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Modafinil treatment modulates functional connectivity in stroke survivors with severe fatigue.

Visser MM, Goodin P, Parsons MW, Lillicrap T, Spratt NJ, Levi CR, Bivard A.

Sci Rep. 2019 Jul 4;9(1):9660. doi: 10.1038/s41598-019-46149-0.


Exploring the relationship between ischemic core volume and clinical outcomes after thrombectomy or thrombolysis.

Chen C, Parsons MW, Levi CR, Spratt NJ, Miteff F, Lin L, Cheng X, Lou M, Kleinig T, Butcher K, Dong Q, Bivard A.

Neurology. 2019 Jul 16;93(3):e283-e292. doi: 10.1212/WNL.0000000000007768. Epub 2019 Jun 17.


Extending thrombolysis to 4·5-9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data.

Campbell BCV, Ma H, Ringleb PA, Parsons MW, Churilov L, Bendszus M, Levi CR, Hsu C, Kleinig TJ, Fatar M, Leys D, Molina C, Wijeratne T, Curtze S, Dewey HM, Barber PA, Butcher KS, De Silva DA, Bladin CF, Yassi N, Pfaff JAR, Sharma G, Bivard A, Desmond PM, Schwab S, Schellinger PD, Yan B, Mitchell PJ, Serena J, Toni D, Thijs V, Hacke W, Davis SM, Donnan GA; EXTEND, ECASS-4, and EPITHET Investigators.

Lancet. 2019 Jul 13;394(10193):139-147. doi: 10.1016/S0140-6736(19)31053-0. Epub 2019 May 22.


When a Slice Is Not Enough! Comparison of Whole-Brain versus Standard Limited-Slice Perfusion Computed Tomography in Patients with Severe Traumatic Brain Injury.

Cooper S, Bendinelli C, Bivard A, Parsons M, Balogh ZJ.

J Clin Med. 2019 May 17;8(5). pii: E701. doi: 10.3390/jcm8050701.


Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke.

Ma H, Campbell BCV, Parsons MW, Churilov L, Levi CR, Hsu C, Kleinig TJ, Wijeratne T, Curtze S, Dewey HM, Miteff F, Tsai CH, Lee JT, Phan TG, Mahant N, Sun MC, Krause M, Sturm J, Grimley R, Chen CH, Hu CJ, Wong AA, Field D, Sun Y, Barber PA, Sabet A, Jannes J, Jeng JS, Clissold B, Markus R, Lin CH, Lien LM, Bladin CF, Christensen S, Yassi N, Sharma G, Bivard A, Desmond PM, Yan B, Mitchell PJ, Thijs V, Carey L, Meretoja A, Davis SM, Donnan GA; EXTEND Investigators.

N Engl J Med. 2019 May 9;380(19):1795-1803. doi: 10.1056/NEJMoa1813046.


Influence of occlusion site and baseline ischemic core on outcome in patients with ischemic stroke.

Tian H, Parsons MW, Levi CR, Lin L, Aviv RI, Spratt NJ, Butcher KS, Lou M, Kleinig TJ, Bivard A.

Neurology. 2019 Jun 4;92(23):e2626-e2643. doi: 10.1212/WNL.0000000000007553. Epub 2019 May 1.


Predicting Modafinil-Treatment Response in Poststroke Fatigue Using Brain Morphometry and Functional Connectivity.

Visser MM, Maréchal B, Goodin P, Lillicrap TP, Garcia-Esperon C, Spratt NJ, Parsons MW, Levi CR, Bivard A.

Stroke. 2019 Mar;50(3):602-609. doi: 10.1161/STROKEAHA.118.023813.


The blood pressure paradox in acute ischemic stroke.

Hong L, Cheng X, Lin L, Bivard A, Ling Y, Butcher K, Dong Q, Parsons M; INSPIRE Study Group.

Ann Neurol. 2019 Mar;85(3):331-339. doi: 10.1002/ana.25428. Epub 2019 Feb 18.


Identification of Corticospinal Tract Lesion for Predicting Outcome in Small Perfusion Stroke.

Zhou Y, Zhang R, Yan S, Zhang M, Chen Z, Hu H, Zhang M, Bivard A, Lin L, Parsons MW, Lou M.

