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Items: 36


Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.

Minor MM, Hollinger FB, McNees AL, Jung SY, Jain A, Hyser JM, Bissig KD, Slagle BL.

Cells. 2020 Mar 30;9(4). pii: E834. doi: 10.3390/cells9040834.


Somatic Liver Knockout (SLiK): A Quick and Efficient Way to Generate Liver-Specific Knockout Mice Using Multiplex CRISPR/Cas9 Gene Editing.

Johnson CG, Chen T, Furey N, Hemmingsen MG, Bissig KD.

Curr Protoc Mol Biol. 2020 Mar;130(1):e117. doi: 10.1002/cpmb.117.


Using CRISPR/Cas9 to model human liver disease.

Alves-Bezerra M, Furey N, Johnson CG, Bissig KD.

JHEP Rep. 2019 Oct 25;1(5):392-402. doi: 10.1016/j.jhepr.2019.09.002. eCollection 2019 Nov. Review.


Small Animal Models for Human Immunodeficiency Virus (HIV), Hepatitis B, and Tuberculosis: Proceedings of an NIAID Workshop.

Akkina R, Barber DL, Bility MT, Bissig KD, Burwitz BJ, Eichelberg K, Endsley JJ, Garcia JV, Hafner R, Karakousis PC, Korba BE, Koshy R, Lambros C, Menne S, Nuermberger EL, Ploss A, Podell BK, Poluektova LY, Sanders-Beer BE, Subbian S, Wahl A.

Curr HIV Res. 2020;18(1):19-28. doi: 10.2174/1570162X18666191223114019.


PARP1 activation increases expression of modified tumor suppressors and pathways underlying development of aggressive hepatoblastoma.

Valanejad L, Cast A, Wright M, Bissig KD, Karns R, Weirauch MT, Timchenko N.

Commun Biol. 2018 Jun 11;1:67. doi: 10.1038/s42003-018-0077-8. eCollection 2018.


Rapid Disruption of Genes Specifically in Livers of Mice Using Multiplex CRISPR/Cas9 Editing.

Pankowicz FP, Barzi M, Kim KH, Legras X, Martins CS, Wooton-Kee CR, Lagor WR, Marini JC, Elsea SH, Bissig-Choisat B, Moore DD, Bissig KD.

Gastroenterology. 2018 Dec;155(6):1967-1970.e6. doi: 10.1053/j.gastro.2018.08.037. Epub 2018 Aug 28.


P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity.

Bissig KD, Han W, Barzi M, Kovalchuk N, Ding L, Fan X, Pankowicz FP, Zhang QY, Ding X.

Drug Metab Dispos. 2018 Nov;46(11):1734-1744. doi: 10.1124/dmd.118.083303. Epub 2018 Aug 9. Review.


Argininosuccinate Lyase Deficiency Causes an Endothelial-Dependent Form of Hypertension.

Kho J, Tian X, Wong WT, Bertin T, Jiang MM, Chen S, Jin Z, Shchelochkov OA, Burrage LC, Reddy AK, Jiang H, Abo-Zahrah R, Ma S, Zhang P, Bissig KD, Kim JJ, Devaraj S, Rodney GG, Erez A, Bryan NS, Nagamani SCS, Lee BH.

Am J Hum Genet. 2018 Aug 2;103(2):276-287. doi: 10.1016/j.ajhg.2018.07.008.


HBsAg-redirected T cells exhibit antiviral activity in HBV-infected human liver chimeric mice.

Kruse RL, Shum T, Tashiro H, Barzi M, Yi Z, Whitten-Bauer C, Legras X, Bissig-Choisat B, Garaigorta U, Gottschalk S, Bissig KD.

Cytotherapy. 2018 May;20(5):697-705. doi: 10.1016/j.jcyt.2018.02.002. Epub 2018 Apr 6.


A Novel Cell Line Based Orthotopic Xenograft Mouse Model That Recapitulates Human Hepatoblastoma.

Woodfield SE, Shi Y, Patel RH, Jin J, Major A, Sarabia SF, Starosolski Z, Zorman B, Gupta SS, Chen Z, Ibarra AM, Bissig KD, Ghaghada KB, Sumazin P, López-Terrada D, Vasudevan SA.

Sci Rep. 2017 Dec 19;7(1):17751. doi: 10.1038/s41598-017-17665-8.


