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Targeted LC-MS/MS for the evaluation of proteomics biomarkers in the blood of neonates with necrotizing enterocolitis and late-onset sepsis.

Chatziioannou AC, Wolters JC, Sarafidis K, Thomaidou A, Agakidis C, Govorukhina N, Kuivenhoven JA, Bischoff R, Theodoridis G.

Anal Bioanal Chem. 2018 Aug 23. doi: 10.1007/s00216-018-1320-3. [Epub ahead of print]


Cigarette Smoking Acutely Decreases Serum Levels of the COPD Biomarker sRAGE.

Pouwels SD, Klont F, Kwiatkowski M, Wiersma VR, Faiz A, van den Berge M, Horvatovich P, Bischoff R, Ten Hacken NHT.

Am J Respir Crit Care Med. 2018 Aug 21. doi: 10.1164/rccm.201807-1249LE. [Epub ahead of print] No abstract available.


LC-MS analysis of key components of the glutathione cycle in tissues and body fluids from mice with myocardial infarction.

Gil A, van der Pol A, van der Meer P, Bischoff R.

J Pharm Biomed Anal. 2018 Oct 25;160:289-296. doi: 10.1016/j.jpba.2018.08.001. Epub 2018 Aug 7.


OPLAH ablation leads to accumulation of 5-oxoproline, oxidative stress, fibrosis and elevated fillings pressures: a murine model for heart failure with a preserved ejection fraction.

van der Pol A, Gil A, Tromp J, Silljé HHW, van Veldhuisen DJ, Voors AA, Hoendermis ES, Grote Beverborg N, Schouten EM, de Boer RA, Bischoff R, van der Meer P.

Cardiovasc Res. 2018 Jul 19. doi: 10.1093/cvr/cvy187. [Epub ahead of print]


Application of Displacement Chromatography to Online Two-Dimensional Liquid Chromatography Coupled to Tandem Mass Spectrometry Improves Peptide Separation Efficiency and Detectability for the Analysis of Complex Proteomes.

Kwiatkowski M, Krösser D, Wurlitzer M, Steffen P, Barcaru A, Krisp C, Horvatovich P, Bischoff R, Schlüter H.

Anal Chem. 2018 Aug 21;90(16):9951-9958. doi: 10.1021/acs.analchem.8b02189. Epub 2018 Aug 1.


Affimers as an Alternative to Antibodies in an Affinity LC-MS Assay for Quantification of the Soluble Receptor of Advanced Glycation End-Products (sRAGE) in Human Serum.

Klont F, Hadderingh M, Horvatovich P, Ten Hacken NHT, Bischoff R.

J Proteome Res. 2018 Aug 3;17(8):2892-2899. doi: 10.1021/acs.jproteome.8b00414. Epub 2018 Jul 26.


One- vs two-phase extraction: re-evaluation of sample preparation procedures for untargeted lipidomics in plasma samples.

Gil A, Zhang W, Wolters JC, Permentier H, Boer T, Horvatovich P, Heiner-Fokkema MR, Reijngoud DJ, Bischoff R.

Anal Bioanal Chem. 2018 Sep;410(23):5859-5870. doi: 10.1007/s00216-018-1200-x. Epub 2018 Jul 2.


Improving selectivity and sensitivity of protein quantitation by LC-HR-MS/MS: determination of somatropin in rat plasma.

Bults P, Meints M, Sonesson A, Knutsson M, Bischoff R, van de Merbel NC.

Bioanalysis. 2018 Jul 1;10(13):1009-1021. doi: 10.4155/bio-2018-0032. Epub 2018 Jun 28.


Proteomic alterations in early stage cervical cancer.

Güzel C, Govorukhina NI, Wisman GBA, Stingl C, Dekker LJM, Klip HG, Hollema H, Guryev V, Horvatovich PL, van der Zee AGJ, Bischoff R, Luider TM.

Oncotarget. 2018 Apr 6;9(26):18128-18147. doi: 10.18632/oncotarget.24773. eCollection 2018 Apr 6.