Stroke. 2018 Nov;49(11):2683-2691. doi: 10.1161/STROKEAHA.118.021426.


Cost-effectiveness of targeted thrombolytic therapy for stroke patients using multi-modal CT compared to usual practice.

Reeves P, Edmunds K, Levi C, Lin L, Cheng X, Aviv R, Kleinig T, Butcher K, Zhang J, Parsons M, Bivard A.

PLoS One. 2018 Oct 23;13(10):e0206203. doi: 10.1371/journal.pone.0206203. eCollection 2018.


Single-phase CT angiography: collateral grade is independent of scan weighting.

Bisson DA, Mahmoudian D, Shatil AS, Waggass G, Zhang L, Levi C, Spratt NJ, Lin L, Liebeskind D, Parsons M, Bivard A, Aviv RI.

Neuroradiology. 2019 Jan;61(1):19-28. doi: 10.1007/s00234-018-2105-2. Epub 2018 Oct 4.


Do powered over-ground lower limb robotic exoskeletons affect outcomes in the rehabilitation of people with acquired brain injury?

Postol N, Marquez J, Spartalis S, Bivard A, Spratt NJ.

Disabil Rehabil Assist Technol. 2018 Sep 21:1-12. doi: 10.1080/17483107.2018.1499137. [Epub ahead of print]


Growth Hormone Deficiency Is Frequent After Recent Stroke.

Lillicrap T, Garcia-Esperon C, Walker FR, Ong LK, Nilsson M, Spratt N, Levi CR, Parsons M, Isgaard J, Bivard A.

Front Neurol. 2018 Sep 6;9:713. doi: 10.3389/fneur.2018.00713. eCollection 2018.


White Matter Degeneration after Ischemic Stroke: A Longitudinal Diffusion Tensor Imaging Study.

Visser MM, Yassi N, Campbell BCV, Desmond PM, Davis SM, Spratt N, Parsons M, Bivard A.

J Neuroimaging. 2019 Jan;29(1):111-118. doi: 10.1111/jon.12556. Epub 2018 Aug 30.


Intravenous Thrombolysis May Not Improve Clinical Outcome of Acute Ischemic Stroke Patients Without a Baseline Vessel Occlusion.

Tian H, Parsons MW, Levi CR, Cheng X, Aviv RI, Spratt NJ, Kleinig TJ, O'Brien B, Butcher KS, Lin L, Zhang J, Dong Q, Chen C, Bivard A.

Front Neurol. 2018 Jun 6;9:405. doi: 10.3389/fneur.2018.00405. eCollection 2018.


Short- and Long-Term Efficacy of Modafinil at Improving Quality of Life in Stroke Survivors: A Post Hoc Sub Study of the Modafinil in Debilitating Fatigue After Stroke Trial.

Lillicrap TP, Levi CR, Holliday E, Parsons MW, Bivard A.

Front Neurol. 2018 Apr 25;9:269. doi: 10.3389/fneur.2018.00269. eCollection 2018.


Computed Tomographic Perfusion Predicts Poor Outcomes in a Randomized Trial of Endovascular Therapy.

Wannamaker R, Guinand T, Menon BK, Demchuk A, Goyal M, Frei D, Bharatha A, Jovin TG, Shankar J, Krings T, Baxter B, Holmstedt C, Swartz R, Dowlatshahi D, Chan R, Tampieri D, Choe H, Burns P, Gentile N, Rempel J, Shuaib A, Buck B, Bivard A, Hill M, Butcher K.

Stroke. 2018 Jun;49(6):1426-1433. doi: 10.1161/STROKEAHA.117.019806. Epub 2018 May 8.


Growth Hormone Improves Cognitive Function After Experimental Stroke.

Ong LK, Chow WZ, TeBay C, Kluge M, Pietrogrande G, Zalewska K, Crock P, Åberg ND, Bivard A, Johnson SJ, Walker FR, Nilsson M, Isgaard J.

Stroke. 2018 May;49(5):1257-1266. doi: 10.1161/STROKEAHA.117.020557. Epub 2018 Apr 10.