Erratum: A novel humanized mouse lacking murine p450 oxidoreductase for studying human drug metabolism.

Barzi M, Pankowicz FP, Zorman B, Liu X, Legras X, Yang D, Borowiak M, Bissig-Choisat B, Sumazin P, Li F, Bissig KD.

Nat Commun. 2017 Oct 17;8(1):984. doi: 10.1038/s41467-017-01314-9.


In Situ Liver Expression of HBsAg/CD3-Bispecific Antibodies for HBV Immunotherapy.

Kruse RL, Shum T, Legras X, Barzi M, Pankowicz FP, Gottschalk S, Bissig KD.

Mol Ther Methods Clin Dev. 2017 Aug 31;7:32-41. doi: 10.1016/j.omtm.2017.08.006. eCollection 2017 Dec 15.


A novel humanized mouse lacking murine P450 oxidoreductase for studying human drug metabolism.

Barzi M, Pankowicz FP, Zorman B, Liu X, Legras X, Yang D, Borowiak M, Bissig-Choisat B, Sumazin P, Li F, Bissig KD.

Nat Commun. 2017 Jun 28;8(1):39. doi: 10.1038/s41467-017-00049-x. Erratum in: Nat Commun. 2017 Oct 17;8(1):984.


Differentiation of spontaneously contracting cardiomyocytes from non-virally reprogrammed human amniotic fluid stem cells.

Velasquez-Mao AJ, Tsao CJM, Monroe MN, Legras X, Bissig-Choisat B, Bissig KD, Ruano R, Jacot JG.

PLoS One. 2017 May 17;12(5):e0177824. doi: 10.1371/journal.pone.0177824. eCollection 2017.


CRISPR/Cas9: at the cutting edge of hepatology.

Pankowicz FP, Jarrett KE, Lagor WR, Bissig KD.

Gut. 2017 Jul;66(7):1329-1340. doi: 10.1136/gutjnl-2016-313565. Epub 2017 May 9. Review.


Somatic genome editing with CRISPR/Cas9 generates and corrects a metabolic disease.

Jarrett KE, Lee CM, Yeh YH, Hsu RH, Gupta R, Zhang M, Rodriguez PJ, Lee CS, Gillard BK, Bissig KD, Pownall HJ, Martin JF, Bao G, Lagor WR.

Sci Rep. 2017 Mar 16;7:44624. doi: 10.1038/srep44624.


Reprogramming metabolic pathways in vivo with CRISPR/Cas9 genome editing to treat hereditary tyrosinaemia.

Pankowicz FP, Barzi M, Legras X, Hubert L, Mi T, Tomolonis JA, Ravishankar M, Sun Q, Yang D, Borowiak M, Sumazin P, Elsea SH, Bissig-Choisat B, Bissig KD.

Nat Commun. 2016 Aug 30;7:12642. doi: 10.1038/ncomms12642.


Liver is liver and blood is blood, and finally the twain have met.

Bissig KD, Paust S, Barzi M.

J Hepatol. 2016 Aug;65(2):245-8. doi: 10.1016/j.jhep.2016.05.018. Epub 2016 May 21. No abstract available.


Novel patient-derived xenograft and cell line models for therapeutic testing of pediatric liver cancer.

Bissig-Choisat B, Kettlun-Leyton C, Legras XD, Zorman B, Barzi M, Chen LL, Amin MD, Huang YH, Pautler RG, Hampton OA, Prakash MM, Yang D, Borowiak M, Muzny D, Doddapaneni HV, Hu J, Shi Y, Gaber MW, Hicks MJ, Thompson PA, Lu Y, Mills GB, Finegold M, Goss JA, Parsons DW, Vasudevan SA, Sumazin P, López-Terrada D, Bissig KD.

J Hepatol. 2016 Aug;65(2):325-33. doi: 10.1016/j.jhep.2016.04.009. Epub 2016 Apr 23.


In vivo reduction of hepatitis B virus antigenemia and viremia by antisense oligonucleotides.

Billioud G, Kruse RL, Carrillo M, Whitten-Bauer C, Gao D, Kim A, Chen L, McCaleb ML, Crosby JR, Hamatake R, Hong Z, Garaigorta U, Swayze E, Bissig KD, Wieland S.

J Hepatol. 2016 Apr;64(4):781-9. doi: 10.1016/j.jhep.2015.11.032. Epub 2015 Nov 30.


