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Items: 45

1.

Vector-mediated l-3,4-dihydroxyphenylalanine delivery reverses motor impairments in a primate model of Parkinson's disease.

Rosenblad C, Li Q, Pioli EY, Dovero S, Antunes AS, Agúndez L, Bardelli M, Linden RM, Henckaerts E, Björklund A, Bezard E, Björklund T.

Brain. 2019 Aug 1;142(8):2402-2416. doi: 10.1093/brain/awz176.

2.

Practical Considerations for the Use of DREADD and Other Chemogenetic Receptors to Regulate Neuronal Activity in the Mammalian Brain.

Aldrin-Kirk P, Björklund T.

Methods Mol Biol. 2019;1937:59-87. doi: 10.1007/978-1-4939-9065-8_4.

PMID:
30706390
3.

Repairing the Brain: Gene Therapy.

Björklund T.

J Parkinsons Dis. 2018;8(s1):S123-S130. doi: 10.3233/JPD-181485.

4.

A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.

Tordo J, O'Leary C, Antunes ASLM, Palomar N, Aldrin-Kirk P, Basche M, Bennett A, D'Souza Z, Gleitz H, Godwin A, Holley RJ, Parker H, Liao AY, Rouse P, Youshani AS, Dridi L, Martins C, Levade T, Stacey KB, Davis DM, Dyer A, Clément N, Björklund T, Ali RR, Agbandje-McKenna M, Rahim AA, Pshezhetsky A, Waddington SN, Linden RM, Bigger BW, Henckaerts E.

Brain. 2018 Jul 1;141(7):2014-2031. doi: 10.1093/brain/awy126.

5.

Molecular barcoding of viral vectors enables mapping and optimization of mRNA trans-splicing.

Davidsson M, Díaz-Fernández P, Torroba M, Schwich OD, Aldrin-Kirk P, Quintino L, Heuer A, Wang G, Lundberg C, Björklund T.

RNA. 2018 May;24(5):673-687. doi: 10.1261/rna.063925.117. Epub 2018 Jan 31.

6.

Chemogenetic modulation of cholinergic interneurons reveals their regulating role on the direct and indirect output pathways from the striatum.

Aldrin-Kirk P, Heuer A, Rylander Ottosson D, Davidsson M, Mattsson B, Björklund T.

Neurobiol Dis. 2018 Jan;109(Pt A):148-162. doi: 10.1016/j.nbd.2017.10.010. Epub 2017 Oct 14.

PMID:
29037828
7.

A novel process of viral vector barcoding and library preparation enables high-diversity library generation and recombination-free paired-end sequencing.

Davidsson M, Diaz-Fernandez P, Schwich OD, Torroba M, Wang G, Björklund T.

Sci Rep. 2016 Nov 22;6:37563. doi: 10.1038/srep37563.

8.

Identification of Multiple QTLs Linked to Neuropathology in the Engrailed-1 Heterozygous Mouse Model of Parkinson's Disease.

Kurowska Z, Jewett M, Brattås PL, Jimenez-Ferrer I, Kenéz X, Björklund T, Nordström U, Brundin P, Swanberg M.

Sci Rep. 2016 Aug 23;6:31701. doi: 10.1038/srep31701.

9.

Cellular Barcoding Links B-1a B Cell Potential to a Fetal Hematopoietic Stem Cell State at the Single-Cell Level.

Kristiansen TA, Jaensson Gyllenbäck E, Zriwil A, Björklund T, Daniel JA, Sitnicka E, Soneji S, Bryder D, Yuan J.

Immunity. 2016 Aug 16;45(2):346-57. doi: 10.1016/j.immuni.2016.07.014.

10.

DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor.

Aldrin-Kirk P, Heuer A, Wang G, Mattsson B, Lundblad M, Parmar M, Björklund T.

Neuron. 2016 Jun 1;90(5):955-68. doi: 10.1016/j.neuron.2016.04.017. Epub 2016 May 5.

11.

Expression of Multiple Functional RNAs or Proteins from One Viral Vector.

Björklund T.

Methods Mol Biol. 2016;1382:41-56. doi: 10.1007/978-1-4939-3271-9_3.

PMID:
26611577
12.

Process Improvement for Interinstitutional Research Contracting.

Varner M, Logan J, Bjorklund T, Whitfield J, Reed P, Lesher L, Sikalis A, Brown B, Drollinger S, Larrabee K, Thompson K, Clark E, Workman M, Boi L.

Clin Transl Sci. 2015 Aug;8(4):334-40. doi: 10.1111/cts.12280. Epub 2015 Jun 17.

13.

Mammographic density: Comparison of visual assessment with fully automatic calculation on a multivendor dataset.

Sacchetto D, Morra L, Agliozzo S, Bernardi D, Björklund T, Brancato B, Bravetti P, Carbonaro LA, Correale L, Fantò C, Favettini E, Martincich L, Milanesio L, Mombelloni S, Monetti F, Morrone D, Pellegrini M, Pesce B, Petrillo A, Saguatti G, Stevanin C, Trimboli RM, Tuttobene P, Valentini M, Marra V, Frigerio A, Bert A, Sardanelli F.

