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Items: 45

1.

Autocrine activin A signalling in ovarian cancer cells regulates secretion of interleukin 6, autophagy, and cachexia.

Pettersen K, Andersen S, van der Veen A, Nonstad U, Hatakeyama S, Lambert C, Lach-Trifilieff E, Moestue S, Kim J, Grønberg BH, Schilb A, Jacobi C, Bjørkøy G.

J Cachexia Sarcopenia Muscle. 2019 Aug 21. doi: 10.1002/jcsm.12489. [Epub ahead of print]

2.

Exercise Reveals Proline Dehydrogenase as a Potential Target in Heart Failure.

Moreira JBN, Wohlwend M, Fenk S, Åmellem I, Flatberg A, Kraljevic J, Marinovic J, Ljubkovic M, Bjørkøy G, Wisløff U.

Prog Cardiovasc Dis. 2019 Mar - Apr;62(2):193-202. doi: 10.1016/j.pcad.2019.03.002. Epub 2019 Mar 10. Review.

PMID:
30867130
3.

A Novel Truncated Form of Nephronectin Is Present in Small Extracellular Vesicles Isolated from 66cl4 Cells.

Toraskar J, Magnussen SN, Hagen L, Sharma A, Hoang L, Bjørkøy G, Svineng G, Steigedal TS.

J Proteome Res. 2019 Mar 1;18(3):1237-1247. doi: 10.1021/acs.jproteome.8b00859. Epub 2019 Feb 13.

PMID:
30707844
4.

Loss of NRF-2 and PGC-1α genes leads to retinal pigment epithelium damage resembling dry age-related macular degeneration.

Felszeghy S, Viiri J, Paterno JJ, Hyttinen JMT, Koskela A, Chen M, Leinonen H, Tanila H, Kivinen N, Koistinen A, Toropainen E, Amadio M, Smedowski A, Reinisalo M, Winiarczyk M, Mackiewicz J, Mutikainen M, Ruotsalainen AK, Kettunen M, Jokivarsi K, Sinha D, Kinnunen K, Petrovski G, Blasiak J, Bjørkøy G, Koskelainen A, Skottman H, Urtti A, Salminen A, Kannan R, Ferrington DA, Xu H, Levonen AL, Tavi P, Kauppinen A, Kaarniranta K.

Redox Biol. 2019 Jan;20:1-12. doi: 10.1016/j.redox.2018.09.011. Epub 2018 Sep 14.

5.

N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2.

Mildenberger J, Johansson I, Sergin I, Kjøbli E, Damås JK, Razani B, Flo TH, Bjørkøy G.

Autophagy. 2017 Oct 3;13(10):1664-1678. doi: 10.1080/15548627.2017.1345411. Epub 2017 Aug 18.

6.

Cancer cachexia associates with a systemic autophagy-inducing activity mimicked by cancer cell-derived IL-6 trans-signaling.

Pettersen K, Andersen S, Degen S, Tadini V, Grosjean J, Hatakeyama S, Tesfahun AN, Moestue S, Kim J, Nonstad U, Romundstad PR, Skorpen F, Sørhaug S, Amundsen T, Grønberg BH, Strasser F, Stephens N, Hoem D, Molven A, Kaasa S, Fearon K, Jacobi C, Bjørkøy G.

Sci Rep. 2017 May 17;7(1):2046. doi: 10.1038/s41598-017-02088-2.

7.

Depletion of the human N-terminal acetyltransferase hNaa30 disrupts Golgi integrity and ARFRP1 localization.

Starheim KK, Kalvik TV, Bjørkøy G, Arnesen T.

Biosci Rep. 2017 Apr 28;37(2). pii: BSR20170066. doi: 10.1042/BSR20170066. Print 2017 Apr 30.

8.

Gastrin activates autophagy and increases migration and survival of gastric adenocarcinoma cells.

Rao SV, Solum G, Niederdorfer B, Nørsett KG, Bjørkøy G, Thommesen L.

BMC Cancer. 2017 Jan 21;17(1):68. doi: 10.1186/s12885-017-3055-5.

9.

Hydroxychloroquine potentiates carfilzomib toxicity towards myeloma cells.