A quantitative LC-MS/MS method for insulin-like growth factor 1 in human plasma.

Bronsema KJ, Klont F, Schalk FB, Bischoff R, Kema IP, van de Merbel NC.

Clin Chem Lab Med. 2018 May 1. pii: /j/cclm.ahead-of-print/cclm-2017-1042/cclm-2017-1042.xml. doi: 10.1515/cclm-2017-1042. [Epub ahead of print]


Developing novel methods for protein, peptide and metabolite analysis.

Bischoff R.

Bioanalysis. 2018 Apr 1;10(7):431-432. doi: 10.4155/bio-2018-3999. Epub 2018 Apr 10.


Assessment of Sample Preparation Bias in Mass Spectrometry-Based Proteomics.

Klont F, Bras L, Wolters JC, Ongay S, Bischoff R, Halmos GB, Horvatovich P.

Anal Chem. 2018 Apr 17;90(8):5405-5413. doi: 10.1021/acs.analchem.8b00600. Epub 2018 Apr 6.


A fully validated liquid chromatography-mass spectrometry method for the quantification of the soluble receptor of advanced glycation end-products (sRAGE) in serum using immunopurification in a 96-well plate format.

Klont F, Pouwels SD, Hermans J, van de Merbel NC, Horvatovich P, Ten Hacken NHT, Bischoff R.

Talanta. 2018 May 15;182:414-421. doi: 10.1016/j.talanta.2018.02.015. Epub 2018 Feb 7.


Global proofing a collaborative care telemental health intervention in Brazil.

Springer PR, Scheeren P, Bischoff RJ, Taylor NC, Cargnin D, Barros E, Falceto OG.

Fam Syst Health. 2018 Jun;36(2):175-181. doi: 10.1037/fsh0000323. Epub 2018 Feb 1.


Cleavable Crosslinkers as Tissue Fixation Reagents for Proteomic Analysis.

Ongay S, Langelaar-Makkinje M, Stoop MP, Liu N, Overkleeft H, Luider TM, Groothuis GMM, Bischoff R.

Chembiochem. 2018 Apr 4;19(7):736-743. doi: 10.1002/cbic.201700625. Epub 2018 Feb 16.


Tutorial: Correction of shifts in single-stage LC-MS(/MS) data.

Mitra V, Smilde AK, Bischoff R, Horvatovich P.

Anal Chim Acta. 2018 Jan 25;999:37-53. doi: 10.1016/j.aca.2017.09.039. Epub 2017 Nov 2. Review.


Running-wheel activity delays mitochondrial respiratory flux decline in aging mouse muscle via a post-transcriptional mechanism.

Stolle S, Ciapaite J, Reijne AC, Talarovicova A, Wolters JC, Aguirre-Gamboa R, van der Vlies P, de Lange K, Neerincx PB, van der Vries G, Deelen P, Swertz MA, Li Y, Bischoff R, Permentier HP, Horvatovitch PL, Groen AK, van Dijk G, Reijngoud DJ, Bakker BM.

Aging Cell. 2018 Feb;17(1). doi: 10.1111/acel.12700. Epub 2017 Nov 9.


Accumulation of 5-oxoproline in myocardial dysfunction and the protective effects of OPLAH.

van der Pol A, Gil A, Silljé HHW, Tromp J, Ovchinnikova ES, Vreeswijk-Baudoin I, Hoes M, Domian IJ, van de Sluis B, van Deursen JM, Voors AA, van Veldhuisen DJ, van Gilst WH, Berezikov E, van der Harst P, de Boer RA, Bischoff R, van der Meer P.

Sci Transl Med. 2017 Nov 8;9(415). pii: eaam8574. doi: 10.1126/scitranslmed.aam8574.


Comparison of Targeted Mass Spectrometry Techniques with an Immunoassay: A Case Study for HSP90α.

Güzel C, Govorukhina NI, Stingl C, Dekker LJM, Boichenko A, van der Zee AGJ, Bischoff RPH, Luider TM.

Proteomics Clin Appl. 2018 Jan;12(1). doi: 10.1002/prca.201700107. Epub 2017 Oct 30.


