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Items: 1 to 50 of 145

1.

The effect of Jun dimerization on neurite outgrowth and motif binding.

Danzi MC, Mehta ST, Dulla K, Zunino G, Cooper DJ, Bixby JL, Lemmon VP.

Mol Cell Neurosci. 2018 Aug 3;92:114-127. doi: 10.1016/j.mcn.2018.08.001. [Epub ahead of print]

PMID:
30077771
2.

Can Chromatin Accessibility be Exploited for Axon Regeneration?

Danzi MC, O'Neill N, Bixby JL, Lemmon VP.

Dev Neurobiol. 2018 Apr 17. doi: 10.1002/dneu.22598. [Epub ahead of print] Review.

PMID:
29664188
3.

Publisher Correction: Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons.

Hervera A, De Virgiliis F, Palmisano I, Zhou L, Tantardini E, Kong G, Hutson T, Danzi MC, Perry RB, Santos CXC, Kapustin AN, Fleck RA, Del Río JA, Carroll T, Lemmon V, Bixby JL, Shah AM, Fainzilber M, Di Giovanni S.

Nat Cell Biol. 2018 Sep;20(9):1098. doi: 10.1038/s41556-018-0063-x.

PMID:
29520084
4.

Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons.

Hervera A, De Virgiliis F, Palmisano I, Zhou L, Tantardini E, Kong G, Hutson T, Danzi MC, Perry RB, Santos CXC, Kapustin AN, Fleck RA, Del Río JA, Carroll T, Lemmon V, Bixby JL, Shah AM, Fainzilber M, Di Giovanni S.

Nat Cell Biol. 2018 Mar;20(3):307-319. doi: 10.1038/s41556-018-0039-x. Epub 2018 Feb 12. Erratum in: Nat Cell Biol. 2018 Mar 8;:.

PMID:
29434374
5.

High Content Screening of Mammalian Primary Cortical Neurons.

Motti D, Blackmore M, Bixby JL, Lemmon VP.

Methods Mol Biol. 2018;1683:293-304. doi: 10.1007/978-1-4939-7357-6_17.

PMID:
29082499
6.

Stress Increases Peripheral Axon Growth and Regeneration through Glucocorticoid Receptor-Dependent Transcriptional Programs.

Lerch JK, Alexander JK, Madalena KM, Motti D, Quach T, Dhamija A, Zha A, Gensel JC, Webster Marketon J, Lemmon VP, Bixby JL, Popovich PG.

eNeuro. 2017 Aug 21;4(4). pii: ENEURO.0246-17.2017. doi: 10.1523/ENEURO.0246-17.2017. eCollection 2017 Jul-Aug.

7.

Identification of miRNAs involved in DRG neurite outgrowth and their putative targets.

Motti D, Lerch JK, Danzi MC, Gans JH, Kuo F, Slepak TI, Bixby JL, Lemmon VP.

FEBS Lett. 2017 Jul;591(14):2091-2105. doi: 10.1002/1873-3468.12718. Epub 2017 Jul 2.

8.

The mTOR Substrate S6 Kinase 1 (S6K1) Is a Negative Regulator of Axon Regeneration and a Potential Drug Target for Central Nervous System Injury.

Al-Ali H, Ding Y, Slepak T, Wu W, Sun Y, Martinez Y, Xu XM, Lemmon VP, Bixby JL.

J Neurosci. 2017 Jul 26;37(30):7079-7095. doi: 10.1523/JNEUROSCI.0931-17.2017. Epub 2017 Jun 16.

9.

Genetically modifying transcription factors to promote CNS axon regeneration.

Mehta ST, Bixby JL, Lemmon VP.

Neural Regen Res. 2017 May;12(5):737-738. doi: 10.4103/1673-5374.206637. No abstract available.

10.

Developing a data sharing community for spinal cord injury research.

Callahan A, Anderson KD, Beattie MS, Bixby JL, Ferguson AR, Fouad K, Jakeman LB, Nielson JL, Popovich PG, Schwab JM, Lemmon VP; FAIR Share Workshop Participants.

Exp Neurol. 2017 Sep;295:135-143. doi: 10.1016/j.expneurol.2017.05.012. Epub 2017 May 30. Review.

PMID:
28576567
11.

Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis.

Gao H, Danzi MC, Choi CS, Taherian M, Dalby-Hansen C, Ellman DG, Madsen PM, Bixby JL, Lemmon VP, Lambertsen KL, Brambilla R.

Cell Rep. 2017 Jan 3;18(1):198-212. doi: 10.1016/j.celrep.2016.11.083.

12.

Generation and characterization of ABBV642, a dual variable domain immunoglobulin molecule (DVD-Ig) that potently neutralizes VEGF and PDGF-BB and is designed for the treatment of exudative age-related macular degeneration.

