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Items: 1 to 50 of 352

1.

Attenuated Mitral Leaflet Enlargement Contributes to Functional Mitral Regurgitation After Myocardial Infarction.

Marsit O, Clavel MA, Côté-Laroche C, Hadjadj S, Bouchard MA, Handschumacher MD, Clisson M, Drolet MC, Boulanger MC, Kim DH, Guerrero JL, Bartko PE, Couet J, Arsenault M, Mathieu P, Pibarot P, Aïkawa E, Bischoff J, Levine RA, Beaudoin J.

J Am Coll Cardiol. 2020 Feb 4;75(4):395-405. doi: 10.1016/j.jacc.2019.11.039.

PMID:
32000951
2.

In silico trials: Verification, validation and uncertainty quantification of predictive models used in the regulatory evaluation of biomedical products.

Viceconti M, Pappalardo F, Rodriguez B, Horner M, Bischoff J, Musuamba Tshinanu F.

Methods. 2020 Jan 25. pii: S1046-2023(19)30245-2. doi: 10.1016/j.ymeth.2020.01.011. [Epub ahead of print]

3.

Diffuse capillary malformation with overgrowth contains somatic PIK3CA variants.

Goss JA, Konczyk DJ, Smits P, Sudduth CL, Bischoff J, Liang MG, Greene AK.

Clin Genet. 2020 Jan 7. doi: 10.1111/cge.13702. [Epub ahead of print]

PMID:
31909475
4.

Computational Model Validation of Contact Mechanics in Total Ankle Arthroplasty.

Dharia MA, Snyder S, Bischoff JE.

J Orthop Res. 2019 Dec 4. doi: 10.1002/jor.24551. [Epub ahead of print]

PMID:
31799739
5.

Oxygen sensing decoded: a Nobel concept in biology.

Griffioen AW, Bischoff J.

Angiogenesis. 2019 Nov;22(4):471-472. doi: 10.1007/s10456-019-09692-y.

PMID:
31673842
6.

Cellular Resistance Mechanisms to Targeted Protein Degradation Converge Toward Impairment of the Engaged Ubiquitin Transfer Pathway.

Ottis P, Palladino C, Thienger P, Britschgi A, Heichinger C, Berrera M, Julien-Laferriere A, Roudnicky F, Kam-Thong T, Bischoff JR, Martoglio B, Pettazzoni P.

ACS Chem Biol. 2019 Oct 18;14(10):2215-2223. doi: 10.1021/acschembio.9b00525. Epub 2019 Oct 8.

PMID:
31553577
7.

A national center for persistent severe pain after groin hernia repair: Five-year prospective data.

Jensen EK, Ringsted TK, Bischoff JM, Petersen MA, Rosenberg J, Kehlet H, Werner MU.

Medicine (Baltimore). 2019 Aug;98(33):e16600. doi: 10.1097/MD.0000000000016600.

8.

R-propranolol is a small molecule inhibitor of the SOX18 transcription factor in a rare vascular syndrome and hemangioma.

Overman J, Fontaine F, Wylie-Sears J, Moustaqil M, Huang L, Meurer M, Chiang IK, Lesieur E, Patel J, Zuegg J, Pasquier E, Sierecki E, Gambin Y, Hamdan M, Khosrotehrani K, Andelfinger G, Bischoff J, Francois M.

Elife. 2019 Jul 30;8. pii: e43026. doi: 10.7554/eLife.43026.

9.

Circulating levels of PRO-C3 reflect liver fibrosis and liver function in HIV positive patients receiving modern cART.

Dold L, Nielsen MJ, Praktiknjo M, Schwarze-Zander C, Boesecke C, Schierwagen R, Mohr R, Wasmuth JC, Jansen C, Bischoff J, Rockstroh JK, Karsdal MA, Spengler U, Trebicka J, Leeming DJ.

PLoS One. 2019 Jul 11;14(7):e0219526. doi: 10.1371/journal.pone.0219526. eCollection 2019.

10.