Physicochemical Parameters Affecting the Electrospray Ionization Efficiency of Amino Acids after Acylation.

Hermans J, Ongay S, Markov V, Bischoff R.

Anal Chem. 2017 Sep 5;89(17):9159-9166. doi: 10.1021/acs.analchem.7b01899. Epub 2017 Aug 16.


Targeting transcription factor lysine acetylation in inflammatory airway diseases.

van den Bosch T, Kwiatkowski M, Bischoff R, Dekker FJ.

Epigenomics. 2017 Jul;9(7):1013-1028. doi: 10.2217/epi-2017-0027. Epub 2017 Jun 15. Review.


Specific Affinity Enrichment of Electrochemically Cleaved Peptides Based on Cu(II)-Mediated Spirolactone Tagging.

Zhang T, de Vries MP, Permentier HP, Bischoff R.

Anal Chem. 2017 Jul 5;89(13):7123-7129. doi: 10.1021/acs.analchem.7b01039. Epub 2017 Jun 19.


The relevance of Ki calculation for bi-substrate enzymes illustrated by kinetic evaluation of a novel lysine (K) acetyltransferase 8 inhibitor.

Wapenaar H, van den Bosch T, Leus NGJ, van der Wouden PE, Eleftheriadis N, Hermans J, Hailu GS, Rotili D, Mai A, Dömling A, Bischoff R, Haisma HJ, Dekker FJ.

Eur J Med Chem. 2017 Aug 18;136:480-486. doi: 10.1016/j.ejmech.2017.05.015. Epub 2017 May 5.


Assuring Consistent Performance of an Insulin-Like Growth Factor 1 MALDImmunoassay by Monitoring Measurement Quality Indicators.

Klont F, Ten Hacken NHT, Horvatovich P, Bakker SJL, Bischoff R.

Anal Chem. 2017 Jun 6;89(11):6188-6195. doi: 10.1021/acs.analchem.7b01125. Epub 2017 May 10.


HDAC1-3 inhibitor MS-275 enhances IL10 expression in RAW264.7 macrophages and reduces cigarette smoke-induced airway inflammation in mice.

Leus NG, van den Bosch T, van der Wouden PE, Krist K, Ourailidou ME, Eleftheriadis N, Kistemaker LE, Bos S, Gjaltema RA, Mekonnen SA, Bischoff R, Gosens R, Haisma HJ, Dekker FJ.

Sci Rep. 2017 Mar 27;7:45047. doi: 10.1038/srep45047.


A 6-alkylsalicylate histone acetyltransferase inhibitor inhibits histone acetylation and pro-inflammatory gene expression in murine precision-cut lung slices.

van den Bosch T, Leus NGJ, Wapenaar H, Boichenko A, Hermans J, Bischoff R, Haisma HJ, Dekker FJ.

Pulm Pharmacol Ther. 2017 Jun;44:88-95. doi: 10.1016/j.pupt.2017.03.006. Epub 2017 Mar 16.


Bioconjugation strategies to couple supramolecular exo-functionalized palladium cages to peptides for biomedical applications.

Han J, Schmidt A, Zhang T, Permentier H, Groothuis GM, Bischoff R, Kühn FE, Horvatovich P, Casini A.

Chem Commun (Camb). 2017 Jan 24;53(8):1405-1408. doi: 10.1039/c6cc08937b.


Relationship between plasma and salivary melatonin and cortisol investigated by LC-MS/MS.

van Faassen M, Bischoff R, Kema IP.

Clin Chem Lab Med. 2017 Aug 28;55(9):1340-1348. doi: 10.1515/cclm-2016-0817.


The degradation of nucleotide triphosphates extracted under boiling ethanol conditions is prevented by the yeast cellular matrix.

Gil A, Siegel D, Bonsing-Vedelaar S, Permentier H, Reijngoud DJ, Dekker F, Bischoff R.

Metabolomics. 2017;13(1):1. Epub 2016 Nov 28.


