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Items: 1 to 50 of 69

1.

GSTZ1 genotypes correlate with dichloroacetate pharmacokinetics and chronic side effects in multiple myeloma patients in a pilot phase 2 clinical trial.

Tian DD, Bennett SK, Coupland LA, Forwood K, Lwin Y, Pooryousef N, Tea I, Truong TT, Neeman T, Crispin P, D'Rozario J, Blackburn AC.

Pharmacol Res Perspect. 2019 Oct 8;7(6):e00526. doi: 10.1002/prp2.526. eCollection 2019 Dec.

2.

The SuprMam1 breast cancer susceptibility locus disrupts the vitamin D/ calcium/ parathyroid hormone pathway and alters bone structure in congenic mice.

Ratnadiwakara M, Rooke M, Ohms SJ, French HJ, Williams RBH, Li RW, Zhang D, Lucas RM, Blackburn AC.

J Steroid Biochem Mol Biol. 2019 Apr;188:48-58. doi: 10.1016/j.jsbmb.2018.12.004. Epub 2018 Dec 7.

PMID:
30529760
3.

Long-term stabilization of metastatic melanoma with sodium dichloroacetate.

Khan A, Andrews D, Shainhouse J, Blackburn AC.

World J Clin Oncol. 2017 Aug 10;8(4):371-377. doi: 10.5306/wjco.v8.i4.371.

4.

Leptin signals via TGFB1 to promote metastatic potential and stemness in breast cancer.

Mishra AK, Parish CR, Wong ML, Licinio J, Blackburn AC.

PLoS One. 2017 May 25;12(5):e0178454. doi: 10.1371/journal.pone.0178454. eCollection 2017.

5.

Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy.

Khan A, Andrews D, Blackburn AC.

World J Clin Cases. 2016 Oct 16;4(10):336-343.

6.

Dichloroacetate Prevents Cisplatin-Induced Nephrotoxicity without Compromising Cisplatin Anticancer Properties.

Galgamuwa R, Hardy K, Dahlstrom JE, Blackburn AC, Wium E, Rooke M, Cappello JY, Tummala P, Patel HR, Chuah A, Tian L, McMorrow L, Board PG, Theodoratos A.

J Am Soc Nephrol. 2016 Nov;27(11):3331-3344. Epub 2016 Mar 9.

7.

13C and 15N natural isotope abundance reflects breast cancer cell metabolism.

Tea I, Martineau E, Antheaume I, Lalande J, Mauve C, Gilard F, Barillé-Nion S, Blackburn AC, Tcherkez G.

Sci Rep. 2016 Sep 28;6:34251. doi: 10.1038/srep34251.

8.

Testosterone regulation of cyclin E kinase: A key factor in determining gender differences in hepatocarcinogenesis.

Pok S, Barn VA, Wong HJ, Blackburn AC, Board P, Farrell GC, Teoh NC.

J Gastroenterol Hepatol. 2016 Jun;31(6):1210-9. doi: 10.1111/jgh.13232.

PMID:
26574916
9.

Activation of LINE-1 Retrotransposon Increases the Risk of Epithelial-Mesenchymal Transition and Metastasis in Epithelial Cancer.

Rangasamy D, Lenka N, Ohms S, Dahlstrom JE, Blackburn AC, Board PG.

Curr Mol Med. 2015;15(7):588-97. Review.

10.

Targeting of two aspects of metabolism in breast cancer treatment.

Gang BP, Dilda PJ, Hogg PJ, Blackburn AC.

Cancer Biol Ther. 2014;15(11):1533-41. doi: 10.4161/15384047.2014.955992.

11.

Comparison of a rational vs. high throughput approach for rapid salt screening and selection.

Collman BM, Miller JM, Seadeek C, Stambek JA, Blackburn AC.

Drug Dev Ind Pharm. 2013 Jan;39(1):29-38. doi: 10.3109/03639045.2012.656272. Epub 2012 Mar 1.

PMID:
22380522
12.

The impact of glutathione transferase kappa deficiency on adiponectin multimerisation in vivo.

Theodoratos A, Blackburn AC, Coggan M, Cappello J, Larter CZ, Matthaei KI, Board PG.

Int J Obes (Lond). 2012 Oct;36(10):1366-9. doi: 10.1038/ijo.2011.267. Epub 2012 Jan 17.

PMID:
22249229
13.

Dichloroacetic acid up-regulates hepatic glutathione synthesis via the induction of glutamate-cysteine ligase.

Theodoratos A, Blackburn AC, Cappello J, Tummala P, Dahlstrom JE, Board PG.

Biochem Pharmacol. 2012 Feb 1;83(3):427-33. doi: 10.1016/j.bcp.2011.11.012. Epub 2011 Nov 23.

PMID:
22127296
14.

Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells.

