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A compendium of ERK targets. Ünal EB et al. FEBS Lett. (2017)

Whither systems medicine? Apweiler R et al. Exp Mol Med. (2018)

Neuronal activity-regulated alternative mRNA splicing. Hermey G et al. Int J Biochem Cell Biol. (2017)

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Items: 1 to 50 of 144


Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium.

Brandt R, Sell T, Lüthen M, Uhlitz F, Klinger B, Riemer P, Giesecke-Thiel C, Schulze S, El-Shimy IA, Kunkel D, Fauler B, Mielke T, Mages N, Herrmann BG, Sers C, Blüthgen N, Morkel M.

Nat Commun. 2019 Jul 2;10(1):2919. doi: 10.1038/s41467-019-10954-y.


The cancer cell proteome and transcriptome predicts sensitivity to targeted and cytotoxic drugs.

Rydenfelt M, Wongchenko M, Klinger B, Yan Y, Blüthgen N.

Life Sci Alliance. 2019 Jun 28;2(4). pii: e201900445. doi: 10.26508/lsa.201900445. Print 2019 Aug.


Food resource exploitation and functional resilience in ant communities found in common Mediterranean habitats.

Arnan X, Molowny-Horas R, Blüthgen N.

Sci Total Environ. 2019 Sep 20;684:126-135. doi: 10.1016/j.scitotenv.2019.05.260. Epub 2019 May 22.


Species-level predation network uncovers high prey specificity in a Neotropical army ant community.

Hoenle PO, Blüthgen N, Brückner A, Kronauer DJC, Fiala B, Donoso DA, Smith MA, Ospina Jara B, von Beeren C.

Mol Ecol. 2019 May;28(9):2423-2440. doi: 10.1111/mec.15078. Epub 2019 May 2.


Tree diversity increases robustness of multi-trophic interactions.

Fornoff F, Klein AM, Blüthgen N, Staab M.

Proc Biol Sci. 2019 Mar 13;286(1898):20182399. doi: 10.1098/rspb.2018.2399.


Isoform-specific Ras signaling is growth factor dependent.

Hood FE, Klinger B, Newlaczyl AU, Sieber A, Dorel M, Oliver SP, Coulson JM, Blüthgen N, Prior IA.

Mol Biol Cell. 2019 Apr 15;30(9):1108-1117. doi: 10.1091/mbc.E18-10-0676. Epub 2019 Feb 20.


Multiple forest attributes underpin the supply of multiple ecosystem services.

Felipe-Lucia MR, Soliveres S, Penone C, Manning P, van der Plas F, Boch S, Prati D, Ammer C, Schall P, Gossner MM, Bauhus J, Buscot F, Blaser S, Blüthgen N, de Frutos A, Ehbrecht M, Frank K, Goldmann K, Hänsel F, Jung K, Kahl T, Nauss T, Oelmann Y, Pena R, Polle A, Renner S, Schloter M, Schöning I, Schrumpf M, Schulze ED, Solly E, Sorkau E, Stempfhuber B, Tschapka M, Weisser WW, Wubet T, Fischer M, Allan E.

Nat Commun. 2018 Nov 16;9(1):4839. doi: 10.1038/s41467-018-07082-4.


Comparative Network Reconstruction using mixed integer programming.

Bosdriesz E, Prahallad A, Klinger B, Sieber A, Bosma A, Bernards R, Blüthgen N, Wessels LFA.

Bioinformatics. 2018 Sep 1;34(17):i997-i1004. doi: 10.1093/bioinformatics/bty616.


Reverse engineering gene regulatory networks by modular response analysis - a benchmark.

Klinger B, Blüthgen N.

Essays Biochem. 2018 Oct 26;62(4):535-547. doi: 10.1042/EBC20180012. Print 2018 Oct 26. Review.


When More Is Less: Dual Phosphorylation Protects Signaling Off State against Overexpression.

Witzel F, Blüthgen N.

Biophys J. 2018 Oct 2;115(7):1383-1392. doi: 10.1016/j.bpj.2018.08.019. Epub 2018 Aug 23.


Unveiling community patterns and trophic niches of tropical and temperate ants using an integrative framework of field data, stable isotopes and fatty acids.

