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Items: 1 to 50 of 90

1.

4-Benzyl and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones: in vitro evaluation of new C-3-amino-substituted and C-5,6-alkyl-substituted analogues against clinically important HIV mutant strains.

Benjahad A, Croisy M, Monneret C, Bisagni E, Mabire D, Coupa S, Poncelet A, Csoka I, Guillemont J, Meyer C, Andries K, Pauwels R, de Béthune MP, Himmel DM, Das K, Arnold E, Nguyen CH, Grierson DS.

J Med Chem. 2005 Mar 24;48(6):1948-64.

PMID:
15771439
2.

Triple-helix directed cleavage of double-stranded DNA by benzoquinoquinoxaline-1,10-phenanthroline conjugates.

Zaid A, Sun JS, Nguyen CH, Bisagni E, Garestier T, Grierson DS, Zain R.

Chembiochem. 2004 Nov 5;5(11):1550-7.

PMID:
15515089
3.

4-benzyl- and 4-benzoyl-3-dimethylaminopyridin-2(1H)-ones, a new family of potent anti-HIV agents: optimization and in vitro evaluation against clinically important HIV mutant strains.

Benjahad A, Courté K, Guillemont J, Mabire D, Coupa S, Poncelet A, Csoka I, Andries K, Pauwels R, de Béthune MP, Monneret C, Bisagni E, Nguyen CH, Grierson DS.

J Med Chem. 2004 Oct 21;47(22):5501-14.

PMID:
15481987
4.

Optimization of triple-helix-directed DNA cleavage by benzoquinoquinoxaline-ethylenediaminetetraacetic acid conjugates.

Zain R, Polverari D, Nguyen CH, Blouquit Y, Bisagni E, Garestier T, Grierson DS, Sun JS.

Chembiochem. 2003 Sep 5;4(9):856-62.

PMID:
12964160
5.

Synthesis and binding properties of oligo-2'-deoxyribonucleotides conjugated with triple-helix-specific intercalators: benzo[e] and benzo[g] pyridoindoles.

Vinogradov S, Roig V, Sergueeva Z, Nguyen CH, Arimondo P, Thuong NT, Bisagni E, Sun JS, Hélène C, Asseline U.

Bioconjug Chem. 2003 Jan-Feb;14(1):120-35.

PMID:
12526701
6.

Diphenyl quinolines and isoquinolines: synthesis and primary biological evaluation.

Croisy-Delcey M, Croisy A, Carrez D, Huel C, Chiaroni A, Ducrot P, Bisagni E, Jin L, Leclercq G.

Bioorg Med Chem. 2000 Nov;8(11):2629-41.

PMID:
11092548
7.

Synthesis and antiviral activity of 4-benzyl pyridinone derivatives as potent and selective non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors.

Dollé V, Nguyen CH, Legraverend M, Aubertin AM, Kirn A, Andreola ML, Ventura M, Tarrago-Litvak L, Bisagni E.

J Med Chem. 2000 Oct 19;43(21):3949-62.

PMID:
11052800
8.

A new family of sequence-specific DNA-cleaving agents directed by triple-helical structures: benzopyridoindole-EDTA conjugates.

Marchand C, Nguyen CH, Ward B, Sun JS, Bisagni E, Garestier T, Hélène C.

Chemistry. 2000 May 2;6(9):1559-63.

PMID:
10839173
9.

Synthesis and evaluation of "AZT-HEPT", "AZT-pyridinone", and "ddC-HEPT" conjugates as inhibitors of HIV reverse transcriptase.

Pontikis R, Dollé V, Guillaumel J, Dechaux E, Note R, Nguyen CH, Legraverend M, Bisagni E, Aubertin AM, Grierson DS, Monneret C.

J Med Chem. 2000 May 18;43(10):1927-39.

PMID:
10821705
10.

In vitro evaluation of a novel 2,6,9-trisubstituted purine acting as a cyclin-dependent kinase inhibitor.

Giocanti N, Sadri R, Legraverend M, Ludwig O, Bisagni E, Leclerc S, Meijer L, Favaudon V.

Ann N Y Acad Sci. 1999;886:180-2. Review. No abstract available.