Evaluation of Total Ankle Arthroplasty Using Highly Crosslinked Ultrahigh-Molecular-Weight Polyethylene Subjected to Physiological Loading.

Bischoff JE, Dharia MA, Hertzler JS, Schipper ON.

Foot Ankle Int. 2019 Aug;40(8):880-887. doi: 10.1177/1071100719847645. Epub 2019 May 15.

PMID:
31091414
11.

Endothelial-to-Mesenchymal Transition.

Bischoff J.

Circ Res. 2019 Apr 12;124(8):1163-1165. doi: 10.1161/CIRCRESAHA.119.314813. Review. No abstract available.

PMID:
30973806
12.

Fibroblast growth factor 21 is independently associated with severe hepatic steatosis in non-obese HIV-infected patients.

Praktiknjo M, Djayadi N, Mohr R, Schierwagen R, Bischoff J, Dold L, Pohlmann A, Schwarze-Zander C, Wasmuth JC, Boesecke C, Rockstroh JK, Trebicka J.

Liver Int. 2019 Aug;39(8):1514-1520. doi: 10.1111/liv.14107. Epub 2019 Apr 5.

PMID:
30916873
13.

Impact of CD4+ blood cell count and HIV viral load on treatment response with direct acting antivirals in HIV and HCV coinfected patients: insights from the German Hepatitis C-Registry.

Bischoff J, Mauss S, Cordes C, Lutz T, Scholten S, Cornberg M, Manns MP, Baumgarten A, Rockstroh JK.

HIV Clin Trials. 2018 Dec;19(6):225-234. doi: 10.1080/15284336.2018.1538193.

PMID:
30890063
14.

A randomized phase II study to determine the efficacy and tolerability of two doses of eribulin plus lapatinib in trastuzumab-pretreated patients with HER-2-positive metastatic breast cancer (E-VITA).

Bischoff J, Barinoff J, Mundhenke C, Bauerschlag DO, Costa SD, Herr D, Lübbe K, Marmé F, Maass N, von Minckwitz G, Grischke EM, Müller V, Schmidt M, Gerber B, Kümmel S, Schumacher C, Krabisch P, Seiler S, Thill M, Nekljudova V, Loibl S.

Anticancer Drugs. 2019 Apr;30(4):394-401. doi: 10.1097/CAD.0000000000000722.

PMID:
30875348
15.

A somatic missense mutation in GNAQ causes capillary malformation.

Bichsel C, Bischoff J.

Curr Opin Hematol. 2019 May;26(3):179-184. doi: 10.1097/MOH.0000000000000500.

PMID:
30870248
16.

Discovery of novel triazolo[4,3-b]pyridazin-3-yl-quinoline derivatives as PIM inhibitors.

Martínez-González S, Rodríguez-Arístegui S, Gómez de la Oliva CA, Hernández AI, González Cantalapiedra E, Varela C, García AB, Rabal O, Oyarzabal J, Bischoff JR, Klett J, Albarrán MI, Cebriá A, Ajenjo N, García-Serelde B, Gómez-Casero E, Cuadrado-Urbano M, Cebrián D, Blanco-Aparicio C, Pastor J.

Eur J Med Chem. 2019 Apr 15;168:87-109. doi: 10.1016/j.ejmech.2019.02.022. Epub 2019 Feb 19.

PMID:
30802730
17.

Has Increased Rollout of Direct Acting Antiviral Therapy Decreased the Burden of Late Presentation and Advanced Liver Disease in Patients Starting Hepatitis C Virus Therapy in Germany?

Bischoff J, Boesecke C, Ingiliz P, Berger F, Simon KG, Lutz T, Schewe CK, Schulze Zur Wiesch J, Hueppe D, Christensen S, Mauss S, Baumgarten A, Rockstroh JK; GECCO study group.

J Clin Gastroenterol. 2020 Feb;54(2):192-199. doi: 10.1097/MCG.0000000000001189.

PMID:
30789853
18.

