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Items: 1 to 50 of 96

1.

The molecular tweezer CLR01 reduces aggregated, pathologic, and seeding-competent α-synuclein in experimental multiple system atrophy.

Herrera-Vaquero M, Bouquio D, Kallab M, Biggs K, Nair G, Ochoa J, Heras-Garvin A, Heid C, Hadrovic I, Poewe W, Wenning GK, Klärner FG, Schrader T, Bitan G, Stefanova N.

Biochim Biophys Acta Mol Basis Dis. 2019 Jul 15. pii: S0925-4439(19)30230-3. doi: 10.1016/j.bbadis.2019.07.007. [Epub ahead of print]

PMID:
31319154
2.

Major Differences between the Self-Assembly and Seeding Behavior of Heparin-Induced and in Vitro Phosphorylated Tau and Their Modulation by Potential Inhibitors.

Despres C, Di J, Cantrelle FX, Li Z, Huvent I, Chambraud B, Zhao J, Chen J, Chen S, Lippens G, Zhang F, Linhardt R, Wang C, Klärner FG, Schrader T, Landrieu I, Bitan G, Smet-Nocca C.

ACS Chem Biol. 2019 Jun 21;14(6):1363-1379. doi: 10.1021/acschembio.9b00325. Epub 2019 May 15.

3.

A Label-Free Platform for Identification of Exosomes from Different Sources.

Yan Z, Dutta S, Liu Z, Yu X, Mesgarzadeh N, Ji F, Bitan G, Xie YH.

ACS Sens. 2019 Feb 22;4(2):488-497. doi: 10.1021/acssensors.8b01564. Epub 2019 Jan 31.

PMID:
30644736
4.

The molecular tweezer CLR01 inhibits aberrant superoxide dismutase 1 (SOD1) self-assembly in vitro and in the G93A-SOD1 mouse model of ALS.

Malik R, Meng H, Wongkongkathep P, Corrales CI, Sepanj N, Atlasi RS, Klärner FG, Schrader T, Spencer MJ, Loo JA, Wiedau M, Bitan G.

J Biol Chem. 2019 Mar 8;294(10):3501-3513. doi: 10.1074/jbc.RA118.005940. Epub 2019 Jan 2.

PMID:
30602569
5.

Investigation of Anti-SOD1 Antibodies Yields New Structural Insight into SOD1 Misfolding and Surprising Behavior of the Antibodies Themselves.

Atlasi RS, Malik R, Corrales CI, Tzeplaeff L, Whitelegge JP, Cashman NR, Bitan G.

ACS Chem Biol. 2018 Sep 21;13(9):2794-2807. doi: 10.1021/acschembio.8b00729. Epub 2018 Aug 30.

6.

Native Top-Down Mass Spectrometry and Ion Mobility Spectrometry of the Interaction of Tau Protein with a Molecular Tweezer Assembly Modulator.

Nshanian M, Lantz C, Wongkongkathep P, Schrader T, Klärner FG, Blümke A, Despres C, Ehrmann M, Smet-Nocca C, Bitan G, Loo JA.

J Am Soc Mass Spectrom. 2019 Jan;30(1):16-23. doi: 10.1007/s13361-018-2027-6. Epub 2018 Jul 30. Erratum in: J Am Soc Mass Spectrom. 2019 Mar;30(3):561.

PMID:
30062477
7.

Preparation of Pure Populations of Amyloid β-Protein Oligomers of Defined Size.

Hayden EY, Conovaloff JL, Mason A, Bitan G, Teplow DB.

Methods Mol Biol. 2018;1779:3-12. doi: 10.1007/978-1-4939-7816-8_1.

8.

Using Molecular Tweezers to Remodel Abnormal Protein Self-Assembly and Inhibit the Toxicity of Amyloidogenic Proteins.

Malik R, Di J, Nair G, Attar A, Taylor K, Teng E, Klärner FG, Schrader T, Bitan G.

Methods Mol Biol. 2018;1777:369-386. doi: 10.1007/978-1-4939-7811-3_24.

9.

The molecular tweezer CLR01 inhibits Ebola and Zika virus infection.