Eur Radiol. 2016 Jan;26(1):175-83. doi: 10.1007/s00330-015-3784-2. Epub 2015 May 1.

PMID:
25929945
14.

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.

Holmqvist S, Chutna O, Bousset L, Aldrin-Kirk P, Li W, Björklund T, Wang ZY, Roybon L, Melki R, Li JY.

Acta Neuropathol. 2014 Dec;128(6):805-20. doi: 10.1007/s00401-014-1343-6. Epub 2014 Oct 9.

PMID:
25296989
15.

Vascular Complications After Radiotherapy in Head and Neck Free Flap Reconstruction: Clinical Outcome Related to Vascular Biology.

Tall J, Björklund TC, Skogh AC, Arnander C, Halle M.

Ann Plast Surg. 2015 Sep;75(3):309-15. doi: 10.1097/SAP.0000000000000081.

PMID:
25003403
16.

Novel AAV-based rat model of forebrain synucleinopathy shows extensive pathologies and progressive loss of cholinergic interneurons.

Aldrin-Kirk P, Davidsson M, Holmqvist S, Li JY, Björklund T.

PLoS One. 2014 Jul 7;9(7):e100869. doi: 10.1371/journal.pone.0100869. eCollection 2014.

17.

Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.

Cederfjäll E, Nilsson N, Sahin G, Chu Y, Nikitidou E, Björklund T, Kordower JH, Kirik D.

Sci Rep. 2013;3:2157. doi: 10.1038/srep02157.

18.

A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP.

Hansen C, Björklund T, Petit GH, Lundblad M, Murmu RP, Brundin P, Li JY.

Neurobiol Dis. 2013 Aug;56:145-55. doi: 10.1016/j.nbd.2013.04.017. Epub 2013 Apr 30.

PMID:
23643841
19.

Dysregulated dopamine storage increases the vulnerability to α-synuclein in nigral neurons.

Ulusoy A, Björklund T, Buck K, Kirik D.

Neurobiol Dis. 2012 Sep;47(3):367-77. doi: 10.1016/j.nbd.2012.05.012. Epub 2012 May 31.

PMID:
22659302
20.

Design of a single AAV vector for coexpression of TH and GCH1 to establish continuous DOPA synthesis in a rat model of Parkinson's disease.

Cederfjäll E, Sahin G, Kirik D, Björklund T.

Mol Ther. 2012 Jul;20(7):1315-26. doi: 10.1038/mt.2012.1. Epub 2012 Jan 31.

21.

Gene therapy for Parkinson's disease shows promise.

Björklund A, Björklund T.

Sci Transl Med. 2011 Apr 20;3(79):79ed1. doi: 10.1126/scitranslmed.3002430. No abstract available.

22.

Mutant huntingtin causes metabolic imbalance by disruption of hypothalamic neurocircuits.

Hult S, Soylu R, Björklund T, Belgardt BF, Mauer J, Brüning JC, Kirik D, Petersén Å.

Cell Metab. 2011 Apr 6;13(4):428-439. doi: 10.1016/j.cmet.2011.02.013.

23.

Gene therapy for dopamine replacement.

Björklund T, Cederfjäll EA, Kirik D.

Prog Brain Res. 2010;184:221-35. doi: 10.1016/S0079-6123(10)84012-9. Review.

PMID:
20887878
24.

A general chemical method to regulate protein stability in the mammalian central nervous system.

Iwamoto M, Björklund T, Lundberg C, Kirik D, Wandless TJ.

Chem Biol. 2010 Sep 24;17(9):981-8. doi: 10.1016/j.chembiol.2010.07.009.

25.

Gene therapy for dopamine replacement in Parkinson's disease.

Björklund A, Björklund T, Kirik D.

Sci Transl Med. 2009 Oct 14;1(2):2ps2. doi: 10.1126/scitranslmed.3000350.

PMID:
20368161
26.

Gene therapy for Parkinson's disease.

Bjorklund T, Kordower JH.

Mov Disord. 2010;25 Suppl 1:S161-73. doi: 10.1002/mds.22785. Review.

PMID:
20187249
27.

Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease.

Björklund T, Carlsson T, Cederfjäll EA, Carta M, Kirik D.

Brain. 2010 Feb;133(Pt 2):496-511. doi: 10.1093/brain/awp314. Epub 2010 Feb 2.

28.

Differential transduction following basal ganglia administration of distinct pseudotyped AAV capsid serotypes in nonhuman primates.

Dodiya HB, Bjorklund T, Stansell J 3rd, Mandel RJ, Kirik D, Kordower JH.

Mol Ther. 2010 Mar;18(3):579-87. doi: 10.1038/mt.2009.216. Epub 2009 Sep 22.

29.

Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats.

Björklund T, Hall H, Breysse N, Soneson C, Carlsson T, Mandel RJ, Carta M, Kirik D.

