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Items: 45

1.

Chromogranin A, the major lumenal protein in chromaffin granules, controls fusion pore expansion.

Abbineni PS, Bittner MA, Axelrod D, Holz RW.

J Gen Physiol. 2018 Nov 30. pii: jgp.201812182. doi: 10.1085/jgp.201812182. [Epub ahead of print]

PMID:
30504267
2.

Slow fusion pore expansion creates a unique reaction chamber for co-packaged cargo.

Bohannon KP, Bittner MA, Lawrence DA, Axelrod D, Holz RW.

J Gen Physiol. 2017 Oct 2;149(10):921-934. doi: 10.1085/jgp.201711842. Epub 2017 Sep 7.

3.

Lumenal protein within secretory granules affects fusion pore expansion.

Weiss AN, Anantharam A, Bittner MA, Axelrod D, Holz RW.

Biophys J. 2014 Jul 1;107(1):26-33. doi: 10.1016/j.bpj.2014.04.064.

4.

Protein mobility within secretory granules.

Weiss AN, Bittner MA, Holz RW, Axelrod D.

Biophys J. 2014 Jul 1;107(1):16-25. doi: 10.1016/j.bpj.2014.04.063.

5.

Discovery of novel insulin-like growth factor-1 receptor inhibitors with unique time-dependent binding kinetics.

Jin M, Petronella BA, Cooke A, Kadalbajoo M, Siu KW, Kleinberg A, May EW, Gokhale PC, Schulz R, Kahler J, Bittner MA, Foreman K, Pachter JA, Wild R, Epstein D, Mulvihill MJ.

ACS Med Chem Lett. 2013 May 23;4(7):627-31. doi: 10.1021/ml400160a. eCollection 2013 Jul 11.

6.

A nibbling mechanism for clathrin-mediated retrieval of secretory granule membrane after exocytosis.

Bittner MA, Aikman RL, Holz RW.

J Biol Chem. 2013 Mar 29;288(13):9177-88. doi: 10.1074/jbc.M113.450361. Epub 2013 Feb 5.

7.

Discovery of potent, selective and orally bioavailable imidazo[1,5-a]pyrazine derived ACK1 inhibitors.

Jin M, Wang J, Kleinberg A, Kadalbajoo M, Siu KW, Cooke A, Bittner MA, Yao Y, Thelemann A, Ji Q, Bhagwat S, Mulvihill KM, Rechka JA, Pachter JA, Crew AP, Epstein D, Mulvihill MJ.

Bioorg Med Chem Lett. 2013 Feb 15;23(4):979-84. doi: 10.1016/j.bmcl.2012.12.042. Epub 2012 Dec 21.

PMID:
23317569
8.

A new role for the dynamin GTPase in the regulation of fusion pore expansion.

Anantharam A, Bittner MA, Aikman RL, Stuenkel EL, Schmid SL, Axelrod D, Holz RW.

Mol Biol Cell. 2011 Jun 1;22(11):1907-18. doi: 10.1091/mbc.E11-02-0101. Epub 2011 Apr 1.

9.

Imidazo[1,5-a]pyrazines: orally efficacious inhibitors of mTORC1 and mTORC2.

Crew AP, Bhagwat SV, Dong H, Bittner MA, Chan A, Chen X, Coate H, Cooke A, Gokhale PC, Honda A, Jin M, Kahler J, Mantis C, Mulvihill MJ, Tavares-Greco PA, Volk B, Wang J, Werner DS, Arnold LD, Pachter JA, Wild R, Gibson NW.

Bioorg Med Chem Lett. 2011 Apr 1;21(7):2092-7. doi: 10.1016/j.bmcl.2011.01.139. Epub 2011 Feb 3.

PMID:
21353551
10.

Potent and selective cyclohexyl-derived imidazopyrazine insulin-like growth factor 1 receptor inhibitors with in vivo efficacy.

Jin M, Kleinberg A, Cooke A, Gokhale PC, Foreman K, Dong H, Siu KW, Bittner MA, Mulvihill KM, Yao Y, Landfair D, O'Connor M, Mak G, Pachter JA, Wild R, Rosenfeld-Franklin M, Ji Q, Mulvihill MJ.

Bioorg Med Chem Lett. 2011 Feb 15;21(4):1176-80. doi: 10.1016/j.bmcl.2010.12.094. Epub 2010 Dec 23.

PMID:
21251824
11.

Discovery of an Orally Efficacious Imidazo[5,1-f][1,2,4]triazine Dual Inhibitor of IGF-1R and IR.

Jin M, Gokhale PC, Cooke A, Foreman K, Buck E, May EW, Feng L, Bittner MA, Kadalbajoo M, Landfair D, Siu KW, Stolz KM, Werner DS, Laufer RS, Li AH, Dong H, Steinig AG, Kleinberg A, Yao Y, Pachter JA, Wild R, Mulvihill MJ.

ACS Med Chem Lett. 2010 Aug 30;1(9):510-5. doi: 10.1021/ml100178g. eCollection 2010 Dec 9.

12.

The structural and functional implications of linked SNARE motifs in SNAP25.

Wang L, Bittner MA, Axelrod D, Holz RW.

Mol Biol Cell. 2008 Sep;19(9):3944-55. doi: 10.1091/mbc.E08-04-0344. Epub 2008 Jul 2.