Use of computed tomography perfusion for acute stroke in routine clinical practice: Complex scenarios, mimics, and artifacts.

Garcia-Esperon C, Bivard A, Levi C, Parsons M.

Int J Stroke. 2018 Jul;13(5):469-472. doi: 10.1177/1747493018765493. Epub 2018 Mar 15. Review.


Correction for Delay and Dispersion Results in More Accurate Cerebral Blood Flow Ischemic Core Measurement in Acute Stroke.

Lin L, Bivard A, Kleinig T, Spratt NJ, Levi CR, Yang Q, Parsons MW.

Stroke. 2018 Apr;49(4):924-930. doi: 10.1161/STROKEAHA.117.019562. Epub 2018 Mar 2.


Tissue Is More Important than Time in Stroke Patients Being Assessed for Thrombolysis.

Bivard A, Spratt N, Miteff F, Levi C, Parsons MW.

Front Neurol. 2018 Feb 5;9:41. doi: 10.3389/fneur.2018.00041. eCollection 2018.


Transient Ischemic Attack Results in Delayed Brain Atrophy and Cognitive Decline.

Bivard A, Lillicrap T, Maréchal B, Garcia-Esperon C, Holliday E, Krishnamurthy V, Levi CR, Parsons M.

Stroke. 2018 Feb;49(2):384-390. doi: 10.1161/STROKEAHA.117.019276. Epub 2018 Jan 4.


Collateral response modulates the time-penumbra relationship in proximal arterial occlusions.

Agarwal S, Bivard A, Warburton E, Parsons M, Levi C.

Neurology. 2018 Jan 23;90(4):e316-e322. doi: 10.1212/WNL.0000000000004858. Epub 2017 Dec 27.


Ischemic core thresholds change with time to reperfusion: A case control study.

Bivard A, Kleinig T, Miteff F, Butcher K, Lin L, Levi C, Parsons M.

Ann Neurol. 2017 Dec;82(6):995-1003. doi: 10.1002/ana.25109.


Author response: Evaluation of hyperacute infarct volume using ASPECTS and brain CT perfusion core volume.

Levi CR, Demeestere J, Garcia-Esperon C, García-Bermejo P, Ombelet F, McElduff P, Bivard A, Parsons M.

Neurology. 2017 Dec 5;89(23):2398-2399. doi: 10.1212/WNL.0000000000004714. No abstract available.


Thresholds for infarction vary between gray matter and white matter in acute ischemic stroke: A CT perfusion study.

Chen C, Bivard A, Lin L, Levi CR, Spratt NJ, Parsons MW.

J Cereb Blood Flow Metab. 2019 Mar;39(3):536-546. doi: 10.1177/0271678X17744453. Epub 2017 Nov 27.


Cerebral blood volume lesion extent predicts functional outcome in patients with vertebral and basilar artery occlusion.

Alemseged F, Shah DG, Bivard A, Kleinig TJ, Yassi N, Diomedi M, Di Giuliano F, Sharma G, Drew R, Yan B, Dowling RJ, Bush S, Sallustio F, Caltagirone C, Mercuri NB, Floris R, Parsons MW, Levi CR, Mitchell PJ, Davis SM, Campbell BC.

Int J Stroke. 2017 Jan 1:1747493017744465. doi: 10.1177/1747493017744465. [Epub ahead of print]


The influence of initial stroke severity on mortality, overall functional outcome and in-hospital placement at 90 days following acute ischemic stroke: A tertiary hospital stroke register study.

Bhaskar S, Stanwell P, Bivard A, Spratt N, Walker R, Kitsos GH, Parsons MW, Evans M, Jordan L, Nilsson M, Attia J, Levi C.

Neurol India. 2017 Nov-Dec;65(6):1252-1259. doi: 10.4103/0028-3886.217947.


Tissue is more important than time: insights into acute ischemic stroke from modern brain imaging.

Bivard A, Parsons M.

Curr Opin Neurol. 2018 Feb;31(1):23-27. doi: 10.1097/WCO.0000000000000520. Review.


A model based on the Pennes bioheat transfer equation is valid in normal brain tissue but not brain tissue suffering focal ischaemia.

Lillicrap T, Tahtalı M, Neely A, Wang X, Bivard A, Lueck C.