Röcker AE, Müller JA, Dietzel E, Harms M, Krüger F, Heid C, Sowislok A, Riber CF, Kupke A, Lippold S, von Einem J, Beer J, Knöll B, Becker S, Schmidt-Chanasit J, Otto M, Vapalahti O, Zelikin AN, Bitan G, Schrader T, Münch J.

Antiviral Res. 2018 Apr;152:26-35. doi: 10.1016/j.antiviral.2018.02.003. Epub 2018 Feb 8.

PMID:
29428508
10.

Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting.

Walsh RR, Krismer F, Galpern WR, Wenning GK, Low PA, Halliday G, Koroshetz WJ, Holton J, Quinn NP, Rascol O, Shaw LM, Eidelberg D, Bower P, Cummings JL, Abler V, Biedenharn J, Bitan G, Brooks DJ, Brundin P, Fernandez H, Fortier P, Freeman R, Gasser T, Hewitt A, Höglinger GU, Huentelman MJ, Jensen PH, Jeromin A, Kang UJ, Kaufmann H, Kellerman L, Khurana V, Klockgether T, Kim WS, Langer C, LeWitt P, Masliah E, Meissner W, Melki R, Ostrowitzki S, Piantadosi S, Poewe W, Robertson D, Roemer C, Schenk D, Schlossmacher M, Schmahmann JD, Seppi K, Shih L, Siderowf A, Stebbins GT, Stefanova N, Tsuji S, Sutton S, Zhang J.

Neurology. 2018 Jan 9;90(2):74-82. doi: 10.1212/WNL.0000000000004798. Epub 2017 Dec 13. Review.

11.

Inhibition of Mutant αB Crystallin-Induced Protein Aggregation by a Molecular Tweezer.

Xu N, Bitan G, Schrader T, Klärner FG, Osinska H, Robbins J.

J Am Heart Assoc. 2017 Aug 8;6(8). pii: e006182. doi: 10.1161/JAHA.117.006182.

12.

A Molecular Tweezer Ameliorates Motor Deficits in Mice Overexpressing α-Synuclein.

Richter F, Subramaniam SR, Magen I, Lee P, Hayes J, Attar A, Zhu C, Franich NR, Bove N, De La Rosa K, Kwong J, Klärner FG, Schrader T, Chesselet MF, Bitan G.

Neurotherapeutics. 2017 Oct;14(4):1107-1119. doi: 10.1007/s13311-017-0544-9.

13.

Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01.

Vöpel T, Bravo-Rodriguez K, Mittal S, Vachharajani S, Gnutt D, Sharma A, Steinhof A, Fatoba O, Ellrichmann G, Nshanian M, Heid C, Loo JA, Klärner FG, Schrader T, Bitan G, Wanker EE, Ebbinghaus S, Sanchez-Garcia E.

J Am Chem Soc. 2017 Apr 26;139(16):5640-5643. doi: 10.1021/jacs.6b11039. Epub 2017 Apr 13.

14.

Computational On-Chip Imaging of Nanoparticles and Biomolecules using Ultraviolet Light.

Daloglu MU, Ray A, Gorocs Z, Xiong M, Malik R, Bitan G, McLeod E, Ozcan A.

Sci Rep. 2017 Mar 9;7:44157. doi: 10.1038/srep44157.

15.

Preparation of pure populations of covalently stabilized amyloid β-protein oligomers of specific sizes.

Hayden EY, Conovaloff JL, Mason A, Bitan G, Teplow DB.

Anal Biochem. 2017 Feb 1;518:78-85. doi: 10.1016/j.ab.2016.10.026. Epub 2016 Oct 31.

16.

Neurotoxicity of the Parkinson Disease-Associated Pesticide Ziram Is Synuclein-Dependent in Zebrafish Embryos.

Lulla A, Barnhill L, Bitan G, Ivanova MI, Nguyen B, O'Donnell K, Stahl MC, Yamashiro C, Klärner FG, Schrader T, Sagasti A, Bronstein JM.

Environ Health Perspect. 2016 Nov;124(11):1766-1775. Epub 2016 Jun 15.

17.

Molecular tweezers for lysine and arginine - powerful inhibitors of pathologic protein aggregation.

Schrader T, Bitan G, Klärner FG.

Chem Commun (Camb). 2016 Oct 15;52(76):11318-34. doi: 10.1039/c6cc04640a. Epub 2016 Aug 22.

18.