PMID:
10667214
11.

Design of a triple-helix-specific cleaving reagent.

Zain R, Marchand C, Sun J, Nguyen CH, Bisagni E, Garestier T, Hélène C.

Chem Biol. 1999 Nov;6(11):771-7.

12.

Synthesis and in vitro evaluation of novel 2,6,9-trisubstituted purines acting as cyclin-dependent kinase inhibitors.

Legraverend M, Ludwig O, Bisagni E, Leclerc S, Meijer L, Giocanti N, Sadri R, Favaudon V.

Bioorg Med Chem. 1999 Jul;7(7):1281-93.

PMID:
10465404
13.

Synthesis of 9-O-substituted derivatives of 9-hydroxy-5, 6-dimethyl-6H-pyrido[4,3-b]carbazole-1-carboxylic acid (2-(dimethylamino)ethyl)amide and their 10- and 11-methyl analogues with improved antitumor activity.

Guillonneau C, PierréA, Charton Y, Guilbaud N, Kraus-Berthier L, Léonce S, Michel A, Bisagni E, Atassi G.

J Med Chem. 1999 Jun 17;42(12):2191-203.

PMID:
10377224
14.

Synthesis of C2 alkynylated purines, a new family of potent inhibitors of cyclin-dependent kinases.

Legraverend M, Ludwig O, Bisagni E, Leclerc S, Meijer L.

Bioorg Med Chem Lett. 1998 Apr 7;8(7):793-8.

PMID:
9871543
15.

Triple helices formed at oligopyrimidine*oligopurine sequences with base pair inversions: effect of a triplex-specific ligand on stability and selectivity.

Kukreti S, Sun JS, Loakes D, Brown DM, Nguyen CH, Bisagni E, Garestier T, Helene C.

Nucleic Acids Res. 1998 May 1;26(9):2179-83.

16.

Synthesis, properties and biological evaluation of substituted furo[3,2-e] and pyrano[3,2-e]pyrido[4,3-b]indoles.

Costache E, Nguyen CH, Guilbaud N, Léonce S, Pierré A, Atassi G, Bisagni E.

Anticancer Drug Des. 1998 Jun;13(4):373-86.

PMID:
9627674
17.
18.

Rational design of a triple helix-specific intercalating ligand.

Escudé C, Nguyen CH, Kukreti S, Janin Y, Sun JS, Bisagni E, Garestier T, Hélène C.

Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3591-6.

19.

Spectroscopic study of the interaction of pazelliptine with nucleic acids.

Renault E, Fontaine-Aupart MP, Tfibel F, Gardes-Albert M, Bisagni E.

J Photochem Photobiol B. 1997 Oct;40(3):218-27.

PMID:
9463113
20.

Synthesis, DNA binding, and cleaving properties of an ellipticine-salen.copper conjugate.

Routier S, Bernier JL, Catteau JP, Colson P, Houssier C, Rivalle C, Bisagni E, Bailly C.

Bioconjug Chem. 1997 Nov-Dec;8(6):789-92.

PMID:
9404650
21.

Genistein analogues: effects on epidermal growth factor receptor tyrosine kinase and on stress-activated pathways.

Croisy-Delcey M, Croisy A, Mousset S, Letourneur M, Bisagni E, Jacquemin-Sablon A, Pierre J.

Biomed Pharmacother. 1997;51(6-7):286-94.

PMID:
9309250
22.
23.

Synthesis and biological evaluation of 6-(9-hydroxy-5-methyl (and 5,6-dimethyl)-6H-pyrido[4,3-b]carbazol-1-yl)picolinic amides as new olivacine derivatives.

Landras C, Jasztold-Howorko R, Pierré A, Léonce S, Guilbaud N, Kraus-Berthier L, Guillonneau C, Rolland Y, Atassi G, Bisagni E.

Chem Pharm Bull (Tokyo). 1996 Nov;44(11):2169-72.

PMID:
8945783
24.

Ligand-induced formation of triple helices with antiparallel third strands containing G and T.

Escudé C, Sun JS, Nguyen CH, Bisagni E, Garestier T, Hélène C.