Combinatorial RNA Interference Therapy Prevents Selection of Pre-existing HBV Variants in Human Liver Chimeric Mice.

Shih YM, Sun CP, Chou HH, Wu TH, Chen CC, Wu PY, Enya Chen YC, Bissig KD, Tao MH.

Sci Rep. 2015 Oct 20;5:15259. doi: 10.1038/srep15259.


Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model.

Bissig-Choisat B, Wang L, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Leyton CK, Leung HE, Kruse RL, Himes RW, Goss JA, Wilson JM, Chan L, Lagor WR, Bissig KD.

Nat Commun. 2015 Jun 17;6:7339. doi: 10.1038/ncomms8339.


The camKK2/camKIV relay is an essential regulator of hepatic cancer.

Lin F, Marcelo KL, Rajapakshe K, Coarfa C, Dean A, Wilganowski N, Robinson H, Sevick E, Bissig KD, Goldie LC, Means AR, York B.

Hepatology. 2015 Aug;62(2):505-20. doi: 10.1002/hep.27832. Epub 2015 May 9.


Response to "Can 'humanized' mice improve drug development in the 21st century?".

Bissig KD, Grompe M.

Trends Pharmacol Sci. 2013 Aug;34(8):425. doi: 10.1016/ Epub 2013 Jul 19. No abstract available.


KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.

Goldman O, Han S, Sourisseau M, Dziedzic N, Hamou W, Corneo B, D'Souza S, Sato T, Kotton DN, Bissig KD, Kalir T, Jacobs A, Evans T, Evans MJ, Gouon-Evans V.

Cell Stem Cell. 2013 Jun 6;12(6):748-60. doi: 10.1016/j.stem.2013.04.026. Erratum in: Cell Stem Cell. 2013 Dec 5;13(6):769. Sourrisseau, Marion [corrected to Sourisseau,].


A high proliferation rate is required for cell reprogramming and maintenance of human embryonic stem cell identity.

Ruiz S, Panopoulos AD, Herrerías A, Bissig KD, Lutz M, Berggren WT, Verma IM, Izpisua Belmonte JC.

Curr Biol. 2011 Jan 11;21(1):45-52. doi: 10.1016/j.cub.2010.11.049. Epub 2010 Dec 17.


Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment.

Bissig KD, Wieland SF, Tran P, Isogawa M, Le TT, Chisari FV, Verma IM.

J Clin Invest. 2010 Mar;120(3):924-30. doi: 10.1172/JCI40094. Epub 2010 Feb 22.


Repopulation of adult and neonatal mice with human hepatocytes: a chimeric animal model.

Bissig KD, Le TT, Woods NB, Verma IM.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20507-11. Epub 2007 Dec 11.


Whole animal copper flux assessed by positron emission tomography in the Long-Evans cinnamon rat--a feasibility study.

Bissig KD, Honer M, Zimmermann K, Summer KH, Solioz M.

Biometals. 2005 Feb;18(1):83-8.


Herpes simplex virus hepatitis 4 years after liver transplantation.

Bissig KD, Zimmermann A, Bernasch D, Furrer H, Dufour JF.

J Gastroenterol. 2003;38(10):1005-8.


Tetrathiomolybdate inhibition of the Enterococcus hirae CopB copper ATPase.

Bissig KD, Voegelin TC, Solioz M.

FEBS Lett. 2001 Nov 2;507(3):367-70.


Interaction of the CopZ copper chaperone with the CopA copper ATPase of Enterococcus hirae assessed by surface plasmon resonance.

Multhaup G, Strausak D, Bissig KD, Solioz M.

Biochem Biophys Res Commun. 2001 Oct 19;288(1):172-7.


Expression of the human Menkes ATPase in Xenopus laevis oocytes.

Bissig KD, La Fontaine S, Mercer JF, Solioz M.

Biol Chem. 2001 Apr;382(4):711-4.


Epidermal growth factor is decreased in liver of rats with biliary cirrhosis but does not act as paracrine growth factor immediately after hepatectomy.

Bissig KD, Marti U, Solioz M, Forestier M, Zimmermann H, Lüthi M, Reichen J.

J Hepatol. 2000 Aug;33(2):275-81.


[How (deficient) copper causes illness].

Solioz M, Bissig KD.

Schweiz Med Wochenschr. 1998 Aug 4;128(31-32):1175-80. Review. German.


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