Modulation of Amyloid β-Protein (Aβ) Assembly by Homologous C-Terminal Fragments as a Strategy for Inhibiting Aβ Toxicity.

Li H, Rahimi F, Bitan G.

ACS Chem Neurosci. 2016 Jul 20;7(7):845-56. doi: 10.1021/acschemneuro.6b00154. Epub 2016 Jul 5. Review.

19.

Reducing synuclein accumulation improves neuronal survival after spinal cord injury.

Fogerson SM, van Brummen AJ, Busch DJ, Allen SR, Roychaudhuri R, Banks SM, Klärner FG, Schrader T, Bitan G, Morgan JR.

Exp Neurol. 2016 Apr;278:105-15. doi: 10.1016/j.expneurol.2016.02.004. Epub 2016 Feb 13.

20.

Mechanism of C-Terminal Fragments of Amyloid β-Protein as Aβ Inhibitors: Do C-Terminal Interactions Play a Key Role in Their Inhibitory Activity?

Zheng X, Wu C, Liu D, Li H, Bitan G, Shea JE, Bowers MT.

J Phys Chem B. 2016 Mar 3;120(8):1615-23. doi: 10.1021/acs.jpcb.5b08177. Epub 2015 Oct 16.

21.

Role of Species-Specific Primary Structure Differences in Aβ42 Assembly and Neurotoxicity.

Roychaudhuri R, Zheng X, Lomakin A, Maiti P, Condron MM, Benedek GB, Bitan G, Bowers MT, Teplow DB.

ACS Chem Neurosci. 2015 Dec 16;6(12):1941-55. doi: 10.1021/acschemneuro.5b00180. Epub 2015 Oct 19.

22.

Toxicity inhibitors protect lipid membranes from disruption by Aβ42.

Malishev R, Nandi S, Kolusheva S, Levi-Kalisman Y, Klärner FG, Schrader T, Bitan G, Jelinek R.

ACS Chem Neurosci. 2015 Nov 18;6(11):1860-9. doi: 10.1021/acschemneuro.5b00200. Epub 2015 Sep 9.

23.

A molecular tweezer antagonizes seminal amyloids and HIV infection.

Lump E, Castellano LM, Meier C, Seeliger J, Erwin N, Sperlich B, Stürzel CM, Usmani S, Hammond RM, von Einem J, Gerold G, Kreppel F, Bravo-Rodriguez K, Pietschmann T, Holmes VM, Palesch D, Zirafi O, Weissman D, Sowislok A, Wettig B, Heid C, Kirchhoff F, Weil T, Klärner FG, Schrader T, Bitan G, Sanchez-Garcia E, Winter R, Shorter J, Münch J.

Elife. 2015 Aug 18;4. pii: e05397. doi: 10.7554/eLife.05397.

24.

The Lys-Specific Molecular Tweezer, CLR01, Modulates Aggregation of the Mutant p53 DNA Binding Domain and Inhibits Its Toxicity.

Herzog G, Shmueli MD, Levy L, Engel L, Gazit E, Klärner FG, Schrader T, Bitan G, Segal D.

Biochemistry. 2015 Jun 23;54(24):3729-38. doi: 10.1021/bi501092p. Epub 2015 Jun 11.

25.

Molecular tweezers inhibit islet amyloid polypeptide assembly and toxicity by a new mechanism.

Lopes DH, Attar A, Nair G, Hayden EY, Du Z, McDaniel K, Dutt S, Bravo-Rodriguez K, Mittal S, Klärner FG, Wang C, Sanchez-Garcia E, Schrader T, Bitan G.

ACS Chem Biol. 2015 Jun 19;10(6):1555-69. doi: 10.1021/acschembio.5b00146. Epub 2015 Apr 16.

26.

Amyloid β-protein assembly: The effect of molecular tweezers CLR01 and CLR03.

Zheng X, Liu D, Klärner FG, Schrader T, Bitan G, Bowers MT.

J Phys Chem B. 2015 Apr 9;119(14):4831-41. doi: 10.1021/acs.jpcb.5b00692. Epub 2015 Mar 16.

27.

Exact modeling of cylindrical metal-dielectric multilayers beyond the effective medium approximation.

Aronovich D, Bitan G, Bartal G.