Rosumek FB, Blüthgen N, Brückner A, Menzel F, Gebauer G, Heethoff M.

PeerJ. 2018 Aug 22;6:e5467. doi: 10.7717/peerj.5467. eCollection 2018.


Systems level expression correlation of Ras GTPase regulators.

Besray Unal E, Kiel C, Benisty H, Campbell A, Pickering K, Blüthgen N, Sansom OJ, Serrano L.

Cell Commun Signal. 2018 Aug 15;16(1):46. doi: 10.1186/s12964-018-0256-8.


Global dung webs: high trophic generalism of dung beetles along the latitudinal diversity gradient.

Frank K, Krell FT, Slade EM, Raine EH, Chiew LY, Schmitt T, Vairappan CS, Walter P, Blüthgen N.

Ecol Lett. 2018 Aug;21(8):1229-1236. doi: 10.1111/ele.13095. Epub 2018 Jun 25.


Modelling signalling networks from perturbation data.

Dorel M, Klinger B, Gross T, Sieber A, Prahallad A, Bosdriesz E, Wessels LFA, Blüthgen N.

Bioinformatics. 2018 Dec 1;34(23):4079-4086. doi: 10.1093/bioinformatics/bty473.


An automated device for the digitization and 3D modelling of insects, combining extended-depth-of-field and all-side multi-view imaging.

Ströbel B, Schmelzle S, Blüthgen N, Heethoff M.

Zookeys. 2018 May 17;(759):1-27. doi: 10.3897/zookeys.759.24584. eCollection 2018.


The gene regulatory network of mESC differentiation: a benchmark for reverse engineering methods.

Meisig J, Blüthgen N.

Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750). pii: 20170222. doi: 10.1098/rstb.2017.0222.


Assessment of stem cell differentiation based on genome-wide expression profiles.

Godoy P, Schmidt-Heck W, Hellwig B, Nell P, Feuerborn D, Rahnenführer J, Kattler K, Walter J, Blüthgen N, Hengstler JG.

Philos Trans R Soc Lond B Biol Sci. 2018 Jul 5;373(1750). pii: 20170221. doi: 10.1098/rstb.2017.0221. Review.


Effects of chronic anthropogenic disturbance and rainfall on the specialization of ant-plant mutualistic networks in the Caatinga, a Brazilian dry forest.

Câmara T, Leal IR, Blüthgen N, Oliveira FMP, Queiroz RT, Arnan X.

J Anim Ecol. 2018 Jul;87(4):1022-1033. doi: 10.1111/1365-2656.12820. Epub 2018 Apr 6.


Whither systems medicine?

Apweiler R, Beissbarth T, Berthold MR, Blüthgen N, Burmeister Y, Dammann O, Deutsch A, Feuerhake F, Franke A, Hasenauer J, Hoffmann S, Höfer T, Jansen PL, Kaderali L, Klingmüller U, Koch I, Kohlbacher O, Kuepfer L, Lammert F, Maier D, Pfeifer N, Radde N, Rehm M, Roeder I, Saez-Rodriguez J, Sax U, Schmeck B, Schuppert A, Seilheimer B, Theis FJ, Vera J, Wolkenhauer O.

Exp Mol Med. 2018 Mar 2;50(3):e453. doi: 10.1038/emm.2017.290. Review.


Perturbation-response genes reveal signaling footprints in cancer gene expression.

Schubert M, Klinger B, Klünemann M, Sieber A, Uhlitz F, Sauer S, Garnett MJ, Blüthgen N, Saez-Rodriguez J.

Nat Commun. 2018 Jan 2;9(1):20. doi: 10.1038/s41467-017-02391-6.


Classification of gene signatures for their information value and functional redundancy.

Cantini L, Calzone L, Martignetti L, Rydenfelt M, Blüthgen N, Barillot E, Zinovyev A.

NPJ Syst Biol Appl. 2017 Dec 19;4:2. doi: 10.1038/s41540-017-0038-8. eCollection 2018.


Intensive land use drives small-scale homogenization of plant- and leafhopper communities and promotes generalists.

Chisté MN, Mody K, Kunz G, Gunczy J, Blüthgen N.

Oecologia. 2018 Feb;186(2):529-540. doi: 10.1007/s00442-017-4031-0. Epub 2017 Dec 4.


