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Items: 1 to 50 of 248

1.

Corynebacterium diphtheriae: Diphtheria Toxin, the tox Operon, and Its Regulation by Fe2+ Activation of apo-DtxR.

Parveen S, Bishai WR, Murphy JR.

Microbiol Spectr. 2019 Jul;7(4). doi: 10.1128/microbiolspec.GPP3-0063-2019.

PMID:
31267892
2.

TRAV1-2+ CD8+ T-cells including oligoconal expansions of MAIT cells are enriched in the airways in human tuberculosis.

Wong EB, Gold MC, Meermeier EW, Xulu BZ, Khuzwayo S, Sullivan ZA, Mahyari E, Rogers Z, Kløverpris H, Sharma PK, Worley AH, Lalloo U, Baijnath P, Ambaram A, Naidoo L, Suleman M, Madansein R, McLaren JE, Ladell K, Miners KL, Price DA, Behar SM, Nielsen M, Kasprowicz VO, Leslie A, Bishai WR, Ndung'u T, Lewinsohn DM.

Commun Biol. 2019 Jun 5;2:203. doi: 10.1038/s42003-019-0442-2. eCollection 2019.

3.

Potential for breath test diagnosis of urease positive pathogens in lung infections.

Bishai WR, Timmins GS.

J Breath Res. 2019 Jun 4;13(3):032002. doi: 10.1088/1752-7163/ab2225.

PMID:
31096193
4.

Advancing the Therapeutic Potential of Indoleamides for Tuberculosis.

Lun S, Tasneen R, Chaira T, Stec J, Onajole OK, Yang TJ, Cooper CB, Mdluli K, Converse PJ, Nuermberger EL, Raj VS, Kozikowski A, Bishai WR.

Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii: e00343-19. doi: 10.1128/AAC.00343-19. Print 2019 Jul.

5.

Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis. Part II.

Zhang W, Lun S, Liu LL, Xiao S, Duan G, Gunosewoyo H, Yang F, Tang J, Bishai WR, Yu LF.

J Med Chem. 2019 Apr 11;62(7):3575-3589. doi: 10.1021/acs.jmedchem.9b00010. Epub 2019 Mar 27.

PMID:
30875203
6.

Second-generation IL-2 receptor-targeted diphtheria fusion toxin exhibits antitumor activity and synergy with anti-PD-1 in melanoma.

Cheung LS, Fu J, Kumar P, Kumar A, Urbanowski ME, Ihms EA, Parveen S, Bullen CK, Patrick GJ, Harrison R, Murphy JR, Pardoll DM, Bishai WR.

Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3100-3105. doi: 10.1073/pnas.1815087116. Epub 2019 Feb 4.

7.

Differential HLA allele frequency in Mycobacterium africanum vs Mycobacterium tuberculosis in Mali.

Kone A, Diarra B, Cohen K, Diabate S, Kone B, Diakite MT, Diarra H, Sanogo M, Togo ACG, Sarro YDS, Baya B, Coulibaly N, Kodio O, Achenbach CJ, Murphy RL, Holl JL, Siddiqui S, Doumbia S, Bishai WR, Diallo S, Maiga M.

HLA. 2019 Jan;93(1):24-31. doi: 10.1111/tan.13448. Epub 2019 Jan 2.

PMID:
30516034
8.

Pharmacologic Exhaustion of Suppressor Cells with Tasquinimod Enhances Bacterial Clearance during Tuberculosis.

Gupta S, Krug S, Pokkali S, Leanderson T, Isaacs JT, Srikrishna G, Bishai WR.

Am J Respir Crit Care Med. 2019 Feb 1;199(3):386-389. doi: 10.1164/rccm.201805-0820LE. No abstract available.

PMID:
30395729
9.

Lysosomal Cathepsin Release Is Required for NLRP3-Inflammasome Activation by Mycobacterium tuberculosis in Infected Macrophages.

Amaral EP, Riteau N, Moayeri M, Maier N, Mayer-Barber KD, Pereira RM, Lage SL, Kubler A, Bishai WR, D'Império-Lima MR, Sher A, Andrade BB.

Front Immunol. 2018 Jun 21;9:1427. doi: 10.3389/fimmu.2018.01427. eCollection 2018.

10.

Matrix Metalloproteinase Inhibition in a Murine Model of Cavitary Tuberculosis Paradoxically Worsens Pathology.