Australas Phys Eng Sci Med. 2017 Dec;40(4):841-850. doi: 10.1007/s13246-017-0595-6. Epub 2017 Nov 2.


Visibility of CT Early Ischemic Change Is Significantly Associated with Time from Stroke Onset to Baseline Scan beyond the First 3 Hours of Stroke Onset.

Gao J, Parsons MW, Kawano H, Levi CR, Evans TJ, Lin L, Bivard A.

J Stroke. 2017 Sep;19(3):340-346. doi: 10.5853/jos.2016.01424. Epub 2017 Sep 29.


Influence of Penumbral Reperfusion on Clinical Outcome Depends on Baseline Ischemic Core Volume.

Chen C, Parsons MW, Clapham M, Oldmeadow C, Levi CR, Lin L, Cheng X, Lou M, Kleinig TJ, Butcher KS, Dong Q, Bivard A.

Stroke. 2017 Oct;48(10):2739-2745. doi: 10.1161/STROKEAHA.117.018587. Epub 2017 Sep 8.


Response by Bivard et al to Letter Regarding Article, "Validating a Predictive Model of Acute Advanced Imaging Biomarkers in Ischemic Stroke".

Bivard A, Levi C, Parsons M.

Stroke. 2017 Aug;48(8):e226. doi: 10.1161/STROKEAHA.117.017613. Epub 2017 Jul 5. No abstract available.


Response by Bivard et al to Letter Regarding Article, "Impact of Computed Tomography Perfusion Imaging on the Response to Tenecteplase in Ischemic Stroke: Analysis of 2 Randomized Controlled Trials".

Bivard A, Muir K, Parsons M.

Circulation. 2017 Jun 13;135(24):e1141-e1142. doi: 10.1161/CIRCULATIONAHA.117.028417. No abstract available.


Tenecteplase in ischemic stroke offers improved recanalization: Analysis of 2 trials.

Bivard A, Huang X, Levi CR, Spratt N, Campbell BCV, Cheripelli BK, Kalladka D, Moreton FC, Ford I, Bladin CF, Davis SM, Donnan GA, Muir KW, Parsons MW.

Neurology. 2017 Jul 4;89(1):62-67. doi: 10.1212/WNL.0000000000004062. Epub 2017 Jun 2.


Evaluation of hyperacute infarct volume using ASPECTS and brain CT perfusion core volume.

Demeestere J, Garcia-Esperon C, Garcia-Bermejo P, Ombelet F, McElduff P, Bivard A, Parsons M, Levi C.

Neurology. 2017 Jun 13;88(24):2248-2253. doi: 10.1212/WNL.0000000000004028. Epub 2017 May 17.


Validation of the National Institutes of Health Stroke Scale-8 to Detect Large Vessel Occlusion in Ischemic Stroke.

Demeestere J, Garcia-Esperon C, Lin L, Bivard A, Ang T, Smoll NR, Garnett A, Loudfoot A, Miteff F, Spratt N, Parsons M, Levi C.

J Stroke Cerebrovasc Dis. 2017 Jul;26(7):1419-1426. doi: 10.1016/j.jstrokecerebrovasdis.2017.03.020. Epub 2017 Apr 27.


Perfusion Abnormalities are Frequently Detected by Early CT Perfusion and Predict Unfavourable Outcome Following Severe Traumatic Brain Injury.

Bendinelli C, Cooper S, Evans T, Bivard A, Pacey D, Parson M, Balogh ZJ.

World J Surg. 2017 Oct;41(10):2512-2520. doi: 10.1007/s00268-017-4030-7.


MIDAS (Modafinil in Debilitating Fatigue After Stroke): A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Trial.

Bivard A, Lillicrap T, Krishnamurthy V, Holliday E, Attia J, Pagram H, Nilsson M, Parsons M, Levi CR.

Stroke. 2017 May;48(5):1293-1298. doi: 10.1161/STROKEAHA.116.016293. Epub 2017 Apr 12.


Platelet microparticles: a biomarker for recanalization in rtPA-treated ischemic stroke patients.

Bivard A, Lincz LF, Maquire J, Parsons M, Levi C.