Biochemistry. 1996 May 7;35(18):5735-40.

PMID:
8639533
25.

Stabilization of triple helical DNA by a benzopyridoquinoxaline intercalator.

Marchand C, Bailly C, Nguyen CH, Bisagni E, Garestier T, Hélène C, Waring MJ.

Biochemistry. 1996 Apr 16;35(15):5022-32.

PMID:
8664295
26.

Alternate strand recognition of double-helical DNA by (T,G)-containing oligonucleotides in the presence of a triple helix-specific ligand.

de Bizemont T, Duval-Valentin G, Sun JS, Bisagni E, Garestier T, Hélène C.

Nucleic Acids Res. 1996 Mar 15;24(6):1136-43.

27.

In vitro cytotoxicity of S16020-2, a new olivacine derivative.

Léonce S, Perez V, Casabianca-Pignede MR, Anstett M, Bisagni E, Pierré A, Atassi G.

Invest New Drugs. 1996;14(2):169-80.

PMID:
8913838
28.

In vivo antitumor activity of S 16020-2, a new olivacine derivative.

Guilbaud N, Kraus-Berthier L, Saint-Dizier D, Rouillon MH, Jan M, Burbridge M, Visalli M, Bisagni E, Pierré A, Atassi G.

Cancer Chemother Pharmacol. 1996;38(6):513-21.

PMID:
8823492
29.

Ligand-induced formation of hoogsteen-paired parallel DNA.

Escudé C, Mohammadi S, Sun JS, Nguyen CH, Bisagni E, Liquier J, Taillandier E, Garestier T, Hélène C.

Chem Biol. 1996 Jan;3(1):57-65.

30.

A new series of pyridinone derivatives as potent non-nucleoside human immunodeficiency virus type 1 specific reverse transcriptase inhibitors.

Dollé V, Fan E, Nguyen CH, Aubertin AM, Kirn A, Andreola ML, Jamieson G, Tarrago-Litvak L, Bisagni E.

J Med Chem. 1995 Nov 10;38(23):4679-86.

PMID:
7473595
31.

Localized chemical reactivity in double-stranded DNA associated with the intercalative binding of benzo[e]pyridoindole and benzo[g]pyridoindole triple-helix-stabilizing ligands.

Bailly C, Marchand C, Hung Nguyen C, Bisagni E, Garestier T, Hélène C, Waring MJ.

Eur J Biochem. 1995 Aug 15;232(1):66-76.

32.

Synthesis and biological evaluation of amino-substituted benzo[f]pyrido[4,3-b] and pyrido[3,4-b]quinoxalines: a new class of antineoplastic agents.

Nguyen CH, Fan E, Riou JF, Bissery MC, Vrignaud P, Lavelle F, Bisagni E.

Anticancer Drug Des. 1995 Jun;10(4):277-97.

PMID:
7786395
33.

Triple-helix specific ligands stabilize H-DNA conformation.

Duval-Valentin G, de Bizemont T, Takasugi M, Mergny JL, Bisagni E, Hélène C.

J Mol Biol. 1995 Apr 14;247(5):847-58.

PMID:
7723037
34.

Reaction of a biscationic distamycin-ellipticine hybrid ligand with DNA. Mode and sequence specificity of binding.

Bailly C, Michaux C, Colson P, Houssier C, Sun JS, Garestier T, Hélène C, Hénichart JP, Rivalle C, Bisagni E, et al.

Biochemistry. 1994 Dec 27;33(51):15348-64.

PMID:
7803398
35.

Synthesis and evaluation of 9-hydroxy-5-methyl-(and 5,6-dimethyl)-6H-pyrido[4,3-b]carbazole-1-N- [(dialkylamino)alkyl]carboxamides, a new promising series of antitumor olivacine derivatives.

Jasztold-Howorko R, Landras C, Pierré A, Atassi G, Guilbaud N, Kraus-Berthier L, Léonce S, Rolland Y, Prost JF, Bisagni E.

J Med Chem. 1994 Jul 22;37(15):2445-52.

PMID:
8057291
36.

Synthesis and biological properties of new benz[h]isoquinoline derivatives.