Ordonez AA, Pokkali S, Sanchez-Bautista J, Klunk MH, Urbanowski ME, Kübler A, Bishai WR, Elkington PT, Jain SK.

J Infect Dis. 2019 Jan 29;219(4):633-636. doi: 10.1093/infdis/jiy373.

PMID:
29920600
11.

Diverse Cavity Types and Evidence that Mechanical Action on the Necrotic Granuloma Drives Tuberculous Cavitation.

Ihms EA, Urbanowski ME, Bishai WR.

Am J Pathol. 2018 Jul;188(7):1666-1675. doi: 10.1016/j.ajpath.2018.04.006. Epub 2018 May 23.

12.

Organoid culture of bladder cancer cells.

Yoshida T, Singh AK, Bishai WR, McConkey DJ, Bivalacqua TJ.

Investig Clin Urol. 2018 May;59(3):149-151. doi: 10.4111/icu.2018.59.3.149. Epub 2018 Apr 30. No abstract available.

13.

Pharmacokinetics of rifapentine and rifampin in a rabbit model of tuberculosis and correlation with clinical trial data.

Rifat D, Prideaux B, Savic RM, Urbanowski ME, Parsons TL, Luna B, Marzinke MA, Ordonez AA, DeMarco VP, Jain SK, Dartois V, Bishai WR, Dooley KE.

Sci Transl Med. 2018 Apr 4;10(435). pii: eaai7786. doi: 10.1126/scitranslmed.aai7786.

14.

Repetitive Aerosol Exposure Promotes Cavitary Tuberculosis and Enables Screening for Targeted Inhibitors of Extensive Lung Destruction.

Urbanowski ME, Ihms EA, Bigelow K, Kübler A, Elkington PT, Bishai WR.

J Infect Dis. 2018 Jun 5;218(1):53-63. doi: 10.1093/infdis/jiy127.

15.

Identification of Novel Coumestan Derivatives as Polyketide Synthase 13 Inhibitors against Mycobacterium tuberculosis.

Zhang W, Lun S, Wang SH, Jiang XW, Yang F, Tang J, Manson AL, Earl AM, Gunosewoyo H, Bishai WR, Yu LF.

J Med Chem. 2018 Feb 8;61(3):791-803. doi: 10.1021/acs.jmedchem.7b01319. Epub 2018 Jan 29.

PMID:
29328655
16.

Ex vivo culture of tumor cells from N-methyl-N-nitrosourea-induced bladder cancer in rats: Development of organoids and an immortalized cell line.

Yoshida T, Kates M, Sopko NA, Liu X, Singh AK, Bishai WR, Joice G, McConkey DJ, Bivalacqua TJ.

Urol Oncol. 2018 Apr;36(4):160.e23-160.e32. doi: 10.1016/j.urolonc.2017.11.024. Epub 2017 Dec 26.

PMID:
29288005
17.

Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives.

Abel L, Fellay J, Haas DW, Schurr E, Srikrishna G, Urbanowski M, Chaturvedi N, Srinivasan S, Johnson DH, Bishai WR.

Lancet Infect Dis. 2018 Mar;18(3):e64-e75. doi: 10.1016/S1473-3099(17)30623-0. Epub 2017 Oct 27. Review.

PMID:
29111156
18.

Partners in Crime: Phenolic Glycolipids and Macrophages.

Singh AK, Bishai WR.

Trends Mol Med. 2017 Nov;23(11):981-983. doi: 10.1016/j.molmed.2017.09.003. Epub 2017 Sep 29.

19.

Suppressor Cell-Depleting Immunotherapy With Denileukin Diftitox is an Effective Host-Directed Therapy for Tuberculosis.

Gupta S, Cheung L, Pokkali S, Winglee K, Guo H, Murphy JR, Bishai WR.

J Infect Dis. 2017 Jun 15;215(12):1883-1887. doi: 10.1093/infdis/jix208.

20.

Drug development: Locking down metabolism.

Bishai WR.

Nat Chem Biol. 2017 Aug 18;13(9):925-926. doi: 10.1038/nchembio.2452. No abstract available.

PMID:
28820877
21.

Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes.

Rockwood N, Costa DL, Amaral EP, Du Bruyn E, Kubler A, Gil-Santana L, Fukutani KF, Scanga CA, Flynn JL, Jackson SH, Wilkinson KA, Bishai WR, Sher A, Wilkinson RJ, Andrade BB.