Global Mental Health in Action: Reducing Disparities One Community at a Time.

Bischoff RJ, Springer PR, Taylor N.

J Marital Fam Ther. 2017 Apr;43(2):276-290. doi: 10.1111/jmft.12202. Epub 2016 Nov 17. Review.


Activity-Dependent Photoaffinity Labeling of Metalloproteases.

Prely L, Klein T, Geurink PP, Paal K, Overkleeft HS, Bischoff R.

Methods Mol Biol. 2017;1491:103-111.


Serum Protein Markers for the Early Detection of Lung Cancer: A Focus on Autoantibodies.

Broodman I, Lindemans J, van Sten J, Bischoff R, Luider T.

J Proteome Res. 2017 Jan 6;16(1):3-13. doi: 10.1021/acs.jproteome.6b00559. Epub 2016 Nov 2. Review.


Proteogenomics: Key Driver for Clinical Discovery and Personalized Medicine.

Barbieri R, Guryev V, Brandsma CA, Suits F, Bischoff R, Horvatovich P.

Adv Exp Med Biol. 2016;926:21-47. Review.


Radiation chemical studies of Gly-Met-Gly in aqueous solution.

Barata-Vallejo S, Ferreri C, Zhang T, Permentier H, Bischoff R, Bobrowski K, Chatgilialoglu C.

Free Radic Res. 2016 Nov;50(sup1):S24-S39. Epub 2016 Oct 25.


Electrochemical Protein Cleavage in a Microfluidic Cell with Integrated Boron Doped Diamond Electrodes.

van den Brink FT, Zhang T, Ma L, Bomer J, Odijk M, Olthuis W, Permentier HP, Bischoff R, van den Berg A.

Anal Chem. 2016 Sep 20;88(18):9190-8. doi: 10.1021/acs.analchem.6b02413. Epub 2016 Aug 26.


Translational Targeted Proteomics Profiling of Mitochondrial Energy Metabolic Pathways in Mouse and Human Samples.

Wolters JC, Ciapaite J, van Eunen K, Niezen-Koning KE, Matton A, Porte RJ, Horvatovich P, Bakker BM, Bischoff R, Permentier HP.

J Proteome Res. 2016 Sep 2;15(9):3204-13. doi: 10.1021/acs.jproteome.6b00419. Epub 2016 Aug 5.


Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction.

van Zutphen T, Ciapaite J, Bloks VW, Ackereley C, Gerding A, Jurdzinski A, de Moraes RA, Zhang L, Wolters JC, Bischoff R, Wanders RJ, Houten SM, Bronte-Tinkew D, Shatseva T, Lewis GF, Groen AK, Reijngoud DJ, Bakker BM, Jonker JW, Kim PK, Bandsma RH.

J Hepatol. 2016 Dec;65(6):1198-1208. doi: 10.1016/j.jhep.2016.05.046. Epub 2016 Jun 14.


Quantitative antibody-free LC-MS/MS analysis of sTRAIL in sputum and saliva at the sub-ng/mL level.

Wilffert D, Donzelli R, Asselman A, Hermans J, Govorukhina N, Ten Hacken NH, Quax WJ, van de Merbel NC, Bischoff R.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 1;1032:205-210. doi: 10.1016/j.jchromb.2016.04.041. Epub 2016 Apr 26.


Efficient and Selective Chemical Labeling of Electrochemically Generated Peptides Based on Spirolactone Chemistry.

Zhang T, Niu X, Yuan T, Tessari M, de Vries MP, Permentier HP, Bischoff R.

Anal Chem. 2016 Jun 21;88(12):6465-71. doi: 10.1021/acs.analchem.6b01154. Epub 2016 Jun 10.


Highly sensitive antibody-free μLC-MS/MS quantification of rhTRAIL in serum.

Wilffert D, Asselman A, Donzelli R, Hermans J, Govorukhina N, Quax WJ, van de Merbel NC, Bischoff R.

Bioanalysis. 2016 May;8(9):881-90. doi: 10.4155/bio.16.30. Epub 2016 Apr 13.