Sun RC, Board PG, Blackburn AC.

Mol Cancer. 2011 Nov 18;10:142. doi: 10.1186/1476-4598-10-142.

15.

Rats: gnawing through the barriers to understanding genetic susceptibility and breast cancer.

Blackburn AC.

Breast Cancer Res. 2011 Oct 12;13(5):112. doi: 10.1186/bcr2939.

16.

Glutathione transferase kappa deficiency causes glomerular nephropathy without overt oxidative stress.

Blackburn AC, Coggan M, Shield AJ, Cappello J, Theodoratos A, Murray TP, Rooke M, Larter CZ, Koina ME, Dahlstrom JE, Matthaei KI, Board PG.

Lab Invest. 2011 Nov;91(11):1572-83. doi: 10.1038/labinvest.2011.107. Epub 2011 Aug 8.

17.

Map making in the 21st century: charting breast cancer susceptibility pathways in rodent models.

Blackburn AC, Jerry DJ.

J Mammary Gland Biol Neoplasia. 2011 Apr;16(1):57-64. doi: 10.1007/s10911-011-9201-9. Epub 2011 Mar 8.

18.

Pathways contributing to development of spontaneous mammary tumors in BALB/c-Trp53+/- mice.

Yan H, Blackburn AC, McLary SC, Tao L, Roberts AL, Xavier EA, Dickinson ES, Seo JH, Arenas RB, Otis CN, Cao QJ, Lawlor RG, Osborne BA, Kittrell FS, Medina D, Jerry DJ.

Am J Pathol. 2010 Mar;176(3):1421-32. doi: 10.2353/ajpath.2010.090438. Epub 2010 Jan 28.

19.

Reversal of the glycolytic phenotype by dichloroacetate inhibits metastatic breast cancer cell growth in vitro and in vivo.

Sun RC, Fadia M, Dahlstrom JE, Parish CR, Board PG, Blackburn AC.

Breast Cancer Res Treat. 2010 Feb;120(1):253-60. doi: 10.1007/s10549-009-0435-9. Epub 2009 Jun 19.

PMID:
19543830
20.

Phenylalanine-induced leucopenia in genetic and dichloroacetic acid generated deficiency of glutathione transferase Zeta.

Theodoratos A, Tu WJ, Cappello J, Blackburn AC, Matthaei K, Board PG.

Biochem Pharmacol. 2009 Apr 15;77(8):1358-63. doi: 10.1016/j.bcp.2009.01.017. Epub 2009 Feb 2.

PMID:
19426674
21.

Deletion of Glu155 causes a deficiency of glutathione transferase Omega 1-1 but does not alter sensitivity to arsenic trioxide and other cytotoxic drugs.

Schmuck E, Cappello J, Coggan M, Brew J, Cavanaugh JA, Blackburn AC, Baker RT, Eyre HJ, Sutherland GR, Board PG.

Int J Biochem Cell Biol. 2008;40(11):2553-9. doi: 10.1016/j.biocel.2008.04.017. Epub 2008 May 18.

PMID:
18571971
22.

Estrogen and progesterone induce persistent increases in p53-dependent apoptosis and suppress mammary tumors in BALB/c-Trp53+/- mice.

Dunphy KA, Blackburn AC, Yan H, O'Connell LR, Jerry DJ.

Breast Cancer Res. 2008;10(3):R43. doi: 10.1186/bcr2094. Epub 2008 May 12.

23.

One-solvent polymorph screen of carbamazepine.

Getsoian A, Lodaya RM, Blackburn AC.

Int J Pharm. 2008 Feb 4;348(1-2):3-9. Epub 2007 Oct 22.

PMID:
17945448
24.

Mammary tumor modifiers in BALB/cJ mice heterozygous for p53.

Koch JG, Gu X, Han Y, El-Naggar AK, Olson MV, Medina D, Jerry DJ, Blackburn AC, Peltz G, Amos CI, Lozano G.

Mamm Genome. 2007 May;18(5):300-9. Epub 2007 Jun 8.

PMID:
17557176
25.

Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk.

Blackburn AC, Hill LZ, Roberts AL, Wang J, Aud D, Jung J, Nikolcheva T, Allard J, Peltz G, Otis CN, Cao QJ, Ricketts RS, Naber SP, Mollenhauer J, Poustka A, Malamud D, Jerry DJ.

Am J Pathol. 2007 Jun;170(6):2030-41.

26.

Automated approach to couple solubility with final pH and crystallinity for pharmaceutical discovery compounds.

Seadeek C, Ando H, Bhattachar SN, Heimbach T, Sonnenberg JL, Blackburn AC.

J Pharm Biomed Anal. 2007 Apr 11;43(5):1660-6. Epub 2007 Jan 5.

PMID:
17270379
27.