Ding K, Eaton L, Bowley D, Rieser M, Chang Q, Harris MC, Clabbers A, Dong F, Shen J, Hackett SF, Touw DS, Bixby J, Zhong S, Benatuil L, Bose S, Grinnell C, Preston GM, Iyer R, Sadhukhan R, Marchie S, Overmeyer G, Ghayur T, van Riet DA, Tang S, Campochario PA, Gu J.

MAbs. 2017 Feb/Mar;9(2):269-284. doi: 10.1080/19420862.2016.1268305.

13.

Phenotypic Screening of Small-Molecule Inhibitors: Implications for Therapeutic Discovery and Drug Target Development in Traumatic Brain Injury.

Al-Ali H, Lemmon VP, Bixby JL.

Methods Mol Biol. 2016;1462:677-88. doi: 10.1007/978-1-4939-3816-2_37.

PMID:
27604745
14.

Phenotypic screening with primary neurons to identify drug targets for regeneration and degeneration.

Cooper DJ, Zunino G, Bixby JL, Lemmon VP.

Mol Cell Neurosci. 2017 Apr;80:161-169. doi: 10.1016/j.mcn.2016.07.001. Epub 2016 Jul 18. Review.

15.

Hyperactivated Stat3 boosts axon regeneration in the CNS.

Mehta ST, Luo X, Park KK, Bixby JL, Lemmon VP.

Exp Neurol. 2016 Jun;280:115-20. doi: 10.1016/j.expneurol.2016.03.004. Epub 2016 Apr 6.

16.

RegenBase: a knowledge base of spinal cord injury biology for translational research.

Callahan A, Abeyruwan SW, Al-Ali H, Sakurai K, Ferguson AR, Popovich PG, Shah NH, Visser U, Bixby JL, Lemmon VP.

Database (Oxford). 2016 Apr 7;2016. pii: baw040. doi: 10.1093/database/baw040. Print 2016.

17.

Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System.

Luo X, Ribeiro M, Bray ER, Lee DH, Yungher BJ, Mehta ST, Thakor KA, Diaz F, Lee JK, Moraes CT, Bixby JL, Lemmon VP, Park KK.

Cell Rep. 2016 Apr 12;15(2):398-410. doi: 10.1016/j.celrep.2016.03.029. Epub 2016 Mar 31.

18.

Treatment with analgesics after mouse sciatic nerve injury does not alter expression of wound healing-associated genes.

Danzi MC, Motti D, Avison DL, Bixby JL, Lemmon VP.

Neural Regen Res. 2016 Jan;11(1):144-9. doi: 10.4103/1673-5374.169637.

19.

Exploiting kinase polypharmacology for nerve regeneration.

Al-Ali H, Bixby JL, Lemmon VP.

Neural Regen Res. 2016 Jan;11(1):71-2. doi: 10.4103/1673-5374.169614. No abstract available.

20.

In vitro models of axon regeneration.

Al-Ali H, Beckerman SR, Bixby JL, Lemmon VP.

Exp Neurol. 2017 Jan;287(Pt 3):423-434. doi: 10.1016/j.expneurol.2016.01.020. Epub 2016 Jan 27. Review.

21.

Changes in expression of the long non-coding RNA FMR4 associate with altered gene expression during differentiation of human neural precursor cells.

Peschansky VJ, Pastori C, Zeier Z, Motti D, Wentzel K, Velmeshev D, Magistri M, Bixby JL, Lemmon VP, Silva JP, Wahlestedt C.

Front Genet. 2015 Aug 10;6:263. doi: 10.3389/fgene.2015.00263. eCollection 2015.

22.

Phenotypic assays to identify agents that induce reactive gliosis: a counter-screen to prioritize compounds for preclinical animal studies.

Beckerman SR, Jimenez JE, Shi Y, Al-Ali H, Bixby JL, Lemmon VP.

Assay Drug Dev Technol. 2015 Sep;13(7):377-88. doi: 10.1089/adt.2015.654. Epub 2015 Jul 31.

23.

Rational Polypharmacology: Systematically Identifying and Engaging Multiple Drug Targets To Promote Axon Growth.

Al-Ali H, Lee DH, Danzi MC, Nassif H, Gautam P, Wennerberg K, Zuercher B, Drewry DH, Lee JK, Lemmon VP, Bixby JL.

ACS Chem Biol. 2015 Aug 21;10(8):1939-51. doi: 10.1021/acschembio.5b00289. Epub 2015 Jun 24.

24.

Axonal regeneration. Systemic administration of epothilone B promotes axon regeneration after spinal cord injury.