HDAC 3-selective inhibitor RGFP966 demonstrates anti-inflammatory properties in RAW 264.7 macrophages and mouse precision-cut lung slices by attenuating NF-κB p65 transcriptional activity.

Leus NG, van der Wouden PE, van den Bosch T, Hooghiemstra WT, Ourailidou ME, Kistemaker LE, Bischoff R, Gosens R, Haisma HJ, Dekker FJ.

Biochem Pharmacol. 2016 May 15;108:58-74. doi: 10.1016/j.bcp.2016.03.010. Epub 2016 Mar 16.


Microbial Flavoprotein Monooxygenases as Mimics of Mammalian Flavin-Containing Monooxygenases for the Enantioselective Preparation of Drug Metabolites.

Gul T, Krzek M, Permentier HP, Fraaije MW, Bischoff R.

Drug Metab Dispos. 2016 Aug;44(8):1270-6. doi: 10.1124/dmd.115.069104. Epub 2016 Mar 16.


Site-specific quantification of lysine acetylation in the N-terminal tail of histone H4 using a double-labelling, targeted UHPLC MS/MS approach.

D'Urzo A, Boichenko AP, van den Bosch T, Hermans J, Dekker F, Andrisano V, Bischoff R.

Anal Bioanal Chem. 2016 May;408(13):3547-53. doi: 10.1007/s00216-016-9431-1. Epub 2016 Mar 11.


Identification of Analytical Factors Affecting Complex Proteomics Profiles Acquired in a Factorial Design Study with Analysis of Variance: Simultaneous Component Analysis.

Mitra V, Govorukhina N, Zwanenburg G, Hoefsloot H, Westra I, Smilde A, Reijmers T, van der Zee AG, Suits F, Bischoff R, Horvatovich P.

Anal Chem. 2016 Apr 19;88(8):4229-38. doi: 10.1021/acs.analchem.5b03483. Epub 2016 Mar 28.


Free Urinary Desmosine and Isodesmosine as COPD Biomarkers: The Relevance of Confounding Factors.

Ongay S, Sikma M, Horvatovich P, Hermans J, Miller BE, Ten Hacken NHT, Bischoff R.

Chronic Obstr Pulm Dis. 2016 Mar 1;3(2):560-569. doi: 10.15326/jcopdf.3.2.2015.0159.


Comparative investigation of the mutagenicity of propenylic and allylic asarone isomers in the Ames fluctuation assay.

Berg K, Bischoff R, Stegmüller S, Cartus A, Schrenk D.

Mutagenesis. 2016 Jul;31(4):443-51. doi: 10.1093/mutage/gew007. Epub 2016 Feb 19.


The histone acetyltransferase p300 inhibitor C646 reduces pro-inflammatory gene expression and inhibits histone deacetylases.

van den Bosch T, Boichenko A, Leus NGJ, Ourailidou ME, Wapenaar H, Rotili D, Mai A, Imhof A, Bischoff R, Haisma HJ, Dekker FJ.

Biochem Pharmacol. 2016 Feb 15;102:130-140. doi: 10.1016/j.bcp.2015.12.010. Epub 2015 Dec 21.


LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma.

Bults P, Bischoff R, Bakker H, Gietema JA, van de Merbel NC.

Anal Chem. 2016 Feb 2;88(3):1871-7. doi: 10.1021/acs.analchem.5b04276. Epub 2016 Jan 8.


Covalent immobilization of a flavoprotein monooxygenase via its flavin cofactor.

Krzek M, van Beek HL, Permentier HP, Bischoff R, Fraaije MW.

Enzyme Microb Technol. 2016 Jan;82:138-143. doi: 10.1016/j.enzmictec.2015.09.006. Epub 2015 Sep 30.


Protein biogenesis machinery is a driver of replicative aging in yeast.

Janssens GE, Meinema AC, González J, Wolters JC, Schmidt A, Guryev V, Bischoff R, Wit EC, Veenhoff LM, Heinemann M.

Elife. 2015 Dec 1;4:e08527. doi: 10.7554/eLife.08527.

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