Myeloid-Specific Deletion of Epsins 1 and 2 Reduces Atherosclerosis by Preventing LRP-1 Downregulation.

Brophy ML, Dong Y, Tao H, Yancey PG, Song K, Zhang K, Wen A, Wu H, Lee Y, Malovichko MV, Sithu SD, Wong S, Yu L, Kocher O, Bischoff J, Srivastava S, Linton MF, Ley K, Chen H.

Circ Res. 2019 Feb 15;124(4):e6-e19. doi: 10.1161/CIRCRESAHA.118.313028.

19.

Association of Somatic GNAQ Mutation With Capillary Malformations in a Case of Choroidal Hemangioma.

Bichsel CA, Goss J, Alomari M, Alexandrescu S, Robb R, Smith LE, Hochman M, Greene AK, Bischoff J.

JAMA Ophthalmol. 2019 Jan 1;137(1):91-95. doi: 10.1001/jamaophthalmol.2018.5141.

20.

Filamin-A as a Balance between Erk/Smad Activities During Cardiac Valve Development.

Toomer K, Sauls K, Fulmer D, Guo L, Moore K, Glover J, Stairley R, Bischoff J, Levine RA, Norris RA.

Anat Rec (Hoboken). 2019 Jan;302(1):117-124. doi: 10.1002/ar.23911. Epub 2018 Oct 5.

21.

Impact of Modeling Assumptions on Stability Predictions in Reverse Total Shoulder Arthroplasty.

Dharia MA, Bischoff JE, Schneider D.

Front Physiol. 2018 Aug 21;9:1116. doi: 10.3389/fphys.2018.01116. eCollection 2018.

22.

Are there any challenges left in hepatitis C virus therapy of HIV-infected patients?

Bischoff J, Rockstroh JK.

Int J Antimicrob Agents. 2018 Aug 23:105527. doi: 10.1016/j.ijantimicag.2018.08.019. [Epub ahead of print]

PMID:
30145247
23.

Epsin deficiency promotes lymphangiogenesis through regulation of VEGFR3 degradation in diabetes.

Wu H, Rahman HNA, Dong Y, Liu X, Lee Y, Wen A, To KH, Xiao L, Birsner AE, Bazinet L, Wong S, Song K, Brophy ML, Mahamud MR, Chang B, Cai X, Pasula S, Kwak S, Yang W, Bischoff J, Xu J, Bielenberg DR, Dixon JB, D'Amato RJ, Srinivasan RS, Chen H.

J Clin Invest. 2018 Aug 31;128(9):4025-4043. doi: 10.1172/JCI96063. Epub 2018 Aug 13.

24.

Checkpoint Inhibitors in Breast Cancer - Current Status and Future Directions.

Bischoff J.

Breast Care (Basel). 2018 Mar;13(1):27-31. doi: 10.1159/000486706. Epub 2018 Feb 20. Review.

25.

Physiological Loading of the Coonrad/Morrey, Nexel, and Discovery Elbow Systems: Evaluation by Finite Element Analysis.

King EA, Favre P, Eldemerdash A, Bischoff JE, Palmer M, Lawton JN.

J Hand Surg Am. 2019 Jan;44(1):61.e1-61.e9. doi: 10.1016/j.jhsa.2018.04.022. Epub 2018 Jun 19.

PMID:
29908927
26.

Design and synthesis of a series of bioavailable fatty acid synthase (FASN) KR domain inhibitors for cancer therapy.

Lu T, Schubert C, Cummings MD, Bignan G, Connolly PJ, Smans K, Ludovici D, Parker MH, Meyer C, Rocaboy C, Alexander R, Grasberger B, De Breucker S, Esser N, Fraiponts E, Gilissen R, Janssens B, Peeters D, Van Nuffel L, Vermeulen P, Bischoff J, Meerpoel L.

Bioorg Med Chem Lett. 2018 Jul 1;28(12):2159-2164. doi: 10.1016/j.bmcl.2018.05.014. Epub 2018 May 8.

PMID:
29779975
27.