Ruschel J, Hellal F, Flynn KC, Dupraz S, Elliott DA, Tedeschi A, Bates M, Sliwinski C, Brook G, Dobrindt K, Peitz M, Brüstle O, Norenberg MD, Blesch A, Weidner N, Bunge MB, Bixby JL, Bradke F.

Science. 2015 Apr 17;348(6232):347-52. doi: 10.1126/science.aaa2958. Epub 2015 Mar 12.

25.

Systematic analysis of intracellular trafficking motifs located within the cytoplasmic domain of simian immunodeficiency virus glycoprotein gp41.

Postler TS, Bixby JG, Desrosiers RC, Yuste E.

PLoS One. 2014 Dec 5;9(12):e114753. doi: 10.1371/journal.pone.0114753. eCollection 2014.

26.

High Content Screening with Primary Neurons.

Al-Ali H, Blackmore M, Bixby JL, Lemmon VP.

In: Sittampalam GS, Coussens NP, Brimacombe K, Grossman A, Arkin M, Auld D, Austin C, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Inglese J, Iversen PW, Kahl SD, Kales SC, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2013 Oct 15 [updated 2014 Oct 1].

27.

Facilitating transparency in spinal cord injury studies using data standards and ontologies.

Lemmon VP, Abeyruwan S, Visser U, Bixby JL.

Neural Regen Res. 2014 Jan 1;9(1):6-7. doi: 10.4103/1673-5374.125322. No abstract available.

28.

Minimum information about a spinal cord injury experiment: a proposed reporting standard for spinal cord injury experiments.

Lemmon VP, Ferguson AR, Popovich PG, Xu XM, Snow DM, Igarashi M, Beattie CE, Bixby JL; MIASCI Consortium.

J Neurotrauma. 2014 Aug 1;31(15):1354-61. doi: 10.1089/neu.2014.3400. Epub 2014 Jul 11.

29.

cJun promotes CNS axon growth.

Lerch JK, Martínez-Ondaro YR, Bixby JL, Lemmon VP.

Mol Cell Neurosci. 2014 Mar;59:97-105. doi: 10.1016/j.mcn.2014.02.002. Epub 2014 Feb 9.

30.

Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration.

Kuboyama T, Luo X, Park K, Blackmore MG, Tojima T, Tohda C, Bixby JL, Lemmon VP, Kamiguchi H.

Exp Neurol. 2013 Oct;248:157-69. doi: 10.1016/j.expneurol.2013.06.011. Epub 2013 Jun 21.

31.

Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling.

Gatto G, Dudanova I, Suetterlin P, Davies AM, Drescher U, Bixby JL, Klein R.

J Neurosci. 2013 Mar 20;33(12):5399-410. doi: 10.1523/JNEUROSCI.4707-12.2013.

32.

Chemical interrogation of the neuronal kinome using a primary cell-based screening assay.

Al-Ali H, Schürer SC, Lemmon VP, Bixby JL.

ACS Chem Biol. 2013 May 17;8(5):1027-36. doi: 10.1021/cb300584e. Epub 2013 Mar 19.

33.

MicroRNAs and neuronal development.

Motti D, Bixby JL, Lemmon VP.

Semin Fetal Neonatal Med. 2012 Dec;17(6):347-52. doi: 10.1016/j.siny.2012.07.008. Epub 2012 Aug 18. Review.

34.

Neuronal hypoxia induces Hsp40-mediated nuclear import of type 3 deiodinase as an adaptive mechanism to reduce cellular metabolism.

Jo S, Kalló I, Bardóczi Z, Arrojo e Drigo R, Zeöld A, Liposits Z, Oliva A, Lemmon VP, Bixby JL, Gereben B, Bianco AC.

J Neurosci. 2012 Jun 20;32(25):8491-500. doi: 10.1523/JNEUROSCI.6514-11.2012.

35.

Peripheral nervous system genes expressed in central neurons induce growth on inhibitory substrates.

Buchser WJ, Smith RP, Pardinas JR, Haddox CL, Hutson T, Moon L, Hoffman SR, Bixby JL, Lemmon VP.

PLoS One. 2012;7(6):e38101. doi: 10.1371/journal.pone.0038101. Epub 2012 Jun 6.

36.

A chemical genetic approach identifies piperazine antipsychotics as promoters of CNS neurite growth on inhibitory substrates.

Johnstone AL, Reierson GW, Smith RP, Goldberg JL, Lemmon VP, Bixby JL.

Mol Cell Neurosci. 2012 Jun;50(2):125-35. doi: 10.1016/j.mcn.2012.04.008. Epub 2012 May 3.

37.

Krüppel-like Factor 7 engineered for transcriptional activation promotes axon regeneration in the adult corticospinal tract.