Janin YL, Carrez D, Riou JF, Bisagni E.

Chem Pharm Bull (Tokyo). 1994 Apr;42(4):892-5.

PMID:
8020124
37.

Photosensitized cross-linking and cleavage of pBR322 and M13 DNA: comparison of 4,4',6-trimethylangelicin and 3-carbethoxypsoralen.

Chen X, Kagan J, Miolo G, Dall'Acqua F, Averbeck D, Bisagni E.

J Photochem Photobiol B. 1994 Jan;22(1):51-7.

PMID:
8151456
38.

Intoplicine (RP 60475) and its derivatives, a new class of antitumor agents inhibiting both topoisomerase I and II activities.

Riou JF, Fossé P, Nguyen CH, Larsen AK, Bissery MC, Grondard L, Saucier JM, Bisagni E, Lavelle F.

Cancer Res. 1993 Dec 15;53(24):5987-93.

PMID:
8261412
39.

Two-photon ionisation of the antitumor drug pazelliptine (BD40) by 355 nm laser photolysis.

Fontaine-Aupart MP, Frejacques M, Renault E, Ferradini C, Gardes-Albert M, Hickel B, Rivalle C, Bisagni E.

J Photochem Photobiol B. 1993 Dec;21(2-3):203-9.

PMID:
8301416
41.

Synthesis and evaluation of new 6-amino-substituted benzo[c]phenanthridine derivatives.

Janin YL, Croisy A, Riou JF, Bisagni E.

J Med Chem. 1993 Nov 12;36(23):3686-92.

PMID:
8246238
42.

Antitumor activity of intoplicine (RP 60475, NSC 645008), a new benzo-pyrido-indole: evaluation against solid tumors and leukemias in mice.

Bissery MC, Nguyen CH, Bisagni E, Vrignaud P, Lavelle F.

Invest New Drugs. 1993 Nov;11(4):263-77.

PMID:
8157469
43.
44.

Binding to DNA, cellular uptake and biological activity of a distamycin-ellipticine hybrid molecule.

Bailly C, Leclere V, Pommery N, Colson P, Houssier C, Rivalle C, Bisagni E, Hénichart JP.

Anticancer Drug Des. 1993 Apr;8(2):145-64.

PMID:
8494604
45.

Binding of a distamycin-ellipticine hybrid molecule to DNA and chromatin: spectroscopic, biochemical, and molecular modeling investigations.

Bourdouxhe C, Colson P, Houssier C, Sun JS, Montenay-Garestier T, Hélène C, Rivalle C, Bisagni E, Waring MJ, Hénichart JP, et al.

Biochemistry. 1992 Dec 15;31(49):12385-96.

PMID:
1463725
46.

Synthesis of psoralens and analogues.

Bisagni E.

J Photochem Photobiol B. 1992 Jun 30;14(1-2):23-46. Review.

PMID:
1432382
47.

Triple helix-specific ligands.

Mergny JL, Duval-Valentin G, Nguyen CH, Perrouault L, Faucon B, Rougée M, Montenay-Garestier T, Bisagni E, Hélène C.

Science. 1992 Jun 19;256(5064):1681-4.

PMID:
1609278
48.

Synthesis and antitumor properties of new 4-methyl-substituted- pyrido[4,3-b]indoles (gamma-carbolines).

Nguyen CH, Bisagni E, Lavelle F, Bissery MC, Huel C.

Anticancer Drug Des. 1992 Jun;7(3):219-33.

PMID:
1610481
49.

Further SAR in the new antitumor 1-amino-substituted gamma-carbolines and 5H-benzo[e]pyrido[4,3-b]indoles series.

Nguyen CH, Lavelle F, Riou JF, Bissery MC, Huel C, Bisagni E.

Anticancer Drug Des. 1992 Jun;7(3):235-51.

PMID:
1319166
50.

DNA-binding properties of a distamycin-ellipticine hybrid molecule.

Bailly C, O'Huigin C, Houssin R, Colson P, Houssier C, Rivalle C, Bisagni E, Henichart JP, Waring MJ.

Mol Pharmacol. 1992 May;41(5):845-55.

PMID:
1588919

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