Consensus guidelines for the use and interpretation of angiogenesis assays.

Nowak-Sliwinska P, Alitalo K, Allen E, Anisimov A, Aplin AC, Auerbach R, Augustin HG, Bates DO, van Beijnum JR, Bender RHF, Bergers G, Bikfalvi A, Bischoff J, Böck BC, Brooks PC, Bussolino F, Cakir B, Carmeliet P, Castranova D, Cimpean AM, Cleaver O, Coukos G, Davis GE, De Palma M, Dimberg A, Dings RPM, Djonov V, Dudley AC, Dufton NP, Fendt SM, Ferrara N, Fruttiger M, Fukumura D, Ghesquière B, Gong Y, Griffin RJ, Harris AL, Hughes CCW, Hultgren NW, Iruela-Arispe ML, Irving M, Jain RK, Kalluri R, Kalucka J, Kerbel RS, Kitajewski J, Klaassen I, Kleinmann HK, Koolwijk P, Kuczynski E, Kwak BR, Marien K, Melero-Martin JM, Munn LL, Nicosia RF, Noel A, Nurro J, Olsson AK, Petrova TV, Pietras K, Pili R, Pollard JW, Post MJ, Quax PHA, Rabinovich GA, Raica M, Randi AM, Ribatti D, Ruegg C, Schlingemann RO, Schulte-Merker S, Smith LEH, Song JW, Stacker SA, Stalin J, Stratman AN, Van de Velde M, van Hinsbergh VWM, Vermeulen PB, Waltenberger J, Weinstein BM, Xin H, Yetkin-Arik B, Yla-Herttuala S, Yoder MC, Griffioen AW.

Angiogenesis. 2018 Aug;21(3):425-532. doi: 10.1007/s10456-018-9613-x. Review.

28.

PTEN (Phosphatase and Tensin Homolog) Connection in Hereditary Hemorrhagic Telangiectasia 2.

Bischoff J.

Arterioscler Thromb Vasc Biol. 2018 May;38(5):984-985. doi: 10.1161/ATVBAHA.118.310921. No abstract available.

29.

Mitral Valve Adaptation: Can We Win the Race?

Kim DH, Dal-Bianco JP, Aikawa E, Bischoff J, Levine RA.

Circ Cardiovasc Imaging. 2018 Apr;11(4):e007642. doi: 10.1161/CIRCIMAGING.118.007642. No abstract available.

30.

Ketamine as an Analgesic Adjuvant in Adult Trauma Intensive Care Unit Patients With Rib Fracture.

Walters MK, Farhat J, Bischoff J, Foss M, Evans C.

Ann Pharmacother. 2018 Sep;52(9):849-854. doi: 10.1177/1060028018768451. Epub 2018 Apr 2.

PMID:
29607659
31.

Rates of sustained virological response 12 weeks after the scheduled end of direct-acting antiviral (DAA)-based hepatitis C virus (HCV) therapy from the National German HCV registry: does HIV coinfection impair the response to DAA combination therapy?

Bischoff J, Mauss S, Cordes C, Lutz T, Scholten S, Moll A, Jäger H, Cornberg M, Manns MP, Baumgarten A, Rockstroh JK.

HIV Med. 2018 Apr;19(4):299-307. doi: 10.1111/hiv.12579. Epub 2018 Jan 25.

PMID:
29368456
32.

Mitral Valve Adaptation to Isolated Annular Dilation: Insights Into the Mechanism of Atrial Functional Mitral Regurgitation.

Kim DH, Heo R, Handschumacher MD, Lee S, Choi YS, Kim KR, Shin Y, Park HK, Bischoff J, Aikawa E, Song JM, Kang DH, Levine RA, Song JK.

JACC Cardiovasc Imaging. 2019 Apr;12(4):665-677. doi: 10.1016/j.jcmg.2017.09.013. Epub 2017 Dec 13.

PMID:
29248661
33.

Mitral Leaflet Changes Following Myocardial Infarction: Clinical Evidence for Maladaptive Valvular Remodeling.