Front Immunol. 2017 May 12;8:542. doi: 10.3389/fimmu.2017.00542. eCollection 2017.

22.

Reply to Levis and Rendini.

Singh DK, Dwivedi VP, Ranganathan A, Bishai WR, Van Kaer L, Das G.

J Infect Dis. 2017 May 1;215(9):1488-1489. doi: 10.1093/infdis/jix084. No abstract available.

23.

Inhibition of innate immune cytosolic surveillance by an M. tuberculosis phosphodiesterase.

Dey RJ, Dey B, Zheng Y, Cheung LS, Zhou J, Sayre D, Kumar P, Guo H, Lamichhane G, Sintim HO, Bishai WR.

Nat Chem Biol. 2017 Feb;13(2):210-217. doi: 10.1038/nchembio.2254. Epub 2016 Dec 12.

PMID:
28106876
24.

Bacterial subversion of cAMP signalling inhibits cathelicidin expression, which is required for innate resistance to Mycobacterium tuberculosis.

Gupta S, Winglee K, Gallo R, Bishai WR.

J Pathol. 2017 May;242(1):52-61. doi: 10.1002/path.4878. Epub 2017 Mar 15.

25.

Genomic analysis of globally diverse Mycobacterium tuberculosis strains provides insights into the emergence and spread of multidrug resistance.

Manson AL, Cohen KA, Abeel T, Desjardins CA, Armstrong DT, Barry CE 3rd, Brand J; TBResist Global Genome Consortium, Chapman SB, Cho SN, Gabrielian A, Gomez J, Jodals AM, Joloba M, Jureen P, Lee JS, Malinga L, Maiga M, Nordenberg D, Noroc E, Romancenco E, Salazar A, Ssengooba W, Velayati AA, Winglee K, Zalutskaya A, Via LE, Cassell GH, Dorman SE, Ellner J, Farnia P, Galagan JE, Rosenthal A, Crudu V, Homorodean D, Hsueh PR, Narayanan S, Pym AS, Skrahina A, Swaminathan S, Van der Walt M, Alland D, Bishai WR, Cohen T, Hoffner S, Birren BW, Earl AM.

Nat Genet. 2017 Mar;49(3):395-402. doi: 10.1038/ng.3767. Epub 2017 Jan 16.

26.

The antifibrotic drug pirfenidone promotes pulmonary cavitation and drug resistance in a mouse model of chronic tuberculosis.

Ahidjo BA, Maiga MC, Ihms EA, Maiga M, Ordonez AA, Cheung LS, Beck S, Andrade BB, Jain S, Bishai WR.

JCI Insight. 2016 Sep 8;1(14):e86017. doi: 10.1172/jci.insight.86017.

27.

Blockade of the Kv1.3 K+ Channel Enhances BCG Vaccine Efficacy by Expanding Central Memory T Lymphocytes.

Singh DK, Dwivedi VP, Ranganathan A, Bishai WR, Van Kaer L, Das G.

J Infect Dis. 2016 Nov 1;214(9):1456-1464. Epub 2016 Aug 28.

PMID:
27571906
28.

Stool microbiome reveals diverse bacterial ureases as confounders of oral urea breath testing for Helicobacter pylori and Mycobacterium tuberculosis in Bamako, Mali.

Maiga M, Cohen K, Baya B, Srikrishna G, Siddiqui S, Sanogo M, Somboro AM, Diarra B, Diallo MH, Mazumdar V, Yoder C, Orsega S, Belson M, Kassambara H, Goita D, Murphy RL, Dao S, Polis M, Diallo S, Timmins GS, Dodd L, Earl AM, Bishai WR.

J Breath Res. 2016 Aug 17;10(3):036012. doi: 10.1088/1752-7155/10/3/036012.

29.

REMap: Operon map of M. tuberculosis based on RNA sequence data.

Pelly S, Winglee K, Xia FF, Stevens RL, Bishai WR, Lamichhane G.

Tuberculosis (Edinb). 2016 Jul;99:70-80. doi: 10.1016/j.tube.2016.04.010. Epub 2016 Apr 29.

30.

Paradoxical Hypersusceptibility of Drug-resistant Mycobacteriumtuberculosis to β-lactam Antibiotics.