An immediate-late gene expression module decodes ERK signal duration.

Uhlitz F, Sieber A, Wyler E, Fritsche-Guenther R, Meisig J, Landthaler M, Klinger B, Blüthgen N.

Mol Syst Biol. 2017 Sep 25;13(9):944. doi: 10.15252/msb.20177986. No abstract available.


Nutrient quality of vertebrate dung as a diet for dung beetles.

Frank K, Brückner A, Hilpert A, Heethoff M, Blüthgen N.

Sci Rep. 2017 Sep 22;7(1):12141. doi: 10.1038/s41598-017-12265-y.


Ants at Plant Wounds: A Little-Known Trophic Interaction with Evolutionary Implications for Ant-Plant Interactions.

Staab M, Fornoff F, Klein AM, Blüthgen N.

Am Nat. 2017 Sep;190(3):442-450. doi: 10.1086/692735. Epub 2017 Jun 23.


Patterns and dynamics of neutral lipid fatty acids in ants - implications for ecological studies.

Rosumek FB, Brückner A, Blüthgen N, Menzel F, Heethoff M.

Front Zool. 2017 Jul 13;14:36. doi: 10.1186/s12983-017-0221-1. eCollection 2017.


A compendium of ERK targets.

Ünal EB, Uhlitz F, Blüthgen N.

FEBS Lett. 2017 Sep;591(17):2607-2615. doi: 10.1002/1873-3468.12740. Epub 2017 Jul 25. Review.


Neuronal activity-regulated alternative mRNA splicing.

Hermey G, Blüthgen N, Kuhl D.

Int J Biochem Cell Biol. 2017 Oct;91(Pt B):184-193. doi: 10.1016/j.biocel.2017.06.002. Epub 2017 Jun 4. Review.


An immediate-late gene expression module decodes ERK signal duration.

Uhlitz F, Sieber A, Wyler E, Fritsche-Guenther R, Meisig J, Landthaler M, Klinger B, Blüthgen N.

Mol Syst Biol. 2017 May 3;13(5):928. doi: 10.15252/msb.20177554. Erratum in: Mol Syst Biol. 2017 Sep 25;13(9):944.


Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids.

Riemer P, Rydenfelt M, Marks M, van Eunen K, Thedieck K, Herrmann BG, Blüthgen N, Sers C, Morkel M.

J Cell Biol. 2017 Jun 5;216(6):1567-1577. doi: 10.1083/jcb.201610058. Epub 2017 Apr 25.


The relationship between epicuticular long-chained hydrocarbons and surface area - volume ratios in insects (Diptera, Hymenoptera, Lepidoptera).

Brückner A, Heethoff M, Blüthgen N.

PLoS One. 2017 Apr 6;12(4):e0175001. doi: 10.1371/journal.pone.0175001. eCollection 2017.


Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type-Specific Dynamic Logic Models.

Eduati F, Doldàn-Martelli V, Klinger B, Cokelaer T, Sieber A, Kogera F, Dorel M, Garnett MJ, Blüthgen N, Saez-Rodriguez J.

Cancer Res. 2017 Jun 15;77(12):3364-3375. doi: 10.1158/0008-5472.CAN-17-0078. Epub 2017 Apr 5.


Profiling the MAPK/ERK dependent and independent activity regulated transcriptional programs in the murine hippocampus in vivo.

Blüthgen N, van Bentum M, Merz B, Kuhl D, Hermey G.

Sci Rep. 2017 Mar 28;7:45101. doi: 10.1038/srep45101.


Ecosystem restoration strengthens pollination network resilience and function.

Kaiser-Bunbury CN, Mougal J, Whittington AE, Valentin T, Gabriel R, Olesen JM, Blüthgen N.

Nature. 2017 Feb 9;542(7640):223-227. doi: 10.1038/nature21071. Epub 2017 Jan 30.


Reciprocal insulation analysis of Hi-C data shows that TADs represent a functionally but not structurally privileged scale in the hierarchical folding of chromosomes.

Zhan Y, Mariani L, Barozzi I, Schulz EG, Blüthgen N, Stadler M, Tiana G, Giorgetti L.

Genome Res. 2017 Mar;27(3):479-490. doi: 10.1101/gr.212803.116. Epub 2017 Jan 5.