Beaudoin J, Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Sullivan S, Bartko PE, Handschumacher MD, Kim DH, Wylie-Sears J, Aaron J, Levine RA.

Circ Cardiovasc Imaging. 2017 Nov;10(11). pii: e006512. doi: 10.1161/CIRCIMAGING.117.006512.

34.

Identification of novel PI3K inhibitors through a scaffold hopping strategy.

Martínez González S, Hernández AI, Álvarez RM, Rodríguez A, Ramos-Lima F, Bischoff JR, Albarrán MI, Cebriá A, Hernández-Encinas E, García-Arocha J, Cebrián D, Blanco-Aparicio C, Pastor J.

Bioorg Med Chem Lett. 2017 Nov 1;27(21):4794-4799. doi: 10.1016/j.bmcl.2017.09.059. Epub 2017 Sep 30.

PMID:
29017786
35.

Effect of Losartan on Mitral Valve Changes After Myocardial Infarction.

Bartko PE, Dal-Bianco JP, Guerrero JL, Beaudoin J, Szymanski C, Kim DH, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Titus JS, Wylie-Sears J, Irvin WS, Messas E, Hagège AA, Carpentier A, Aikawa E, Bischoff J, Levine RA; Leducq Transatlantic Mitral Network.

J Am Coll Cardiol. 2017 Sep 5;70(10):1232-1244. doi: 10.1016/j.jacc.2017.07.734.

36.

Methanotroph-derived bacteriohopanepolyol signatures as a function of temperature related growth, survival, cell death and preservation in the geological record.

Osborne KA, Gray ND, Sherry A, Leary P, Mejeha O, Bischoff J, Rush D, Sidgwick FR, Birgel D, Kalyuzhnaya MG, Talbot HM.

Environ Microbiol Rep. 2017 Oct;9(5):492-500. doi: 10.1111/1758-2229.12570. Epub 2017 Oct 2.

PMID:
28772060
37.

Influence of Geometry and Depth of Resections on Bone Support for Total Ankle Replacement.

Bischoff JE, Schon L, Saltzman C.

Foot Ankle Int. 2017 Sep;38(9):1026-1034. doi: 10.1177/1071100717712508. Epub 2017 Jul 5.

PMID:
28675940
38.

Generation of tricyclic imidazo[1,2-a]pyrazines as novel PI3K inhibitors by application of a conformational restriction strategy.

Martínez González S, Rodríguez-Arístegui S, Hernández AI, Varela C, González Cantalapiedra E, Álvarez RM, Rodríguez Hergueta A, Bischoff JR, Albarrán MI, Cebriá A, Cendón E, Cebrián D, Alfonso P, Pastor J.

Bioorg Med Chem Lett. 2017 Jun 1;27(11):2536-2543. doi: 10.1016/j.bmcl.2017.03.090. Epub 2017 Apr 2.

PMID:
28404374
39.

Endothelial colony forming cells and mesenchymal progenitor cells form blood vessels and increase blood flow in ischemic muscle.

Kang KT, Lin RZ, Kuppermann D, Melero-Martin JM, Bischoff J.

Sci Rep. 2017 Apr 10;7(1):770. doi: 10.1038/s41598-017-00809-1.

40.

A somatic GNA11 mutation is associated with extremity capillary malformation and overgrowth.

Couto JA, Ayturk UM, Konczyk DJ, Goss JA, Huang AY, Hann S, Reeve JL, Liang MG, Bischoff J, Warman ML, Greene AK.

Angiogenesis. 2017 Aug;20(3):303-306. doi: 10.1007/s10456-016-9538-1. Epub 2017 Jan 24.

41.

Somatic GNAQ Mutation is Enriched in Brain Endothelial Cells in Sturge-Weber Syndrome.

Huang L, Couto JA, Pinto A, Alexandrescu S, Madsen JR, Greene AK, Sahin M, Bischoff J.

Pediatr Neurol. 2017 Feb;67:59-63. doi: 10.1016/j.pediatrneurol.2016.10.010. Epub 2016 Oct 21.

