-weighted imaging for cancer.

Barnes A, Alonzi R, Blackledge M, Charles-Edwards G, Collins DJ, Cook G, Coutts G, Goh V, Graves M, Kelly C, Koh DM, McCallum H, Miquel ME, O'Connor J, Padhani A, Pearson R, Priest A, Rockall A, Stirling J, Taylor S, Tunariu N, van der Meulen J, Walls D, Winfield J, Punwani S.

Br J Radiol. 2018 Jan;91(1081):20170577. doi: 10.1259/bjr.20170577. Epub 2017 Dec 7.


Whole-Body MRI: Current Applications in Oncology.

Morone M, Bali MA, Tunariu N, Messiou C, Blackledge M, Grazioli L, Koh DM.

AJR Am J Roentgenol. 2017 Dec;209(6):W336-W349. doi: 10.2214/AJR.17.17984. Epub 2017 Oct 5. Review.


Structural and Kinetic Characterization of the Intrinsically Disordered Protein SeV NTAIL through Enhanced Sampling Simulations.

Bernetti M, Masetti M, Pietrucci F, Blackledge M, Jensen MR, Recanatini M, Mollica L, Cavalli A.

J Phys Chem B. 2017 Oct 19;121(41):9572-9582. doi: 10.1021/acs.jpcb.7b08925. Epub 2017 Oct 4.


Analytical Description of NMR Relaxation Highlights Correlated Dynamics in Intrinsically Disordered Proteins.

Salvi N, Abyzov A, Blackledge M.

Angew Chem Int Ed Engl. 2017 Nov 6;56(45):14020-14024. doi: 10.1002/anie.201706740. Epub 2017 Sep 14.


The LC8 Recognition Motif Preferentially Samples Polyproline II Structure in Its Free State.

Morgan JL, Jensen MR, Ozenne V, Blackledge M, Barbar E.

Biochemistry. 2017 Sep 5;56(35):4656-4666. doi: 10.1021/acs.biochem.7b00552. Epub 2017 Aug 23.


2-aminoimidazoles potentiate ß-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing ß-lactamase secretion and increasing cell envelope permeability.

Jeon AB, Obregón-Henao A, Ackart DF, Podell BK, Belardinelli JM, Jackson M, Nguyen TV, Blackledge MS, Melander RJ, Melander C, Johnson BK, Abramovitch RB, Basaraba RJ.

PLoS One. 2017 Jul 27;12(7):e0180925. doi: 10.1371/journal.pone.0180925. eCollection 2017.


Structural Characterization of the SMRT Corepressor Interacting with Histone Deacetylase 7.

Desravines DC, Serna Martin I, Schneider R, Mas PJ, Aleksandrova N, Jensen MR, Blackledge M, Hart DJ.

Sci Rep. 2017 Jun 16;7(1):3678. doi: 10.1038/s41598-017-03718-5.


Targeting of Streptococcus mutans Biofilms by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral Microbiome.

Garcia SS, Blackledge MS, Michalek S, Su L, Ptacek T, Eipers P, Morrow C, Lefkowitz EJ, Melander C, Wu H.

J Dent Res. 2017 Jul;96(7):807-814. doi: 10.1177/0022034517698096. Epub 2017 Mar 10.


Mouse Rif1 is a regulatory subunit of protein phosphatase 1 (PP1).

Sukackaite R, Cornacchia D, Jensen MR, Mas PJ, Blackledge M, Enervald E, Duan G, Auchynnikava T, Köhn M, Hart DJ, Buonomo SBC.

Sci Rep. 2017 May 18;7(1):2119. doi: 10.1038/s41598-017-01910-1.


Diffusion-weighted (DW) MRI in lung cancers: ADC test-retest repeatability.

Weller A, Papoutsaki MV, Waterton JC, Chiti A, Stroobants S, Kuijer J, Blackledge M, Morgan V, deSouza NM.

Eur Radiol. 2017 Nov;27(11):4552-4562. doi: 10.1007/s00330-017-4828-6. Epub 2017 Apr 10.


A Combined NMR and SAXS Analysis of the Partially Folded Cataract-Associated V75D γD-Crystallin.

Whitley MJ, Xi Z, Bartko JC, Jensen MR, Blackledge M, Gronenborn AM.

Biophys J. 2017 Mar 28;112(6):1135-1146. doi: 10.1016/j.bpj.2017.02.010.


Extracranial Soft-Tissue Tumors: Repeatability of Apparent Diffusion Coefficient Estimates from Diffusion-weighted MR Imaging.

Winfield JM, Tunariu N, Rata M, Miyazaki K, Jerome NP, Germuska M, Blackledge MD, Collins DJ, de Bono JS, Yap TA, deSouza NM, Doran SJ, Koh DM, Leach MO, Messiou C, Orton MR.

Radiology. 2017 Jul;284(1):88-99. doi: 10.1148/radiol.2017161965. Epub 2017 Mar 16.


Dynamic Descriptions of Highly Flexible Molecules from NMR Dipolar Couplings: Physical Basis and Limitations.

Salvi N, Salmon L, Blackledge M.

J Am Chem Soc. 2017 Apr 12;139(14):5011-5014. doi: 10.1021/jacs.7b01566. Epub 2017 Mar 29.


The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to β-Lactam Antibiotics in a Pattern Distinct from β-Lactamase Inhibitors.

Nguyen TV, Blackledge MS, Lindsey EA, Minrovic BM, Ackart DF, Jeon AB, Obregón-Henao A, Melander RJ, Basaraba RJ, Melander C.