Comparison of a teratogenic transcriptome-based predictive test based on human embryonic versus inducible pluripotent stem cells.

Shinde V, Perumal Srinivasan S, Henry M, Rotshteyn T, Hescheler J, Rahnenführer J, Grinberg M, Meisig J, Blüthgen N, Waldmann T, Leist M, Hengstler JG, Sachinidis A.

Stem Cell Res Ther. 2016 Dec 30;7(1):190. doi: 10.1186/s13287-016-0449-2.


Ecological networks are more sensitive to plant than to animal extinction under climate change.

Schleuning M, Fründ J, Schweiger O, Welk E, Albrecht J, Albrecht M, Beil M, Benadi G, Blüthgen N, Bruelheide H, Böhning-Gaese K, Dehling DM, Dormann CF, Exeler N, Farwig N, Harpke A, Hickler T, Kratochwil A, Kuhlmann M, Kühn I, Michez D, Mudri-Stojnić S, Plein M, Rasmont P, Schwabe A, Settele J, Vujić A, Weiner CN, Wiemers M, Hof C.

Nat Commun. 2016 Dec 23;7:13965. doi: 10.1038/ncomms13965.


Land-use intensification causes multitrophic homogenization of grassland communities.

Gossner MM, Lewinsohn TM, Kahl T, Grassein F, Boch S, Prati D, Birkhofer K, Renner SC, Sikorski J, Wubet T, Arndt H, Baumgartner V, Blaser S, Blüthgen N, Börschig C, Buscot F, Diekötter T, Jorge LR, Jung K, Keyel AC, Klein AM, Klemmer S, Krauss J, Lange M, Müller J, Overmann J, Pašalić E, Penone C, Perović DJ, Purschke O, Schall P, Socher SA, Sonnemann I, Tschapka M, Tscharntke T, Türke M, Venter PC, Weiner CN, Werner M, Wolters V, Wurst S, Westphal C, Fischer M, Weisser WW, Allan E.

Nature. 2016 Dec 8;540(7632):266-269. doi: 10.1038/nature20575. Epub 2016 Nov 30.


Biodiversity at multiple trophic levels is needed for ecosystem multifunctionality.

Soliveres S, van der Plas F, Manning P, Prati D, Gossner MM, Renner SC, Alt F, Arndt H, Baumgartner V, Binkenstein J, Birkhofer K, Blaser S, Blüthgen N, Boch S, Böhm S, Börschig C, Buscot F, Diekötter T, Heinze J, Hölzel N, Jung K, Klaus VH, Kleinebecker T, Klemmer S, Krauss J, Lange M, Morris EK, Müller J, Oelmann Y, Overmann J, Pašalić E, Rillig MC, Schaefer HM, Schloter M, Schmitt B, Schöning I, Schrumpf M, Sikorski J, Socher SA, Solly EF, Sonnemann I, Sorkau E, Steckel J, Steffan-Dewenter I, Stempfhuber B, Tschapka M, Türke M, Venter PC, Weiner CN, Weisser WW, Werner M, Westphal C, Wilcke W, Wolters V, Wubet T, Wurst S, Fischer M, Allan E.

Nature. 2016 Aug 25;536(7617):456-9. Epub 2016 Aug 17.


Natural Cubic Spline Regression Modeling Followed by Dynamic Network Reconstruction for the Identification of Radiation-Sensitivity Gene Association Networks from Time-Course Transcriptome Data.

Michna A, Braselmann H, Selmansberger M, Dietz A, Hess J, Gomolka M, Hornhardt S, Blüthgen N, Zitzelsberger H, Unger K.

PLoS One. 2016 Aug 9;11(8):e0160791. doi: 10.1371/journal.pone.0160791. eCollection 2016.


Host specificity in a diverse Neotropical tick community: an assessment using quantitative network analysis and host phylogeny.

Esser HJ, Herre EA, Blüthgen N, Loaiza JR, Bermúdez SE, Jansen PA.

Parasit Vectors. 2016 Jun 29;9(1):372. doi: 10.1186/s13071-016-1655-6.


Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue.