Deficiency of glutathione transferase zeta causes oxidative stress and activation of antioxidant response pathways.

Blackburn AC, Matthaei KI, Lim C, Taylor MC, Cappello JY, Hayes JD, Anders MW, Board PG.

Mol Pharmacol. 2006 Feb;69(2):650-7. Epub 2005 Nov 8.

PMID:
16278372
29.

Identifying the stable polymorph early in the drug discovery-development process.

Miller JM, Collman BM, Greene LR, Grant DJ, Blackburn AC.

Pharm Dev Technol. 2005;10(2):291-7.

PMID:
15926678
30.

Rapid, small-scale determination of organic solvent solubility using a thermogravimetric analyzer.

Greene LR, Blackburn AC, Miller JM.

J Pharm Biomed Anal. 2005 Sep 1;39(1-2):344-7.

PMID:
15869856
31.

Loss of heterozygosity occurs via mitotic recombination in Trp53+/- mice and associates with mammary tumor susceptibility of the BALB/c strain.

Blackburn AC, McLary SC, Naeem R, Luszcz J, Stockton DW, Donehower LA, Mohammed M, Mailhes JB, Soferr T, Naber SP, Otis CN, Jerry DJ.

Cancer Res. 2004 Aug 1;64(15):5140-7.

32.
33.

BALB/c alleles for Prkdc and Cdkn2a interact to modify tumor susceptibility in Trp53+/- mice.

Blackburn AC, Brown JS, Naber SP, Otis CN, Wood JT, Jerry DJ.

Cancer Res. 2003 May 15;63(10):2364-8.

35.

Knockout and transgenic mice of Trp53: what have we learned about p53 in breast cancer?

Blackburn AC, Jerry DJ.

Breast Cancer Res. 2002;4(3):101-11. Epub 2002 Apr 18. Review.

36.

Hormonal control of p53 and chemoprevention.

Jerry DJ, Minter LM, Becker KA, Blackburn AC.

Breast Cancer Res. 2002;4(3):91-4. Epub 2002 Mar 26. Review.

37.

GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase.

Blackburn AC, Coggan M, Tzeng HF, Lantum H, Polekhina G, Parker MW, Anders MW, Board PG.

Pharmacogenetics. 2001 Nov;11(8):671-8.

PMID:
11692075
38.
39.

Identification of novel glutathione transferases and polymorphic variants by expressed sequence tag database analysis.

Board PG, Chelvanayagam G, Jermiin LS, Tetlow N, Tzeng HF, Anders MW, Blackburn AC.

Drug Metab Dispos. 2001 Apr;29(4 Pt 2):544-7.

PMID:
11259348
40.

Zeta class glutathione transferase polymorphisms and Parkinson's disease.

Taylor MC, Board PG, Blackburn AC, Mellick GD, Le Couteur DG.

J Neurol Neurosurg Psychiatry. 2001 Mar;70(3):407. No abstract available.

41.

Polymorphism- and species-dependent inactivation of glutathione transferase zeta by dichloroacetate.

Tzeng HF, Blackburn AC, Board PG, Anders MW.

Chem Res Toxicol. 2000 Apr;13(4):231-6.

PMID:
10775321
42.

Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis.

Blackburn AC, Tzeng HF, Anders MW, Board PG.

Pharmacogenetics. 2000 Feb;10(1):49-57.

PMID:
10739172
43.

Protein carbonyl formation on mucosal proteins in vitro and in dextran sulfate-induced colitis.

Blackburn AC, Doe WF, Buffinton GD.

Free Radic Biol Med. 1999 Aug;27(3-4):262-70.

PMID:
10468197
44.

Design and synthesis of novel quinoxaline-2,3-dione AMPA/GlyN receptor antagonists: amino acid derivatives.

Nikam SS, Cordon JJ, Ortwine DF, Heimbach TH, Blackburn AC, Vartanian MG, Nelson CB, Schwarz RD, Boxer PA, Rafferty MF.

J Med Chem. 1999 Jun 17;42(12):2266-71.

PMID:
10377233
45.
46.

Parkinson's disease, pesticides, and glutathione transferase polymorphisms.

Menegon A, Board PG, Blackburn AC, Mellick GD, Le Couteur DG.

Lancet. 1998 Oct 24;352(9137):1344-6.

PMID:
9802272
47.

Salicylate hydroxylation as an indicator of hydroxyl radical generation in dextran sulfate-induced colitis.

Blackburn AC, Doe WF, Buffinton GD.

Free Radic Biol Med. 1998 Aug;25(3):305-13.

PMID:
9680176
48.
49.
50.

1,4-dimethoxy-2-naphthoic acid.

Blackburn AC, Gerkin RE.

Acta Crystallogr C. 1997 Oct 15;53 ( Pt 10):1425-7.

PMID:
9362552

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