Baranowska K, Misund K, Starheim KK, Holien T, Johansson I, Darvekar S, Buene G, Waage A, Bjørkøy G, Sundan A.

Oncotarget. 2016 Oct 25;7(43):70845-70856. doi: 10.18632/oncotarget.12226.

10.

Intracellular glutathione determines bortezomib cytotoxicity in multiple myeloma cells.

Starheim KK, Holien T, Misund K, Johansson I, Baranowska KA, Sponaas AM, Hella H, Buene G, Waage A, Sundan A, Bjørkøy G.

Blood Cancer J. 2016 Jul 15;6(7):e446. doi: 10.1038/bcj.2016.56.

11.

Treatment with aromatase inhibitors stimulates the expression of epidermal growth factor receptor-1 and neuregulin 1 in ER positive/HER-2/neu non-amplified primary breast cancers.

Flågeng MH, Larionov A, Geisler J, Knappskog S, Prestvik WS, Bjørkøy G, Lilleng PK, Dixon JM, Miller WR, Lønning PE, Mellgren G.

J Steroid Biochem Mol Biol. 2017 Jan;165(Pt B):228-235. doi: 10.1016/j.jsbmb.2016.06.011. Epub 2016 Jun 22.

PMID:
27343990
12.

DHA-induced stress response in human colon cancer cells - Focus on oxidative stress and autophagy.

Pettersen K, Monsen VT, Hakvåg Pettersen CH, Overland HB, Pettersen G, Samdal H, Tesfahun AN, Lundemo AG, Bjørkøy G, Schønberg SA.

Free Radic Biol Med. 2016 Jan;90:158-72. doi: 10.1016/j.freeradbiomed.2015.11.018. Epub 2015 Nov 14.

13.

The marine n-3 PUFA DHA evokes cytoprotection against oxidative stress and protein misfolding by inducing autophagy and NFE2L2 in human retinal pigment epithelial cells.

Johansson I, Monsen VT, Pettersen K, Mildenberger J, Misund K, Kaarniranta K, Schønberg S, Bjørkøy G.

Autophagy. 2015;11(9):1636-51. doi: 10.1080/15548627.2015.1061170.

14.

Regulator of Chromosome Condensation 2 Identifies High-Risk Patients within Both Major Phenotypes of Colorectal Cancer.

Bruun J, Kolberg M, Ahlquist TC, Røyrvik EC, Nome T, Leithe E, Lind GE, Merok MA, Rognum TO, Bjørkøy G, Johansen T, Lindblom A, Sun XF, Svindland A, Liestøl K, Nesbakken A, Skotheim RI, Lothe RA.

Clin Cancer Res. 2015 Aug 15;21(16):3759-70. doi: 10.1158/1078-0432.CCR-14-3294. Epub 2015 Apr 24.

15.

MRI reveals the in vivo cellular and vascular response to BEZ235 in ovarian cancer xenografts with different PI3-kinase pathway activity.

Cebulla J, Huuse EM, Pettersen K, van der Veen A, Kim E, Andersen S, Prestvik WS, Bofin AM, Pathak AP, Bjørkøy G, Bathen TF, Moestue SA.

Br J Cancer. 2015 Feb 3;112(3):504-13. doi: 10.1038/bjc.2014.628. Epub 2014 Dec 23.

16.

Endocytosis of secreted carboxyl ester lipase in a syndrome of diabetes and pancreatic exocrine dysfunction.

Torsvik J, Johansson BB, Dalva M, Marie M, Fjeld K, Johansson S, Bjørkøy G, Saraste J, Njølstad PR, Molven A.

J Biol Chem. 2014 Oct 17;289(42):29097-111. doi: 10.1074/jbc.M114.574244. Epub 2014 Aug 25.

17.

Identification of new 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines as highly potent EGFR-TK inhibitors with Src-family activity.

Kaspersen SJ, Han J, Nørsett KG, Rydså L, Kjøbli E, Bugge S, Bjørkøy G, Sundby E, Hoff BH.

Eur J Pharm Sci. 2014 Aug 1;59:69-82. doi: 10.1016/j.ejps.2014.04.011. Epub 2014 Apr 24.