Godoy P, Widera A, Schmidt-Heck W, Campos G, Meyer C, Cadenas C, Reif R, Stöber R, Hammad S, Pütter L, Gianmoena K, Marchan R, Ghallab A, Edlund K, Nüssler A, Thasler WE, Damm G, Seehofer D, Weiss TS, Dirsch O, Dahmen U, Gebhardt R, Chaudhari U, Meganathan K, Sachinidis A, Kelm J, Hofmann U, Zahedi RP, Guthke R, Blüthgen N, Dooley S, Hengstler JG.

Arch Toxicol. 2016 Oct;90(10):2513-29. doi: 10.1007/s00204-016-1761-4. Epub 2016 Jun 23.


Surface area-volume ratios in insects.

Kühsel S, Brückner A, Schmelzle S, Heethoff M, Blüthgen N.

Insect Sci. 2017 Oct;24(5):829-841. doi: 10.1111/1744-7917.12362. Epub 2016 Aug 15.


Locally rare species influence grassland ecosystem multifunctionality.

Soliveres S, Manning P, Prati D, Gossner MM, Alt F, Arndt H, Baumgartner V, Binkenstein J, Birkhofer K, Blaser S, Blüthgen N, Boch S, Böhm S, Börschig C, Buscot F, Diekötter T, Heinze J, Hölzel N, Jung K, Klaus VH, Klein AM, Kleinebecker T, Klemmer S, Krauss J, Lange M, Morris EK, Müller J, Oelmann Y, Overmann J, Pašalić E, Renner SC, Rillig MC, Schaefer HM, Schloter M, Schmitt B, Schöning I, Schrumpf M, Sikorski J, Socher SA, Solly EF, Sonnemann I, Sorkau E, Steckel J, Steffan-Dewenter I, Stempfhuber B, Tschapka M, Türke M, Venter P, Weiner CN, Weisser WW, Werner M, Westphal C, Wilcke W, Wolters V, Wubet T, Wurst S, Fischer M, Allan E.

Philos Trans R Soc Lond B Biol Sci. 2016 May 19;371(1694). pii: 20150269. doi: 10.1098/rstb.2015.0269.


The relation between circadian asynchrony, functional redundancy, and trophic performance in tropical ant communities.

Houadria M, Blüthgen N, Salas-Lopez A, Schmitt MI, Arndt J, Schneider E, Orivel J, Menzel F.

Ecology. 2016 Jan;97(1):225-35.


Studying the Complex Communities of Ants and Their Symbionts Using Ecological Network Analysis.

Ivens AB, von Beeren C, Blüthgen N, Kronauer DJ.

Annu Rev Entomol. 2016;61:353-71. doi: 10.1146/annurev-ento-010715-023719. Review.


Stem Cell-Derived Immature Human Dorsal Root Ganglia Neurons to Identify Peripheral Neurotoxicants.

Hoelting L, Klima S, Karreman C, Grinberg M, Meisig J, Henry M, Rotshteyn T, Rahnenführer J, Blüthgen N, Sachinidis A, Waldmann T, Leist M.

Stem Cells Transl Med. 2016 Apr;5(4):476-87. doi: 10.5966/sctm.2015-0108. Epub 2016 Mar 1.


Land use imperils plant and animal community stability through changes in asynchrony rather than diversity.

Blüthgen N, Simons NK, Jung K, Prati D, Renner SC, Boch S, Fischer M, Hölzel N, Klaus VH, Kleinebecker T, Tschapka M, Weisser WW, Gossner MM.

Nat Commun. 2016 Feb 12;7:10697. doi: 10.1038/ncomms10697.


Effects of RAF inhibitors on PI3K/AKT signalling depend on mutational status of the RAS/RAF signalling axis.

Fritsche-Guenther R, Witzel F, Kempa S, Brummer T, Sers C, Blüthgen N.

Oncotarget. 2016 Feb 16;7(7):7960-9. doi: 10.18632/oncotarget.6959.


Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A.

Rohwer N, Bindel F, Grimm C, Lin SJ, Wappler J, Klinger B, Blüthgen N, Du Bois I, Schmeck B, Lehrach H, de Graauw M, Goncalves E, Saez-Rodriguez J, Tan P, Grabsch HI, Prigione A, Kempa S, Cramer T.

Oncotarget. 2016 Feb 9;7(6):6693-710. doi: 10.18632/oncotarget.6793.

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