Cohen KA, El-Hay T, Wyres KL, Weissbrod O, Munsamy V, Yanover C, Aharonov R, Shaham O, Conway TC, Goldschmidt Y, Bishai WR, Pym AS.

EBioMedicine. 2016 Jul;9:170-179. doi: 10.1016/j.ebiom.2016.05.041. Epub 2016 Jun 1.

31.

Indole-2-carboxamide-based MmpL3 Inhibitors Show Exceptional Antitubercular Activity in an Animal Model of Tuberculosis Infection.

Stec J, Onajole OK, Lun S, Guo H, Merenbloom B, Vistoli G, Bishai WR, Kozikowski AP.

J Med Chem. 2016 Jul 14;59(13):6232-47. doi: 10.1021/acs.jmedchem.6b00415. Epub 2016 Jun 22.

PMID:
27275668
32.

Phosphodiesterase inhibitors as adjunctive therapies for tuberculosis.

Ahidjo BA, Bishai WR.

EBioMedicine. 2016 Feb 9;4:7-8. doi: 10.1016/j.ebiom.2016.02.016. eCollection 2016 Feb. No abstract available.

33.

Erratum to "Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis" [EBioMedicine 2 (8), August 2015, 868-873].

Maiga M, Ahidjo BA, Maiga MC, Cheung L, Pelly S, Lun S, Bougoudogo F, Bishai WR.

EBioMedicine. 2015 Oct 19;2(11):1834. doi: 10.1016/j.ebiom.2015.10.019. eCollection 2015 Nov. No abstract available.

34.

Whole Genome Sequencing of Mycobacterium africanum Strains from Mali Provides Insights into the Mechanisms of Geographic Restriction.

Winglee K, Manson McGuire A, Maiga M, Abeel T, Shea T, Desjardins CA, Diarra B, Baya B, Sanogo M, Diallo S, Earl AM, Bishai WR.

PLoS Negl Trop Dis. 2016 Jan 11;10(1):e0004332. doi: 10.1371/journal.pntd.0004332. eCollection 2016 Jan.

35.

Roflumilast, a Type 4 Phosphodiesterase Inhibitor, Shows Promising Adjunctive, Host-Directed Therapeutic Activity in a Mouse Model of Tuberculosis.

Maiga MC, Ahidjo BA, Maiga M, Bishai WR.

Antimicrob Agents Chemother. 2015 Dec;59(12):7888-90. doi: 10.1128/AAC.02145-15. Epub 2015 Oct 5.

36.

Efficacy of Adjunctive Tofacitinib Therapy in Mouse Models of Tuberculosis.

Maiga M, Ahidjo BA, Maiga MC, Cheung L, Pelly S, Lun S, Bougoudogo F, Bishai WR.

EBioMedicine. 2015 Jul 14;2(8):868-73. doi: 10.1016/j.ebiom.2015.07.014. eCollection 2015 Aug. Erratum in: EBioMedicine. 2015 Nov;2(11):1834.

37.

Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal.

Cohen KA, Abeel T, Manson McGuire A, Desjardins CA, Munsamy V, Shea TP, Walker BJ, Bantubani N, Almeida DV, Alvarado L, Chapman SB, Mvelase NR, Duffy EY, Fitzgerald MG, Govender P, Gujja S, Hamilton S, Howarth C, Larimer JD, Maharaj K, Pearson MD, Priest ME, Zeng Q, Padayatchi N, Grosset J, Young SK, Wortman J, Mlisana KP, O'Donnell MR, Birren BW, Bishai WR, Pym AS, Earl AM.

PLoS Med. 2015 Sep 29;12(9):e1001880. doi: 10.1371/journal.pmed.1001880. eCollection 2015 Sep.

38.

Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis.

Kubler A, Larsson C, Luna B, Andrade BB, Amaral EP, Urbanowski M, Orandle M, Bock K, Ammerman NC, Cheung LS, Winglee K, Halushka M, Park JK, Sher A, Friedland JS, Elkington PT, Bishai WR.

J Infect Dis. 2016 Feb 15;213(4):618-27. doi: 10.1093/infdis/jiv458. Epub 2015 Sep 27.

39.

Can the addition of verapamil to bedaquiline-containing regimens improve tuberculosis treatment outcomes? A novel approach to optimizing TB treatment.

Srikrishna G, Gupta S, Dooley KE, Bishai WR.