PMID:
24769040
18.

Structure-activity study leading to identification of a highly active thienopyrimidine based EGFR inhibitor.

Bugge S, Kaspersen SJ, Larsen S, Nonstad U, Bjørkøy G, Sundby E, Hoff BH.

Eur J Med Chem. 2014 Mar 21;75:354-74. doi: 10.1016/j.ejmech.2014.01.042. Epub 2014 Jan 31.

PMID:
24556149
19.

Metabolic biomarkers for response to PI3K inhibition in basal-like breast cancer.

Moestue SA, Dam CG, Gorad SS, Kristian A, Bofin A, Mælandsmo GM, Engebråten O, Gribbestad IS, Bjørkøy G.

Breast Cancer Res. 2013 Feb 28;15(1):R16. doi: 10.1186/bcr3391.

20.

Synthesis and in vitro EGFR (ErbB1) tyrosine kinase inhibitory activity of 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines.

Kaspersen SJ, Sørum C, Willassen V, Fuglseth E, Kjøbli E, Bjørkøy G, Sundby E, Hoff BH.

Eur J Med Chem. 2011 Dec;46(12):6002-14. doi: 10.1016/j.ejmech.2011.10.012. Epub 2011 Oct 15.

PMID:
22018877
21.

Transforming growth factor-β-inducible early response gene 1 is a novel substrate for atypical protein kinase Cs.

Alemu EA, Sjøttem E, Outzen H, Larsen KB, Holm T, Bjørkøy G, Johansen T.

Cell Mol Life Sci. 2011 Jun;68(11):1953-68. doi: 10.1007/s00018-010-0541-1. Epub 2010 Oct 17.

22.

Autophagic degradation of dBruce controls DNA fragmentation in nurse cells during late Drosophila melanogaster oogenesis.

Nezis IP, Shravage BV, Sagona AP, Lamark T, Bjørkøy G, Johansen T, Rusten TE, Brech A, Baehrecke EH, Stenmark H.

J Cell Biol. 2010 Aug 23;190(4):523-31. doi: 10.1083/jcb.201002035. Epub 2010 Aug 16.

23.

Pax6 localizes to chromatin-rich territories and displays a slow nuclear mobility altered by disease mutations.

Elvenes J, Sjøttem E, Holm T, Bjørkøy G, Johansen T.

Cell Mol Life Sci. 2010 Dec;67(23):4079-94. doi: 10.1007/s00018-010-0429-0. Epub 2010 Jun 25.

PMID:
20577777
24.

A reporter cell system to monitor autophagy based on p62/SQSTM1.

Larsen KB, Lamark T, Øvervatn A, Harneshaug I, Johansen T, Bjørkøy G.

Autophagy. 2010 Aug;6(6):784-93. Epub 2010 Aug 28.

PMID:
20574168
25.

p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy.

Clausen TH, Lamark T, Isakson P, Finley K, Larsen KB, Brech A, Øvervatn A, Stenmark H, Bjørkøy G, Simonsen A, Johansen T.

Autophagy. 2010 Apr;6(3):330-44. Epub 2010 Apr 11.

PMID:
20168092
26.

FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport.

Pankiv S, Alemu EA, Brech A, Bruun JA, Lamark T, Overvatn A, Bjørkøy G, Johansen T.

J Cell Biol. 2010 Jan 25;188(2):253-69. doi: 10.1083/jcb.200907015.

27.

Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies.

Pankiv S, Lamark T, Bruun JA, Øvervatn A, Bjørkøy G, Johansen T.

J Biol Chem. 2010 Feb 19;285(8):5941-53. doi: 10.1074/jbc.M109.039925. Epub 2009 Dec 15.

28.

A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.

Kirkin V, Lamark T, Sou YS, Bjørkøy G, Nunn JL, Bruun JA, Shvets E, McEwan DG, Clausen TH, Wild P, Bilusic I, Theurillat JP, Øvervatn A, Ishii T, Elazar Z, Komatsu M, Dikic I, Johansen T.

Mol Cell. 2009 Feb 27;33(4):505-16. doi: 10.1016/j.molcel.2009.01.020.

29.