Angew Chem Int Ed Engl. 2017 Mar 27;56(14):3940-3944. doi: 10.1002/anie.201612006. Epub 2017 Mar 1.


Diffusion-weighted Imaging as a Treatment Response Biomarker for Evaluating Bone Metastases in Prostate Cancer: A Pilot Study.

Perez-Lopez R, Mateo J, Mossop H, Blackledge MD, Collins DJ, Rata M, Morgan VA, Macdonald A, Sandhu S, Lorente D, Rescigno P, Zafeiriou Z, Bianchini D, Porta N, Hall E, Leach MO, de Bono JS, Koh DM, Tunariu N.

Radiology. 2017 Apr;283(1):168-177. doi: 10.1148/radiol.2016160646. Epub 2016 Nov 22.


T2-adjusted computed diffusion-weighted imaging: A novel method to enhance tumour visualisation.

Cheng L, Blackledge MD, Collins DJ, Orton MR, Jerome NP, Feiweier T, Rata M, Morgan V, Tunariu N, Leach MO, Koh DM.

Comput Biol Med. 2016 Dec 1;79:92-98. doi: 10.1016/j.compbiomed.2016.09.022. Epub 2016 Oct 1.


Investigating the Role of Large-Scale Domain Dynamics in Protein-Protein Interactions.

Delaforge E, Milles S, Huang JR, Bouvier D, Jensen MR, Sattler M, Hart DJ, Blackledge M.

Front Mol Biosci. 2016 Sep 13;3:54. doi: 10.3389/fmolb.2016.00054. eCollection 2016. Review.


Binding Mechanisms of Intrinsically Disordered Proteins: Theory, Simulation, and Experiment.

Mollica L, Bessa LM, Hanoulle X, Jensen MR, Blackledge M, Schneider R.

Front Mol Biosci. 2016 Sep 9;3:52. doi: 10.3389/fmolb.2016.00052. eCollection 2016. Review.


Structural and dynamics studies of a truncated variant of CI repressor from bacteriophage TP901-1.

Rasmussen KK, Frandsen KE, Boeri Erba E, Pedersen M, Varming AK, Hammer K, Kilstrup M, Thulstrup PW, Blackledge M, Jensen MR, Lo Leggio L.

Sci Rep. 2016 Jul 12;6:29574. doi: 10.1038/srep29574.


Multi-Timescale Dynamics in Intrinsically Disordered Proteins from NMR Relaxation and Molecular Simulation.

Salvi N, Abyzov A, Blackledge M.

J Phys Chem Lett. 2016 Jul 7;7(13):2483-9. doi: 10.1021/acs.jpclett.6b00885. Epub 2016 Jun 20.


Self-Assembly of Measles Virus Nucleocapsid-like Particles: Kinetics and RNA Sequence Dependence.

Milles S, Jensen MR, Communie G, Maurin D, Schoehn G, Ruigrok RW, Blackledge M.

Angew Chem Int Ed Engl. 2016 Aug 1;55(32):9356-60. doi: 10.1002/anie.201602619. Epub 2016 Jun 6.


SAXS/SANS on Supercharged Proteins Reveals Residue-Specific Modifications of the Hydration Shell.

Kim HS, Martel A, Girard E, Moulin M, Härtlein M, Madern D, Blackledge M, Franzetti B, Gabel F.

Biophys J. 2016 May 24;110(10):2185-94. doi: 10.1016/j.bpj.2016.04.013.


The Role of Dynamics and Allostery in the Inhibition of the eIF4E/eIF4G Translation Initiation Factor Complex.

Salvi N, Papadopoulos E, Blackledge M, Wagner G.

Angew Chem Int Ed Engl. 2016 Jun 13;55(25):7176-9. doi: 10.1002/anie.201603254. Epub 2016 May 10.


Inter- and Intra-Observer Repeatability of Quantitative Whole-Body, Diffusion-Weighted Imaging (WBDWI) in Metastatic Bone Disease.

Blackledge MD, Tunariu N, Orton MR, Padhani AR, Collins DJ, Leach MO, Koh DM.

PLoS One. 2016 Apr 28;11(4):e0153840. doi: 10.1371/journal.pone.0153840. eCollection 2016.


Identification of Dynamic Modes in an Intrinsically Disordered Protein Using Temperature-Dependent NMR Relaxation.

Abyzov A, Salvi N, Schneider R, Maurin D, Ruigrok RW, Jensen MR, Blackledge M.

J Am Chem Soc. 2016 May 18;138(19):6240-51. doi: 10.1021/jacs.6b02424. Epub 2016 May 6.


Ensemble Structure of the Highly Flexible Complex Formed between Vesicular Stomatitis Virus Unassembled Nucleoprotein and its Phosphoprotein Chaperone.

Yabukarski F, Leyrat C, Martinez N, Communie G, Ivanov I, Ribeiro EA Jr, Buisson M, Gerard FC, Bourhis JM, Jensen MR, Bernadó P, Blackledge M, Jamin M.

J Mol Biol. 2016 Jul 3;428(13):2671-94. doi: 10.1016/j.jmb.2016.04.010. Epub 2016 Apr 21.


Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer.

Akoury E, Mukrasch MD, Biernat J, Tepper K, Ozenne V, Mandelkow E, Blackledge M, Zweckstetter M.

Protein Sci. 2016 May;25(5):1010-20. doi: 10.1002/pro.2911. Epub 2016 Mar 24.

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