J Neurochem. 2009 Oct;111(2):355-67. doi: 10.1111/j.1471-4159.2009.06340.x. Epub 2009 Aug 17.

30.

Dose optimization for long-term rAAV-mediated RNA interference in the nigrostriatal projection neurons.

Ulusoy A, Sahin G, Björklund T, Aebischer P, Kirik D.

Mol Ther. 2009 Sep;17(9):1574-84. doi: 10.1038/mt.2009.142. Epub 2009 Jul 7.

31.

Scientific rationale for the development of gene therapy strategies for Parkinson's disease.

Björklund T, Kirik D.

Biochim Biophys Acta. 2009 Jul;1792(7):703-13. doi: 10.1016/j.bbadis.2009.02.009. Epub 2009 Feb 27. Review.

32.

Positron emission tomography imaging demonstrates correlation between behavioral recovery and correction of dopamine neurotransmission after gene therapy.

Leriche L, Björklund T, Breysse N, Besret L, Grégoire MC, Carlsson T, Dollé F, Mandel RJ, Déglon N, Hantraye P, Kirik D.

J Neurosci. 2009 Feb 4;29(5):1544-53. doi: 10.1523/JNEUROSCI.4491-08.2009.

33.

Applications of lentiviral vectors for biology and gene therapy of neurological disorders.

Lundberg C, Björklund T, Carlsson T, Jakobsson J, Hantraye P, Déglon N, Kirik D.

Curr Gene Ther. 2008 Dec;8(6):461-73. Review.

PMID:
19075629
34.

In vivo gene delivery for development of mammalian models for Parkinson's disease.

Ulusoy A, Bjorklund T, Hermening S, Kirik D.

Exp Neurol. 2008 Jan;209(1):89-100. Epub 2007 Sep 22. Review.

PMID:
18028909
35.

Restoration of the striatal dopamine synthesis for Parkinson's disease: viral vector-mediated enzyme replacement strategy.

Carlsson T, Björklund T, Kirik D.

Curr Gene Ther. 2007 Apr;7(2):109-20. Review.

PMID:
17430130
36.

Long-term consequences of human alpha-synuclein overexpression in the primate ventral midbrain.

Eslamboli A, Romero-Ramos M, Burger C, Bjorklund T, Muzyczka N, Mandel RJ, Baker H, Ridley RM, Kirik D.

Brain. 2007 Mar;130(Pt 3):799-815. Epub 2007 Feb 15.

PMID:
17303591
37.

Morphometric and psychometric comparisons between non-substance-abusing patients with posttraumatic stress disorder and normal controls.

Emdad R, Bonekamp D, Sondergaard HP, Bjorklund T, Agartz I, Ingvar M, Theorell T.

Psychother Psychosom. 2006;75(2):122-32.

PMID:
16508348
38.

Imaging in cell-based therapy for neurodegenerative diseases.

Kirik D, Breysse N, Björklund T, Besret L, Hantraye P.

Eur J Nucl Med Mol Imaging. 2005 Dec;32 Suppl 2:S417-34. Review.

PMID:
16267643
39.

Quality of life and patient satisfaction in breast cancer patients after immediate breast reconstruction: a prospective study.

Elder EE, Brandberg Y, Björklund T, Rylander R, Lagergren J, Jurell G, Wickman M, Sandelin K.

Breast. 2005 Jun;14(3):201-8.

PMID:
15927829
40.

Objective evaluation of two differently-shaped permanent expander prostheses used for breast reconstruction.

Edsander-Nord A, Björklund T, Jurell G, Wickman M.

Scand J Plast Reconstr Surg Hand Surg. 2004;38(4):204-8.

PMID:
15370801
41.

Exciton delocalization and superradiance in tetracene thin films and nanoaggregates.

Lim SH, Bjorklund TG, Spano FC, Bardeen CJ.

Phys Rev Lett. 2004 Mar 12;92(10):107402. Epub 2004 Mar 12.

PMID:
15089241
42.

Expression of genetic and environmental variation during ageing : 2. Selection for increased lifespan in Drosophila melanogaster.

Engström G, Liljedahl LE, Björklund T.

Theor Appl Genet. 1992 Oct;85(1):26-32. doi: 10.1007/BF00223841.

PMID:
24197225
43.

[Public health nurses as supporters of young people's self-esteem].

Björklund T.

Sairaanhoitaja. 1991;(4):15-7. Finnish.

PMID:
1888914
44.

Expression of genetic and environmental variation during ageing : 1. Estimation of variance components for number of adult offspring in Drosophila melanogaster.

Engström G, Liljedahl LE, Rasmuson M, Björklund T.

Theor Appl Genet. 1989 Jan;77(1):119-22. doi: 10.1007/BF00292325.

PMID:
24232483
45.

Search for age-dependent as compared to mutagen-induced mutations on the X-chromosome affecting viability in Drosophila melanogaster males.

Björklund T, Engström G, McKay T, Liljedahl L.

Genet Sel Evol. 1988;20(4):409-16. doi: 10.1186/1297-9686-20-4-409. No abstract available.

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