42.

EGFL6 Regulates the Asymmetric Division, Maintenance, and Metastasis of ALDH+ Ovarian Cancer Cells.

Bai S, Ingram P, Chen YC, Deng N, Pearson A, Niknafs YS, O'Hayer P, Wang Y, Zhang ZY, Boscolo E, Bischoff J, Yoon E, Buckanovich RJ.

Cancer Res. 2016 Nov 1;76(21):6396-6409. Erratum in: Cancer Res. 2017 Apr 15;77(8):2175.

43.

CD45 Expression in Mitral Valve Endothelial Cells After Myocardial Infarction.

Bischoff J, Casanovas G, Wylie-Sears J, Kim DH, Bartko PE, Guerrero JL, Dal-Bianco JP, Beaudoin J, Garcia ML, Sullivan SM, Seybolt MM, Morris BA, Keegan J, Irvin WS, Aikawa E, Levine RA.

Circ Res. 2016 Nov 11;119(11):1215-1225. doi: 10.1161/CIRCRESAHA.116.309598. Epub 2016 Oct 6.

44.

Analysis of non-derivatised bacteriohopanepolyols by ultrahigh-performance liquid chromatography/tandem mass spectrometry.

Talbot HM, Sidgwick FR, Bischoff J, Osborne KA, Rush D, Sherry A, Spencer-Jones CL.

Rapid Commun Mass Spectrom. 2016 Oct 15;30(19):2087-98. doi: 10.1002/rcm.7696.

PMID:
27472174
45.

Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma.

Ayturk UM, Couto JA, Hann S, Mulliken JB, Williams KL, Huang AY, Fishman SJ, Boyd TK, Kozakewich HPW, Bischoff J, Greene AK, Warman ML.

Am J Hum Genet. 2016 Jun 2;98(6):1271. doi: 10.1016/j.ajhg.2016.05.010. Epub 2016 Jun 2. No abstract available.

46.
47.

Somatic Activating Mutations in GNAQ and GNA11 Are Associated with Congenital Hemangioma.

Ayturk UM, Couto JA, Hann S, Mulliken JB, Williams KL, Huang AY, Fishman SJ, Boyd TK, Kozakewich HP, Bischoff J, Greene AK, Warman ML.

Am J Hum Genet. 2016 Apr 7;98(4):789-95. doi: 10.1016/j.ajhg.2016.03.009. Erratum in: Am J Hum Genet. 2016 Jun 2;98 (6):1271.

48.

3D Ultrasound: seeing is understanding-from imaging to pathophysiology to developing therapies in secondary MR.

Dal-Bianco JP, Bartko PE, Beaudoin J, Aikawa E, Bischoff J, Levine RA.

Eur Heart J Cardiovasc Imaging. 2016 May;17(5):510-1. doi: 10.1093/ehjci/jew029. Epub 2016 Mar 13. No abstract available.

49.

Altered ratios of pro- and anti-angiogenic VEGF-A variants and pericyte expression of DLL4 disrupt vascular maturation in infantile haemangioma.

Ye X, Abou-Rayyah Y, Bischoff J, Ritchie A, Sebire NJ, Watts P, Churchill AJ, Bates DO.

J Pathol. 2016 Jun;239(2):139-51. doi: 10.1002/path.4715.

50.

Myocardial Infarction Alters Adaptation of the Tethered Mitral Valve.

Dal-Bianco JP, Aikawa E, Bischoff J, Guerrero JL, Hjortnaes J, Beaudoin J, Szymanski C, Bartko PE, Seybolt MM, Handschumacher MD, Sullivan S, Garcia ML, Mauskapf A, Titus JS, Wylie-Sears J, Irvin WS, Chaput M, Messas E, Hagège AA, Carpentier A, Levine RA; Leducq Transatlantic Mitral Network.

J Am Coll Cardiol. 2016 Jan 26;67(3):275-87. doi: 10.1016/j.jacc.2015.10.092.

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