Ann Clin Transl Neurol. 2017 Jan 25;4(3):175-179. doi: 10.1002/acn3.392. eCollection 2017 Mar.


The Basilar Artery on Computed Tomography Angiography Prognostic Score for Basilar Artery Occlusion.

Alemseged F, Shah DG, Diomedi M, Sallustio F, Bivard A, Sharma G, Mitchell PJ, Dowling RJ, Bush S, Yan B, Caltagirone C, Floris R, Parsons MW, Levi CR, Davis SM, Campbell BC.

Stroke. 2017 Mar;48(3):631-637. doi: 10.1161/STROKEAHA.116.015492. Epub 2017 Feb 22.


Validating a Predictive Model of Acute Advanced Imaging Biomarkers in Ischemic Stroke.

Bivard A, Levi C, Lin L, Cheng X, Aviv R, Spratt NJ, Lou M, Kleinig T, O'Brien B, Butcher K, Zhang J, Jannes J, Dong Q, Parsons M.

Stroke. 2017 Mar;48(3):645-650. doi: 10.1161/STROKEAHA.116.015143. Epub 2017 Jan 19.


Perfusion computed tomography in patients with stroke thrombolysis.

Kawano H, Bivard A, Lin L, Ma H, Cheng X, Aviv R, O'Brien B, Butcher K, Lou M, Zhang J, Jannes J, Dong Q, Levi CR, Parsons MW.

Brain. 2017 Mar 1;140(3):684-691. doi: 10.1093/brain/aww338.


Impact of Computed Tomography Perfusion Imaging on the Response to Tenecteplase in Ischemic Stroke: Analysis of 2 Randomized Controlled Trials.

Bivard A, Huang X, McElduff P, Levi CR, Campbell BC, Cheripelli BK, Kalladka D, Moreton FC, Ford I, Bladin CF, Davis SM, Donnan GA, Muir KW, Parsons MW.

Circulation. 2017 Jan 31;135(5):440-448. doi: 10.1161/CIRCULATIONAHA.116.022582. Epub 2016 Dec 13.


Association of Cortical Vein Filling with Clot Location and Clinical Outcomes in Acute Ischaemic Stroke Patients.

Bhaskar S, Bivard A, Stanwell P, Attia JR, Parsons M, Nilsson M, Levi C.

Sci Rep. 2016 Dec 5;6:38525. doi: 10.1038/srep38525.


The establishment of a telestroke service using multimodal CT imaging decision assistance: "Turning on the fog lights".

Demeestere J, Sewell C, Rudd J, Ang T, Jordan L, Wills J, Garcia-Esperon C, Miteff F, Krishnamurthy V, Spratt N, Lin L, Bivard A, Parsons M, Levi C.

J Clin Neurosci. 2017 Mar;37:1-5. doi: 10.1016/j.jocn.2016.10.018. Epub 2016 Nov 23. Review.


Immunity and stroke, the hurdles of stroke research translation.

Pagram H, Bivard A, Lincz LF, Levi C.

Int J Stroke. 2017 Feb;12(2):123-131. doi: 10.1177/1747493016676622. Epub 2016 Oct 26. Review.


Peripheral Immune Cell Counts and Advanced Imaging as Biomarkers of Stroke Outcome.

Pagram H, Bivard A, Lincz LF, Levi C.

Cerebrovasc Dis Extra. 2016;6(3):120-128. doi: 10.1159/000450620. Epub 2016 Jan 22.


Modafinil In Debilitating fatigue After Stroke (MIDAS): study protocol for a randomised, double-blinded, placebo-controlled, crossover trial.

Lillicrap T, Krishnamurthy V, Attia J, Nilsson M, Levi CR, Parsons MW, Bivard A.

Trials. 2016 Aug 17;17(1):410. doi: 10.1186/s13063-016-1537-4.


Quantifying reperfusion of the ischemic region on whole-brain computed tomography perfusion.

Lin L, Cheng X, Bivard A, Levi CR, Dong Q, Parsons MW.

J Cereb Blood Flow Metab. 2017 Jun;37(6):2125-2136. doi: 10.1177/0271678X16661338. Epub 2016 Jan 1.

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