Opt Lett. 2014 Nov 15;39(22):6517-20. doi: 10.1364/OL.39.006517.

PMID:
25490508
28.

Safety and pharmacological characterization of the molecular tweezer CLR01 - a broad-spectrum inhibitor of amyloid proteins' toxicity.

Attar A, Chan WT, Klärner FG, Schrader T, Bitan G.

BMC Pharmacol Toxicol. 2014 Apr 16;15:23. doi: 10.1186/2050-6511-15-23.

29.

Molecular basis for preventing α-synuclein aggregation by a molecular tweezer.

Acharya S, Safaie BM, Wongkongkathep P, Ivanova MI, Attar A, Klärner FG, Schrader T, Loo JA, Bitan G, Lapidus LJ.

J Biol Chem. 2014 Apr 11;289(15):10727-37. doi: 10.1074/jbc.M113.524520. Epub 2014 Feb 24.

30.

Molecular tweezers targeting transthyretin amyloidosis.

Ferreira N, Pereira-Henriques A, Attar A, Klärner FG, Schrader T, Bitan G, Gales L, Saraiva MJ, Almeida MR.

Neurotherapeutics. 2014 Apr;11(2):450-61. doi: 10.1007/s13311-013-0256-8.

31.

A shortened Barnes maze protocol reveals memory deficits at 4-months of age in the triple-transgenic mouse model of Alzheimer's disease.

Attar A, Liu T, Chan WT, Hayes J, Nejad M, Lei K, Bitan G.

PLoS One. 2013 Nov 13;8(11):e80355. doi: 10.1371/journal.pone.0080355. eCollection 2013.

33.

Tranilast binds to aβ monomers and promotes aβ fibrillation.

Connors CR, Rosenman DJ, Lopes DH, Mittal S, Bitan G, Sorci M, Belfort G, Garcia A, Wang C.

Biochemistry. 2013 Jun 11;52(23):3995-4002. doi: 10.1021/bi400426t. Epub 2013 May 31.

34.

Protection of primary neurons and mouse brain from Alzheimer's pathology by molecular tweezers.

Attar A, Ripoli C, Riccardi E, Maiti P, Li Puma DD, Liu T, Hayes J, Jones MR, Lichti-Kaiser K, Yang F, Gale GD, Tseng CH, Tan M, Xie CW, Straudinger JL, Klärner FG, Schrader T, Frautschy SA, Grassi C, Bitan G.

Brain. 2012 Dec;135(Pt 12):3735-48. doi: 10.1093/brain/aws289. Epub 2012 Nov 26.

35.

Effects of different amyloid β-protein analogues on synaptic function.

Ripoli C, Piacentini R, Riccardi E, Leone L, Li Puma DD, Bitan G, Grassi C.

Neurobiol Aging. 2013 Apr;34(4):1032-44. doi: 10.1016/j.neurobiolaging.2012.06.027. Epub 2012 Oct 6.

PMID:
23046860
36.

A key role for lysine residues in amyloid β-protein folding, assembly, and toxicity.

Sinha S, Lopes DH, Bitan G.

ACS Chem Neurosci. 2012 Jun 20;3(6):473-81. doi: 10.1021/cn3000247. Epub 2012 Mar 16.

37.

Comparison of three amyloid assembly inhibitors: the sugar scyllo-inositol, the polyphenol epigallocatechin gallate, and the molecular tweezer CLR01.

Sinha S, Du Z, Maiti P, Klärner FG, Schrader T, Wang C, Bitan G.

ACS Chem Neurosci. 2012 Jun 20;3(6):451-8. doi: 10.1021/cn200133x. Epub 2012 Mar 7.

38.

Plasma methionine sulfoxide in persons with familial Alzheimer's disease mutations.

Ringman JM, Fithian AT, Gylys K, Cummings JL, Coppola G, Elashoff D, Pratico D, Moskovitz J, Bitan G.

Dement Geriatr Cogn Disord. 2012;33(4):219-25. doi: 10.1159/000338546. Epub 2012 May 14.

39.

Zn2+-Aβ40 complexes form metastable quasi-spherical oligomers that are cytotoxic to cultured hippocampal neurons.

Solomonov I, Korkotian E, Born B, Feldman Y, Bitler A, Rahimi F, Li H, Bitan G, Sagi I.