Monitoring autophagic degradation of p62/SQSTM1.

Bjørkøy G, Lamark T, Pankiv S, Øvervatn A, Brech A, Johansen T.

Methods Enzymol. 2009;452:181-97. doi: 10.1016/S0076-6879(08)03612-4.

PMID:
19200883
30.

Cell death during Drosophila melanogaster early oogenesis is mediated through autophagy.

Nezis IP, Lamark T, Velentzas AD, Rusten TE, Bjørkøy G, Johansen T, Papassideri IS, Stravopodis DJ, Margaritis LH, Stenmark H, Brech A.

Autophagy. 2009 Apr;5(3):298-302. Epub 2009 Apr 19.

PMID:
19066465
31.

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.

Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Øvervatn A, Bjørkøy G, Johansen T.

J Biol Chem. 2007 Aug 17;282(33):24131-45. Epub 2007 Jun 19.

32.

p62/SQSTM1: a missing link between protein aggregates and the autophagy machinery.

Bjørkøy G, Lamark T, Johansen T.

Autophagy. 2006 Apr-Jun;2(2):138-9. Epub 2006 Apr 14.

PMID:
16874037
33.

Radiation-induced upregulation of gamma-glutamyltransferase in colon carcinoma cells is mediated through the Ras signal transduction pathway.

Pankiv S, Møller S, Bjørkøy G, Moens U, Huseby NE.

Biochim Biophys Acta. 2006 Feb;1760(2):151-7. Epub 2005 Dec 9.

PMID:
16386375
34.

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death.

Bjørkøy G, Lamark T, Brech A, Outzen H, Perander M, Overvatn A, Stenmark H, Johansen T.

J Cell Biol. 2005 Nov 21;171(4):603-14. Epub 2005 Nov 14.

35.

Detection of mRNA transcripts of truncated opiate precursor (POMC) in human cartilage.

Andjelkov N, Elvenes J, Figenschau Y, Bjorkoy G, Knutsen G, Seternes T, Johansen O.

Cell Biochem Funct. 2006 May-Jun;24(3):229-35.

PMID:
15898126
36.

The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactions.

Bruun JA, Thomassen EI, Kristiansen K, Tylden G, Holm T, Mikkola I, Bjørkøy G, Johansen T.

Nucleic Acids Res. 2005 May 10;33(8):2661-75. Print 2005.

37.

Intracellular and surface distribution of monocyte tissue factor: application to intersubject variability.

Egorina EM, Sovershaev MA, Bjørkøy G, Gruber FX, Olsen JO, Parhami-Seren B, Mann KG, Østerud B.

Arterioscler Thromb Vasc Biol. 2005 Jul;25(7):1493-8. Epub 2005 Apr 28.

38.

Expression of functional mu-opioid receptors in human osteoarthritic cartilage and chondrocytes.

Elvenes J, Andjelkov N, Figenschau Y, Seternes T, Bjørkøy G, Johansen O.

Biochem Biophys Res Commun. 2003 Nov 7;311(1):202-7.

PMID:
14575714
39.

Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins.

Lamark T, Perander M, Outzen H, Kristiansen K, Øvervatn A, Michaelsen E, Bjørkøy G, Johansen T.

J Biol Chem. 2003 Sep 5;278(36):34568-81. Epub 2003 Jun 17.

40.

Nuclear import and export signals enable rapid nucleocytoplasmic shuttling of the atypical protein kinase C lambda.

Perander M, Bjorkoy G, Johansen T.

J Biol Chem. 2001 Apr 20;276(16):13015-24. Epub 2000 Dec 13.

41.
42.

[Oncogenes--"reckless drivers" on signal pathways controlling cell division].

Johansen T, Bjørkøy G.

Tidsskr Nor Laegeforen. 1998 May 10;118(12):1880-5. Review. Norwegian.

PMID:
9638058
44.

Evidence for a bifurcation of the mitogenic signaling pathway activated by Ras and phosphatidylcholine-hydrolyzing phospholipase C.

Bjørkøy G, Overvatn A, Diaz-Meco MT, Moscat J, Johansen T.

J Biol Chem. 1995 Sep 8;270(36):21299-306.

45.

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