Future Microbiol. 2015;10(8):1257-60. doi: 10.2217/FMB.15.56. Epub 2015 Jul 30. No abstract available.

40.

Computer-aided pulmonary image analysis in small animal models.

Xu Z, Bagci U, Mansoor A, Kramer-Marek G, Luna B, Kubler A, Dey B, Foster B, Papadakis GZ, Camp JV, Jonsson CB, Bishai WR, Jain S, Udupa JK, Mollura DJ.

Med Phys. 2015 Jul;42(7):3896-910. doi: 10.1118/1.4921618.

41.

Latent and Active Tuberculosis Infection Increase Immune Activation in Individuals Co-Infected with HIV.

Sullivan ZA, Wong EB, Ndung'u T, Kasprowicz VO, Bishai WR.

EBioMedicine. 2015 Apr 1;2(4):334-340.

42.

Molecular Basis of Drug Resistance in Mycobacterium tuberculosis.

Cohen KA, Bishai WR, Pym AS.

Microbiol Spectr. 2014 Jun;2(3). doi: 10.1128/microbiolspec.MGM2-0036-2013. Review.

PMID:
26103975
43.

Immunogenicity without Efficacy of an Adenoviral Tuberculosis Vaccine in a Stringent Mouse Model for Immunotherapy during Treatment.

Alyahya SA, Nolan ST, Smith CM, Bishai WR, Sadoff J, Lamichhane G.

PLoS One. 2015 May 21;10(5):e0127907. doi: 10.1371/journal.pone.0127907. eCollection 2015.

44.

In vivo biosynthesis of terpene nucleosides provides unique chemical markers of Mycobacterium tuberculosis infection.

Young DC, Layre E, Pan SJ, Tapley A, Adamson J, Seshadri C, Wu Z, Buter J, Minnaard AJ, Coscolla M, Gagneux S, Copin R, Ernst JD, Bishai WR, Snider BB, Moody DB.

Chem Biol. 2015 Apr 23;22(4):516-526. doi: 10.1016/j.chembiol.2015.03.015.

45.

Mycobacterium tuberculosis TlyA Protein Negatively Regulates T Helper (Th) 1 and Th17 Differentiation and Promotes Tuberculosis Pathogenesis.

Rahman MA, Sobia P, Dwivedi VP, Bhawsar A, Singh DK, Sharma P, Moodley P, Van Kaer L, Bishai WR, Das G.

J Biol Chem. 2015 Jun 5;290(23):14407-17. doi: 10.1074/jbc.M115.653600. Epub 2015 Apr 6.

46.

Targeting the cell wall of Mycobacterium tuberculosis: a molecular modeling investigation of the interaction of imipenem and meropenem with L,D-transpeptidase 2.

Silva JR, Bishai WR, Govender T, Lamichhane G, Maguire GE, Kruger HG, Lameira J, Alves CN.

J Biomol Struct Dyn. 2016;34(2):304-17. doi: 10.1080/07391102.2015.1029000. Epub 2015 Jul 24.

PMID:
25762064
47.

High expression of CD26 accurately identifies human bacteria-reactive MR1-restricted MAIT cells.

Sharma PK, Wong EB, Napier RJ, Bishai WR, Ndung'u T, Kasprowicz VO, Lewinsohn DA, Lewinsohn DM, Gold MC.

Immunology. 2015 Jul;145(3):443-53. doi: 10.1111/imm.12461. Epub 2015 Mar 29.

48.

A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis.

Dey B, Dey RJ, Cheung LS, Pokkali S, Guo H, Lee JH, Bishai WR.

Nat Med. 2015 Apr;21(4):401-6. doi: 10.1038/nm.3813. Epub 2015 Mar 2.

49.

Revisiting Anti-tuberculosis Activity of Pyrazinamide in Mice.

Almeida DV, Tyagi S, Li S, Wallengren K, Pym AS, Ammerman NC, Bishai WR, Grosset JH.

Mycobact Dis. 2014 May 5;4:145.

50.

Verapamil increases the bactericidal activity of bedaquiline against Mycobacterium tuberculosis in a mouse model.

Gupta S, Tyagi S, Bishai WR.

Antimicrob Agents Chemother. 2015 Jan;59(1):673-6. doi: 10.1128/AAC.04019-14. Epub 2014 Oct 20.

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