J Biol Chem. 2012 Jun 8;287(24):20555-64. doi: 10.1074/jbc.M112.344036. Epub 2012 Apr 23.

40.

Preparation of stable amyloid β-protein oligomers of defined assembly order.

Rosensweig C, Ono K, Murakami K, Lowenstein DK, Bitan G, Teplow DB.

Methods Mol Biol. 2012;849:23-31. doi: 10.1007/978-1-61779-551-0_3.

41.

Application of photochemical cross-linking to the study of oligomerization of amyloidogenic proteins.

Lopes DH, Sinha S, Rosensweig C, Bitan G.

Methods Mol Biol. 2012;849:11-21. doi: 10.1007/978-1-61779-551-0_2.

PMID:
22528080
42.

Design of β-amyloid aggregation inhibitors from a predicted structural motif.

Novick PA, Lopes DH, Branson KM, Esteras-Chopo A, Graef IA, Bitan G, Pande VS.

J Med Chem. 2012 Apr 12;55(7):3002-10. doi: 10.1021/jm201332p. Epub 2012 Mar 15.

43.

A novel "molecular tweezer" inhibitor of α-synuclein neurotoxicity in vitro and in vivo.

Prabhudesai S, Sinha S, Attar A, Kotagiri A, Fitzmaurice AG, Lakshmanan R, Ivanova MI, Loo JA, Klärner FG, Schrader T, Stahl M, Bitan G, Bronstein JM.

Neurotherapeutics. 2012 Apr;9(2):464-76. doi: 10.1007/s13311-012-0105-1. Erratum in: Neurotherapeutics. 2012 Apr;9(2):486. Lakshmanan, Ravi [corrected to Lakshmanan, Rajeswari].

44.

Modulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanisms.

Liu T, Bitan G.

ChemMedChem. 2012 Mar 5;7(3):359-74. doi: 10.1002/cmdc.201100585. Epub 2012 Feb 9. Review.

PMID:
22323134
45.

A two-step strategy for structure-activity relationship studies of N-methylated aβ42 C-terminal fragments as aβ42 toxicity inhibitors.

Li H, Zemel R, Lopes DH, Monien BH, Bitan G.

ChemMedChem. 2012 Mar 5;7(3):515-22. doi: 10.1002/cmdc.201100584. Epub 2012 Feb 3.

46.

Aβ(39-42) modulates Aβ oligomerization but not fibril formation.

Gessel MM, Wu C, Li H, Bitan G, Shea JE, Bowers MT.

Biochemistry. 2012 Jan 10;51(1):108-17. doi: 10.1021/bi201520b. Epub 2011 Dec 23.

47.

C-terminal tetrapeptides inhibit Aβ42-induced neurotoxicity primarily through specific interaction at the N-terminus of Aβ42.

Li H, Du Z, Lopes DH, Fradinger EA, Wang C, Bitan G.

J Med Chem. 2011 Dec 22;54(24):8451-60. doi: 10.1021/jm200982p. Epub 2011 Nov 28.

48.

Induction of methionine-sulfoxide reductases protects neurons from amyloid β-protein insults in vitro and in vivo.

Moskovitz J, Maiti P, Lopes DH, Oien DB, Attar A, Liu T, Mittal S, Hayes J, Bitan G.

Biochemistry. 2011 Dec 13;50(49):10687-97. doi: 10.1021/bi201426b. Epub 2011 Nov 14.

49.

Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins.

Sinha S, Lopes DH, Du Z, Pang ES, Shanmugam A, Lomakin A, Talbiersky P, Tennstaedt A, McDaniel K, Bakshi R, Kuo PY, Ehrmann M, Benedek GB, Loo JA, Klärner FG, Schrader T, Wang C, Bitan G.

J Am Chem Soc. 2011 Oct 26;133(42):16958-69. doi: 10.1021/ja206279b. Epub 2011 Sep 29.

50.

Structural basis for Aβ1–42 toxicity inhibition by Aβ C-terminal fragments: discrete molecular dynamics study.

Urbanc B, Betnel M, Cruz L, Li H, Fradinger EA, Monien BH, Bitan G.

J Mol Biol. 2011 Jul 8;410(2):316-28. doi: 10.1016/j.jmb.2011.05.021. Epub 2011 May 23.

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