13.

Motion matters: secretory granule motion adjacent to the plasma membrane and exocytosis.

Allersma MW, Bittner MA, Axelrod D, Holz RW.

Mol Biol Cell. 2006 May;17(5):2424-38. Epub 2006 Mar 1.

14.

OSI-930: a novel selective inhibitor of Kit and kinase insert domain receptor tyrosine kinases with antitumor activity in mouse xenograft models.

Garton AJ, Crew AP, Franklin M, Cooke AR, Wynne GM, Castaldo L, Kahler J, Winski SL, Franks A, Brown EN, Bittner MA, Keily JF, Briner P, Hidden C, Srebernak MC, Pirrit C, O'Connor M, Chan A, Vulevic B, Henninger D, Hart K, Sennello R, Li AH, Zhang T, Richardson F, Emerson DL, Castelhano AL, Arnold LD, Gibson NW.

Cancer Res. 2006 Jan 15;66(2):1015-24.

15.
16.

Rim, a component of the presynaptic active zone and modulator of exocytosis, binds 14-3-3 through its N terminus.

Sun L, Bittner MA, Holz RW.

J Biol Chem. 2003 Oct 3;278(40):38301-9. Epub 2003 Jul 18.

17.
18.

Inequities in access to and use of drinking water services in Latin America and the Caribbean.

Soares LC, Griesinger MO, Dachs JN, Bittner MA, Tavares S.

Rev Panam Salud Publica. 2002 May-Jun;11(5-6):386-96. Review.

PMID:
12162835
19.

Protein-tyrosine phosphatase-sigma is a novel member of the functional family of alpha-latrotoxin receptors.

Krasnoperov V, Bittner MA, Mo W, Buryanovsky L, Neubert TA, Holz RW, Ichtchenko K, Petrenko AG.

J Biol Chem. 2002 Sep 27;277(39):35887-95. Epub 2002 Jul 10.

20.

Intravenous ethanol/cocaine self-administration initiates high intake of intravenous ethanol alone.

Ikegami A, Olsen CM, Fleming SM, Guerra EE, Bittner MA, Wagner J, Duvauchelle CL.

Pharmacol Biochem Behav. 2002 Jul;72(4):787-94.

PMID:
12062567
21.

Rab3a binding and secretion-enhancing domains in Rim1 are separate and unique. Studies in adrenal chromaffin cells.

Sun L, Bittner MA, Holz RW.

J Biol Chem. 2001 Apr 20;276(16):12911-7. Epub 2001 Jan 26.

24.
25.

A novel ubiquitously expressed alpha-latrotoxin receptor is a member of the CIRL family of G-protein-coupled receptors.

Ichtchenko K, Bittner MA, Krasnoperov V, Little AR, Chepurny O, Holz RW, Petrenko AG.

J Biol Chem. 1999 Feb 26;274(9):5491-8.

26.

Regulation of exocytosis by cyclin-dependent kinase 5 via phosphorylation of Munc18.

Fletcher AI, Shuang R, Giovannucci DR, Zhang L, Bittner MA, Stuenkel EL.

J Biol Chem. 1999 Feb 12;274(7):4027-35.

28.

A Ca2+-independent receptor for alpha-latrotoxin, CIRL, mediates effects on secretion via multiple mechanisms.

Bittner MA, Krasnoperov VG, Stuenkel EL, Petrenko AG, Holz RW.

J Neurosci. 1998 Apr 15;18(8):2914-22.

29.

alpha-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor.

Krasnoperov VG, Bittner MA, Beavis R, Kuang Y, Salnikow KV, Chepurny OG, Little AR, Plotnikov AN, Wu D, Holz RW, Petrenko AG.

Neuron. 1997 Jun;18(6):925-37.

30.

Evidence that syntaxin 1A is involved in storage in the secretory pathway.

Bittner MA, Bennett MK, Holz RW.

J Biol Chem. 1996 May 10;271(19):11214-21.

31.
32.

A temperature-sensitive step in exocytosis.

Bittner MA, Holz RW.

J Biol Chem. 1992 Aug 15;267(23):16226-9.

33.
34.

Regulated exocytotic fusion I: Chromaffin cells and PC12 cells.

Holz RW, Bittner MA, Senter RA.

Methods Enzymol. 1992;219:165-78. No abstract available.

PMID:
1487990
35.

Mechanisms involved in calcium-dependent exocytosis.

Holz RW, Senyshyn J, Bittner MA.

Ann N Y Acad Sci. 1991;635:382-92. Review. No abstract available.

36.

Phorbol esters enhance exocytosis from chromaffin cells by two mechanisms.

Bittner MA, Holz RW.

J Neurochem. 1990 Jan;54(1):205-10.

37.
38.
39.

MgATP-independent and MgATP-dependent exocytosis. Evidence that MgATP primes adrenal chromaffin cells to undergo exocytosis.

Holz RW, Bittner MA, Peppers SC, Senter RA, Eberhard DA.

J Biol Chem. 1989 Apr 5;264(10):5412-9.

41.
42.
43.
44.

Induction and decay of aryl hydrocarbon hydroxylase activity in mouse 3T3 cells.

Bittner MA, Ruddon RW.

Mol Pharmacol. 1976 Nov;12(6):966-76. No abstract available.

PMID:
1034201

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