Blackmore MG, Wang Z, Lerch JK, Motti D, Zhang YP, Shields CB, Lee JK, Goldberg JL, Lemmon VP, Bixby JL.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7517-22. doi: 10.1073/pnas.1120684109. Epub 2012 Apr 23.

38.

High-content analysis of proapoptotic EphA4 dependence receptor functions using small-molecule libraries.

Nelersa CM, Barreras H, Runko E, Ricard J, Shi Y, Glass SJ, Bixby JL, Lemmon VP, Liebl DJ.

J Biomol Screen. 2012 Jul;17(6):785-95. doi: 10.1177/1087057112440880. Epub 2012 Apr 4.

39.

Dyrk kinases regulate phosphorylation of doublecortin, cytoskeletal organization, and neuronal morphology.

Slepak TI, Salay LD, Lemmon VP, Bixby JL.

Cytoskeleton (Hoboken). 2012 Jul;69(7):514-27. doi: 10.1002/cm.21021. Epub 2012 Mar 7.

40.

Isoform diversity and regulation in peripheral and central neurons revealed through RNA-Seq.

Lerch JK, Kuo F, Motti D, Morris R, Bixby JL, Lemmon VP.

PLoS One. 2012;7(1):e30417. doi: 10.1371/journal.pone.0030417. Epub 2012 Jan 17.

41.

Optimization of a 96-Well Electroporation Assay for Postnatal Rat CNS Neurons Suitable for Cost-Effective Medium-Throughput Screening of Genes that Promote Neurite Outgrowth.

Hutson TH, Buchser WJ, Bixby JL, Lemmon VP, Moon LD.

Front Mol Neurosci. 2011 Dec 23;4:55. doi: 10.3389/fnmol.2011.00055. eCollection 2011.

42.

Isoform diversity and its importance for axon regeneration.

Lerch JK, Bixby JL, Lemmon VP.

Neuropathology. 2012 Aug;32(4):420-31. doi: 10.1111/j.1440-1789.2011.01280.x. Epub 2011 Dec 13. Review.

43.

Challenges in small screening laboratories: implementing an on-demand laboratory information management system.

Lemmon VP, Jia Y, Shi Y, Holbrook SD, Bixby JL, Buchser W.

Comb Chem High Throughput Screen. 2011 Nov;14(9):742-8.

44.

Interaction of an intracellular pentraxin with a BTB-Kelch protein is associated with ubiquitylation, aggregation and neuronal apoptosis.

Tseng LA, Bixby JL.

Mol Cell Neurosci. 2011 Aug;47(4):254-64. doi: 10.1016/j.mcn.2011.04.005. Epub 2011 Apr 28.

45.

Microtubule stabilization reduces scarring and causes axon regeneration after spinal cord injury.

Hellal F, Hurtado A, Ruschel J, Flynn KC, Laskowski CJ, Umlauf M, Kapitein LC, Strikis D, Lemmon V, Bixby J, Hoogenraad CC, Bradke F.

Science. 2011 Feb 18;331(6019):928-31. doi: 10.1126/science.1201148. Epub 2011 Jan 27.

46.

Diversity of envelope genes from an uncloned stock of SIVmac251.

Bixby JG, Laur O, Johnson WE, Desrosiers RC.

AIDS Res Hum Retroviruses. 2010 Oct;26(10):1115-31. doi: 10.1089/aid.2010.0029. Epub 2010 Sep 13.

47.

Transcriptional profiling of intrinsic PNS factors in the postnatal mouse.

Smith RP, Lerch-Haner JK, Pardinas JR, Buchser WJ, Bixby JL, Lemmon VP.

Mol Cell Neurosci. 2011 Jan;46(1):32-44. doi: 10.1016/j.mcn.2010.07.015. Epub 2010 Aug 7.

48.

Kinase/phosphatase overexpression reveals pathways regulating hippocampal neuron morphology.

Buchser WJ, Slepak TI, Gutierrez-Arenas O, Bixby JL, Lemmon VP.

Mol Syst Biol. 2010 Jul;6:391. doi: 10.1038/msb.2010.52.

49.

A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration.

Usher LC, Johnstone A, Ertürk A, Hu Y, Strikis D, Wanner IB, Moorman S, Lee JW, Min J, Ha HH, Duan Y, Hoffman S, Goldberg JL, Bradke F, Chang YT, Lemmon VP, Bixby JL.

J Neurosci. 2010 Mar 31;30(13):4693-706. doi: 10.1523/JNEUROSCI.0302-10.2010.

50.

High content screening of cortical neurons identifies novel regulators of axon growth.

Blackmore MG, Moore DL, Smith RP, Goldberg JL, Bixby JL, Lemmon VP.

Mol Cell Neurosci. 2010 May;44(1):43-54. doi: 10.1016/j.mcn.2010.02.002. Epub 2010 Feb 14.

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